公开(公告)号：US10362975B2

公开(公告)日：2019-07-30

申请号：US15394327

申请日：2016-12-29

Applicant: DexCom, Inc.

Inventor： Rui Ma ,  Naresh C. Bhavaraju ,  Thomas Stuart Hamilton ,  Jonathan Hughes ,  Jeff Jackson ,  David I-Chun Lee ,  Peter C. Simpson ,  Stephen J. Vanslyke

IPC: A61B5/1495 ,  G01N33/66 ,  A61B5/145 ,  A61B5/1486

Abstract: Systems and methods are disclosed which provide for a “factory-calibrated” sensor. In doing so, the systems and methods include predictive prospective modeling of sensor behavior, and also include predictive modeling of physiology. With these two correction factors, a consistent determination of sensitivity can be achieved, thus achieving factory calibration.

公开(公告)号：US20190120785A1

公开(公告)日：2019-04-25

申请号：US16168742

申请日：2018-10-23

Applicant: DexCom, Inc.

Inventor： Jason Halac ,  John Charles Barry ,  Becky L. Clark ,  Chris W. Dring ,  John Michael Gray ,  Kris Elliot Higley ,  Jeff Jackson ,  David A. Keller ,  Ted Tang Lee ,  Jason Mitchell ,  Kenneth Pirondini ,  David Rego ,  Ryan Everett Schoonmaker ,  Peter C. Simpson ,  Craig Thomas Gadd ,  Kyle Thomas Stewart

IPC: G01N27/327 ,  A61B5/1486 ,  A61B5/145 ,  A61B5/1495 ,  A61B5/1473 ,  A61B5/1459 ,  G01N33/66

Abstract: Pre-connected analyte sensors are provided. A pre-connected analyte sensor includes a sensor carrier attached to an analyte sensor. The sensor carrier includes a substrate configured for mechanical coupling of the sensor to testing, calibration, or wearable equipment. The sensor carrier also includes conductive contacts for electrically coupling sensor electrodes to the testing, calibration, or wearable equipment.

公开(公告)号：US20190117131A1

公开(公告)日：2019-04-25

申请号：US16168688

申请日：2018-10-23

Applicant: DexCom, Inc.

Inventor： Jason Halac ,  John Charles Barry ,  Becky L. Clark ,  Chris W. Dring ,  John Michael Gray ,  Kris Elliot Higley ,  Jeff Jackson ,  David A. Keller ,  Ted Tang Lee ,  Jason Mitchell ,  Kenneth Pirondini ,  David Rego ,  Ryan Everett Schoonmaker ,  Peter C. Simpson ,  Craig Thomas Gadd ,  Kyle Thomas Stewart

IPC: A61B5/1473 ,  A61B5/1486 ,  A61B5/145 ,  A61B5/1495 ,  A61B5/1459 ,  G01N33/66 ,  G01N27/327

Abstract: Pre-connected analyte sensors are provided. A pre-connected analyte sensor includes a sensor carrier attached to an analyte sensor. The sensor carrier includes a substrate configured for mechanical coupling of the sensor to testing, calibration, or wearable equipment. The sensor carrier also includes conductive contacts for electrically coupling sensor electrodes to the testing, calibration, or wearable equipment.

公开(公告)号：US20180000388A1

公开(公告)日：2018-01-04

申请号：US15683657

申请日：2017-08-22

Applicant: DexCom, Inc.

Inventor： Peter C. Simpson ,  Robert J. Boock ,  Paul V. Neale ,  Sebastian Böhm ,  Matthew Wightlin ,  Jack Pryor ,  Jason Mitchell ,  Jeff Jackson ,  Kaushik Patel ,  Antonio C. Llevares

IPC: A61B5/1473 ,  A61B5/1486 ,  A61B5/145 ,  B05C3/10

Abstract: Analyte sensors and methods of manufacturing same are provided, including analyte sensors comprising multi-axis flexibility. For example, a multi-electrode sensor system 800 comprising two working electrodes and at least one reference/counter electrode is provided. The sensor system 800 comprises first and second elongated bodies E1, E2, each formed of a conductive core or of a core with a conductive layer deposited thereon, insulating layer 810 that separates the conductive layer 820 from the elongated body, a membrane layer deposited on top of the elongated bodies E1, E2, and working electrodes 802′, 802″ formed by removing portions of the conductive layer 820 and the insulating layer 810, thereby exposing electroactive surface of the elongated bodies E1, E2.

