公开(公告)号：US20230234917A1

公开(公告)日：2023-07-27

申请号：US18001238

申请日：2021-06-09

Applicant: SENDA BIOSCIENCES, INC.

Inventor： Spencer Cory PECK ,  Jenny LIU ,  Timothy F. BRIGGS ,  John Robert PROUDFOOT ,  William MCELROY ,  Robert Walter MYERS ,  Steven John TAYLOR

IPC: C07C237/10 ,  A61P35/00 ,  C07K5/062 ,  C07D305/08 ,  C07C275/14 ,  C07C271/20 ,  C07F9/40 ,  C07F9/42 ,  C07C317/08 ,  C07F5/02 ,  C07C237/22 ,  C07D263/32 ,  C07D233/64 ,  C07D257/04 ,  C07D249/08 ,  C07D271/06 ,  C07D271/10 ,  C07D249/04 ,  C07C255/29 ,  C07D213/40 ,  C07D333/20 ,  C07D235/16

CPC classification number: C07C237/10 ,  A61P35/00 ,  C07K5/06026 ,  C07D305/08 ,  C07C275/14 ,  C07C271/20 ,  C07F9/4006 ,  C07F9/425 ,  C07C317/08 ,  C07F5/027 ,  C07C237/22 ,  C07D263/32 ,  C07D233/64 ,  C07D257/04 ,  C07D249/08 ,  C07D271/06 ,  C07D271/10 ,  C07D249/04 ,  C07C255/29 ,  C07D213/40 ,  C07D333/20 ,  C07D235/16 ,  C07C2601/14

Abstract: The present disclosure relates to compounds of formulas (A) and (I), pharmaceutically acceptable salts thereof, and solvates of any of the foregoing, pharmaceutical compositions comprising the same, methods of preparing the same, intermediate compounds useful for preparing the same, and methods for treating or prophylaxis of diseases, in particular cancer, such as colorectal cancer, using the same.

公开(公告)号：US20180346392A9

公开(公告)日：2018-12-06

申请号：US15573224

申请日：2016-05-11

Applicant: BASF SE

Inventor： Barbara Nave ,  Joachim Dickhaut ,  Peter Nesvadba ,  Mihiret Tekeste Sisay ,  Alexander Wissemeier ,  Wolfram Zerulla ,  Gregor Pasda ,  Olof Wallquist ,  Allan F. Cunningham

IPC: C05G3/08 ,  C07C323/48 ,  C07D249/12 ,  C07D233/42 ,  C07D235/28 ,  C07D239/38 ,  C07C317/08 ,  C07C323/47 ,  C07D495/04 ,  C07D221/04 ,  C07D285/125 ,  C07D405/04 ,  C07D417/04 ,  C07D277/74 ,  C07D401/04 ,  C07C317/18 ,  C07C317/10 ,  C07C323/07 ,  C07C321/20 ,  C07D285/135 ,  C07C321/28 ,  C07D241/18 ,  C07D241/44 ,  C05C3/00 ,  C05F11/00 ,  C05C9/00

CPC classification number: C05G3/08 ,  C05C3/00 ,  C05C9/00 ,  C05F11/00 ,  C07C317/08 ,  C07C317/10 ,  C07C317/18 ,  C07C321/20 ,  C07C321/28 ,  C07C323/07 ,  C07C323/47 ,  C07C323/48 ,  C07C337/08 ,  C07D221/04 ,  C07D233/42 ,  C07D235/28 ,  C07D239/38 ,  C07D241/18 ,  C07D241/44 ,  C07D249/12 ,  C07D277/74 ,  C07D285/125 ,  C07D285/135 ,  C07D401/04 ,  C07D405/04 ,  C07D417/04 ,  C07D495/04 ,  Y02E50/343 ,  Y02P60/218 ,  Y02W30/47

Abstract: Provided herein are a use of thioether compounds of formula I as nitrification inhibitors, and agricultural mixtures and compositions including the thioether compounds.

公开(公告)号：US20180051005A1

公开(公告)日：2018-02-22

申请号：US15680041

申请日：2017-08-17

Applicant: Gilead Sciences, Inc.

