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公开(公告)号：US09846143B2
公开(公告)日：2017-12-19
申请号：US15438986
申请日：2017-02-22
Applicant: DH Technologies Development PTE Ltd. , Voislav Blagojevic , Diethard Bohme
Inventor： Voislav Blagojevic , Diethard Bohme , Thomas R. Covey , Bradley B. Schneider
CPC classification number: G01N27/624
Abstract: A method and system for performing an ion mobility based analysis that ionizes the components of a sample into ions; provides a field asymmetric waveform ion mobility or differential mobility spectrometry ion mobility based filter that comprises at least two electrodes, the at least two electrodes being spaced apart such that a constant sized gap is formed there between, through which a drift gas flows; introducing said ions into the drift gas, wherein said drift gas also comprises a mixture of liquid modifiers.
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公开(公告)号：US20170316926A1
公开(公告)日：2017-11-02
申请号：US15581172
申请日：2017-04-28
Inventor： Don W. Arnold , Thomas R. Covey , German Augusto Gomez Rios , Chang Liu , Janusz B. Pawliszyn
CPC classification number: H01J49/0404 , G01N1/405 , H01J49/0031 , H01J49/0459
Abstract: Methods and systems for delivering a liquid sample to an ion source for the generation of ions and subsequent analysis by mass spectrometry are provided herein. In accordance with various aspects of the present teachings, MS-based systems and methods are provided in which a desorption solvent utilized in a sampling interface to desorb one or more analyte species from an SPME device is fluidly coupled to an ion source for ionizing the one or more analyte species desorbed into the desorption solvent for subsequent mass spectrometric analysis (e.g., without a liquid chromatography (LC) column between the sampling interface and the ion source). In accordance with various aspects of the methods and systems described herein, the configuration the sampling interface can be optimized so as to reduce the fluid volume dead space about the fluid inlet so as to concentrate the one or more analyte species desorbed at optimized conditions from the SPME substrate in a decreased volume of the desorption solvent when the SPME device is inserted into sampling interface.
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公开(公告)号：US20160334369A1
公开(公告)日：2016-11-17
申请号：US15107487
申请日：2014-11-18
Applicant: DH TECHNOLOGIES DEVELOPMENT PTE LTD.
Inventor： Thomas R. Covey , Bradley Schneider , Erkinjon Nazarov
CPC classification number: G01N27/624 , H01J49/0031
Abstract: A method and apparatus for performing differential mobility spectrometer (DMS) which includes decreasing the amount of time that ions spend inside fringing fields generated by the DMS. The apparatus includes an entrance electrode plate sealingly engaged to the entrance of the DMS, and is electrically separated from the parallel plate electrodes of the DMS, the entrance electrode plate has an aperture for allowing the traversal of ions into the DMS; wherein the cross-sectional area of the aperture is less than the cross-sectional area of the ion path, the ion path being located between the two parallel plate electrodes of the DMS. The entrance electrode plate may also have a focusing potential applied to it for focusing of ions.
Abstract translation: 一种用于执行差分迁移率光谱仪（DMS）的方法和装置，其包括减少离子在由DMS产生的边缘场内消耗的时间量。 该装置包括密封地接合到DMS的入口的入口电极板，并且与DMS的平行板电极电隔离，入口电极板具有用于允许离子穿过DMS的孔; 其中所述孔的横截面面积小于所述离子路径的横截面面积，所述离子路径位于所述DMS的两个平行板电极之间。 入口电极板还可以具有施加到其上用于聚焦离子的聚焦电势。
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公开(公告)号：US09176028B2
公开(公告)日：2015-11-03
申请号：US13644941
申请日：2012-10-04
Applicant: UT-BATTELLE, LLC , DH Technologies Development Pte. Ltd.
Inventor： Mariam S. ElNaggar , Gary J. Van Berkel , Thomas R. Covey
CPC classification number: G01N1/14 , G01N2001/028
Abstract: A system for sampling a surface includes a sampling probe having a housing and a socket, and a rolling sampling sphere within the socket. The housing has a sampling fluid supply conduit and a sampling fluid exhaust conduit. The sampling fluid supply conduit supplies sampling fluid to the sampling sphere. The sampling fluid exhaust conduit has an inlet opening for receiving sampling fluid carried from the surface by the sampling sphere. A surface sampling probe and a method for sampling a surface are also disclosed.
Abstract translation: 用于对表面进行采样的系统包括具有壳体和插座的采样探针以及插座内的滚动采样球。 壳体具有取样流体供应管道和采样流体排出管道。 采样流体供应管道将采样流体提供给采样球体。 取样流体排出管道具有入口开口，用于接收由取样球体从表面携带的取样流体。 还公开了表面采样探针和用于对表面进行取样的方法。
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公开(公告)号：US20230245877A1
公开(公告)日：2023-08-03
申请号：US18298881
申请日：2023-04-11
Applicant: DH Technologies Development Pte. Ltd.
Inventor： John J. Corr , Thomas R. Covey , Peter Kovarik , Bradley B. Schneider
CPC classification number: H01J49/107 , H01J49/0031 , H01J49/165
Abstract: In one aspect, an ion source for use in a mass spectrometry system is disclosed, which comprises a housing, a first and a second ion probe coupled to said housing, and a first and a second emitter configured for coupling, respectively, to said first and second ion probes. The first ion probe is configured for receiving a sample at a flow rate in nanoflow regime and the second ion probe is configured for receiving a sample at a flow rate above the nanoflow regime. Each of the ion probes includes a discharge end (herein also referred to as the discharge tip) for ionizing at least one constituent of the received sample. In some embodiment, each ion probe receives the sample from a liquid chromatography (LC) column. Further, the ion probes can be interchangeably disposed within the housing.
