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公开(公告)号：US4737488A
公开(公告)日：1988-04-12
申请号：US676160
申请日：1984-11-29
申请人： Oswald Lockhoff , Bernd-Wieland Kruger , Peter Stadler , Karl G. Metzger , Hans-Georg Opitz , Klaus Schaller , Klaus G. Stunkel , Hans-Joachim Zeiler
发明人： Oswald Lockhoff , Bernd-Wieland Kruger , Peter Stadler , Karl G. Metzger , Hans-Georg Opitz , Klaus Schaller , Klaus G. Stunkel , Hans-Joachim Zeiler
摘要： Compounds of the formula ##STR1## wherein R.sup.1 is hydrogen, an optionally substituted aromatic hydrocarbon radical, an aralkyl radical or an optionally substituted aliphatic hydrocarbon radical having up to 45 C atoms,R.sup.2 is an optionally substituted aromatic hydrocarbon radical, an aralkyl radical or an optionally substituted aliphatic hydrocarbon radical having 5-50 C atoms,X is O, S, NH or NR, R being an alkyl radical having up to 20 C atoms, andZ is a glycosyl radical bonded via the anomeric carbon atom,or pharmaceutically acceptable salts thereof stimulate the immune system.
摘要翻译： 其中R 1是氢，任选取代的芳族烃基，芳烷基或具有至多45个C原子的任选取代的脂族烃基的式的化合物，R 2是任选取代的芳族烃基，芳烷基或 任选取代的具有5-50个碳原子的脂族烃基，X是O，S，NH或NR，R是具有至多20个C原子的烷基，Z是通过端基异碳键键合的糖基，或药学上可接受的 其盐刺激免疫系统。
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42.发明授权Substituted O-sulphonyl-glycosylamides, processes for their preparation and their use as medicaments 失效取代的O-磺酰基 - 糖基酰胺，其制备方法及其作为药物的用途
公开(公告)号：US4699899A
公开(公告)日：1987-10-13
申请号：US832482
申请日：1986-02-21
申请人： Bernd-Wieland Kruger , Yutaka Hayauchi , Oswald Lockhoff , Peter Stadler , Karl G. Metzger , Klaus G. Stunkel , Hans-Joachim Zeiler
发明人： Bernd-Wieland Kruger , Yutaka Hayauchi , Oswald Lockhoff , Peter Stadler , Karl G. Metzger , Klaus G. Stunkel , Hans-Joachim Zeiler
IPC分类号： C07H13/00 , A61K31/70 , A61K31/7024 , A61K31/7028 , A61P31/00 , A61P37/04 , C07H1/00 , C07H13/12 , C07H15/04 , C07H15/12
CPC分类号： C07H13/12 , C07H15/04 , Y10S514/885
摘要： Novel compounds of the formula ##STR1## in which X is hydrogen or --CH.sub.2 --OR.sup.5,Z represents OR.sup.4, NH.sub.2 or ##STR2## R.sup.2, R.sup.3, R.sup.4 and R.sup.5 each independently is hydrogen or ##STR3## at least one of R.sup.2, R.sup.3, R.sup.4 and R.sup.5 being ##STR4## Y and W each independently is oxygen, sulphur, NH or CH.sub.2, and R.sup.1, R.sup.6, R.sup.7 and R.sup.8 each independently is an optionally substituted hydrocarbon radical with up to 50 C atoms,stimulate the immune system.
摘要翻译： 式中，X为氢或-CH 2 OR 5的新颖化合物，Z为OR 4，NH 2或R 2，R 3，R 4和R 5各自独立地为氢或R 2，R 3， ，R 4和R 5是Y，W各自独立地是氧，硫，NH或CH 2，R 1，R 6，R 7和R 8各自独立地是具有至多50个C原子的任选取代的烃基，刺激免疫系统。
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公开(公告)号：USRE33948E
公开(公告)日：1992-06-02
申请号：US400200
申请日：1989-08-29
IPC分类号： A23K20/195 , A61K31/43 , A61K31/545 , A61K31/546 , A61P31/04 , C07D499/00 , C07D499/10 , C07D499/12 , C07D499/64 , C07D499/70 , C07D501/06 , C07D501/20 , C07D501/22 , C07D501/34 , C07D501/57 , C07D501/59
CPC分类号： C07D499/00 , A23K20/195 , Y02P20/55
摘要： Antibacterially active and animal growth-promoting novel .beta.-lactam compounds of the formula ##STR1## in which R.sup.1 represents the radical ##STR2## Y representing N or CR.sup.9, or Y--R.sup.7 representing ##STR3## Z representing O, S, or NR.sup.10, and R.sup.2 represents hydrogen or a protective group.
