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41.发明申请公开(公告)号：US20190209839A1
公开(公告)日：2019-07-11
申请号：US16284852
申请日：2019-02-25
申请人： ElectroCore, Inc.
发明人： Bruce J. Simon , Joseph P. Errico , John T. Raffle
CPC分类号： A61N1/36014 , A61N1/0456 , A61N1/36053 , A61N1/36114 , A61N1/36171 , A61N1/36178 , A61N1/362 , A61N1/3625 , A61N1/375 , A61N2/006 , A61N2/02
摘要： Energy is transmitted noninvasively to a patient using electrode-based stimulation devices or magnetic stimulation devices that are designed to non-invasively stimulate nerves selectively. The devices produce impulses that are used to treat atrial fibrillation, by stimulating a vagus nerve of a patient. The devices are also used to forecast the imminent onset of atrial fibrillation and then avert it by stimulating a vagus nerve.
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公开(公告)号：US20230059748A1
公开(公告)日：2023-02-23
申请号：US17981371
申请日：2022-11-04
申请人： ELECTROCORE, INC
发明人： BRUCE J. SIMON , Joseph P. Errico , John T. Raffle
摘要： Devices, systems and methods are disclosed for treating a variety of diseases and disorders. A device for treating a disorder in a patient comprises a housing having a contact surface for contacting an outer skin surface of the patient and an energy source within the housing. The energy source is configured to transmit electrical impulses through the outer skin surface of the patient to a selected nerve within the patient. The electrical impulses include bursts of pulses having a burst frequency between 1 Hz and 5000 Hz and a burst duration between 100 microseconds and 20,000 microseconds.
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公开(公告)号：US11534600B2
公开(公告)日：2022-12-27
申请号：US16662140
申请日：2019-10-24
申请人： ElectroCore, Inc.
发明人： Bruce J. Simon , Joseph P. Errico , John T. Raffle
摘要： Devices, systems and methods are disclosed for treating or preventing an autism spectrum disorder, a pervasive developmental disorder, or a disorder of psychological development. The methods comprise transmitting impulses of energy non-invasively to selected nerve fibers, particularly those in a vagus nerve. The nerve stimulation may be used as a behavior conditioning tool, by producing euphoria in an autistic individual. Vagus nerve stimulation is also used to modulate circulating serotonin levels in a pregnant woman so as to reduce the risk of having an autistic child; modulate the levels of growth factors within a child; promote balance of neuronal excitation/inhibition; modulate the activity of abnormal resting state neuronal networks; increase respiratory sinus arrhythmia; and avert episodes of motor stereotypies with the aid of forecasting methods.
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公开(公告)号：US11458325B2
公开(公告)日：2022-10-04
申请号：US16830607
申请日：2020-03-26
申请人： ElectroCore, Inc.
IPC分类号： A61N1/36 , A61N1/378 , A61N1/375 , A61N2/00 , A61N1/40 , A61H23/00 , A61H23/02 , A61H31/00 , A61H39/00 , A61N2/02 , A61N5/06 , A61N7/00
摘要： Devices, systems and methods are provided for treating a disease or disorder in a patient. The methods include positioning a surface of a housing in contact with an outer skin surface of the patient and applying sufficient energy to an energy transmitter within the housing via a power supply to generate an electrical impulse at or near a vagus nerve of the patient. The electrical impulse is sufficient to modulate fibers of the vagus nerve and treat the disease or disorder.
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公开(公告)号：US20220118252A1
公开(公告)日：2022-04-21
申请号：US17522010
申请日：2021-11-09
申请人： electroCore, Inc.
发明人： Bruce J. Simon , Joseph P. Errico , John T. Raffle
摘要： Devices, systems and methods are disclosed that allow a patient to self-treat a medical condition, such as headache, by noninvasive stimulation of a nerve. A system comprises a stimulator having an interface configured to contact an outer skin surface of a patient and an energy source coupled to the interface. The energy source transmits an electrical impulse through the interface transcutaneously through the outer skin surface of the patient to a nerve of the patient such that the nerve is modulated. The system further comprises a mobile device coupled to the stimulator to transmit data to the stimulator. The data includes a therapy regimen to reduce one or more symptoms of a headache in the patient.
