-
公开(公告)号:US07750184B2
公开(公告)日:2010-07-06
申请号:US10577967
申请日:2004-11-08
申请人: Robert Peter Gajewski , Charles David Jones , Jared Harris Linebarger , Jianliang Lu , Tianwei Ma , Sunil Nagpal , Ying Kwong Yee
发明人: Robert Peter Gajewski , Charles David Jones , Jared Harris Linebarger , Jianliang Lu , Tianwei Ma , Sunil Nagpal , Ying Kwong Yee
IPC分类号: C07C303/00 , C07C305/00 , A01N41/06
CPC分类号: C07C311/08 , C07C309/65 , C07C309/66 , C07C309/70 , C07C311/09 , C07C311/48 , C07C317/04 , C07C323/49 , C07C323/67 , C07C2601/08 , C07C2601/14
摘要: The present invention relates to novel, non-secosteroidal, sulfonate and sulfonamide functional diaryl compounds with vitamin D receptor (VDR) modulating activity that are less hypercalcemic than 1α,25 dihydroxy vitamin D3. These compounds are useful for treating bone disease and psoriasis.
摘要翻译: 本发明涉及具有维生素D受体(VDR)调节活性的新型非磺酰基磺酸和磺酰胺官能二芳基化合物,其比1α,25二羟基维生素D3低钙血红素。 这些化合物可用于治疗骨病和牛皮癣。
-
公开(公告)号:US07595345B2
公开(公告)日:2009-09-29
申请号:US10579562
申请日:2004-11-16
申请人: Emilio Enrique Bunel , Robert Peter Gajewski , Charles David Jones , Jianliang Lu , Sunil Nagpal , Tianwei Ma , Ying Kwong Yee
发明人: Emilio Enrique Bunel , Robert Peter Gajewski , Charles David Jones , Jianliang Lu , Sunil Nagpal , Tianwei Ma , Ying Kwong Yee
IPC分类号: A61K31/166 , C07C233/64
CPC分类号: C07C235/42 , C07C65/19 , C07C69/92 , C07C235/84 , C07C2601/08 , C07C2601/14 , C07D257/04 , C07D257/06
摘要: The present invention relates to novel, non-secosteroidal, hydroxyl substituted, carbon-linked diaryl compounds with vitamin D receptor (VDR) modulating activity that are less hypercalcemic than 1?,25 dihydroxy vitamin D3. These compounds are useful for treating bone disease and psoriasis.
摘要翻译: 本发明涉及具有维生素D受体(VDR)调节活性的新颖的非甾体,羟基取代的碳链的二芳基化合物,其比1α,25二羟基维生素D3低的高钙血症。 这些化合物可用于治疗骨病和牛皮癣。
-
公开(公告)号:US07582775B2
公开(公告)日:2009-09-01
申请号:US10579564
申请日:2004-11-16
申请人: Jianliang Lu , Tainwei Ma , Sunil Nagpal , Quanrong Shen , Alan M. Warshawsky , Ying Kwong Yee , Michael John Rupp
发明人: Jianliang Lu , Tainwei Ma , Sunil Nagpal , Quanrong Shen , Alan M. Warshawsky , Ying Kwong Yee , Michael John Rupp
IPC分类号: C07D333/00
CPC分类号: C07D333/68 , C07D333/70
摘要: The present invention relates to novel, non-secosteroidal, phenyl-benzothiophene compounds with vitamin D receptor (VDR) modulating activity that are less hypercalcemic than 1α,25 dihydroxy vitamin D3. These compounds are useful for treating bone disease and psoriasis.
摘要翻译: 本发明涉及具有维生素D受体(VDR)调节活性的新型非异构体苯基 - 苯并噻吩化合物,其比1α,25二羟基维生素D3低钙高。 这些化合物可用于治疗骨病和牛皮癣。
-
公开(公告)号:US5030643A
公开(公告)日:1991-07-09
申请号:US380059
申请日:1989-07-14
IPC分类号: C07D209/12 , A61K31/38 , A61K31/381 , A61K31/40 , A61K31/403 , A61K31/404 , A61K31/41 , A61K31/415 , A61K31/4184 , A61K31/425 , A61K31/428 , A61K31/44 , A61K31/4427 , A61K31/443 , A61K31/4433 , A61K31/535 , A61K31/5355 , A61K31/536 , A61K31/538 , A61K31/54 , A61K31/541 , A61K31/5415 , A61P9/00 , A61P11/00 , A61P11/14 , A61P17/00 , A61P27/16 , A61P29/00 , A61P37/04 , A61P37/08 , A61P43/00 , C07D209/08 , C07D209/18 , C07D231/56 , C07D235/04 , C07D235/06 , C07D235/08 , C07D249/18 , C07D265/36 , C07D275/04 , C07D279/16 , C07D333/52 , C07D333/56 , C07D333/58 , C07D333/60 , C07D401/12 , C07D403/10 , C07D405/12 , C07D409/10 , C07D409/12 , C07D413/10 , C07D413/12
CPC分类号: C07D231/56 , C07D209/18 , C07D235/04 , C07D249/18 , C07D265/36 , C07D333/60 , C07D403/10
摘要: The invention concerns novel, pharmaceutically useful, amide derivatives of certain benzoheterocyclylalkanoic acids (and related tetrazoles and acylsulphonamides) of the formula I and salts thereof, wherein the radicals R.sup.1, R.sup.2, L, X, Y, Z, A.sup.1, Q, A.sup.2 and M have the meanings set out in the specification. The invention also includes pharmaceutical compositions incorporating a formula I compound or a salt thereof, a process for the manufacture of the said compound, together with intermediates for use in the latter process. ##STR1##
-
公开(公告)号:US07659296B2
公开(公告)日:2010-02-09
申请号:US11721676
申请日:2005-12-19
IPC分类号: A61K31/423 , C07D417/02 , C07D498/04 , C07D263/08
CPC分类号: C07D263/56
摘要: The present invention relates to novel, non-secosteroidal, phenyl-benzoxazole compounds of Formula (I) wherein the variables R, R′, RP, RP3, LP1, LP2, ZP, RB, RB′, LXB and ZXB are as hereinafter defined, their preparation, pharmaceutical compositions, and methods of use.
