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198 条记录 (耗时 0.054 秒)

    Oligonucleotide inhibition of cell adhesion
    43.
    发明授权
    Oligonucleotide inhibition of cell adhesion 失效
    寡核苷酸抑制细胞粘附

    公开(公告)号：US06300491B1

    公开(公告)日：2001-10-09

    申请号：US09009490

    申请日：1998-01-20

    申请人： C. Frank Bennett ,  Christopher K. Mirabelli

    发明人： C. Frank Bennett ,  Christopher K. Mirabelli

    IPC分类号： C07H2102

    CPC分类号： C07H21/04 ,  A61K38/00 ,  A61K48/00 ,  C07K14/70525 ,  C07K14/70542 ,  C07K14/70564 ,  C12N15/1138 ,  C12N2310/315 ,  C12N2310/322 ,  C12N2310/352 ,  C12N2310/3533

    摘要： Compositions and methods are provided for the treatment and diagnosis of diseases amenable to treatment through modulation of the synthesis or metabolism of intercellular adhesion molecules. In accordance with preferred embodiments, oligonucleotides are provided which are specifically hybridizable with nucleic acids encoding intercellular adhesion molecule-1, vascular cell adhesion molecule-1, and endothelial leukocyte adhesion molecule-1. The oligonucleotide comprises nucleotide units sufficient in identity and number to effect said specific hybridization. In other preferred embodiments, the oligonucleotides are specifically hybridizable with a transcription initiation site, a translation initiation site, 5′-untranslated sequences, 3′-untranslated sequences, and intervening sequences. Methods of treating animals suffering from disease amenable to therapeutic intervention by modulating cell adhesion proteins with an oligonucleotide specifically hybridizable with RNA or DNA corresponding to one of the foregoing proteins are disclosed. Methods for treatment of diseases responding to modulation cell adhesion molecules are disclosed.

    摘要翻译： 提供组合物和方法，用于治疗和诊断适于通过调节细胞间粘附分子的合成或代谢来治疗的疾病。 根据优选实施方案，提供了与编码细胞间粘附分子-1，血管细胞粘附分子-1和内皮细胞粘附分子-1的核酸特异性杂交的寡核苷酸。 所述寡核苷酸包含足以实现所述特异性杂交的同一性和数目的核苷酸单元。 在其它优选实施方案中，寡核苷酸与转录起始位点，翻译起始位点，5'-非翻译序列，3'非翻译序列和插入序列特异性杂交。 公开了通过用与上述蛋白质之一相对应的RNA或DNA特异性杂交的寡核苷酸调节细胞粘附蛋白来治疗患有治疗性干预的疾病的方法。 公开了治疗响应于调节细胞粘附分子的疾病的方法。

    Antisense modulation of integrin-linked kinase expression
    46.
    发明授权
    Antisense modulation of integrin-linked kinase expression 有权
    整合素连接激酶表达的反义调控

    公开(公告)号：US06177273B1

    公开(公告)日：2001-01-23

    申请号：US09428219

    申请日：1999-10-26

    申请人： C. Frank Bennett ,  Lex M. Cowsert

    发明人： C. Frank Bennett ,  Lex M. Cowsert

    IPC分类号： C07H2104

    CPC分类号： C12Q1/6883 ,  A61K48/00 ,  C07B2200/11 ,  C07H21/00 ,  C12N9/1205 ,  C12N15/1137 ,  C12N2310/321 ,  C12N2310/3341 ,  Y02P20/582

    摘要： Antisense compounds, compositions and methods are provided for modulating the expression of Integrin-linked kinase. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding Integrin-linked kinase. Methods of using these compounds for modulation of Integrin-linked kinase expression and for treatment of diseases associated with expression of Integrin-linked kinase are provided.

    摘要翻译： 提供反义化合物，组合物和方法用于调节整联蛋白连接的激酶的表达。 组合物包含针对编码整联蛋白连接的激酶的核酸的反义化合物，特别是反义寡核苷酸。 提供了使用这些化合物调节整联蛋白连接的激酶表达和治疗与整联蛋白连接的激酶表达相关的疾病的方法。