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18 条记录 (耗时 0.037 秒)

    Phosphorylated glycosyl-amides, -ureas, -carbamates and -thiocarbamates and method of use
    7.
    发明授权
    Phosphorylated glycosyl-amides, -ureas, -carbamates and -thiocarbamates and method of use 失效
    磷酸化糖基酰胺， - 脲， - 氨基甲酸酯和 - 硫代氨基甲酸酯及其使用方法

    公开(公告)号：US4686208A

    公开(公告)日：1987-08-11

    申请号：US673811

    申请日：1984-11-21

    申请人： Oswald Lockhoff ,  Bernd-Wieland Kruger ,  Peter Stadler ,  Arnold Paessens ,  Gert Streissle ,  Peter Taylor ,  Hans-Joachim Zeiler ,  Karl-Georg Metzger

    发明人： Oswald Lockhoff ,  Bernd-Wieland Kruger ,  Peter Stadler ,  Arnold Paessens ,  Gert Streissle ,  Peter Taylor ,  Hans-Joachim Zeiler ,  Karl-Georg Metzger

    IPC分类号： A61K31/70 ,  C07H13/06 ,  C07H13/12 ,  C07H5/06

    CPC分类号： C07H13/06 ,  C07H13/12

    摘要： Compounds of the formula ##STR1## in which R.sup.1 represents an optionally substituted, straight-chain or branched, saturated, monounsaturated or polyunsaturated alkyl radical, an optionally substituted, saturated or one- or polyunsaturated cycloalkyl radical or an optionally substituted aryl radical or aralkyl radical,X represents CH.sub.2, O, S, NH or N-alkyl with up to 20 C atoms,R.sup.2 has the meaning of R.sup.1, and can represent hydrogen if X denotes CH.sub.2, the radicals R.sup.3 independently of one another represent hydrogen, an acyl radical or alkyl radical with in each case up to 20 C atoms, a silyl radical and/or a phosphoric acid or phosphoric acid ester radical andR.sup.4 denotes hydrogen, methyl or --CH.sub.2 --OR.sup.3, with the proviso that one of the radicals R.sup.3 always represents a phosphoric acid or phosphoric acid ester radical, which stimulate a patient's immune system and are thereby effective in combating viral disease and bacterial infection.

    摘要翻译： 式“IMAGE”的化合物，其中R 1表示任选取代的直链或支链饱和的单不饱和或多不饱和烷基，任选取代的饱和或一或多不饱和环烷基或任选取代的芳基或芳烷基 X表示CH 2，O，S，NH或具有多达20个C原子的N-烷基，R 2具有R 1的含义，如果X表示CH 2，则可表示氢，基团R 3彼此独立地表示氢，酰基 或烷基，在每种情况下最多达20个C原子，甲硅烷基和/或磷酸或磷酸酯基，R4表示氢，甲基或-CH2-OR3，条件是基团R3之一总是表示 磷酸或磷酸酯基，其刺激患者的免疫系统，从而有效地对抗病毒性疾病和细菌感染。

    N-glycosylamide derivatives, processes for their preparation and their use as medicaments
    9.
    发明授权
    N-glycosylamide derivatives, processes for their preparation and their use as medicaments 失效
    N-糖酰胺衍生物，其制备方法及其作为药物的用途

    公开(公告)号：US4891425A

    公开(公告)日：1990-01-02

    申请号：US7703

    申请日：1987-01-28

    申请人： Oswald Lockhoff ,  Yutaka Hayauchi ,  Peter Stadler ,  Helmut Brunner

    发明人： Oswald Lockhoff ,  Yutaka Hayauchi ,  Peter Stadler ,  Helmut Brunner

    IPC分类号： A01N57/16 ,  A61K31/70 ,  A61K31/7028 ,  A61P31/04 ,  A61P37/00 ,  C07H13/04 ,  C07H15/04 ,  C07H15/12 ,  C07H15/18