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公开(公告)号：US20210392447A1
公开(公告)日：2021-12-16
申请号：US17461886
申请日：2021-08-30
申请人： ElectroCore, Inc.
发明人： Bruce J. Simon , Joseph P. Errico , John T. Raffle
摘要： Vagal nerve stimulation devices and methods are provided for treating medical conditions, such as conditions associated with insufficient dopamine and/or endogenous opioids in the brain. A device includes one or more electrodes having a contact surface for contacting an outer skin surface of a patient and an energy source coupled to the electrodes. The energy source generates one or more electrical impulses and transmits the electrical impulses to the electrodes and transcutaneously through the outer skin surface of the patient at or near a vagus nerve. The one or more electrical impulses is sufficient to modulate the vagus nerve and release dopamine and/or endogenous opioids in a brain of the patient.
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公开(公告)号：US20200246616A1
公开(公告)日：2020-08-06
申请号：US16838451
申请日：2020-04-02
申请人： ELECTROCORE, INC.
发明人： Bruce J. Simon , Joseph P. Errico , John T. Raffle
摘要： Devices and methods are provided for treating a patient that include delivering an electrical signal to a target nerve within the patient. The electrical signal has parameters selected to modulate the target nerve for therapeutic purposes to treat a disease or disorder in the patient.
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公开(公告)号：US20200246615A1
公开(公告)日：2020-08-06
申请号：US16837812
申请日：2020-04-01
申请人： ElectroCore, Inc.
发明人： Bruce J. Simon , Joseph P. Errico , John T. Raffle
摘要： Methods and devices for stimulating a nerve in a patient include emitting an electrical signal near a target nerve within the patient. The electrical signal comprises bursts with a frequency of 1 to 100 Hz. Each of the bursts has 2 to 20 pulses with a duration of about 50 microseconds to about 1000 microseconds.
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49.发明申请公开(公告)号：US20190329022A1
公开(公告)日：2019-10-31
申请号：US16404443
申请日：2019-05-06
申请人： ElectroCore, Inc.
发明人： Bruce J. Simon , Joseph P. Errico , John T. Raffle
摘要： Transcutaneous electrical nerve stimulation devices and magnetic stimulation devices are disclosed, along with methods of treating medical disorders using energy that is delivered noninvasively by such devices. The disorders comprise migraine and other primary headaches such as cluster headaches, including nasal or paranasal sinus symptoms that resemble an immune-mediated response (“sinus” headaches). The devices and methods may also be used to treat rhinitis, sinusitis, or rhinosinusitis, irrespective of whether those disorders are co-morbid with a headache. They may also be used to treat other disorders that may be co-morbid with migraine or cluster headaches, such as anxiety disorders. In preferred embodiments of the disclosed methods, one or both of the patient's vagus nerves are stimulated non-invasively. In other embodiments, parts of the sympathetic nervous system and/or the adrenal glands are stimulated.
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公开(公告)号：US20190184162A1
公开(公告)日：2019-06-20
申请号：US16278945
申请日：2019-02-19
申请人： ElectroCore, Inc.
发明人： Bruce J. Simon , Joseph P. Errico , John T. Raffle
CPC分类号： A61N1/36007 , A61N1/0456 , A61N1/205 , A61N1/36 , A61N1/36014 , A61N1/40 , A61N2/006 , A61N2/02
摘要： Devices, systems and methods are disclosed for treating or preventing gastroparesis, functional dyspepsia, and other functional gastrointestinal disorders. The methods comprise transmitting impulses of energy non-invasively to selected nerve fibers, particularly those in a vagus nerve. The methods provide damaged interstitial cells of Cajal (ICC) with trophic factors via vagal afferent nerve fibers, thereby reversing ICC damage, and as a consequence improving gastric motility. The methods also increase levels of inhibitory neurotransmitters in the brain so as to decrease neural activity within the area postrema, or they deactivate a resting state neural network containing parts of the anterior insula and anterior cingulate cortex, which will thereby reduce abnormal interoception and visceral hypersensitivity.
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