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公开(公告)号：US4748163A
公开(公告)日：1988-05-31
申请号：US832483
申请日：1986-02-21
IPC分类号： A23K20/195 , A61K31/43 , A61K31/545 , A61K31/546 , A61P31/04 , C07D499/00 , C07D499/10 , C07D499/12 , C07D499/64 , C07D499/70 , C07D501/06 , C07D501/20 , C07D501/22 , C07D501/34 , C07D501/57 , C07D501/59
CPC分类号： C07D499/00 , A23K20/195 , Y02P20/55
摘要： Antibacterially active and animal growth-promoting novel .beta.-lactam compounds of the formula ##STR1## in which R.sup.1 represents the radical ##STR2## Y representing N or CR.sup.9, or Y--R.sup.7 representing >C.dbd.O or >C.dbd.N--R.sup.7,Z representing O, S, or NR.sup.10, andR.sup.2 represents hydrogen or a protective group.
摘要翻译： 其中R 1表示代表N或CR 9的基团，或表示> C = O或> C = N-R 7的Y-R 7，所述式为“IMAGE”的抗菌活性和动物生长促进性新型β-内酰胺化合物， Z代表O，S或NR10，R 2表示氢或保护基。
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45.发明授权7-[2-(2- aminothiazol-4-yl)-2-oximino-acetamido-3-quaternary-ammonium-methyl-3-cep hem-4-carboxylates 失效7- [2-（2-氨基噻唑-4-基）-2-肟基 - 乙酰氨基-3-季铵甲基-3-头孢烯-4-羧酸酯
公开(公告)号：US4686216A
公开(公告)日：1987-08-11
申请号：US730985
申请日：1985-05-06
IPC分类号： A23K20/195 , A61K20060101 , A61K31/545 , A61K31/546 , A61P31/04 , C07D20060101 , C07D277/40 , C07D417/14 , C07D501/18 , C07D501/24 , C07D501/42 , C07D501/46 , C07D501/56 , C07D501/59
CPC分类号： C07D501/46
摘要： Novel cephalosporins of the formula ##STR1## in which R.sup.1 is an aliphatic or cycloaliphatic hydrocarbyl radical of up to 6 carbon atoms which is optionally substituted by a carboxyl group, ##STR2## R.sup.2 and R.sup.3 each independently is an optionally substituted aliphatic or cycloaliphatic hydrocarbyl radical of up to 6 carbon atoms, but is not unsubstituted methyl,or pharmaceutically acceptable salts thereof, are effective antibacterially and promote the growth of animals.
摘要翻译： 式（IMAGE）的新型头孢菌素，其中R 1是任选被羧基取代的至多6个碳原子的脂族或脂环族烃基，R 2和R 3各自独立地是 具有至多6个碳原子的任选取代的脂族或脂环族烃基，但不是未取代的甲基或其药学上可接受的盐是有效的，有利于促进动物的生长。
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46.发明授权6-fluoro-7-chloro-1-cyclopropyl-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid 失效6-氟-7-氯-1-环丙基-4-氧代-1,4-二氢 - 喹啉-3-羧酸
公开(公告)号：US4620007A
公开(公告)日：1986-10-28
申请号：US807554
申请日：1985-12-11
IPC分类号： C07D215/56 , C07D471/04 , C07D215/14
CPC分类号： C07D471/04 , C07D215/56
摘要： The invention relates to 7-amino-1-cyclo-propyl-4-oxo-1,4-dihydro-naphthyridine (or quinoline)-3-carboxylic acids of Formula I as defined in the specifications. Also included in the invention is a process for the preparation of said compounds of Formula I and Ia. Further, the invention includes compositions containing the compounds of Formula I or Ia and the use of said compounds and compositions as antibacterial agents.
