公开(公告)号：US08538517B2

公开(公告)日：2013-09-17

申请号：US13618739

申请日：2012-09-14

申请人： Arkady Glukhovsky ,  Yitzhak Zilberman ,  Arthur Prochazka ,  Mark Chamberlain ,  Ross Davis ,  Joseph Schulman

发明人： Arkady Glukhovsky ,  Yitzhak Zilberman ,  Arthur Prochazka ,  Mark Chamberlain ,  Ross Davis ,  Joseph Schulman

IPC分类号： A61N1/00

CPC分类号： A61N1/05 ,  A61N1/0456 ,  A61N1/0551 ,  A61N1/36017 ,  A61N1/36021 ,  A61N1/36071

摘要： The present invention provides improvements to an implant, system and method using passive electrical conductors which route electrical current to either external or implanted electrical devices, to multiple target body tissues and to selective target body tissues. The passive electrical conductor extends from subcutaneous tissue located below either a surface cathodic electrode or a surface anodic electrode a) to a target tissue to route electrical signals from the target body tissue to devices external to the body; b) to implanted electrical devices to deliver electrical current to such devices, or c) to multiple target body tissues or to selective target body tissues to stimulate the target body tissues. The conductor has specialized ends for achieving such purposes.

摘要翻译： 本发明提供对使用无源电导体的植入物，系统和方法的改进，所述无源电导体将电流传送到外部或植入的电气装置，多个靶体组织和选择性靶体组织。 无源电导体从位于表面阴极电极或表面阳极电极a）下方的皮下组织延伸到目标组织，以将电信号从目标体组织传递到身体外部的装置; b）植入电气装置以将电流传递到这种装置，或c）到多个靶体组织或选择性靶组织以刺激靶体组织。 导体具有实现此目的的专门目的。

公开(公告)号：US08368770B2

公开(公告)日：2013-02-05

申请号：US13424684

申请日：2012-03-20

申请人： Arkady Glukhovsky ,  Gavriel Meron ,  Doron Adler ,  Ofra Zinati ,  Jerome Avron

发明人： Arkady Glukhovsky ,  Gavriel Meron ,  Doron Adler ,  Ofra Zinati ,  Jerome Avron

IPC分类号： H04N5/225

CPC分类号： A61B1/045 ,  A61B1/00002 ,  A61B1/00006 ,  A61B1/00009 ,  A61B1/00016 ,  A61B1/00036 ,  A61B1/00045 ,  A61B1/00055 ,  A61B1/00158 ,  A61B1/041 ,  A61B5/0031 ,  A61B5/076 ,  A61B8/0841 ,  A61B2560/0209 ,  H04N5/232 ,  H04N5/77 ,  H04N5/772 ,  H04N5/783 ,  H04N7/18

摘要： An in-vivo imaging device including a camera may include a frame storage device. Systems and methods which vary the frame capture rate of the camera and/or frame display rate of the display unit of in-vivo camera systems are discussed. The capture rate is varied based on physical measurements related to the motion of the camera. Alternatively, the frame capture rate is varied based on comparative image processing of a plurality of frames. The frame display rate of the system is varied based on comparative image processing of a multiplicity of frames. Both the frame capture and the frame display rates of such systems can be varied concurrently.

摘要翻译： 包括相机的体内成像装置可以包括帧存储装置。 讨论了改变摄像机的帧捕获速率和/或体内相机系统的显示单元的帧显示速率的系统和方法。 捕获率根据与相机运动相关的物理测量而变化。 或者，基于多个帧的比较图像处理来改变帧捕获率。 基于多个帧的比较图像处理来改变系统的帧显示速率。 这种系统的帧捕获和帧显示速率可以同时变化。

公开(公告)号：US08216130B2

公开(公告)日：2012-07-10

申请号：US12854483

申请日：2010-08-11

申请人： Arkady Glukhovsky ,  Mordechsi Frisch ,  Tal Davidson ,  Gavriel Meron

发明人： Arkady Glukhovsky ,  Mordechsi Frisch ,  Tal Davidson ,  Gavriel Meron

IPC分类号： A61B1/04

CPC分类号： A61B1/041 ,  A61B1/00016 ,  A61B1/00036 ,  A61B1/00055 ,  A61B1/04 ,  A61B5/073 ,  A61B5/14539 ,  A61B2560/0209

摘要： A device, system and method for selectively activating or altering the operational mode of an autonomous in vivo device in response to in vivo conditions. They system may include an in vivo sensing device with a condition tester, and a controller. The in vivo sensing device may be in communications with an external receiver. The condition tester may include at least one layer of a dissolvable material coated on at least a portion of the autonomous device. The layer may dissolve when exposed to a specific material of a specified site along the GI tract. A sensor may be exposed when the layer dissolves or a switch autonomously activated with the layer dissolves.

