公开(公告)号：US11359214B2

公开(公告)日：2022-06-14

申请号：US17002064

申请日：2020-08-25

Applicant: GenVec, Inc.

Inventor： Douglas E. Brough ,  Jason G. D. Gall ,  Duncan McVey

IPC: C12N15/86 ,  C07K14/005 ,  C12N7/00 ,  A61K48/00

Abstract: The invention provides an adenovirus or adenoviral vector characterized by comprising one or more particular nucleic acid sequences or one or more particular amino acid sequences, or portions thereof, pertaining to, for example, an adenoviral pIX protein, DNA polymerase protein, penton protein, hexon protein, and/or fiber protein.

公开(公告)号：US20190100561A1

公开(公告)日：2019-04-04

申请号：US16156520

申请日：2018-10-10

Applicant: GenVec, Inc.

Inventor： Lisa Wei ,  Douglas E. Brough ,  Christopher Lazarski

IPC: C07K14/005 ,  A61K39/12 ,  A61K39/245 ,  C12N7/00 ,  A61K39/00

Abstract: Herpes Simplex Virus (HSV) antigens that elicit an HSV-specific immune response and can be used to treat or prevent HSV infection are provided. Nucleic acid sequences, polypeptides, vectors, and compositions, as well as methods to induce an immune response against HSV, treat or prevent HSV disease, induce a T cell response against HSV, and induce an antibody response against HSV also are provided.

公开(公告)号：US20190055579A1

公开(公告)日：2019-02-21

申请号：US16043501

申请日：2018-07-24

Applicant: GenVec, Inc.

Inventor： Douglas E. Brough ,  Jason G.D. Gall ,  Duncan McVey

IPC: C12N15/86 ,  C12N7/00 ,  C07K14/005

Abstract: The invention provides an adenovirus or adenoviral vector characterized by comprising one or more particular nucleic acid sequences or one or more particular amino acid sequences, or portions thereof, pertaining to, for example, an adenoviral pIX protein, DNA polymerase protein, penton protein, hexon protein, and/or fiber protein.

公开(公告)号：US20180153979A1

公开(公告)日：2018-06-07

申请号：US15800975

申请日：2017-11-01

Applicant: GenVec, Inc.

Inventor： Ping Chen ,  Duncan McVey ,  Douglas E. Brough ,  Joseph Bruder

IPC: A61K39/015 ,  A61K39/00

CPC classification number: A61K39/015 ,  A61K2039/5256 ,  A61K2039/53 ,  Y02A50/412

Abstract: The invention is directed to a composition comprising one or more polypeptides or one or more nucleic acid sequences that can induce a protective immune response against Plasmodium species that infect humans. The invention also is directed to a method of using such compositions to induce a protective immune response against a Plasmodium parasite in a mammal.

公开(公告)号：US20180100164A1

公开(公告)日：2018-04-12

申请号：US15700279

申请日：2017-09-11

Applicant: GenVec, Inc.

Inventor： Lisa Wei ,  Douglas E. Brough ,  C. Richter King

IPC: C12N15/86 ,  A61K48/00

CPC classification number: C12N15/86 ,  A61K48/00 ,  A61K48/0008 ,  C12N2710/10021 ,  C12N2710/10043 ,  C12N2710/10322 ,  C12N2710/10343 ,  C12N2710/10345 ,  C12N2710/16634 ,  C12N2810/6018

Abstract: The invention provides a replication-deficient serotype 28 adenoviral vector characterized by comprising a portion of a serotype 45 adenoviral hexon protein and/or a portion of a serotype 45 fiber protein in place of the endogenous serotype 28 hexon and/or fiber protein.

公开(公告)号：US09790519B2

公开(公告)日：2017-10-17

申请号：US14403651

申请日：2013-05-28

Applicant: GenVec, Inc.

Inventor： Lisa Wei ,  Douglas E. Brough ,  C. Richter King

IPC: C12N15/861 ,  C12N15/00 ,  A61K48/00 ,  C12N15/86

CPC classification number: C12N15/86 ,  A61K48/00 ,  A61K48/0008 ,  C12N2710/10021 ,  C12N2710/10043 ,  C12N2710/10322 ,  C12N2710/10343 ,  C12N2710/10345 ,  C12N2710/16634 ,  C12N2810/6018

Abstract: The invention provides a replication-deficient serotype 28 adenoviral vector characterized by comprising a portion of a serotype 45 adenoviral hexon protein and/or a portion of a serotype 45 fiber protein in place of the endogenous serotype 28 hexon and/or fiber protein.

