公开(公告)号：US20060257781A1

公开(公告)日：2006-11-16

申请号：US11300657

申请日：2005-12-12

申请人： Didier Benoit ,  Adam Safir ,  Han-Ting Chang ,  Dominique Charmot ,  Isao Nishimura ,  Akimasa Soyano ,  Kenji Okamoto ,  Yong Wang

发明人： Didier Benoit ,  Adam Safir ,  Han-Ting Chang ,  Dominique Charmot ,  Isao Nishimura ,  Akimasa Soyano ,  Kenji Okamoto ,  Yong Wang

IPC分类号： G03C1/00

CPC分类号： C08F220/18 ,  C08F20/18 ,  C08F220/28 ,  G03F7/0397

摘要： The present invention is directed to the preparation of photoresist polymers via living free radical polymerization techniques. Sterically bulky ester monomers are utilized as the polymerization components. Use of chain transfer agents is included in polymerization processing conditions. Cleavage of polymer terminal end groups that include a heteroatom are described.

公开(公告)号：US20060122346A9

公开(公告)日：2006-06-08

申请号：US10877110

申请日：2004-06-25

申请人： Didier Benoit ,  Adam Safir ,  Han-Ting Chang ,  Dominique Charmot ,  Kenji Okamoto ,  Isao Nishimura ,  Yong Wang

发明人： Didier Benoit ,  Adam Safir ,  Han-Ting Chang ,  Dominique Charmot ,  Kenji Okamoto ,  Isao Nishimura ,  Yong Wang

IPC分类号： C08F2/00

CPC分类号： C08F220/30 ,  C08F2/38 ,  C08F20/30 ,  C08F220/18 ,  C08F293/005 ,  G03F7/0046 ,  G03F7/0397

摘要： The present invention is directed to the preparation of photoresist polymers via living free radical polymerization techniques. Sterically bulky ester monomers are utilized as the polymerization components. Use of chain transfer agents is included in polymerization processing conditions. Cleavage of polymer terminal end groups that include a heteroatom are described.

摘要翻译： 本发明涉及通过活性自由基聚合技术制备光致抗蚀剂聚合物。 用作单体体积大的酯单体作为聚合组分。 链转移剂的使用包括在聚合工艺条件中。 描述了包含杂原子的聚合物末端基团的切割。

公开(公告)号：US20070135383A1

公开(公告)日：2007-06-14

申请号：US11593176

申请日：2006-11-03

申请人： Han-Ting Chang ,  Dominque Charmot ,  Tomasz Glinka ,  Michael Cope ,  Elizabeth Goka ,  Jun Shao ,  Damien Cartigny ,  Shiah-yun Chen ,  Jerry Buysse

发明人： Han-Ting Chang ,  Dominque Charmot ,  Tomasz Glinka ,  Michael Cope ,  Elizabeth Goka ,  Jun Shao ,  Damien Cartigny ,  Shiah-yun Chen ,  Jerry Buysse

IPC分类号： A61K31/685 ,  A61K31/66 ,  A61K31/503 ,  A61K31/4745 ,  A61K31/405 ,  A61K31/365

CPC分类号： A61K31/404 ,  A61K9/0019 ,  A61K9/0095 ,  A61K31/41 ,  A61K31/66 ,  A61K47/10 ,  A61K47/20 ,  A61K47/55 ,  A61K47/58

摘要： The present invention provides methods and compositions for the treatment of phospholipase-related conditions. In particular, the invention provides a method of treating insulin-related, weight-related conditions and/or cholesterol-related conditions in an animal subject. The method generally involves the administration of a non-absorbed and/or effluxed phospholipase A2 inhibitor that is localized in a gastrointestinal lumen.

摘要翻译： 本发明提供了治疗磷脂酶相关病症的方法和组合物。 特别地，本发明提供了一种在动物受试者中治疗胰岛素相关，体重相关病症和/或胆固醇相关病症的方法。 该方法通常涉及施用定位在胃肠腔中的未吸收和/或流出的磷脂酶A2抑制剂。

公开(公告)号：US5859281A

公开(公告)日：1999-01-12

申请号：US651819

申请日：1996-05-21

申请人： K. Barry Sharpless ,  Guigen Li ,  Han-Ting Chang

发明人： K. Barry Sharpless ,  Guigen Li ,  Han-Ting Chang

IPC分类号： C07C213/00 ,  C07C303/40 ,  C07C311/04 ,  C07C311/06 ,  C07C311/07 ,  C07C311/17 ,  C07C311/19 ,  C07C311/20 ,  C07C311/29 ,  C07C311/42 ,  C07C303/00

CPC分类号： C07C303/40 ,  C07C213/00 ,  C07B2200/07 ,  C07C2101/14

摘要： .beta.-Hydroxyamines and .beta.-hydroxysulfonamides are synthesized from olefin substrates by means on a catalyzed asymmetric addition reaction. The addition reaction is catalyzed by osmium and is co-catalyzed by chiral ligands. The chiral ligands, in addition to being co-catalysts with the osmium, also serve to direct the addition reaction regioselectively and enantioselectively. Divalent ligands are preferred over monovalent ligands because of their enhance regio- and enantio-selectivity. Sulfonamides are employed as an oxidant nitrogen source for the production of .beta.-hydroxysulfonamides. Excellent yields and enantiomeric efficiencies are achieved with co-solvents containing a 50/50 (v/v) mixtures of water and organic solvent. .beta.-Hydroxyamines are obtained by deprotecting the corresponding .beta.-hydroxysulfonamides.

摘要翻译： 通过催化不对称加成反应由烯烃底物合成β-羟基胺和β-羟基磺酰胺。 加成反应由锇催化并被手性配体共催化。 除了与锇共助催化剂之外，手性配体还用于区域选择地和对映选择性地引导加成反应。 二价配体优于一价配体，因为它们具有增强的区域和对映选择性。 磺酰胺被用作生产β-羟基磺酰胺的氧化剂氮源。 使用含有水和有机溶剂的50/50（v / v）混合物的共溶剂可获得优异的收率和对映体效率。 通过脱保护相应的β-羟基磺酰胺得到β-羟基胺。