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公开(公告)号：US06228871B1
公开(公告)日：2001-05-08
申请号：US09343652
申请日：1999-06-29
申请人： Mark E. Fraley , Randall W. Hungate , William F. Hoffman , William R. Huckle , Richard L. Kendall , Kenneth A. Thomas, Jr.
发明人： Mark E. Fraley , Randall W. Hungate , William F. Hoffman , William R. Huckle , Richard L. Kendall , Kenneth A. Thomas, Jr.
IPC分类号： C07D40102
CPC分类号： C07D409/04 , C07D263/48 , C07D413/04 , C07D413/14
摘要： The present invention relates to compounds which inhibit tyrosine kinase enzymes, compositions which contain tyrosine kinase inhibiting compounds and methods of using tyrosine kinase inhibitors to treat tyrosine kinase-dependent diseases and conditions such as angiogenenesis, cancer, atherosclerosis, diabetic retinopathy or autoimmune diseases, in mammals.
摘要翻译： 本发明涉及抑制酪氨酸激酶的化合物，含有酪氨酸激酶抑制化合物的组合物和使用酪氨酸激酶抑制剂治疗酪氨酸激酶依赖性疾病和病症如血管生成，癌症，动脉粥样硬化，糖尿病性视网膜病变或自身免疫性疾病的方法 哺乳动物。
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公开(公告)号：US5668289A
公开(公告)日：1997-09-16
申请号：US669189
申请日：1996-06-24
申请人： Philip E. Sanderson , Adel M. Naylor-Olsen , Dona L. Dyer , Joseph P. Vacca , Richard C. A. Isaacs , Bruce D. Dorsey , Mark E. Fraley
发明人： Philip E. Sanderson , Adel M. Naylor-Olsen , Dona L. Dyer , Joseph P. Vacca , Richard C. A. Isaacs , Bruce D. Dorsey , Mark E. Fraley
IPC分类号： A61K38/00 , C07K5/078 , C07D211/86 , A61K31/44
CPC分类号： C07K5/06139 , A61K38/00
摘要： Compounds of the invention are useful in inhibiting thrombin and associated thrombotic occlusions and have the following structure: ##STR1## for example: ##STR2##
摘要翻译： 本发明的化合物可用于抑制凝血酶和相关的血栓闭塞，并具有以下结构：
例如： -
43.发明申请公开(公告)号：US20140005214A1
公开(公告)日：2014-01-02
申请号：US14005595
申请日：2012-03-14
IPC分类号： C07D401/12
CPC分类号： C07D401/12 , A61K31/445
摘要： The present invention is directed to piperidinone carboxamide spirohydantoin derivatives which are antagonists of CGRP receptors and useful in the treatment or prevention of diseases in which the CGRP is involved, such as migraine. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.
摘要翻译： 本发明涉及作为CGRP受体的拮抗剂的哌啶酮甲酰胺螺乙内酰脲衍生物，其可用于治疗或预防涉及CGRP的疾病，例如偏头痛。 本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及CGRP的疾病中的用途。
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公开(公告)号：US08063090B2
公开(公告)日：2011-11-22
申请号：US12532031
申请日：2008-03-19
IPC分类号： A61K31/415 , C07D233/64
CPC分类号： C07D231/12
摘要： The present invention relates to diphenylmethyl imidazole mineralocorticoid receptor modulators compounds having the structure and their use in treating cardiovascular events.
摘要翻译： 本发明涉及二苯基甲基咪唑盐皮质激素受体调节剂，其结构及其在治疗心血管事件中的应用。
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公开(公告)号：US20110160229A1
公开(公告)日：2011-06-30
申请号：US13060775
申请日：2009-08-31
IPC分类号： A61K31/52 , C07D471/04 , C07D473/34 , A61K31/437 , A61P25/28 , A61P9/00 , A61P25/00 , A61P19/10 , A61P25/16 , A61P25/18 , A61P9/12
CPC分类号： C07D471/04
摘要： The present invention is directed to AHCY inhibitors of formula (I): which are useful in the treatment of diseases characterized by high homocysteine levels, such as Alzheimer's disease. The invention is also directed to pharmaceutical compositions comprising the compounds, and to the use of the compounds and compositions in the treatment of diseases characterized by high homocysteine levels.
摘要翻译： 本发明涉及式（I）的AHCY抑制剂：其可用于治疗以高同型半胱氨酸水平为特征的疾病，例如阿尔茨海默氏病。 本发明还涉及包含该化合物的药物组合物，以及该化合物和组合物在治疗以高同型半胱氨酸水平为特征的疾病中的用途。
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公开(公告)号：US07618971B2
公开(公告)日：2009-11-17
申请号：US11630224
申请日：2005-06-27
IPC分类号： A61K31/496 , A61K31/4196 , A61K31/4155 , C07D403/06 , C07D249/08 , C07D231/06
CPC分类号： C07D231/12 , C07D401/06 , C07D401/14 , C07D403/06 , C07D403/12 , C07D403/14 , C07D413/14 , C07D487/08 , C07D491/107 , C07D491/113
摘要： The present invention relates to dihydropyrazole compounds that are useful for treating cellular proliferative diseases, for treating disorders associated with KSP kinesin activity, and for inhibiting KSP kinesin. The invention also related to compositions which comprise these compounds, and methods of using them to treat cancer in mammals.