摘要翻译： 一种用于响应于体内条件选择性地激活或改变自主体内器械的操作模式的装置，系统和方法。 它们的系统可以包括具有条件测试器的体内感测装置和控制器。 体内感测装置可以与外部接收器通信。 条件测试器可以包括涂覆在自主装置的至少一部分上的至少一层可溶解材料。 暴露于胃肠道指定部位的特定材料时，该层可能会溶解。 当层溶解时，传感器可能被暴露，或者在层被溶解时自主激活的开关。

公开(公告)号：US07813789B2

公开(公告)日：2010-10-12

申请号：US11221841

申请日：2005-09-09

申请人： Arkady Glukhovsky

发明人： Arkady Glukhovsky

IPC分类号： A61B6/00

CPC分类号： A61B1/041 ,  A61B1/00096 ,  A61B1/05 ,  A61B1/0676 ,  A61B1/0684

摘要： An in-vivo device may include an optical system, and a method for viewing in-vivo sites. A dome or cover may cover an end of the device, protecting optical elements such as illumination devices or imagers, which may be behind the dome. The dome may be forward projecting and may have a convex shape. The field of view of the imager may be for example forward looking. Illumination element(s) and a receiving unit or imager may be disposed behind a single optical window, which for example may enable obtaining of images free of backscatter and stray light. The convex shape of the dome may be defined such that it may have a shape having an isolated area. At least one illumination element and at least one receiving unit may be geometrically positioned (for example in the isolated area) such that rays from the illumination elements, some of which are internally reflected from the internal and/or external surface of the optical window, will not be incident on the receiving unit.

摘要翻译： 体内装置可以包括光学系统和用于观察体内部位的方法。 圆顶或盖可以覆盖设备的一端，保护可能在圆顶后面的诸如照明设备或成像器的光学元件。 圆顶可以是向前突出的并且可以具有凸形。 成像器的视野可以是例如向前看。 照明元件和接收单元或成像器可以设置在单个光学窗口的后面，这例如可以使得能够获得没有反向散射和杂散光的图像。 圆顶的凸形可以被限定为具有隔离区域的形状。 至少一个照明元件和至少一个接收单元可以被几何地定位（例如在隔离区域中），使得来自照明元件的射线，其中一些照明元件的一部分从光学窗口的内部和/或外部表面内部反射， 不会在接收单元发生事故。

公开(公告)号：US07664174B2

公开(公告)日：2010-02-16

申请号：US10551436

申请日：2004-03-29

申请人： Dov Avni ,  Gavriel Meron ,  Eli Horn ,  Ofra Zinaty ,  Arkady Glukhovsky

发明人： Dov Avni ,  Gavriel Meron ,  Eli Horn ,  Ofra Zinaty ,  Arkady Glukhovsky

IPC分类号： H04N7/12 ,  H04N11/02 ,  H04N11/04 ,  H04B1/66

CPC分类号： A61B1/041 ,  A61B1/00016 ,  H04N5/3456 ,  H04N19/59

摘要： A device, system and method may enable the obtaining of in vivo images from within body lumens or cavities, such as images the gastrointestinal (GI) tract, where the data such as image data is typically transmitted or otherwise sent to a receiving system in compressed or diluted form. The image may be reconstructed and for example displayed to a user.

摘要翻译： 装置，系统和方法可以使得能够从体腔或空腔（例如胃肠道（GI））的图像中获得体内图像，其中诸如图像数据的数据通常被传送或以其他方式发送到压缩的接收系统 或稀释形式。 图像可以被重建并且例如显示给用户。

公开(公告)号：US07604589B2

公开(公告)日：2009-10-20

申请号：US10950694

申请日：2004-09-28

申请人： Arkady Glukhovsky ,  Gavriel Meron ,  Alex Blijevsky

发明人： Arkady Glukhovsky ,  Gavriel Meron ,  Alex Blijevsky

IPC分类号： A61B1/00

CPC分类号： A61B1/041

摘要： A system and method may determine the orientation of an in-vivo imaging device relative to the earth's gravitation field. Some embodiments may enable indication of specific locations where other methods provide non-satisfactory imaging coverage. The system may include an in-vivo imaging system with a container or shell containing an orientation object. The container may be placed in at least one optical dome or optical field of an in-vivo imaging device, such as an autonomous capsule. The location of the orientation object's image on the in-vivo imaging device imager, as well as size of the image, may be determined as functions of the location of the orientation object inside the container, for each image acquired.

摘要翻译： 系统和方法可以确定体内成像装置相对于地球引力场的取向。 一些实施例可以使得能够指示其他方法提供不令人满意的成像覆盖的特定位置。 该系统可以包括体内成像系统，其具有包含取向对象的容器或壳体。 容器可以放置在诸如自主胶囊的体内成像装置的至少一个光学圆顶或光学领域中。 定向对象的图像在体内成像装置成像器上的位置以及图像的尺寸可以被确定为对于所获取的每个图像的容器内的取向对象的位置的函数。

