公开(公告)号：US20230312567A1

公开(公告)日：2023-10-05

申请号：US18110126

申请日：2023-02-15

Applicant: Gilead Sciences, Inc.

Inventor： Chienhung Chou ,  Darryl Kato ,  Scott E. Lazerwith ,  John O. Link ,  Scott D. Schroeder ,  Winston C. Tse ,  Jennifer R. Zhang

IPC: C07D471/04 ,  A61K45/06 ,  C07D403/12 ,  C07D498/04 ,  C07D513/04 ,  C07D519/00

CPC classification number: C07D471/04 ,  A61K45/06 ,  C07D403/12 ,  C07D498/04 ,  C07D513/04 ,  C07D519/00

Abstract: The present disclosure relates generally to certain compounds, pharmaceutical compositions comprising said compounds, and methods of making and using said compounds and pharmaceutical compositions. The compounds and compositions disclosed herein may be used for the treatment or prevention of a Retroviridae viral infection, including an infection caused by the HIV virus.

公开(公告)号：US20230002407A1

公开(公告)日：2023-01-05

申请号：US17317041

申请日：2021-05-11

Applicant: Gilead Sciences, Inc.

Inventor： Elizabeth M. Bacon ,  Gayatri Balan ,  Chien-Hung Chou ,  Christopher T. Clark ,  Jeromy J. Cottell ,  Musong Kim ,  Thorsten A. Kirschberg ,  John O. Link ,  Gary Phillips ,  Scott D. Schroeder ,  Neil H. Squires ,  Kirk L. Stevens ,  James G. Taylor ,  William J. Watkins ,  Nathan E. Wright ,  Sheila M. Zipfel

IPC: C07D498/04 ,  C07D405/14 ,  C07D413/14 ,  C07D401/12 ,  C07D409/14 ,  C07D417/14 ,  C07D471/04 ,  C07D495/04 ,  C07D401/14 ,  C07B59/00

Abstract: The present disclosure relates generally to modulators of Cot (cancer Osaka thyroid) and methods of use and manufacture thereof.

公开(公告)号：US20220411434A1

公开(公告)日：2022-12-29

申请号：US17748853

申请日：2022-05-19

Applicant: Gilead Sciences, Inc.

Inventor： Elbert Chin ,  John O. Link ,  James G. Taylor ,  Zheng-Yu Yang

IPC: C07D491/052 ,  A61P31/14

Abstract: Provided herein are compounds of Formula (I): the formula(I): wherein the various substituents are defined herein,

公开(公告)号：US20220402931A1

公开(公告)日：2022-12-22

申请号：US17748470

申请日：2022-05-19

Applicant: Gilead Sciences, Inc.

Inventor： Elbert Chin ,  John O. Link ,  Ezra Roberts ,  James G. Taylor ,  Zheng-Yu Yang

IPC: C07D493/06

Abstract: Provided herein are compounds and methods for the treatment or prevention of Zika virus infection. For example, a compound of the formula(I): Wherein the variable substituents are described herein.

公开(公告)号：US11052087B2

公开(公告)日：2021-07-06

申请号：US16525203

申请日：2019-07-29

Applicant: Gilead Sciences, Inc.

Inventor： Elbert Chin ,  Darryl Kato ,  John O. Link ,  Nathan Shapiro ,  Zheng-Yu Yang

IPC: A61K31/506 ,  A61K31/4995 ,  C07D487/08 ,  A61P31/18

Abstract: The invention provides compounds having Formula (I): or a pharmaceutically acceptable salt thereof, as well as pharmaceutical compositions comprising the same, processes for their preparation, and methods of treating and preventing HIV infection by their administration.

公开(公告)号：US20200030327A1

公开(公告)日：2020-01-30

申请号：US16525203

申请日：2019-07-29

Applicant: Gilead Sciences, Inc.

Inventor： Elbert Chin ,  Darryl Kato ,  John O. Link ,  Nathan Shapiro ,  Zheng-Yu Yang

IPC: A61K31/506 ,  C07D487/08 ,  A61K31/4995 ,  A61P31/18

Abstract: The invention provides compounds having Formula (I): or a pharmaceutically acceptable salt thereof, as well as pharmaceutical compositions comprising the same, processes for their preparation, and methods of treating and preventing HIV infection by their administration.

