公开(公告)号：US6113795A

公开(公告)日：2000-09-05

申请号：US193660

申请日：1998-11-17

申请人： Bala Subramaniam ,  Roger A. Rajewski ,  David J. Bochniak

发明人： Bala Subramaniam ,  Roger A. Rajewski ,  David J. Bochniak

IPC分类号： B01D11/04 ,  B01D61/14 ,  C30B7/00 ,  B01D61/00

CPC分类号： B01D11/0407 ,  B01D61/14 ,  C30B29/605 ,  C30B7/00

摘要： Processes and apparatuses are provided for continuously harvesting particles from organic solution-laden near-critical and supercritical fluids. Broadly, the processes and apparatuses utilize a filter or separator comprising a thin membrane supported on a sintered stainless steel tube. A feed stream comprising the desired particles, a supercritical antisolvent for the particles (preferably CO.sub.2), and a solvent for the particles, is contacted with the membrane layer of the filter under supercritical conditions for the mixture of antisolvent and solvent. The preferred antisolvents are substantially miscible with the solvent and have a critical temperature of less than 160.degree. C. The desired particles are retained by the filter while the solvent and most of the antisolvent pass through the filter, resulting in separation of the particles from the solvent.

摘要翻译： 提供了从有机溶液附近临界和超临界流体中连续收集颗粒的方法和装置。 广泛地，该方法和设备利用一种过滤器或分离器，其包括负载在烧结的不锈钢管上的薄膜。 包含所需颗粒的进料流，用于颗粒的超临界反溶剂（优选CO 2）和颗粒的溶剂在超临界条件下与反应溶剂和溶剂的混合物与过滤器的膜层接触。 优选的反溶剂与溶剂基本上是可混溶的并且具有小于160℃的临界温度。所需的颗粒被过滤器保留，而溶剂和大部分反溶剂通过过滤器，导致颗粒从 溶剂。

公开(公告)号：US5833891A

公开(公告)日：1998-11-10

申请号：US805215

申请日：1997-02-27

申请人： Bala Subramaniam ,  Said Saim ,  Roger A. Rajewski ,  Valentino Stella

发明人： Bala Subramaniam ,  Said Saim ,  Roger A. Rajewski ,  Valentino Stella

IPC分类号： A61K9/16 ,  A61K9/50 ,  B01J2/04 ,  B05D1/02 ,  B01D11/00

CPC分类号： A61K9/1676 ,  A61K9/1688 ,  B01J2/04 ,  B05D1/025 ,  A61K9/1694 ,  A61K9/5089 ,  B05D2401/90

摘要： Improved methods and apparatus for particle precipitation and coating using near- or supercritical fluid conditions are described. A fluid dispersion having a continuous phase dispersant and at least one precipitatable substance therein is contacted with a supercritical fluid (SCF) antisolvent so as to generate focused high frequency antisolvent sonic waves, breaking up the dispersion into extremely small droplets; the enhanced mass transfer rates between the droplets and the antisolvent causes precipitation of very small particles on the order of 0.1-10 .mu.m. In coating processes, a turbulent fluidized flow of core particles is created using an SCF antisolvent in an enclosed zone. The core particles are contacted therein at near- or supercritical conditions by a fluid dispersion containing a dispersant together with a precipitatable substance. The antisolvent depletes the dispersant and the substance is precipitated onto the fluidized core particles. In another aspect of the invention, a process for preparing and administering a medicament using only a single container is provided. In such method, a fluid dispersion having a dispersant with the medicament therein is contacted with an antisolvent at near- or supercritical conditions within a use container, so as to directly precipitate small particles of the medicament in the container. The antisolvent is then removed and the use container is sealed with the medicament particles therein. Thereafter, dose(s) of the medicament can be withdrawn from the use container and administered to a patient.