    CPC分类号： C07H13/04 ,  C07H15/04

    摘要： A N-glycosylamide derivative of the formula (I) ##STR1## in which R.sup.1 denotes hydrogen or a saturated or mono- or polyunsaturated alkyl radical with one to 50 carbon atoms,R.sup.2 denotes hydrogen or a saturated or mono- or polyunsaturated alkyl radical with one to 50 carbon atoms,R.sup.3 denotes hydrogen or an acyl radical with up to 20 carbon atoms,R.sup.4 denotes hydrogen or an alkyl radical with up to 4 carbon atoms andR.sup.5 and R.sup.6 independently of one another denote hydrogen or an acyl radical with up to 10 carbon atoms or a saturated or an unsaturated alkyl radical or an aralkyl radical with up to 10 carbon atoms, orR.sup.5 l and R.sup.6 together denote a grouping ##STR2## wherein R.sup.7 and R.sup.8 independently of one another denote hydrogen or lower alkyl with up to 5 carbon atoms or an unsubstituted or substituted aryl radical with up to 10 C atoms in the aromatic part. The N-glycosylamide derivatives exhibiting a broad defense-increasing action in the body.

    摘要翻译： 式（I）的N-糖酰胺衍生物其中R 1表示氢或具有1至50个碳原子的饱和或单或多不饱和烷基，R 2表示氢或饱和或单或多不饱和的 具有1至50个碳原子的烷基，R 3表示氢或至多20个碳原子的酰基，R 4表示氢或具有至多4个碳原子的烷基，R 5和R 6彼此独立地表示氢或酰基 具有至多10个碳原子或饱和或不饱和的烷基或具有至多10个碳原子的芳烷基，或者R 5和R 6一起表示分组，其中R 7和R 8彼此独立地表示氢或低级烷基 具有多至5个碳原子的芳族部分或未被取代的或取代的芳基，其中芳族部分中具有至多10个C原子。 N-糖酰胺衍生物在体内表现出广泛的防御增加作用。

    Substituted N-glycosylamides, process for their preparation, and their use as medicaments
    10.
    发明授权
    Substituted N-glycosylamides, process for their preparation, and their use as medicaments 失效
    取代的N-甲酰胺，其制备方法及其作为药物的用途

    公开(公告)号：US5070190A

    公开(公告)日：1991-12-03

    申请号：US336497

    申请日：1989-04-12

    申请人： Oswald Lockhoff ,  John Goossens ,  Helmut Brunner ,  Michael Sperzel ,  Klaus G. Stunkel

    发明人： Oswald Lockhoff ,  John Goossens ,  Helmut Brunner ,  Michael Sperzel ,  Klaus G. Stunkel

    IPC分类号： A61K31/70 ,  A61K31/7028 ,  A61P37/04 ,  C07H15/12

    CPC分类号： C07H15/12 ,  Y10S514/885

    摘要： The invention relates to new N-glycosylamides of the general formula I ##STR1## in which R.sup.1 denotes a saturated alkyl radical or a singly, doubly or triply unsaturated alkenyl radical having up to 50 carbon atoms,R.sup.2 denotes a saturated alkyl radical or a singly, doubly or triply unsaturated alkenyl radical having up to 50 carbon atoms,A represents --CO-- or represents a group ##STR2## in which R.sup.3 represents hydrogen, C.sub.1 -C.sub.7 alkyl, hydroxymethyl, 1-hydroxyethyl, mercaptomethyl, 2-methylthioethyl, 3-aminopropyl, 2-ureidopropyl, 3-guanidylpropyl, 4-aminobutyl, carboxymethyl, carbamoylmethyl, 2-carboxyethyl, 2-carbamoylethyl, benzyl, 4-hydroxybenzyl, 3-indolylmethyl or 4-imidazolylmethyl, andn represents 0 to 10,and which are substituted in the sugar residue with an amino acid residue, as well as process for their preparation and their use as medicaments.

    摘要翻译： 本发明涉及通式Ⅰ“IMAGE”的新的N-糖基酰胺，其中R 1表示饱和的烷基或具有至多50个碳原子的单，双或三不饱和烯基，R2表示饱和的烷基或单 ，具有至多50个碳原子的双或三重不饱和烯基，A表示-CO-或代表其中R3表示氢，C1-C7烷基，羟甲基，1-羟乙基，巯基甲基，2-甲硫基乙基， 氨基丙基，2-脲基丙基，3-胍基丙基，4-氨基丁基，羧甲基，氨基甲酰基甲基，2-羧基乙基，2-氨基甲酰基乙基，苄基，4-羟基苄基，3-吲哚基甲基或4-咪唑基甲基，n表示0〜10， 在糖残基中用氨基酸残基取代，以及其制备方法及其作为药物的用途。