公开(公告)号：US20170246318A1

公开(公告)日：2017-08-31

申请号：US15492016

申请日：2017-04-20

Applicant: GenVec, Inc.

Inventor： Duncan McVey ,  Douglas E. Brough ,  Jason G.D. Gall

IPC: A61K48/00 ,  A61K39/155 ,  C12N7/00 ,  C12N15/86 ,  C07K14/005

CPC classification number: A61K48/005 ,  A61K39/155 ,  A61K2039/5254 ,  A61K2039/5256 ,  A61K2039/53 ,  C07K14/005 ,  C12N7/00 ,  C12N15/86 ,  C12N2710/10322 ,  C12N2710/10333 ,  C12N2710/10334 ,  C12N2710/10343 ,  C12N2760/18534 ,  C12N2760/18571

Abstract: The invention provides an adenovirus or adenoviral vector characterized by comprising one or more particular nucleic acid sequences or one or more particular amino acid sequences, or portions thereof, pertaining to, for example, an adenoviral pIX protein, DNA polymerase protein, penton protein, hexon protein, and/or fiber protein.

公开(公告)号：US09676824B2

公开(公告)日：2017-06-13

申请号：US14403397

申请日：2013-05-16

Applicant: GenVec, Inc.

Inventor： Lisa Wei ,  Douglas E. Brough ,  Christopher Lazarski

IPC: C07K14/005 ,  A61K39/12 ,  C12N7/00 ,  A61K39/245 ,  A61K39/00

CPC classification number: C07K14/005 ,  A61K39/12 ,  A61K39/245 ,  A61K2039/53 ,  A61K2039/545 ,  C12N7/00 ,  C12N2710/10043 ,  C12N2710/16622 ,  C12N2710/16634 ,  C12N2799/022 ,  C12N2800/22

Abstract: Herpes Simplex Virus (HSV) antigens that elicit an HSV-specific immune response and can be used to treat or prevent HSV infection are provided. Nucleic acid sequences, polypeptides, vectors, and compositions, as well as methods to induce an immune response against HSV, treat or prevent HSV disease, induce a T cell response against HSV, and induce an antibody response against HSV also are provided.

公开(公告)号：US09617560B2

公开(公告)日：2017-04-11

申请号：US14349470

申请日：2012-10-05

Applicant: GenVec, Inc.

Inventor： Douglas E. Brough ,  Jason G. D. Gall ,  Duncan McVey

IPC: C12N15/86 ,  C07K14/005 ,  C12N7/00

CPC classification number: C12N15/86 ,  A61K48/00 ,  C07K14/005 ,  C12N7/00 ,  C12N2710/10322 ,  C12N2710/10333 ,  C12N2710/10343 ,  C12N2760/18034 ,  C12N2760/18522 ,  C12N2840/60

Abstract: The invention provides an adenovirus or adenoviral vector characterized by comprising one or more particular nucleic acid sequences or one or more particular amino acid sequences, or portions thereof, pertaining to, for example, an adenoviral pIX protein, DNA polymerase protein, penton protein, hexon protein, and/or fiber protein.

公开(公告)号：US09233153B2

公开(公告)日：2016-01-12

申请号：US14349421

申请日：2012-10-05

Applicant: GenVec, Inc.

Inventor： Jason G. D. Gall ,  Duncan McVey ,  Douglas E. Brough

IPC: C07K14/005 ,  C12N15/86 ,  A61K39/155

CPC classification number: C12N15/86 ,  A61K39/155 ,  A61K48/00 ,  C07K14/005 ,  C12N7/00 ,  C12N2710/10043 ,  C12N2710/10322 ,  C12N2710/10333 ,  C12N2710/10343

Abstract: The invention provides an adenovirus or adenoviral vector characterized by comprising one or more particular nucleic acid sequences or one or more particular amino acid sequences, or portions thereof, pertaining to, for example, an adenoviral pIX protein, DNA polymerase protein, penton protein, hexon protein, and/or fiber protein.

Abstract translation: 本发明提供了一种腺病毒或腺病毒载体，其特征在于包含一个或多个特定的核酸序列或一个或多个特定的氨基酸序列或其部分，涉及例如腺病毒pIX蛋白，DNA聚合酶蛋白，penton蛋白，六邻体 蛋白质和/或纤维蛋白质。