摘要翻译： 描述了使用近或超临界流体条件改进颗粒沉淀和涂层的方法和装置。 具有连续相分散剂和至少一种可沉淀物质的流体分散体与超临界流体（SCF）反溶剂接触，以产生聚焦的高频反溶剂声波，将分散体分解成极小的液滴; 液滴和抗溶剂之间的增强的传质速率导致非常小的颗粒的沉淀约0.1-10μm。 在涂覆过程中，使用封闭区域中的SCF反溶剂产生核心颗粒的湍流流化流。 核心颗粒在近或超临界条件下通过含有分散剂和可沉淀物质的流体分散体接触。 反溶剂消耗分散剂，物质沉淀在流化核心颗粒上。 在本发明的另一方面，提供了仅使用单一容器制备和施用药物的方法。 在这种方法中，将具有药物的分散剂的流体分散体与使用容器内的近临界或超临界条件下的反溶剂接触，从而将药物的小颗粒直接沉淀在容器中。 然后将抗溶剂除去，并将使用容器用其中的药物颗粒密封。 此后，药物的剂量可以从使用容器中取出并给予患者。

公开(公告)号：US5690809A

公开(公告)日：1997-11-25

申请号：US634293

申请日：1996-04-18

申请人： Bala Subramaniam ,  Said Saim ,  Michael C. Clark

发明人： Bala Subramaniam ,  Said Saim ,  Michael C. Clark

IPC分类号： B01J3/00 ,  C07C2/54 ,  C07C5/22 ,  C07C6/12 ,  C10G25/00 ,  C10G9/16

CPC分类号： B01J3/008 ,  C07C2/54 ,  C07C5/2206 ,  C07C5/226 ,  C07C6/12 ,  C10G25/00 ,  C07C2521/04 ,  C07C2523/42 ,  Y02P20/544 ,  Y10S585/95

摘要： An improved process is provided for in situ mitigation of coke buildup and porous catalyst used for the processing of hydrocarbon feed stocks. The process exhibits improved catalyst activity over extended periods and the process comprises the pretreatment of hydrocarbon feed stocks to reduce impurities in the feed stocks in the form of peroxides and oxygen compounds that promote the formation of coke precursors, which precursors are typically in the form of olefinic oligomers. The process includes contacting the pretreated feed stream with a suitable catalyst under sub-critical, near-critical and supercritical conditions.

摘要翻译： 提供了一种改进的方法，用于原位缓解用于加氢烃原料的焦炭积聚和多孔催化剂。 该方法在长时间内表现出改善的催化剂活性，并且该方法包括预处理烃原料以减少促进焦炭前体形成的过氧化物和氧化合物形式的原料中的杂质，该前体通常为 烯属低聚物。 该方法包括在亚临界，接近临界和超临界条件下使预处理的进料流与合适的催化剂接触。

公开(公告)号：US11870620B2

公开(公告)日：2024-01-09

申请号：US17646359

申请日：2021-12-29

申请人： Bala Subramaniam

发明人： Bala Subramaniam

IPC分类号： H04L27/01 ,  H04L25/03

CPC分类号： H04L27/01 ,  H04L25/03019 ,  H04L25/03891

摘要： A receiver and method for compensating for linear impairments at a receiver including receiving an Rx signal including an asymmetric response of a satellite filter; pre-equalizing the Rx signal with a coefficient; and demodulating, after the pre-equalizing, the Rx signal.

公开(公告)号：US10484136B2

公开(公告)日：2019-11-19

申请号：US15615358

申请日：2017-06-06

申请人： Sri Bhat ,  Bala Subramaniam ,  Yanlai Liu

发明人： Sri Bhat ,  Bala Subramaniam ,  Yanlai Liu

IPC分类号： H04L1/00 ,  G06F12/06 ,  G11C7/10 ,  G11C7/18 ,  H04L27/20

摘要： A deinterleaver device, a method for deinterleaving, an interleaver device, and a method for interleaving are provided. The method for deinterleaving includes: providing a memory and a stream count for a frame; virtually dividing the memory into equal sections, wherein a section count equals the stream count; calculating a write address for a sample of the samples based on a location of the sample in the frame and a correspondence of the location to one of the sections; receiving the sample; and writing the received sample to the write address, wherein the calculating and the write address corresponds to a correct deinterleaving location in one of the sections for the sample.

公开(公告)号：US20150191442A1

公开(公告)日：2015-07-09

申请号：US14409503

申请日：2013-06-27

申请人： Bala Subramaniam ,  Anand Ramanathan ,  Madhav Ghanta ,  Wenjuan Yan

发明人： Bala Subramaniam ,  Anand Ramanathan ,  Madhav Ghanta ,  Wenjuan Yan

IPC分类号： C07D301/19

CPC分类号： C07D301/19 ,  C07D301/12

摘要： A process for epoxidizing an olefin comprising contacting an olefin with an oxidant in the presence of an insoluble oxidation catalyst in a solvent system comprising an organic water-miscible solvent to form an alkylene oxide. The insoluble oxidation catalyst comprises a metal, preferably selected from the group consisting of tungsten, cerium, and niobium. The metal is directly incorporated within a solid mesoporous silicate support, such as one selected from the group consisting of KIT-5, KIT-6, and TUD-1.

