公开(公告)号：US11827662B2

公开(公告)日：2023-11-28

申请号：US17715366

申请日：2022-04-07

Applicant: Gilead Sciences, Inc.

Inventor： Eda Y. Canales ,  Manoj C. Desai ,  Eric Gorman ,  Jiayao Li ,  Roland D. Saito ,  James G. Taylor ,  Nathan E. Wright

IPC: C07D401/14 ,  C07F9/6558

CPC classification number: C07F9/65583 ,  C07D401/14

Abstract: The present disclosure relates generally to modulators of Cot (cancer Osaka thyroid) and methods of use and manufacture thereof.

公开(公告)号：US11702404B2

公开(公告)日：2023-07-18

申请号：US17077729

申请日：2020-10-22

Applicant: Gilead Sciences, Inc.

Inventor： Stephen E. Ammann ,  Gediminas J. Brizgys ,  James S. Cassidy ,  Elbert Chin ,  Chienhung Chou ,  Jeromy J. Cottell ,  Michael Graupe ,  Chao-I Hung ,  Kavoos Kolahdouzan ,  Scott D. Schroeder ,  Nathan D. Shapiro ,  Daniel G. Shore ,  Suzanne M. Szewczyk ,  James G. Taylor ,  Rhiannon Thomas-Tran ,  Nathan E. Wright ,  Zheng-Yu Yang ,  Sheila M. Zipfel

IPC: C07D401/10 ,  C07D401/14 ,  C07D405/14 ,  C07D409/14 ,  C07D413/14 ,  C07D417/14 ,  C07D471/04 ,  A61K45/06 ,  C07D235/16 ,  C07D403/06 ,  C07D493/08

CPC classification number: C07D401/14 ,  A61K45/06 ,  C07D235/16 ,  C07D401/10 ,  C07D403/06 ,  C07D405/14 ,  C07D409/14 ,  C07D413/14 ,  C07D417/14 ,  C07D471/04 ,  C07D493/08

Abstract: The present disclosure provides GLP-1R agonists, and compositions, methods, and kits thereof. Such compounds are generally useful for treating a GLP-1R mediated disease or condition in a human.

公开(公告)号：US20230000848A1

公开(公告)日：2023-01-05

申请号：US17831044

申请日：2022-06-02

Applicant: Gilead Sciences, Inc.

Inventor： David G. Breckenridge ,  Grant R. Budas ,  Ruchi Gupta ,  James G. Taylor ,  Matthew R. Warr ,  Nathan E. Wright

IPC: A61K31/4439 ,  A61P1/16 ,  A61K45/06

Abstract: The present disclosure relates generally to methods of using modulators of COT (cancer Osaka thyroid) for treating, stabilizing, or lessening the severity or progression of liver disease, in particular, Nonalcoholic fatty liver disease (NAFLD) or nonalcoholic steatohepatitis (NASH).

公开(公告)号：US11535622B2

公开(公告)日：2022-12-27

申请号：US17110734

申请日：2020-12-03

Applicant: Gilead Sciences, Inc.

Inventor： Stephen Ammann ,  Elizabeth M. Bacon ,  Gediminas Brizgys ,  Elbert Chin ,  Chienhung Chou ,  Jeromy J. Cottell ,  Marilyn Ndukwe ,  James G. Taylor ,  Nathan E. Wright ,  Zheng-Yu Yang ,  Sheila M. Zipfel

IPC: A61K31/5025 ,  C07D487/04

Abstract: A compound of Formula (I): pharmaceutically acceptable salts thereof, deuterated analogs thereof, compositions thereof, and methods of treating disease using a compound thereof, wherein the variable substituents are disclosed herein.

公开(公告)号：US20220402910A1

公开(公告)日：2022-12-22

申请号：US17204463

申请日：2021-03-17

Applicant: Gilead Sciences, Inc.

Inventor： Stephen Ammann ,  Elizabeth M. Bacon ,  Gediminas Brizgys ,  Elbert Chin ,  Chienhung Chou ,  Jeromy J. Cottell ,  Marilyn Ndukwe ,  Marina Shatskikh ,  James G. Taylor ,  Nathan E. Wright ,  Zheng-Yu Yang ,  Sheila M. Zipfel

IPC: C07D471/04 ,  C07D487/04

Abstract: A compound of Formula (I): pharmaceutically acceptable salts thereof, deuterated analogs thereof, compositions thereof, and methods of treating disease using a compound thereof are disclosed.

公开(公告)号：US20220306614A1

公开(公告)日：2022-09-29

申请号：US17690851

申请日：2022-03-09

Applicant: Gilead Sciences, Inc.