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公开(公告)号：US20090233896A1
公开(公告)日：2009-09-17
申请号：US11921598
申请日：2006-06-05
申请人： Kenneth L. Arrington , Vadim Y. Dudkin , Mark E. Fraley , Jacob M. Hoffman , Constantine Kreatsoulas , Cheng Wang
发明人： Kenneth L. Arrington , Vadim Y. Dudkin , Mark E. Fraley , Jacob M. Hoffman , Constantine Kreatsoulas , Cheng Wang
IPC分类号： A61K31/397 , C07D413/14 , A61K31/5377 , C07D401/14 , A61K31/506 , C07D403/00 , A61K31/496 , A61P35/00
CPC分类号： C07D417/14 , C07D417/04 , C07D417/12
摘要： The instant invention provides for compounds which comprise substituted pyridyl aminothiazoles that inhibit CHK1 activity. The invention also provides for compositions comprising such inhibitory compounds and methods of inhibiting CHK1 activity by administering the compound to a patient in need of treatment of cancer.
摘要翻译： 本发明提供了包含抑制CHK1活性的取代的吡啶基氨基噻唑的化合物。 本发明还提供了包含这种抑制化合物的组合物和通过将该化合物给予需要治疗癌症的患者来抑制CHK1活性的方法。
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公开(公告)号：US07553838B2
公开(公告)日：2009-06-30
申请号：US11630302
申请日：2005-06-27
申请人： Mark E. Fraley , George D. Hartman
发明人： Mark E. Fraley , George D. Hartman
IPC分类号： C07D403/06 , C07D403/14 , A61K31/496
CPC分类号： C07D231/06 , C07D487/08
摘要： The present invention relates to dihydropyrazole compounds that are useful for treating cellular proliferative diseases, for treating disorders associated with KSP kinesin activity, and for inhibiting KSP kinesin. The invention also related to compositions which comprise these compounds, and methods of using them to treat cancer in mammals.
摘要翻译： 本发明涉及可用于治疗细胞增殖性疾病，治疗与KSP驱动蛋白活性相关的疾病和用于抑制KSP驱动蛋白的二氢吡唑化合物。 本发明还涉及包含这些化合物的组合物，以及使用它们治疗哺乳动物癌症的方法。
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![Substituted pyrazolo[3,4-d] pyrimidinones as a mitotic kinesin inhibitor](/abs-image/US/2007/08/28/US07262186B2/abs.jpg.150x150.jpg)
49.发明授权Substituted pyrazolo[3,4-d] pyrimidinones as a mitotic kinesin inhibitor 失效取代的吡唑并[3,4-d]嘧啶酮作为有丝分裂驱动蛋白抑制剂公开(公告)号：US07262186B2
公开(公告)日：2007-08-28
申请号：US10497385
申请日：2002-12-02
IPC分类号： C07D487/04 , C07D413/12 , C07D243/08 , A61K31/519 , A61K31/497 , A61K31/5355 , A61K31/551
CPC分类号： C07D487/04 , C07D519/00
摘要： The present invention relates to azolopyriniidinone compounds that are useful for treating cellular proliferative diseases, for treating disorders associated with KSP kinesin activity, and for inhibiting KSP kinesin. The invention also related to compositions which comprise these compounds, and methods of using them to treat cancer in mammals.
摘要翻译： 本发明涉及可用于治疗细胞增殖性疾病，用于治疗与KSP驱动蛋白活性相关的病症和用于抑制KSP驱动蛋白的偶氮吡啶酮酮化合物。 本发明还涉及包含这些化合物的组合物，以及使用它们治疗哺乳动物癌症的方法。
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公开(公告)号：US07169788B2
公开(公告)日：2007-01-30
申请号：US10489647
申请日：2002-10-25
IPC分类号： A61K31/496 , A61K31/4704 , C07D401/04 , C07D401/14
CPC分类号： C07D401/04 , C07D401/14
摘要： The present invention relates to compounds which inhibit, regulate and/or modulate tyrosine kinase signal transduction, compositions which contain these compounds, and methods of using them to treat tyrosine kinase-dependent diseases and conditions, such as angiogenesis, cancer, tumor growth, atherosclerosis, age related macular degeneration, diabetic retinopathy, inflammatory diseases, and the like in mammals.
摘要翻译： 本发明涉及抑制，调节和/或调节酪氨酸激酶信号转导的化合物，含有这些化合物的组合物及其用于治疗酪氨酸激酶依赖性疾病和病症如血管生成，癌症，肿瘤生长，动脉粥样硬化的方法 ，年龄相关性黄斑变性，糖尿病性视网膜病变，炎症性疾病等。
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