摘要翻译： 一种使烯烃环氧化的方法，包括使烯烃与氧化剂在不溶性氧化催化剂存在下在包含有机水混溶性溶剂的溶剂体系中接触以形成烯化氧。 不溶性氧化催化剂包含优选选自钨，铈和铌的金属。 将金属直接掺入固体介孔硅酸盐载体中，例如选自KIT-5，KIT-6和TUD-1的一种。

公开(公告)号：US20110028773A1

公开(公告)日：2011-02-03

申请号：US12846407

申请日：2010-07-29

申请人： Bala Subramaniam ,  Jackson W. Ford ,  Raghunath V. Chaudhari

发明人： Bala Subramaniam ,  Jackson W. Ford ,  Raghunath V. Chaudhari

IPC分类号： C07C1/00

CPC分类号： C10G3/42 ,  C10G3/47 ,  C10G3/48 ,  C10G3/50 ,  C10G3/54 ,  C10G2300/1011 ,  C10G2300/4006 ,  C10G2300/4012 ,  C10G2300/4018 ,  C10G2300/44 ,  Y02P30/20

摘要： A process for the complete deoxygenation of an oxygenate, especially those from bio-oils comprises forming a reaction mixture comprising the oxygenate, molecular hydrogen, and a hydrodeoxygenation catalyst in a solvent. The reaction mixture is maintained at a temperature that is 0.7 to 1.3 times the solvent critical temperature in absolute temperature units (K). Complete deoxygenation occurs via a hydrodeoxygenation pathway and a decarbonylation pathway.

摘要翻译： 含氧化合物，特别是生物油完全脱氧的方法包括在溶剂中形成包含含氧化合物，分子氢和加氢脱氧催化剂的反应混合物。 将反应混合物保持在溶剂临界温度的绝对温度单位（K）的0.7至1.3倍的温度。 完全脱氧通过加氢脱氧途径和脱羰途径发生。

公开(公告)号：US20100331599A1

公开(公告)日：2010-12-30

申请号：US12797450

申请日：2010-06-09

申请人： Bala Subramaniam ,  Aaron Scurto ,  Shengwei Tang

发明人： Bala Subramaniam ,  Aaron Scurto ,  Shengwei Tang

IPC分类号： C07C2/58 ,  B01J37/30

CPC分类号： B01J31/0222 ,  B01J31/0239 ,  B01J31/0284 ,  B01J31/0285 ,  B01J31/0289 ,  C07C2/62 ,  C07C11/02

摘要： An alkylation catalyst can include: a Brønsted acid ionic liquid; and a strong Brønsted acid that is not considered an ionic liquid. The Brønsted acid ionic liquid can be selected from the group consisting of [BMIm]HSO4, [MBSIm]HSO4, [MBSIm]OTf, [MPSIm]OTf, and [OMIm]HSO4 or the like. In one aspect, the strong Brønsted acid is selected from the group consisting of sulfuric acid, hydrochloric acid (HCl), hydrobromic acid (HBr), HF, hydrogen iodide (HI), phosphoric acid, trifluoromethanesulfonic (triflic) acid. In one aspect, the strong Brønsted acid is present at more than about 50 wt % of the composition; however, the Brønsted acid can vary from about 10 wt % to about 99 wt %, more preferably about 20 wt % to about 90 wt %, and most preferably about 40 wt % to about 80 wt %.

摘要翻译： 烷基化催化剂可以包括：布朗斯台德酸离子液体; 和强烈的布朗斯台德酸，不被认为是离子液体。 布朗斯台德酸性离子液体可以选自[BMIm] HSO4，[MBSIm] HSO4，[MBSIm] OTf，[MPSIm] OTf和[OMIm] HSO4等。 一方面，强布朗斯台德酸选自硫酸，盐酸（HCl），氢溴酸（HBr），HF，碘化氢（HI），磷酸，三氟甲磺酸（三氟）酸。 在一个方面，强布朗斯台德酸以组合物的大于约50重量％存在; 然而，布朗斯台德酸可以在约10重量％至约99重量％，更优选约20重量％至约90重量％，最优选约40重量％至约80重量％的范围内变化。