Inventor： Gediminas J. Brizgys ,  Chienhung Chou ,  Jeromy J. Cottell ,  Chao-I Hung ,  Michael L. Mitchell ,  Scott D. Schroeder ,  Nathan D. Shapiro ,  Suzanne M. Szewczyk ,  James G. Taylor ,  Nathan E. Wright ,  Sheila M. Zipfel

IPC: C07D405/14 ,  A61K31/4545 ,  A61K45/06 ,  C07D401/14 ,  A61K31/4725 ,  C07D413/14 ,  C07D417/14

Abstract: The present disclosure provides GLP-1R agonists, and compositions, methods, and kits thereof. Such compounds are generally useful for treating a GLP-1R mediated disease or condition in a human.

公开(公告)号：US20210053988A1

公开(公告)日：2021-02-25

申请号：US16868119

申请日：2020-05-06

Applicant: Gilead Sciences, Inc.

Inventor： Elizabeth M. Bacon ,  Zhenhong R. Cai ,  Xiaowu Chen ,  Jeromy J. Cottell ,  Manoj C. Desai ,  Mingzhe Ji ,  Haolun Jin ,  Scott E. Lazerwith ,  Michael R. Mish ,  Philip Anthony Morganelli ,  Hyung-Jung Pyun ,  James G. Taylor ,  Teresa Alejandra Trejo Martin

IPC: C07D498/14 ,  A61K31/537 ,  C07D471/22 ,  A61K31/529 ,  A61K31/551 ,  A61K31/498 ,  C07D471/18 ,  A61K45/06 ,  C07D498/18 ,  A61K31/4985 ,  C07D487/14 ,  A61K31/553

Abstract: Compounds for use in the treatment of human immunodeficiency virus (HIV) infection are disclosed. The compounds have the following Formula (I): including stereoisomers and pharmaceutically acceptable salts thereof, wherein R1, X, W, Y1, Y2, Z1, and Z4 are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.

公开(公告)号：US20200079769A1

公开(公告)日：2020-03-12

申请号：US16539834

申请日：2019-08-13

Applicant: Gilead Sciences, Inc.

Inventor： Stephen Ammann ,  Elizabeth M. Bacon ,  Gediminas Brizgys ,  Elbert Chin ,  Chienhung Chou ,  Jeromy J. Cottell ,  Marilyn Ndukwe ,  Marina Shatskikh ,  James G. Taylor ,  Nathan E. Wright ,  Zheng-Yu Yang ,  Sheila M. Zipfel

IPC: C07D471/04 ,  C07D487/04

Abstract: A compound of Formula (I): pharmaceutically acceptable salts thereof, deuterated analogs thereof, compositions thereof, and methods of treating disease using a compound thereof are disclosed.

公开(公告)号：US20200048261A1

公开(公告)日：2020-02-13

申请号：US16537385

申请日：2019-08-09

Applicant: Gilead Sciences, Inc.

Inventor： Stephen Ammann ,  Elizabeth M. Bacon ,  Gediminas Brizgys ,  Elbert Chin ,  Chienhung Chou ,  Jeromy J. Cottell ,  Marilyn Ndukwe ,  James G. Taylor ,  Nathan E. Wright ,  Zheng-Yu Yang ,  Sheila M. Zipfel

IPC: C07D487/04

Abstract: A compound of Formula (I): pharmaceutically acceptable salts thereof, deuterated analogs thereof, compositions thereof, and methods of treating disease using a compound thereof are disclosed.

公开(公告)号：US20170313745A1

公开(公告)日：2017-11-02

申请号：US15455508

申请日：2017-03-10

Applicant: Gilead Sciences, Inc.

Inventor： Kyla L. Bjornson ,  Kapil K. Karki ,  John O. Link ,  Hyung-jung Pyun ,  Adam J. Schrier ,  Kirk L. Stevens ,  James G. Taylor ,  Randall W. Vivian ,  Jeff Zablocki ,  Sheila M. Zipfel

IPC: C07K7/64 ,  C07D487/02 ,  C07D487/00 ,  C07D203/02 ,  A61K31/519 ,  C07D498/22 ,  A61K31/437

CPC classification number: C07K7/64 ,  A61K31/437 ,  A61K31/519 ,  C07D203/02 ,  C07D487/00 ,  C07D487/02 ,  C07D498/22

Abstract: Compounds of formula I: or pharmaceutically acceptable salts thereof, wherein the various substituents are defined herein, methods of using said compounds, and pharmaceutical compositions containing said compounds.