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    DEVELOPMENT OF DENGUE VIRUS VACCINE COMPONENTS
    43.
    发明申请
    DEVELOPMENT OF DENGUE VIRUS VACCINE COMPONENTS 有权
    登革热疫苗组分的研制

    公开(公告)号：US20100104598A1

    公开(公告)日：2010-04-29

    申请号：US12376756

    申请日：2007-08-15

    申请人： Stephen S. Whitehead ,  Joseph E. Blaney ,  Brian R. Murphy

    发明人： Stephen S. Whitehead ,  Joseph E. Blaney ,  Brian R. Murphy

    IPC分类号： A61K39/12 ,  C07H21/04 ,  C12N7/01 ,  A61P31/12

    CPC分类号： C12N7/045 ,  A61K2039/5254 ,  C07K14/005 ,  C07K14/1825 ,  C12N7/00 ,  C12N2770/24122 ,  C12N2770/24162 ,  Y02A50/386

    摘要： The invention is related to a dengue virus or chimeric dengue virus that contains a mutation in the 3′ untranslated region (3′-UTR) comprising a Δ30 mutation that removes the TL-2 homologous structure in each of the dengue virus serotypes 1, 2, 3, and 4, and nucleotides additional to the Δ30 mutation deleted from the 3′-UTR that removes sequence in the 5′ direction as far as the 5′ boundary of the TL-3 homologous structure in each of the dengue virus serotypes 1, 2, 3, and 4, or a replacement of the 3′-UTR of a dengue virus of a first serotype with the 3′-UTR of a dengue virus of a second serotype, optionally containing the Δ30 mutation and nucleotides additional to the Δ30 mutation deleted from the 3′-UTR; and immunogenic compositions, methods of inducing an immune response, and methods of producing a dengue virus or chimeric dengue virus.

    摘要翻译： 本发明涉及在3'非翻译区（3'-UTR）中含有突变的登革热病毒或嵌合登革热病毒，其包含在每个登革热病毒血清型1中除去TL-2同源结构的＆Dgr 30突变 ，2,3和4，以及从3'-UTR缺失的＆Dgr 30突变体附加的核苷酸，其去除在5'方向上的序列，直到每个的TL-3同源结构的5'边界 登革热病毒血清型1,2,3和4，或用第二血清型登革病毒的3'-UTR替换第一血清型登革病毒的3'-UTR，任选含有'Dgr 30 来自3'-UTR缺失的＆Dgr 30突变的突变和核苷酸; 和免疫原性组合物，诱导免疫应答的方法，以及产生登革热病毒或嵌合登革病毒的方法。

    Detection of boilerplate content
    45.
    发明授权
    Detection of boilerplate content 有权
    检测样板内容

    公开(公告)号：US08898296B2

    公开(公告)日：2014-11-25

    申请号：US13564034

    申请日：2012-08-01

    申请人： Jian Zeng ,  Youlin Li ,  Brian R. Murphy ,  Yuzhu Shen

    发明人： Jian Zeng ,  Youlin Li ,  Brian R. Murphy ,  Yuzhu Shen

    IPC分类号： G06F15/173 ,  G06F17/30

    CPC分类号： G06F17/30864

    摘要： Methods, systems, and apparatus, including computer programs encoded on computer storage media, for generating query recommendations. One method provides selecting one or more nodes of an object model that models a resource as a hierarchy of nodes, and determining that the selected nodes exhibit one or more predefined traits that are characteristic of boilerplate content, wherein boilerplate content comprises content that is repeated in multiple resources of a particular web site or content which is not relevant to the main content of a resource. A score associated with the selected nodes is adjusted responsive to determining that the selected nodes exhibit the predefined traits, and information is provided to a query recommendation engine, the information including textual content associated with the selected nodes, and the information identifying the adjusted score associated with the selected nodes.