Inventor： Michael Graupe ,  Steven J. Henry ,  John O. Link ,  Charles William Rowe ,  Roland D. Saito ,  Scott D. Schroeder ,  Dimitrios Stefanidis ,  Winston C. Tse ,  Jennifer R. Zhang

IPC: C07D401/14 ,  A61K31/4439 ,  A61K45/06 ,  A61K31/675 ,  A61K31/537 ,  A61K31/7076 ,  C07F5/02 ,  C07D231/54 ,  C07C317/08

CPC classification number: C07D401/14 ,  A61K31/4439 ,  A61K31/537 ,  A61K31/675 ,  A61K31/7076 ,  A61K45/06 ,  C07C317/08 ,  C07D231/54 ,  C07F5/025

Abstract: The present disclosure relates to a compound of formula (Ia), (Ib), (IIa), and (IIb): which are useful in the treatment of a Retroviridae viral infection including an infection caused by the HIV virus.

公开(公告)号：US09598544B2

公开(公告)日：2017-03-21

申请号：US14184540

申请日：2014-02-19

Applicant: University of Washington

Inventor： Shaoyi Jiang ,  Shengfu Chen ,  Yung Chang ,  Zheng Zhang

IPC: C07C317/08 ,  C07C317/28 ,  C07C317/44 ,  C07C317/50 ,  A61K49/18 ,  C08J3/075 ,  C09D5/16 ,  C09D7/12 ,  C08F120/36 ,  C08F292/00 ,  B82Y30/00 ,  C08K3/16 ,  C08K3/34 ,  C08K9/08 ,  C08F220/36

CPC classification number: C08J3/075 ,  A61K49/18 ,  B82Y30/00 ,  C07C317/08 ,  C07C317/28 ,  C07C317/44 ,  C07C317/50 ,  C08F120/36 ,  C08F292/00 ,  C08F2220/365 ,  C08F2438/01 ,  C08K3/16 ,  C08K3/34 ,  C08K9/08 ,  C09D5/1637 ,  C09D7/62 ,  C09D7/67 ,  C09D7/68

Abstract: Nanoparticles zwitterionic polymers grafted thereto or grafted therefrom, and methods for making and using the nanoparticles. Zwitterionic nanogels, and methods for making and using the nanogels.

公开(公告)号：US20150087628A1

公开(公告)日：2015-03-26

申请号：US14391369

申请日：2013-04-10

Applicant: The Regents of the University of California

Inventor： Jonathan Ostrem ,  Ulf Peters ,  Kevan M. Shokat

IPC: C07D487/04 ,  C07D401/12 ,  C12N9/14 ,  C07D211/62 ,  C07D409/04 ,  C07D401/06 ,  C07D211/58

CPC classification number: C07D495/04 ,  A61K38/1709 ,  C07C235/20 ,  C07C317/08 ,  C07D207/14 ,  C07D211/58 ,  C07D211/62 ,  C07D231/40 ,  C07D295/185 ,  C07D295/26 ,  C07D401/04 ,  C07D401/06 ,  C07D401/12 ,  C07D405/12 ,  C07D409/04 ,  C07D413/12 ,  C07D417/12 ,  C07D471/10 ,  C07D487/04 ,  C07D487/10 ,  C12N9/14 ,  C12Q1/6886 ,  C12Q2600/156 ,  C12Q2600/158 ,  C12Y306/05002 ,  G01N2500/04

Abstract: K-Ras is the most frequently mutated oncogene in human cancer. Disclosed herein are compositions and methods for modulating K-Ras and treating cancer.

Abstract translation: K-Ras是人类癌症中最常见的突变致癌基因。 本文公开了调节K-Ras和治疗癌症的组合物和方法。

公开(公告)号：US08404390B2

公开(公告)日：2013-03-26

申请号：US12596300

申请日：2008-04-15

Applicant: Koji Abe ,  Kazuhiro Miyoshi ,  Yoshihiro Ushigoe ,  Manabu Takase ,  Kazuyuki Kawabe

Inventor： Koji Abe ,  Kazuhiro Miyoshi ,  Yoshihiro Ushigoe ,  Manabu Takase ,  Kazuyuki Kawabe

IPC: H01M6/16

CPC classification number: C07C317/08 ,  C07C317/18 ,  H01M10/052 ,  H01M10/0525 ,  H01M10/0567 ,  H01M10/0569 ,  H01M10/4235 ,  Y02T10/7011

