公开(公告)号：US20130158377A1

公开(公告)日：2013-06-20

申请号：US13762197

申请日：2013-02-07

Applicant: California Institute of Technology

Inventor： Morteza Gharib ,  Adrianus I. Aria ,  Elijah Bodhi Sansom

IPC: A61M37/00 ,  A61N5/06 ,  A61M5/44 ,  A61B5/145 ,  A61M25/10 ,  A61N1/30

CPC classification number: A61M37/0015 ,  A61B5/14532 ,  A61K47/6957 ,  A61L27/443 ,  A61L27/54 ,  A61L27/56 ,  A61L2300/258 ,  A61L2300/416 ,  A61L2300/602 ,  A61L2300/606 ,  A61L2400/12 ,  A61M5/44 ,  A61M25/104 ,  A61M37/0092 ,  A61M2037/0023 ,  A61M2037/0053 ,  A61M2037/0061 ,  A61N1/306 ,  A61N5/062 ,  B29C70/64 ,  B29K2105/162 ,  B82Y5/00 ,  B82Y30/00 ,  B82Y40/00 ,  C01B32/15

Abstract: The present invention relates to a nano-enhanced device for substance transfer between the device and a tissue. The device comprises a substrate with substantially aligned carbon nanotubes anchored within the substrate, and with at least one end of the carbon nanotubes protruding from the substrate. The protruding nanotube ends may be coated with a drug for delivery of the drug into body tissue. The present invention may be incorporated into an angioplasty catheter balloon or into a patch that is worn on the skin. The carbon nanotubes can be grouped in clusters to effectively form nano-needles which can transfer fluid to or from the subdermal tissue. The nano-needles can be used in conjunction with a sensor to ascertain body fluid information such as pH, glucose level, etc.

Abstract translation: 本发明涉及一种纳米增强器件，用于器件与组织之间的物质转移。 该装置包括基本上对准的碳纳米管的衬底，锚定在衬底内，并且碳纳米管的至少一端从衬底突出。 突出的纳米管末端可以涂覆有用于将药物递送到身体组织中的药物。 本发明可以并入血管成形术导管球囊或穿在皮肤上的贴剂中。 碳纳米管可以分组成簇以有效地形成可以将流体传送到皮下组织或从皮下组织传递流体的纳米针。 纳米针可与传感器结合使用，以确定体液信息，如pH值，葡萄糖水平等。

公开(公告)号：US12269581B2

公开(公告)日：2025-04-08

申请号：US17655296

申请日：2022-03-17

Applicant: California Institute of Technology ,  Toofon, Inc.

Inventor： Michael V. Ol ,  Morteza Gharib

IPC: B64C13/20 ,  B64C11/46 ,  B64C29/00 ,  B64C39/08 ,  B64U10/20 ,  B64U30/10 ,  B64U30/24 ,  B64U30/295 ,  B64U50/13

Abstract: A system of a multi-rotor aircraft that capitalizes on the advantages of fixed wing elements combined with rotary wing structures. The fixed wing elements can help to generate lift once the aircraft is airborne and can thus reduce the need for larger lifting rotors which can allow for longer flight times and distances. Additionally, the systems disclosed herein take advantage of a partial in-wing configuration with a number of rotors to reduce the overall footprint of the vehicle while maintaining the flight efficiency that comes with combining features of fixed and rotary wing elements, and increasing operator safety by shrouding rotating parts. The unique configurations allow for a decoupling of the pitch, yaw and roll authority to reduce the complexity in control systems and improve the flight efficiency of the aircraft. Additional configurations implement the use of smaller thrust rotors that can be used to generate thrust as well as control yaw and thus counteract any remaining unbalanced torque.

公开(公告)号：US11957438B2

公开(公告)日：2024-04-16

申请号：US18452227

申请日：2023-08-18

Applicant: California Institute of Technology

Inventor： Morteza Gharib ,  Niema M. Pahlevan

IPC: A61B5/02 ,  A61B5/00 ,  A61B5/021 ,  A61B5/022 ,  A61B5/0285 ,  A61B5/318 ,  A61B7/00

CPC classification number: A61B5/02028 ,  A61B5/0006 ,  A61B5/021 ,  A61B5/02233 ,  A61B5/0285 ,  A61B5/318 ,  A61B7/00

Abstract: A non-invasive and convenient method and apparatus for approximation of left ventricular end diastolic pressure (LVEDP) can be used in both hospital/clinic environments and nursing home or home environments. The method and apparatus use non-invasive sensors and a new “cardiac triangle” computational method to obtain an approximation of LVEDP. The computational method uses hemodynamic and electrocardiogram (ECG) waveforms as input, which can be collected by a portable device or devices.

公开(公告)号：US20230211870A1

公开(公告)日：2023-07-06

申请号：US17818291

申请日：2022-08-08

Applicant: California Institute of Technology

Inventor： Morteza Gharib

IPC: B64C11/00 ,  B64C11/06

CPC classification number: B64C11/001 ,  B64C11/06

Abstract: A system and method for improving the flight control and efficiency of an aerial vehicle. Many embodiments are directed to a rotor-shroud assembly system where a plurality of rotor blades are connected to the internal side of a shroud and are set up to pivot through the use of a pitching mechanism. The entire assembly is configured to rotate when attached to a motor.

