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    Novel tumor antigen useful in diagnosis and therapy of prostate and colon cancer
    49.
    发明申请
    Novel tumor antigen useful in diagnosis and therapy of prostate and colon cancer 审中-公开
    用于诊断和治疗前列腺癌和结肠癌的新型肿瘤抗原

    公开(公告)号：US20060275304A1

    公开(公告)日：2006-12-07

    申请号：US11200973

    申请日：2005-08-09

    申请人： Daniel Afar ,  Rene Hubert ,  Kahan Leong ,  Arthur Raitano ,  Douglas Saffran ,  Stephen Mitchell

    发明人： Daniel Afar ,  Rene Hubert ,  Kahan Leong ,  Arthur Raitano ,  Douglas Saffran ,  Stephen Mitchell

    IPC分类号： A61K39/395 ,  C12Q1/68 ,  C07H21/04 ,  C12P21/06 ,  C07K16/30 ,  C07K14/82 ,  C07K16/46

    CPC分类号： C07K16/40 ,  A61K38/00 ,  C12N9/6421

    摘要： Compositions for the diagnosis and therapy of prostate and colon cancer, derived from or based on a novel prostate-specific, androgen-regulated, cell surface serine protease termed 20P1F12/TMPRSS2 are described. A full length cDNA comprising the entire coding sequence of the 20P1F12/TMPRSS2 gene (also designated 20P1F12-GTC1 herein) is provided (FIG. 1). Among the compositions provides are antibodies that bind to 20P1F12/TMPRSS2 proteins and polypeptide fragments thereof, including antibodies labeled with a detectable marker or toxin or therapeutic composition. Several monoclonal antibodies specifically reactive with 20P1F12/TMPRSS2 are also described herein.

    摘要翻译： 描述了源自或基于称为20P1F12 / TMPRSS2的新型前列腺特异性，雄激素调节的细胞表面丝氨酸蛋白酶的前列腺和结肠癌的诊断和治疗的组合物。 提供了包含20P1F12 / TMPRSS2基因（本文中也称为20P1F12-GTC1）的整个编码序列的全长cDNA（图1）。 组合物中提供的是与20P1F12 / TMPRSS2蛋白及其多肽片段结合的抗体，包括用可检测标记或毒素或治疗组合物标记的抗体。 本文还描述了与20P1F12 / TMPRSS2特异性反应的几种单克隆抗体。

    Novel serpentine transmembrane antigens expressed in human cancers and uses thereof
    50.
    发明申请
    Novel serpentine transmembrane antigens expressed in human cancers and uses thereof 有权
    在人类癌症中表达的新型蛇纹石跨膜抗原及其用途

    公开(公告)号：US20050202454A1

    公开(公告)日：2005-09-15

    申请号：US10858887

    申请日：2004-06-01

    申请人： Daniel Afar ,  Rene Hubert ,  Kahan Leong ,  Arthur Raitano ,  Douglas Saffran ,  Stephen Mitchell

    发明人： Daniel Afar ,  Rene Hubert ,  Kahan Leong ,  Arthur Raitano ,  Douglas Saffran ,  Stephen Mitchell

    IPC分类号： G01N33/574 ,  A61K38/00 ,  A61K39/395 ,  A61P35/00 ,  C07K14/47 ,  C07K14/705 ,  C07K16/18 ,  C12N5/10 ,  C12N15/09 ,  C12P21/00 ,  C12P21/08 ,  C12Q1/68 ,  C07H21/04 ,  C07K14/82 ,  C07K16/30

    CPC分类号： C07K14/4748 ,  C07K14/705 ,  C07K14/723 ,  C07K16/28 ,  C07K16/3069 ,  C07K2317/34 ,  C07K2319/00 ,  Y10T436/143333

    摘要： Described is a novel family of cell surface serpentine transmembrane antigens. Two of the proteins in this family are exclusively or predominantly expressed in the prostate, as well as in prostate cancer, and thus members of this family have been termed “STRAP” (Serpentine TRansmembrane Antigens of the Prostate). Four particular human STRAPs are described and characterized herein. The human STRAPs exhibit a high degree of structural conservation among them but show no significant structural homology to any known human proteins. The prototype member of the STRAP family, STRAP-1, appears to be a type IIIa membrane protein expressed predominantly in prostate cells in normal human tissues. Structurally, STRAP-1 is a 339 amino acid protein characterized by a molecular topology of six transmembrane domains and intracellular N- and C-termini, suggesting that it folds in a “serpentine” manner into three extracellular and two intracellular loops. STRAP-1 protein expression is maintained at high levels across various stages of prostate cancer. Moreover, STRAP-1 is highly over-expressed in certain other human cancers.

    摘要翻译： 描述了一种新型的细胞表面蛇纹石跨膜抗原家族。 这个家族中的两个蛋白质完全或主要地在前列腺中表达，也是在前列腺癌中，因此这个家族的成员被称为“前列腺的蛇纹石逆转膜抗原”。 本文描述和表征了四种特定的人类STRAP。 人类STRAP在其中表现出高度的结构保守性，但与任何已知的人类蛋白质没有显着的结构同源性。 STRAP家族STRAP-1的原型成员似乎是主要在正常人体组织中的前列腺细胞中表达的IIIa型膜蛋白。 在结构上，STRAP-1是一种339个氨基酸的蛋白质，其特征在于六个跨膜结构域和细胞内N-和C-末端的分子拓扑结构，表明它以“蛇纹石”的方式折叠成三个胞外和两个细胞内环。 STRAP-1蛋白表达在前列腺癌的各个阶段保持在高水平。 此外，STRAP-1在某些其他人类癌症中高度过度表达。