摘要翻译: 本发明涉及式(I)的新型非异构体苯基 - 苯并恶唑化合物,其中变量R,R',RP,RP3,LP1,LP2,ZP,RB,RB',LXB和ZXB如下文所定义 ,它们的制备,药物组合物和使用方法。
-
公开(公告)号:US07601850B2
公开(公告)日:2009-10-13
申请号:US10515403
申请日:2003-05-22
申请人: Karl Robert Dahnke , Robert Peter Gajewski , Charles David Jones , Jared Harris Linebarger , Jianliang Lu , Tianwei Ma , Sunil Nagpal , Todd Parker Simard , Ying Kwong Yee , Emilio Enrique Bunel , Ryan Edward Stites
发明人: Karl Robert Dahnke , Robert Peter Gajewski , Charles David Jones , Jared Harris Linebarger , Jianliang Lu , Tianwei Ma , Sunil Nagpal , Todd Parker Simard , Ying Kwong Yee , Emilio Enrique Bunel , Ryan Edward Stites
IPC分类号: C07D333/06 , C07D333/26
CPC分类号: C07F9/655345 , C07D333/18 , C07D333/20 , C07D333/22 , C07D333/24 , C07D333/34 , C07D333/38 , C07D333/40 , C07D409/06 , C07D409/12 , C07D413/04
摘要: The present invention relates to novel, non-secosteroidal, phenyl-thiophene compounds with vitamin D receptor (VDR) modulating activity that are less hypercalcemic than 1α,25 dihydroxy vitamin D3. These compounds are useful for treating bone disease and psoriasis.
摘要翻译: 本发明涉及具有维生素D受体(VDR)调节活性的新型非甾体类苯基噻吩化合物,其比1α,25二羟基维生素D3低钙高。 这些化合物可用于治疗骨病和牛皮癣。
-
公开(公告)号:US07468449B2
公开(公告)日:2008-12-23
申请号:US10578991
申请日:2004-11-16
申请人: Robert Peter Gajewski , Charles David Jones , Jianliang Lu , Tianwei Ma , Sunil Nagpal , Ying Kwong Yee
发明人: Robert Peter Gajewski , Charles David Jones , Jianliang Lu , Tianwei Ma , Sunil Nagpal , Ying Kwong Yee
IPC分类号: C07D307/02 , A61K31/34
CPC分类号: C07D307/68
摘要: The present invention relates to novel, non-secosteroidal, phenyl-furan compounds with vitamin D receptor (VDR) modulating activity that are less hypercalcemic than 1α,25dihydroxy vitamin D3. These compounds are useful for treating bone disease and psoriasis.
摘要翻译: 本发明涉及具有维生素D受体(VDR)调节活性的新型非甾体甾体苯基呋喃化合物,其比1α,25二羟基维生素D3低钙高。 这些化合物可用于治疗骨病和牛皮癣。
-
公开(公告)号:US20080119407A1
公开(公告)日:2008-05-22
申请号:US11721676
申请日:2005-12-19
IPC分类号: A61K31/423 , C07D263/56 , A61K38/23 , A61P25/00 , A61P35/00 , A61P3/00 , A61P19/00
CPC分类号: C07D263/56
摘要: The present invention relates to novel, non-secosteroidal, phenyl-benzoxazole compounds of Formula (I) wherein the variables R, R′, RP, RP3, LP1, LP2, ZP, RB, RB′, LXB and ZXB are as hereinafter defined, their preparation, pharmaceutical compositions, and methods of use.
摘要翻译: 本发明涉及式(I)的新型非异构体苯基 - 苯并恶唑化合物,其中变量R,R',RP,RP 3,L P1, L P2,ZP,RB,RB',L XB和Z XB SUB>如下文所定义,它们的制备,药物组合物和方法 使用。
-
-
-
-
-
-
-