公开(公告)号：US20170188906A1

公开(公告)日：2017-07-06

申请号：US15394327

申请日：2016-12-29

Applicant: DexCom, Inc.

Inventor： Rui Ma ,  Naresh C. Bhavaraju ,  Thomas Stuart Hamilton ,  Jonathan Hughes ,  Jeff Jackson ,  David I-Chun Lee ,  Peter C. Simpson ,  Stephen J. Vanslyke

IPC: A61B5/1495 ,  G01N33/66 ,  A61B5/145

CPC classification number: A61B5/1495 ,  A61B5/14532 ,  A61B5/14865 ,  G01N33/66

Abstract: Systems and methods are disclosed which provide for a “factory-calibrated” sensor. In doing so, the systems and methods include predictive prospective modeling of sensor behavior, and also include predictive modeling of physiology. With these two correction factors, a consistent determination of sensitivity can be achieved, thus achieving factory calibration.

公开(公告)号：US20140343386A1

公开(公告)日：2014-11-20

申请号：US14451332

申请日：2014-08-04

Applicant: DexCom, Inc.

Inventor： Robert J. Boock ,  Jeff Jackson ,  Huashi Zhang ,  Jason Mitchell

IPC: A61B5/1473 ,  A61B5/145

Abstract: Described here are embodiments of processes and systems for the continuous manufacturing of implantable continuous analyte sensors. In some embodiments, a method is provided for sequentially advancing an elongated conductive body through a plurality of stations, each configured to treat the elongated conductive body. In some of these embodiments, one or more of the stations is configured to coat the elongated conductive body using a meniscus coating process, whereby a solution formed of a polymer and a solvent is prepared, the solution is continuously circulated to provide a meniscus on a top portion of a vessel holding the solution, and the elongated conductive body is advanced through the meniscus. The method may also comprise the step of removing excess coating material from the elongated conductive body by advancing the elongated conductive body through a die orifice.

Abstract translation: 这里描述了用于连续制造可植入的连续分析物传感器的方法和系统的实施方案。 在一些实施例中，提供了一种用于使细长导电体顺序地前进穿过多个台的方法，每个台被构造成处理细长导电体。 在这些实施例中的一些实施例中，一个或多个工位被配置为使用弯液面涂覆工艺涂覆细长导电体，由此制备由聚合物和溶剂形成的溶液，该溶液被连续循环以在 保持溶液的容器的顶部，并且细长导电体前进通过弯液面。 该方法还可以包括通过使细长导电体通过模头孔从细长导电体去除多余涂层材料的步骤。

公开(公告)号：US20140123893A1

公开(公告)日：2014-05-08

申请号：US14155814

申请日：2014-01-15

Applicant: DexCom, Inc.

Inventor： Robert Boock ,  Jeff Jackson ,  Huashi Zhang ,  Jason Mitchell

IPC: B05C3/10

Abstract: Described here are embodiments of processes and systems for the continuous manufacturing of implantable continuous analyte sensors. In some embodiments, a method is provided for sequentially advancing an elongated conductive body through a plurality of stations, each configured to treat the elongated conductive body. In some of these embodiments, one or more of the stations is configured to coat the elongated conductive body using a meniscus coating process, whereby a solution formed of a polymer and a solvent is prepared, the solution is continuously circulated to provide a meniscus on a top portion of a vessel holding the solution, and the elongated conductive body is advanced through the meniscus. The method may also comprise the step of removing excess coating material from the elongated conductive body by advancing the elongated conductive body through a die orifice. For example, a provided elongated conductive body 510 is advanced through a pre-coating treatment station 520, through a coating station 530, through a thickness control station 540, through a drying or curing station 550, through a thickness measurement station 560, and through a post-coating treatment station 570.

Abstract translation: 这里描述了用于连续制造可植入的连续分析物传感器的方法和系统的实施方案。 在一些实施例中，提供了一种用于使细长导电体顺序地前进穿过多个台的方法，每个台被构造成处理细长导电体。 在这些实施例中的一些实施例中，一个或多个工位被配置为使用弯液面涂覆工艺涂覆细长导电体，由此制备由聚合物和溶剂形成的溶液，该溶液被连续循环以在 保持溶液的容器的顶部，并且细长导电体前进通过弯液面。 该方法还可以包括通过使细长导电体通过模头孔从细长导电体去除多余涂层材料的步骤。 例如，提供的细长导电体510通过预涂处理站520，穿过涂覆站530，通过厚度控制站540，穿过干燥或固化站550，穿过厚度测量站560，并通过 后涂层处理站570。

公开(公告)号：US20250040058A1

公开(公告)日：2025-01-30

申请号：US18916623

申请日：2024-10-15

Applicant: DexCom, Inc.

