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41.发明授权Process for the preparation of organic compounds containing a sulfinyl or sulfonyl group 失效制备含亚磺酰基或磺酰基的有机化合物的方法公开(公告)号：US06998490B2
公开(公告)日：2006-02-14
申请号：US10801608
申请日：2004-03-17
IPC分类号： C07C317/02
CPC分类号： C07D401/12 , C07C315/02 , C07C317/44
摘要： A process for the oxidation of thioethers to sulfoxides or sulfones or for the oxidation of sulfoxides to sulfones by treatment of thioethers or sulfoxides with an oxidizing amount of ε-phthalimidoperhexanoic acid is particularly useful for the preparation of compounds of industrial interest, in particular pharmaceuticals for human or veterinary use.
摘要翻译： 通过用氧化量的ε-邻苯二甲酰亚氨基己酸处理硫醚或亚砜，将硫醚氧化成亚砜或砜或将亚砜氧化成砜的方法特别适用于制备工业上有用的化合物，特别是用于 人类或兽医用途。
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公开(公告)号：US20050222437A1
公开(公告)日：2005-10-06
申请号：US11092553
申请日：2005-03-29
IPC分类号： C07C215/54 , C07D311/20 , C07D311/02
CPC分类号： C07D311/20
摘要： A process for the preparation of 6-methyl-4-(R)-phenyl-chroman-2-one and 6-methyl-4-(S)-phenyl-chroman-2-one, intermediates for the synthesis of tolterodine and its (S) enantiomer, by reaction of 6-methyl-coumarin with phenylboronic acids, esters and derivatives thereof, in the presence of chiral catalysts.
摘要翻译： 制备6-甲基-4-（R） - 苯基 - 苯并二氢吡喃-2-酮和6-甲基-4-（S） - 苯基 - 苯并二氢吡喃-2-酮的方法，用于合成托特罗定及其 （S）对映体，通过6-甲基香豆素与苯基硼酸，其酯及其衍生物在手性催化剂存在下的反应。
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公开(公告)号：US20050165236A1
公开(公告)日：2005-07-28
申请号：US10979209
申请日：2004-11-03
IPC分类号： C07D471/04 , C07D471/02 , C07D233/64
CPC分类号： C07D471/04
摘要： Novel intermediates useful for the preparation of Imiquimod and a process for the preparation of Imiquimod by means of said intermediates.
摘要翻译： 用于制备咪喹莫特的新型中间体和通过所述中间体制备咪喹莫特的方法。
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公开(公告)号：US20050119339A1
公开(公告)日：2005-06-02
申请号：US10625558
申请日：2003-07-24
IPC分类号： C07C201/02 , C07B53/00 , C07B61/00 , C07C203/04 , A61K31/21
CPC分类号： C07C201/02 , C07C203/04
摘要： A process for obtaining nitroxyalklesters of the 2(S)(6-methoxy-2-naphthyl)-propanoic acid having an enantiomeric excess higher than or equal to 95%, preferably higher than or equal to 98%, characterized in that an halide of the 2-(S)-(6 methoxy-2-naphthyl)propanoic acid of formula A-Hal, wherein A is the acid acyl residue, is reacted in an inert orgariic solvent with an aliphatic nitroxyalkanol HO—Y—ONO2, wherein Y is a C2-C20 alkylene or a cycloalkylene from 3 to 8 carbon atoms, or an alkylene as defined containing a cycloalkylene as defined, in the presence of an inorganic base.
摘要翻译： 一种获得具有高于或等于95％，优选高于或等于98％的对映异构体过量的2（S）（6-甲氧基-2-萘基） - 丙酸的硝基螺旋体的方法，其特征在于， 其中A是酸酰基残基的式A-Hal的2-（S） - （6-甲氧基-2-萘基）丙酸在惰性溶剂中与脂族硝基链烷醇HO-Y-ONO 2，其中Y是C 2 -C 20亚烷基或3至8个碳原子的亚环烷基，或如所定义的含有如所定义的亚环烷基的亚烷基 在无机碱存在下进行。
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公开(公告)号：US20050090672A1
公开(公告)日：2005-04-28
申请号：US10969354
申请日：2004-10-21
IPC分类号： A61K31/4178 , A61P9/12 , C07C237/06 , C07C237/20 , C07D233/54 , C07D233/60 , C07D233/68 , C07D233/70 , C07D403/10
CPC分类号： C07D233/70 , C07C237/06 , C07D233/68 , C07D403/10
摘要： A process for the preparation of benzylimidazole derivatives useful as intermediates for preparation of losartan, novel intermediates for their preparation and a process for the preparation of losartan.