公开(公告)号：US20220212792A1

公开(公告)日：2022-07-07

申请号：US17647337

申请日：2022-01-06

Applicant: California Institute of Technology ,  Toofon, Inc.

Inventor： Morteza Gharib ,  Michael V. Ol ,  David Jeon ,  Amir Emadi

IPC: B64C39/02 ,  G06T7/11 ,  G05D1/10

Abstract: A network of high-resolution cameras for monitoring and controlling a drone within a specific operational environment such that the latency time for communication between the cameras and drone is less than that of human controlled drones. The drone can communication drone health data to the network of cameras where such information can be combined with visual image data of the drone to determine the appropriate flight path of the drone within the operational environment. The drone can then subsequently be controlled by the network of cameras by maintaining a constant visual image and flight control data of the drone as it operates within the environment.

公开(公告)号：US20210228348A1

公开(公告)日：2021-07-29

申请号：US17231892

申请日：2021-04-15

Applicant: Foldax, Inc. ,  California Institute of Technology

Inventor： Jason G. Beith ,  Morteza Gharib ,  Stephanie Rider ,  Manuel Bedrossian

IPC: A61F2/24

Abstract: Improved prosthetic heart valves, their methods of manufacture, and systems and devices for manufacturing the valves are described. The prosthetic heart valves can be configured for transcatheter implantation. The prosthetic heart valves can have artificial leaflets. The prosthetic heart valves can be manufactured in numerous ways, such as by polymeric dipping processes.

公开(公告)号：US11056712B2

公开(公告)日：2021-07-06

申请号：US15411544

申请日：2017-01-20

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY

Inventor： Isabelle M. Darolles ,  Azin Fahimi ,  Cong Wang ,  Adrianus I. Aria ,  Luciana Cendon ,  Morteza Gharib

IPC: H01M10/0525 ,  H01M4/66 ,  H01M4/38 ,  H01M10/0565 ,  H01M10/0585 ,  H01M4/13

Abstract: Features for rechargeable lithium ion batteries, the batteries optionally employing vertically aligned carbon nanotube scaffolding, are described. Methods of manufacture and a solid polymer electrolyte are described for 3-dimensional battery architectures using the vertically aligned carbon nanotubes. Poly(ethylene)oxide bis(azide) and graphene poly(lactic acid) composite coatings are also described for use in such batteries or others.

公开(公告)号：US20200275077A9

公开(公告)日：2020-08-27

申请号：US16209089

申请日：2018-12-04

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY

Inventor： Morteza Gharib ,  Alexei Harvard ,  Scott Hsieh ,  Jian Lu

IPC: H04N13/207 ,  H04N13/214 ,  G06T7/70 ,  G06T7/593

Abstract: Hardware and software configurations, optionally, for performing profilometry of an object are disclosed. An advantageous imaging device is described. An advantageous approach to determining imager position is also described. Each aspect described may be used independently of the other. Moreover, the teaching may find use in other fields including velocimetry, etc.

公开(公告)号：US20180239168A1

公开(公告)日：2018-08-23

申请号：US15932290

申请日：2018-02-16

Applicant: The Regents of the University of California ,  California Institute of Technology

Inventor： Daniel M. Schwartz ,  Scott E. Fraser ,  Morteza Gharib ,  Sean A. Mendoza ,  Kevin A. Mendoza ,  Nicholas T. Rinella

IPC: G02C7/04 ,  B41M3/00 ,  B41M5/00

Abstract: A sclera or contact lens with an image of an eye that is fenestrated, or uniformly speckled with many sub-millimeter sized transparent regions or holes, is disclosed. The micro fenestrated contact lens can be worn on a strabismic, or misaligned, eye so that its image is aligned with the wearer's dominant eye. The fenestrations allow the wearer to see through the opaque or translucent image printed on the contact lens, thus allowing binocular vision even though his or her strabismic eye is covered.

公开(公告)号：US20170258343A1

公开(公告)日：2017-09-14

申请号：US15598968

申请日：2017-05-18

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY

Inventor： Niema Pahlevan ,  Peyman Tavallali ,  Thomas Yizhao Hou ,  Morteza Gharib

IPC: A61B5/024 ,  A61B5/00 ,  A61B5/02 ,  A61B5/05 ,  A61B8/00 ,  A61B8/02 ,  A61B8/06 ,  A61B8/08

CPC classification number: A61B5/02416 ,  A61B5/0004 ,  A61B5/0013 ,  A61B5/0077 ,  A61B5/02028 ,  A61B5/02405 ,  A61B5/02438 ,  A61B5/0507 ,  A61B5/7235 ,  A61B5/7278 ,  A61B5/7282 ,  A61B5/746 ,  A61B8/02 ,  A61B8/06 ,  A61B8/5223 ,  A61B8/565

Abstract: Hardware and software methodology are described for cardiac health measurement. Hemodynamic waveforms variously acquired for a subject are analyzed to calculate or approximate intrinsic frequencies in two domains in two domains across the Dicrotic Notch. The intrinsic frequencies provide metrics/ measures that correlate to the cardiac health of the subject. The systems may be used for monitoring a condition and/or is diagnosis. Exemplary uses include identifying (diagnosing) the presence of arrhythmia, heat failure, atrial fibrillation, aneurysms, vessel stenosis or aortic valve dysfunction and the necessity for valve replacement and/or monitoring congestive heart failure progression, together with identifying the acute need for hospitalization in connection with daily testing for any such condition.