Abstract: The present invention provides (1) a sulfone compounds having a propargyl group, (2) a nonaqueous electrolytic solution for lithium secondary batteries, which comprises an electrolyte salt dissolved in a nonaqueous solvent and contains a sulfone compound having a specific structure that has an SO2 group with a propargyl group or a vinyl group bonding thereto, in an amount of from 0.01 to 10% by weight of the nonaqueous electrolytic solution, and which can prevent gas generation and is excellent in battery characteristics such as cycle property and the like, and (3) a lithium secondary battery comprising a positive electrode, a negative electrode and a nonaqueous electrolytic solution of an electrolyte salt dissolved in a nonaqueous solvent, wherein the nonaqueous electrolytic solution contains a sulfone compound having a specific structure, in an amount of from 0.01 to 10% by weight of the nonaqueous electrolytic solution.

Abstract translation: 本发明提供（1）具有炔丙基的砜化合物，（2）锂二次电池用非水电解液，其包含溶解在非水溶剂中的电解质盐，并含有具有SO 2的特定结构的砜化合物 与非水电解液的重量比为0.01〜10重量％的炔丙基或与其结合的乙烯基，能够防止气体产生，并且电池特性如循环特性等优异， （3）一种锂二次电池，其包含正极，负极和溶解在非水溶剂中的电解质盐的非水电解液，其中所述非水电解液含有特定结构的砜化合物，其量为0.01 至10重量％的非水电解液。

公开(公告)号：US20110166404A1

公开(公告)日：2011-07-07

申请号：US13047535

申请日：2011-03-14

Applicant: Sang Ho Koo ,  Eun Ho Choi ,  Joo-Won Suh

Inventor： Sang Ho Koo ,  Eun Ho Choi ,  Joo-Won Suh

IPC: C07C1/32

CPC classification number: C07C317/24 ,  C07C1/322 ,  C07C11/21 ,  C07C315/04 ,  C07C317/18 ,  C07C403/24 ,  C09B61/00 ,  C07C317/08 ,  C07C317/10

Abstract: The novel C dialdehyde compound which can be efficiently utilized in the synthesis of carotenoid compounds based on the sulfone chemistry, the preparation method of the same, and the expeditious and practical synthetic processes for lycopene and β-carotene by the use of the above novel compound are disclosed. The syntheses of lycopene and β-carotene are characterized by the processes of the coupling reaction between two equivalents of geranyl sulfone or cyclic geranyl sulfone and the above C dialdehyde, the functional group transformation reactions of the diol in the resulting C 40 coupling products to X's (either halogens or ethers), and the double elimination reactions of the functional groups of the benzenesulfonyl and X to produce the fully conjugated polyene chain of the carotenoids.

公开(公告)号：US07906235B2

公开(公告)日：2011-03-15

申请号：US10926283

申请日：2004-08-25

Applicant: Christophe Michot ,  Michel Armand ,  Michel Gauthier ,  Yves Choquette

Inventor： Christophe Michot ,  Michel Armand ,  Michel Gauthier ,  Yves Choquette