公开(公告)号：US10336762B2

公开(公告)日：2019-07-02

申请号：US15898095

申请日：2018-02-15

Applicant: Gilead Sciences, Inc.

Inventor： Elizabeth M. Bacon ,  Gediminas Brizgys ,  Elbert Chin ,  Chienhung Chou ,  Jeromy J. Cottell ,  John O. Link ,  James G. Taylor ,  Winston C. Tse ,  Nathan E. Wright ,  Zheng-Yu Yang ,  Jennifer R. Zhang ,  Sheila M. Zipfel

IPC: C07D401/04 ,  C07D413/04 ,  C07D487/04 ,  C07D453/00 ,  C07D519/00 ,  A61P29/00

Abstract: Provided is a compound of Formula (I) wherein the variable groups are defined herein.

公开(公告)号：US10059695B2

公开(公告)日：2018-08-28

申请号：US15634314

申请日：2017-06-27

Applicant: Gilead Sciences, Inc.

Inventor： Gayatri Balan ,  Chien-Hung Chou ,  Musong Kim ,  Thorsten A. Kirschberg ,  John O. Link ,  Gary Phillips ,  Roland D. Saito ,  Neil H. Squires ,  James G. Taylor ,  William J. Watkins ,  Nathan E. Wright

IPC: C07D403/12 ,  C07D401/14 ,  C07D405/14 ,  C07D417/14

CPC classification number: C07D403/12 ,  C07D401/14 ,  C07D405/14 ,  C07D417/14

Abstract: The present disclosure relates generally to modulators of Cot (cancer Osaka thyroid) and methods of use and manufacture thereof.

公开(公告)号：US20180237455A1

公开(公告)日：2018-08-23

申请号：US15891163

申请日：2018-02-07

Applicant: Gilead Sciences, Inc.

Inventor： Elizabeth M. Bacon ,  Gayatri Balan ,  Chien-Hung Chou ,  Christopher T. Clark ,  Jeromy J. Cottell ,  Musong Kim ,  Thorsten A. Kirschberg ,  John O. Link ,  Gary Phillips ,  Scott D. Schroeder ,  Neil H. Squires ,  Kirk L. Stevens ,  James G. Taylor ,  William J. Watkins ,  Nathan E. Wright ,  Sheila M. Zipfel

IPC: C07D498/04 ,  C07D495/04 ,  C07D471/04 ,  C07D417/14 ,  C07D409/14 ,  C07D401/12 ,  C07B59/00 ,  C07D405/14 ,  C07D401/14 ,  C07D413/14

CPC classification number: C07D498/04 ,  C07B59/002 ,  C07B2200/05 ,  C07D401/12 ,  C07D401/14 ,  C07D405/14 ,  C07D409/14 ,  C07D413/14 ,  C07D417/14 ,  C07D471/04 ,  C07D495/04

Abstract: The present disclosure relates generally to modulators of Cot (cancer Osaka thyroid) and methods of use and manufacture thereof.

公开(公告)号：US20180051005A1

公开(公告)日：2018-02-22

申请号：US15680041

申请日：2017-08-17

Applicant: Gilead Sciences, Inc.

Inventor： Michael Graupe ,  Steven J. Henry ,  John O. Link ,  Charles William Rowe ,  Roland D. Saito ,  Scott D. Schroeder ,  Dimitrios Stefanidis ,  Winston C. Tse ,  Jennifer R. Zhang

IPC: C07D401/14 ,  A61K31/4439 ,  A61K45/06 ,  A61K31/675 ,  A61K31/537 ,  A61K31/7076 ,  C07F5/02 ,  C07D231/54 ,  C07C317/08

CPC classification number: C07D401/14 ,  A61K31/4439 ,  A61K31/537 ,  A61K31/675 ,  A61K31/7076 ,  A61K45/06 ,  C07C317/08 ,  C07D231/54 ,  C07F5/025

Abstract: The present disclosure relates to a compound of formula (Ia), (Ib), (IIa), and (IIb): which are useful in the treatment of a Retroviridae viral infection including an infection caused by the HIV virus.