公开(公告)号：US07561908B2

公开(公告)日：2009-07-14

申请号：US11140291

申请日：2005-05-31

申请人： Arkady Glukhovsky ,  Baruch Erlich

发明人： Arkady Glukhovsky ,  Baruch Erlich

IPC分类号： A61B5/05 ,  A61B6/00

CPC分类号： H04W52/06 ,  A61B1/00016 ,  A61B1/00036 ,  A61B1/041 ,  A61B5/0031 ,  A61B5/01 ,  A61B5/073 ,  A61B5/14539 ,  A61B2017/00137 ,  A61B2560/0209 ,  H04W52/08 ,  H04W52/10

摘要： A device and system enables obtaining data such as in vivo images from within body lumens or cavities, such as images of the gastrointestinal (GI) tract. A device may include an imaging system and a radio frequency (RF) transmitter for transmitting signals from an imaging device to a receiving system. The signal strength of the transmitter may be varied or changed to account for, for example, the amount of signal attenuation resulting from body tissues.

摘要翻译： 装置和系统能够从体腔或空腔（例如胃肠道（GI））的图像中获得诸如体内图像的数据。 设备可以包括成像系统和用于将信号从成像设备传输到接收系统的射频（RF）发射机。 发射机的信号强度可以改变或改变，以解决例如由身体组织引起的信号衰减的量。

公开(公告)号：US07548263B2

公开(公告)日：2009-06-16

申请号：US10106817

申请日：2002-03-26

申请人： Dov Avni ,  Arkady Glukhovsky

发明人： Dov Avni ,  Arkady Glukhovsky

IPC分类号： H04N9/64 ,  H04N7/18

摘要： An imaging device having an in vivo CMOS image sensor, at least one illumination source and a controller. The controller controls the illumination source to illuminate for a first period and to be shut off for a subsequent period.

公开(公告)号：US20090054952A1

公开(公告)日：2009-02-26

申请号：US12197849

申请日：2008-08-25

申请人： Arkady Glukhovsky ,  Kevin Wilkin ,  John Gord ,  Einan Regev

发明人： Arkady Glukhovsky ,  Kevin Wilkin ,  John Gord ,  Einan Regev

IPC分类号： A61N1/36 ,  A61N1/02

CPC分类号： A61N1/36017 ,  A61N1/36021 ,  A61N1/3625 ,  A61N1/3756

摘要： In some embodiments, an apparatus includes a substrate, a power source, a connector, electrical circuitry, and an electrode assembly. The substrate has a first surface and a second surface different than the first surface. The power source has a positive terminal and a negative terminal Each of the positive terminal and the negative terminal are coupled to the substrate. The power source is configured to provide power to an external stimulator coupled to the apparatus. The connector is disposed proximate to the first surface of the substrate and is electrically coupled to at least one of the positive terminal and the negative terminal of the power source. The connector is configured to electrically couple the external stimulator to the power source. The electrical circuitry is coupled to the substrate. The electrical circuitry is configured to electrically couple the connector to at least one of the positive terminal and the negative terminal of the power source. At least one of the connector or the electrical circuitry is configured to prevent a short circuit of the electrical circuit. The electrode assembly is coupled to the second surface of the substrate. At least one electrode of the electrode assembly is configured to contact bodily tissue and to facilitate transmission of an electrical current through the bodily tissue.

摘要翻译： 在一些实施例中，装置包括基板，电源，连接器，电路和电极组件。 基板具有与第一表面不同的第一表面和第二表面。 电源具有正极端子和负极端子正极端子和负极端子各自耦接到基板。 电源被配置为向耦合到该设备的外部刺激器提供电力。 连接器设置在基板的第一表面附近并且电耦合到电源的正极端子和负极端子中的至少一个。 连接器被配置为将外部刺激器电耦合到电源。 电路耦合到衬底。 电路被配置为将连接器电耦合到电源的正极端子和负极端子中的至少一个。 连接器或电路中的至少一个被配置为防止电路的短路。 电极组件耦合到衬底的第二表面。 电极组件的至少一个电极构造成接触身体组织并且促进电流通过身体组织的传播。

公开(公告)号：US07492935B2

公开(公告)日：2009-02-17

申请号：US10875517

申请日：2004-06-25

申请人： Arkady Glukhovsky

发明人： Arkady Glukhovsky

IPC分类号： G06K9/00

CPC分类号： A61B1/041 ,  A61B1/04 ,  A61B5/0031 ,  G06F19/00 ,  H04N19/507

摘要： An in-vivo device, system, and method are described where an in-vivo device may transmit an image stream to an external receiving device. Reducing the size of the image data necessary for transmission may conserve energy consumed by the in-vivo device during transmission. An image data comparator unit incorporated within the in-vivo device may compare a captured image to a previously transmitted image and transmit, for example, only captured images that are substantially dissimilar to a previously captured image.

摘要翻译： 描述了体内装置，系统和方法，其中体内装置可将图像流传输到外部接收装置。 减少传输所需的图像数据的大小可以节省在传输期间由体内装置消耗的能量。 结合在体内装置中的图像数据比较器单元可以将捕获的图像与先前发送的图像进行比较，并且例如仅传送与先前捕获的图像基本不相似的捕获图像。