公开(公告)号：US20100317901A1

公开(公告)日：2010-12-16

申请号：US12797084

申请日：2010-06-09

申请人： Raghunath V. Chaudhari ,  Debdut S. Roy ,  Bala Subramaniam

发明人： Raghunath V. Chaudhari ,  Debdut S. Roy ,  Bala Subramaniam

IPC分类号： C07C29/00 ,  B01J23/46 ,  B01J31/02 ,  B01J27/188 ,  B01J23/56 ,  B01J21/18 ,  B01J21/08 ,  B01J29/068 ,  C09K3/00

CPC分类号： B01J35/006 ,  B01J23/462 ,  B01J29/126 ,  B01J29/166 ,  B01J31/1633 ,  B01J31/1805 ,  B01J2229/20 ,  B01J2231/641 ,  B01J2531/821 ,  C07C29/132 ,  C07C29/60 ,  Y02P20/52 ,  C07C31/26 ,  C07C31/205 ,  C07C31/202

摘要： A catalyst composition can include: a support; a ruthenium catalyst (Ru) nanoparticle; and a linker linking the Ru nanoparticle to the support, wherein the linker is stable under hydrogenolysis conditions. In one aspect, the linker can include 3-aminopropyl trimethoxysilane (APTS) or derivatives thereof, such as those with amine functionality. In another aspect, the linker can include phosphotungstic acid (PTA) or other similar solid acid agents. In another aspect, the support can be selected from alumina, carbon, silica, a zeolite, TiO2, ZrO2, or another suitable material. A specific example of a support includes zeolite, such as a NaY zeolite. The Ru nanoparticle can have a size range from about 1 nm to about 25 nm, and can be obtained by reduction of Ru salts.

摘要翻译： 催化剂组合物可以包括：载体; 钌催化剂（Ru）纳米颗粒; 和将Ru纳米颗粒连接到载体的接头，其中接头在氢解条件下是稳定的。 在一个方面，接头可以包括3-氨基丙基三甲氧基硅烷（APTS）或其衍生物，例如具有胺官能团的那些。 另一方面，接头可以包括磷钨酸（PTA）或其它类似的固体酸剂。 另一方面，载体可以选自氧化铝，碳，二氧化硅，沸石，TiO 2，ZrO 2或其它合适的材料。 载体的具体实例包括沸石，例如NaY沸石。 Ru纳米颗粒可以具有约1nm至约25nm的尺寸范围，并且可以通过还原Ru盐获得。

公开(公告)号：US20090197821A1

公开(公告)日：2009-08-06

申请号：US12394833

申请日：2009-02-27

申请人： Jeffrey M. Jonas ,  Roger A. Rajewski ,  Bala Subramaniam ,  Katherine F. Terranova

发明人： Jeffrey M. Jonas ,  Roger A. Rajewski ,  Bala Subramaniam ,  Katherine F. Terranova

IPC分类号： A61K31/7048 ,  A61K31/337 ,  A61K31/4745 ,  A61K31/407 ,  A61K31/704 ,  A61P35/00

CPC分类号： A61K9/10 ,  A61K9/0019 ,  A61K9/14 ,  A61K9/1688 ,  A61K47/44

摘要： The present embodiment of the invention is generally directed to compositions comprising suspensions of poorly water-soluble compounds recrystallized in nanoparticulate sizes ranging from 0.1 to 5 μm. In addition, the embodiment of the invention is directed to methods for preparation and administration of these compositions to a patient for prevention and treatment of disease states. In particular, the embodiment of the invention is directed to compositions comprising suspensions of poorly water-soluble compounds, such as antimitotics and antibiotics, in nanoparticulates and methods of prevention and treatment of chronic disease states, such as cancer, by intraperitoneal and intravenous administration of such compositions

摘要翻译： 本发明的本实施方案通常涉及包含以0.1至5μm的纳米颗粒尺寸重结晶的难溶于水的化合物的悬浮液的组合物。 此外，本发明的实施方案涉及用于制备和施用这些组合物给患者以预防和治疗疾病状态的方法。 特别地，本发明的实施方案涉及包含难溶性水溶性化合物如抗虚证和抗生素的悬浮液在纳米颗粒中的组合物，以及通过腹膜内和静脉内施用预防和治疗慢性疾病状态如癌症的方法 这样的组合物