    摘要翻译： 方法，系统和装置，包括在计算机存储介质上编码的计算机程序，用于产生查询建议。 一种方法提供选择将资源建模为节点层级的对象模型的一个或多个节点，并且确定所选择的节点表现出一个或多个具有样板内容特性的预定义特征，其中，样板内容包括在 特定网站的多个资源或与资源的主要内容无关的内容。 响应于确定所选择的节点呈现预定特征而调整与所选择的节点相关联的分数，并且向查询推荐引擎提供信息，所述信息包括与所选择的节点相关联的文本内容，以及标识相关调整分数的信息 与选定的节点。

    Development of dengue virus vaccine components
    46.
    发明授权
    Development of dengue virus vaccine components 有权
    发展登革热病毒疫苗组件

    公开(公告)号：US08337860B2

    公开(公告)日：2012-12-25

    申请号：US12376756

    申请日：2007-08-15

    申请人： Stephen S. Whitehead ,  Joseph E. Blaney ,  Brian R. Murphy

    发明人： Stephen S. Whitehead ,  Joseph E. Blaney ,  Brian R. Murphy

    IPC分类号： A61K39/12 ,  A61K39/295 ,  A61K48/00 ,  C12N7/01 ,  C12N7/04 ,  C12N15/40 ,  C12N15/83

    CPC分类号： C12N7/045 ,  A61K2039/5254 ,  C07K14/005 ,  C07K14/1825 ,  C12N7/00 ,  C12N2770/24122 ,  C12N2770/24162 ,  Y02A50/386

    摘要： The invention is related to a dengue virus or chimeric dengue virus that contains a mutation in the 3′ untranslated region (3′-UTR) comprising a Δ30 mutation that removes the TL-2 homologous structure in each of the dengue virus serotypes 1, 2, 3, and 4, and nucleotides additional to the Δ30 mutation deleted from the 3′-UTR that removes sequence in the 5′ direction as far as the 5′ boundary of the TL-3 homologous structure in each of the dengue virus serotypes 1, 2, 3, and 4, or a replacement of the 3′-UTR of a dengue virus of a first serotype with the 3′-UTR of a dengue virus of a second serotype, optionally containing the Δ30 mutation and nucleotides additional to the Δ30 mutation deleted from the 3′-UTR; and immunogenic compositions, methods of inducing an immune response, and methods of producing a dengue virus or chimeric dengue virus.

    摘要翻译： 本发明涉及在3'非翻译区（3'-UTR）中含有突变的登革热病毒或嵌合登革热病毒，其包含在每个登革热病毒血清型1中除去TL-2同源结构的＆Dgr 30突变 ，2,3和4，以及从3'-UTR缺失的＆Dgr 30突变体附加的核苷酸，其去除在5'方向上的序列，直到每个的TL-3同源结构的5'边界 登革热病毒血清型1,2,3和4，或用第二血清型登革病毒的3'-UTR替换第一血清型登革病毒的3'-UTR，任选含有'Dgr 30 来自3'-UTR缺失的＆Dgr 30突变的突变和核苷酸; 和免疫原性组合物，诱导免疫应答的方法，以及产生登革热病毒或嵌合登革病毒的方法。

    DETECTION OF BOILERPLATE CONTENT
    47.
    发明申请
    DETECTION OF BOILERPLATE CONTENT 有权
    检测锅炉内容物

    公开(公告)号：US20120297025A1

    公开(公告)日：2012-11-22

    申请号：US13564034

    申请日：2012-08-01

    申请人： Jian Zeng ,  Youlin Li ,  Brian R. Murphy ,  Yuzhu Shen

    发明人： Jian Zeng ,  Youlin Li ,  Brian R. Murphy ,  Yuzhu Shen

    IPC分类号： G06F15/16

    CPC分类号： G06F17/30864

    摘要： Methods, systems, and apparatus, including computer programs encoded on computer storage media, for generating query recommendations. One method provides selecting one or more nodes of an object model that models a resource as a hierarchy of nodes, and determining that the selected nodes exhibit one or more predefined traits that are characteristic of boilerplate content, wherein boilerplate content comprises content that is repeated in multiple resources of a particular web site or content which is not relevant to the main content of a resource. A score associated with the selected nodes is adjusted responsive to determining that the selected nodes exhibit the predefined traits, and information is provided to a query recommendation engine, the information including textual content associated with the selected nodes, and the information identifying the adjusted score associated with the selected nodes.

    摘要翻译： 方法，系统和装置，包括在计算机存储介质上编码的计算机程序，用于产生查询建议。 一种方法提供选择将资源建模为节点层级的对象模型的一个或多个节点，并且确定所选择的节点表现出一个或多个具有样板内容特性的预定义特征，其中，样板内容包括在 特定网站的多个资源或与资源的主要内容无关的内容。 响应于确定所选择的节点呈现预定特征而调整与所选择的节点相关联的分数，并且向查询推荐引擎提供信息，所述信息包括与所选择的节点相关联的文本内容，以及标识相关调整分数的信息 与选定的节点。