摘要翻译： 制备用作制备氯沙坦的中间体的苄基咪唑衍生物的制备方法，其制备的新型中间体和氯沙坦的制备方法。
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46.发明授权Process for the preparation of the enantiomers of 2-(2-fluoro-4-biphenyl)propionic acid 失效制备2-（2-氟-4-联苯基）丙酸对映异构体的方法
公开(公告)号：US5840964A
公开(公告)日：1998-11-24
申请号：US577377
申请日：1995-12-22
申请人： Claudio Pozzoli , Graziano Castaldi
发明人： Claudio Pozzoli , Graziano Castaldi
IPC分类号： C07B53/00 , C07B57/00 , C07C51/06 , C07C51/487 , C07C51/60 , C07C57/58 , C07C57/76 , C07C69/65 , C07D263/06 , C07D319/06 , C07B55/00
CPC分类号： C07D319/06 , C07B57/00 , C07C51/487 , C07C57/58
摘要： A process for the preparation of 2-(2-fluoro-4-biphenyl)propianic acid enantiomers comprising a II order resolution of ketals of formula ##STR1## wherein R.sub.1 ad R.sub.2 have the meanings reported in the description; the asterisk shows the chiral carbon atom and the asymmetric carbon atoms marked by .alpha. and .beta. have both R or S configuration is described.
摘要翻译： 制备2-（2-氟-4-联苯基）丙酸对映异构体的方法，其包含式（III）的缩酮的II级拆分，其中R1-R2具有说明书中报道的含义; 星号显示手性碳原子，并且描述由α和β标记的不对称碳原子具有R或S构型。
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47.发明授权Photochromatic and thermochromatic spiro-oxazepin-oxazine compounds and the process for their preparation 失效光敏和热敏螺旋氧化烯 - 氧化合物及其制备方法
公开(公告)号：US5110922A
公开(公告)日：1992-05-05
申请号：US738335
申请日：1991-07-31
IPC分类号： C07D267/20 , C07D498/10 , C09K9/02 , G11B7/244
CPC分类号： C07D267/20 , C09K9/02 , G11B7/244
摘要： New photochromatic and thermochromatic compounds of the spiro-oxazepin-oxazine class are definable by the general formula (I): ##STR1## where the substituents R and R.sub.1 -R.sub.12 are defined in the description.The process for the preparation of the compounds (I) is described, as is their use as photochromatic and thermochromatic agents.
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公开(公告)号：US08203002B2
公开(公告)日：2012-06-19
申请号：US12776588
申请日：2010-05-10
IPC分类号： C07D277/82
CPC分类号： C07D277/82
摘要： Intermediates useful for the preparation of pramipexole and the use thereof in such synthesis.
摘要翻译： 可用于制备普拉克索的中间体及其在此类合成中的应用。
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公开(公告)号：US07741490B2
公开(公告)日：2010-06-22
申请号：US10593269
申请日：2005-03-11
IPC分类号： C07D277/82
CPC分类号： C07D277/82
摘要： Intermediates useful for the preparation of pramipexole and the use thereof in such synthesis.
摘要翻译： 可用于制备普拉克索的中间体及其在此类合成中的应用。
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公开(公告)号：US07345189B2
公开(公告)日：2008-03-18
申请号：US11392909
申请日：2006-03-30
IPC分类号： C07C69/76
CPC分类号： C07C51/412 , C07C51/02 , C07C67/343 , C07C2603/74 , C07C65/26 , C07C69/94
摘要： A process for the preparation of a compound of formula (I), or a salt thereof wherein R is H, C1-C8 alkyl, aryl or aryl-C1-C8 alkyl; comprising the reaction between a compound of formula (II) wherein R1 and R2 are independently hydrogen, C1-C8 alkyl, aryl, aryl-C1-C8 alkyl, or R1 and R2, taken together, form a —(CH2)m—V—(CH2)n— group, in which V is NR3 or C(R3)2 wherein R3 is hydrogen, C1-C8 alkyl, aryl or aryl-C1-C8 alkyl; and m and n, which can be the same or different, are 1 or 2; with a compound of formula (III) in which R4 and R5 are independently C1-C8 alkyl, aryl or aryl-C1-C8 alkyl; in the presence of a Ni (II) salt, an organic ligand and a basic agent, to obtain a compound of formula (I) wherein R is C1-C8 alkyl, aryl or aryl-C1-C8 alkyl and, if desired, its conversion to a compound of formula (I) wherein R is hydrogen or to a salt thereof.
摘要翻译： 制备式（I）化合物或其盐的方法，其中R为H，C 1 -C 8烷基，芳基或芳基-C C 1 -C 8烷基; 包括其中R 1和R 2独立地是氢，C 1 -C 8的式（II）化合物之间的反应 烷基，芳基，芳基-C 1 -C 8烷基或R 1和R 2
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