Inventor： Jason Halac ,  John Charles Barry ,  Becky L. Clark ,  Chris W. Dring ,  John Michael Gray ,  Kris Elliot Higley ,  Jeff Jackson ,  David A. Keller ,  Ted Tang Lee ,  Jason Mitchell ,  Kenneth Pirondini ,  David Rego ,  Ryan Everett Schoonmaker ,  Peter C. Simpson ,  Craig Thomas Gadd ,  Kyle Thomas Stewart ,  John Stanley Hayes

IPC: H05K3/32 ,  A61B5/00 ,  A61B5/145 ,  A61B5/1459 ,  A61B5/1473 ,  A61B5/1486 ,  A61B5/1495 ,  A61M5/00 ,  A61M5/142 ,  A61M5/172 ,  A61M5/178 ,  A61M5/20 ,  A61M5/30 ,  A61M11/00 ,  A61M15/00 ,  A61M35/00 ,  G01N27/327 ,  G01N33/66 ,  G16H20/17 ,  G16H40/63

Abstract: Pre-connected analyte sensors are provided. A pre-connected analyte sensor includes a sensor carrier attached to an analyte sensor. The sensor carrier includes a substrate configured for mechanical coupling of the sensor to testing, calibration, or wearable equipment. The sensor carrier also includes conductive contacts for electrically coupling sensor electrodes to the testing, calibration, or wearable equipment.

公开(公告)号：US20240341645A1

公开(公告)日：2024-10-17

申请号：US18626950

申请日：2024-04-04

Applicant: Dexcom, Inc.

Inventor： Rui Ma ,  Naresh C. Bhavaraju ,  Thomas Hamilton ,  Johathan M. Hughes ,  Jeff Jackson ,  David Lee ,  Peter C. Simpson ,  Stephen J. Vanslyke

IPC: A61B5/1495 ,  A61B5/145 ,  A61B5/1486 ,  G01N33/66

CPC classification number: A61B5/1495 ,  A61B5/14532 ,  G01N33/66 ,  A61B5/14865

Abstract: Systems and methods are disclosed which provide for a “factory-calibrated” sensor. In doing so, the systems and methods include predictive prospective modeling of sensor behavior, and also include predictive modeling of physiology. With these two correction factors, a consistent determination of sensitivity can be achieved, thus achieving factory calibration.

公开(公告)号：US11656195B2

公开(公告)日：2023-05-23

申请号：US16402101

申请日：2019-05-02

Applicant: DexCom, Inc.

Inventor： Naresh C. Bhavaraju ,  Becky L. Clark ,  Vincent P. Crabtree ,  Chris W. Dring ,  Arturo Garcia ,  Jason Halac ,  Jonathan Hughes ,  Jeff Jackson ,  Lauren Hruby Jepson ,  David I-Chun Lee ,  Ted Tang Lee ,  Rui Ma ,  Zebediah L. McDaniel ,  Jason Mitchell ,  Andrew Attila Pal ,  Daiting Rong ,  Disha B. Sheth ,  Peter C. Simpson ,  Stephen J. Vanslyke ,  Matthew D. Wightlin ,  Anna Leigh Davis ,  Hari Hampapuram ,  Aditya Sagar Mandapaka ,  Alexander Leroy Teeter ,  Liang Wang

IPC: G01N27/327 ,  A61B5/145 ,  A61B5/1495

CPC classification number: G01N27/3274 ,  A61B5/1495 ,  A61B5/14532 ,  A61B2560/0223

Abstract: Systems and methods are provided that address the need to frequently calibrate analyte sensors, according to implementation. In more detail, systems and methods provide a preconnected analyte sensor system that physically combines an analyte sensor to measurement electronics during the manufacturing phase of the sensor and in some cases in subsequent life phases of the sensor, so as to allow an improved recognition of sensor environment over time to improve subsequent calibration of the sensor.