摘要翻译： 本发明涉及规格中定义的式I的7-氨基-1-环丙基-4-氧代-1,4-二氢 - 萘啶（或喹啉）-3-羧酸。 本发明还包括制备所述式I和Ia化合物的方法。 此外，本发明包括含有式I或Ia化合物的组合物以及所述化合物和组合物作为抗菌剂的用途。
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47.发明授权7-amino-1-cyclopropyl-4-oxo-1,4-dihydro-quinoline- and naphthyridine-3-carboxylic acids, processes for their preparation and antibacterial agents containing these compounds 失效7-氨基-1-环丙基-4-氧代-1,4-二氢喹啉和萘啶-3-羧酸，其制备和包含这些化合物的抗菌剂的方法
公开(公告)号：US5077429A
公开(公告)日：1991-12-31
申请号：US846789
申请日：1986-04-01
IPC分类号： C07D215/56 , C07D471/04
CPC分类号： C07D471/04 , C07D215/56
摘要： The invention relates to 7-amino-1-cyclo-propyl-4-oxo-1,4-dihydro-naphthyridine (or quinoline)-3-carboxylic acids of Formula I as defined in the specification. Also included in the invention is a process for the preparation of said compounds of Formula I and Ia. Further, the invention includes compositions containing the compounds of Formula I or Ia and the use of said compounds and compositions as antibacterial agents.
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公开(公告)号：US4980353A
公开(公告)日：1990-12-25
申请号：US862863
申请日：1986-05-13
IPC分类号： A23K1/16 , A61K31/47 , A61K31/495 , A61P3/00 , A61P31/04 , C07C67/00 , C07C201/00 , C07C205/58 , C07C205/61 , C07D215/56 , C07D401/04
CPC分类号： C07D215/56 , C07C205/58 , C07C205/61 , C07D401/04
摘要： Antibacterially active and animal growth promoting novel 1-aryl-4-quinolone-3-carboxylic acids of the formula ##STR1## in which X is halogen or nitro,X.sup.2 is halogen,R is optionally substituted phenyl, andA is halogen or optionally substituted piperazine or pyrrolidine,or pharmaceutically useable hydrates, acid additions salts, alkali metal, alkaline earth metal, silver or guanidinium salts thereof, and/or esters thereof.
摘要翻译： 促进新的式（ⅠA-芳基-4-喹诺酮-3-羧酸，其中X是卤素或硝基，X 2是卤素，R是任意取代的苯基，A是卤素或任意取代的） 哌嗪或吡咯烷，或其药学上可用的水合物，酸加成盐，碱金属，碱土金属，银或胍盐，和/或其酯。
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公开(公告)号：US4973685A
公开(公告)日：1990-11-27
申请号：US250597
申请日：1988-09-28
IPC分类号： A61K31/43 , A61K31/545 , A61K31/546 , A61P31/04 , C07D499/00 , C07D499/64 , C07D499/68 , C07D499/70 , C07D499/90 , C07D501/20 , C07D501/34 , C07D501/36 , C07D501/46 , C07D501/56
CPC分类号： C07D499/00
摘要： Heteroannellated penicillins and cephalosporins of the formula ##STR1## in which R.sup.1 --stands for a radical of the formula ##STR2##
摘要翻译： 具有式（Ⅰ）的无意义的青霉素和头孢菌素，其中R1代表下式的基团：
+ TR -
公开(公告)号：US4847375A
公开(公告)日：1989-07-11
申请号：US874249
申请日：1986-06-13
IPC分类号： A61K31/535 , A61K31/55 , A61P31/04 , C07D471/06 , C07D498/06
CPC分类号： C07D471/06
摘要： As antibacterials and animal growth promoters, the compounds of the formula ##STR1## in which Y is --COOH, --COOR.sup.7 or --CONR.sup.8, R.sup.9,X.sup.1 is H, nitro, alkyl or halogen,R.sup.10 and R.sup.11 preferably complete a piperazine ring,Z is oxygen or NR.sup.15,n is 0 or 1, andthe others can have various meanings,and pharmaceutically acceptable hydrate, alkali metal, alkaline earth metal, silver or guanidinium salt or ester thereof.
摘要翻译： 作为抗菌剂和动物生长促进剂，其中Y是-COOH，-COOR7或-CONR8，R9，X1的式“IMAGE”的化合物是H，硝基，烷基或卤素，R10和R11优选完成哌嗪环Z 是氧或NR15，n是0或1，其他可以具有各种含义，以及药学上可接受的水合物，碱金属，碱土金属，银或胍盐或其酯。
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