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Patent Agency Ranking
46.发明公开公开(公告)号：US20230176010A1
公开(公告)日：2023-06-08
申请号：US17918521
申请日：2021-04-13
Applicant: DH Technologies Development Pte. Ltd.
Inventor： Thomas R. Covey , Yang Kang , Bradley B. Schneider
IPC: G01N27/624 , G01N27/623 , H01J49/24
CPC classification number: G01N27/624 , G01N27/623 , H01J49/24
Abstract: A system and method are provided for controlling the temperature gradient along a differential mobility spectrometer having a differential mobility spectrometer having an inlet and an outlet, wherein the inlet is configured to receive ions transported from an ion source by a transport gas. The differential mobility spectrometer has an internal operating pressure, electrodes, and at least one voltage source for providing DC and RF voltages to the electrodes for separating ions that are transported from the inlet to the outlet. A gas port is provided near the outlet for introducing a throttle gas to control the flow rate of the transport gas through the differential mobility spectrometer and thereby adjust the ion residence time. A heater is provided for controlling the temperature of the throttle gas to minimize the temperature gradient between the inlet and outlet of the differential mobility spectrometer. A method of calibrating a DMS is also disclosed.
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公开(公告)号：US11189477B2
公开(公告)日：2021-11-30
申请号：US16639411
申请日：2018-08-10
Applicant: DH Technologies Development Pte. Ltd.
Inventor： Thomas R. Covey , Peter Kovarik
Abstract: Systems and methods for atmospheric pressure chemical ionization are provided herein. In various aspects, the APCI apparatus, systems, and methods can provide an asymmetric sample spray into a vaporization chamber asymmetrically (e.g., off axis from the longitudinal axis of the vaporization chamber) so as to increase the interaction of the molecules in the sample spray with the vaporization chamber's sidewalls (and expose more of the molecules to the heat generated thereby), which can thereby result in improved consistency and/or efficiency of ion formation, and/or increased sensitivity relative to conventional APCI techniques.
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公开(公告)号：US20210134579A1
公开(公告)日：2021-05-06
申请号：US16639411
申请日：2018-08-10
Applicant: DH Technologies Development Pte. Ltd.
Inventor： Thomas R. Covey , Peter Kovarik
Abstract: Systems and methods for atmospheric pressure chemical ionization are provided herein. In various aspects, the APCI apparatus, systems, and methods can provide an asymmetric sample spray into a vaporization chamber asymmetrically (e.g., off axis from the longitudinal axis of the vaporization chamber) so as to increase the interaction of the molecules in the sample spray with the vaporization chamber's sidewalls (and expose more of the molecules to the heat generated thereby), which can thereby result in improved consistency and/or efficiency of ion formation, and/or increased sensitivity relative to conventional APCI techniques.
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公开(公告)号：US10818486B2
公开(公告)日：2020-10-27
申请号：US16062936
申请日：2016-12-08
Applicant: DH Technologies Development Pte. Ltd.
Inventor： John J. Corr , Thomas R. Covey , Peter Kovarik
Abstract: Methods and systems are provided for reducing the occurrence of unwanted electrical discharge when operating an electrospray ion source to generate ions for mass spectrometric analysis. In accordance with various aspects of the applicant's teachings, the methods and systems described herein can provide for controlling the ion emission current so as to limit the onset of avalanche of electrical discharge between the electrospray electrode and the counter electrode under ionization conditions that typically tend to increase the likelihood of such discharge (arcing), while nonetheless providing for maximal ionization efficiency. In various aspects, emission currents between the electrospray electrode and the counter electrode through which the ions are transmitted to a downstream mass analyzer can be maintained at elevated levels, below 10 μA, for example, without the electric potential between the electrospray electrode and the counter electrode initiating the electrical discharge avalanche that results from the dielectric breakdown of the air gap therebetween, which can cause sputtering and effect the long-term operation of the ESI source.
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公开(公告)号：US20190221415A1
公开(公告)日：2019-07-18
申请号：US16335077
申请日：2017-09-13
Applicant: DH Technologies Development Pte. Ltd.
Inventor： Thomas R. Covey , Yves LeBlanc , Bradley B. Schneider
CPC classification number: H01J49/067 , G01N30/7233 , G01N30/84
Abstract: Because most ion optics of mass spectrometry systems are subject to ion deposition and may exhibit significantly different behavior following substantial contamination (e.g., loss of sensitivity), fouled surfaces must be regularly cleaned to maintain sensitivity. While the surfaces of front-end components (e.g., curtain plates, orifice plates, Qjet, Q0, IQ0) may be relatively easy to clean, the fouling of components contained within the downstream high-vacuum chambers (e.g., Q1, IQ1) can incur substantial delays and expense as the high-vacuum chambers must be vented and substantially disassembled prior to cleaning. Methods and systems for controlling contamination of components of mass spectrometer systems are provided herein. By reducing the transmission of contaminating ions during non-data acquisition periods, the present teachings can increase throughput, improve robustness, and/or decrease the downtime typically required to vent/disassemble/clean the fouled components.
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