IPC: C07C309/85 ,  C07C317/12 ,  C07C245/00 ,  H01M6/04

CPC classification number: B01J31/0224 ,  B01J31/0215 ,  B01J31/0222 ,  B01J31/0225 ,  B01J31/0227 ,  B01J31/0235 ,  B01J31/0239 ,  B01J31/0247 ,  B01J31/0251 ,  B01J31/0252 ,  B01J31/0267 ,  B01J31/0271 ,  B01J31/0281 ,  B01J31/0288 ,  B01J31/0289 ,  B01J31/04 ,  B01J31/06 ,  B01J31/068 ,  B01J31/124 ,  B01J31/1815 ,  B01J31/2208 ,  B01J2231/122 ,  B01J2231/14 ,  B01J2231/326 ,  B01J2231/341 ,  B01J2231/348 ,  B01J2231/4205 ,  B01J2231/543 ,  B01J2531/35 ,  B01J2531/824 ,  C07B37/02 ,  C07B37/12 ,  C07C45/46 ,  C07C45/69 ,  C07C67/00 ,  C07C255/10 ,  C07C255/17 ,  C07C255/27 ,  C07C255/46 ,  C07C255/65 ,  C07C257/14 ,  C07C311/03 ,  C07C311/04 ,  C07C311/09 ,  C07C311/48 ,  C07C317/04 ,  C07C317/08 ,  C07C317/14 ,  C07C317/22 ,  C07C317/24 ,  C07C317/34 ,  C07C317/44 ,  C07C2601/10 ,  C07C2602/42 ,  C07D207/452 ,  C07D213/76 ,  C07D219/10 ,  C07D231/18 ,  C07D233/90 ,  C07D239/60 ,  C07D241/42 ,  C07D249/04 ,  C07D249/10 ,  C07D249/12 ,  C07D251/70 ,  C07D277/64 ,  C07D277/82 ,  C07D285/125 ,  C07D285/135 ,  C07D285/15 ,  C07D285/16 ,  C07D303/34 ,  C07D307/54 ,  C07D307/64 ,  C07D311/52 ,  C07D311/58 ,  C07D311/82 ,  C07D319/06 ,  C07D333/16 ,  C07D333/24 ,  C07D405/06 ,  C07D409/12 ,  C07D417/10 ,  C07D417/14 ,  C07F17/02 ,  C08F4/04 ,  C08G65/3344 ,  C09B69/00 ,  C09B69/02 ,  C09B69/10 ,  G02F1/1525 ,  G02F2001/151 ,  H01B1/122 ,  H01B1/128 ,  H01G9/022 ,  H01G9/038 ,  H01G11/02 ,  H01G11/62 ,  H01M4/00 ,  H01M4/02 ,  H01M4/131 ,  H01M4/133 ,  H01M4/134 ,  H01M4/382 ,  H01M4/405 ,  H01M4/48 ,  H01M4/485 ,  H01M4/505 ,  H01M4/525 ,  H01M4/5815 ,  H01M4/5825 ,  H01M4/60 ,  H01M4/625 ,  H01M4/661 ,  H01M6/00 ,  H01M6/04 ,  H01M6/164 ,  H01M6/166 ,  H01M6/168 ,  H01M6/181 ,  H01M6/183 ,  H01M10/052 ,  H01M10/0525 ,  H01M10/0565 ,  H01M10/0567 ,  H01M10/0568 ,  Y02E60/13 ,  Y10S430/127 ,  Y10T29/49108 ,  Y10T428/2918 ,  C07C49/84 ,  C07C49/553

Abstract: The invention relates to ionic compounds in which the anionic load has been delocalized. A compound disclosed by the invention includes an anionic portion combined with at least one cationic portion Mm+ in sufficient numbers to ensure overall electronic neutrality; the compound is further comprised of M as a hydroxonium, a nitrosonium NO+, an ammonium —NH4+, a metallic cation with the valence m, an organic cation with the valence m, or an organometallic cation with the valence m. The anionic load is carried by a pentacyclical nucleus of tetrazapentalene derivative bearing electroattractive substituents. The compounds can be used notably for ionic conducting materials, electronic conducting materials, colorant, and the catalysis of various chemical reactions.

Abstract translation: 本发明涉及其中阴离子负荷已经离域的离子化合物。 本发明公开的化合物包括与足够数量的至少一个阳离子部分Mm +组合的阴离子部分以确保整体电子中性; 该化合物还包含作为氢氧化物的M，亚硝鎓NO +，铵NH4 +，价数m的金属阳离子，价数m的有机阳离子或价数m的有机金属阳离子。 阴离子负载由带有电吸引取代基的四嗪基衍生物的五环核承载。 这些化合物可以特别用于离子导电材料，电子导电材料，着色剂和各种化学反应的催化。

公开(公告)号：US20090318732A1

公开(公告)日：2009-12-24

申请号：US12308028

申请日：2007-05-23

Applicant: Sang Ho Koo ,  Eun Ho Choi

Inventor： Sang Ho Koo ,  Eun Ho Choi

IPC: C07C403/02 ,  C07C317/24 ,  C07C315/04 ,  C07C317/16 ,  C07C2/02

CPC classification number: C07C317/24 ,  C07C1/322 ,  C07C11/21 ,  C07C315/04 ,  C07C317/18 ,  C07C403/24 ,  C09B61/00 ,  C07C317/08 ,  C07C317/10

Abstract: The novel C dialdehyde compound which can be efficiently utilized in the synthesis of carotenoid compounds based on the sulfone chemistry, the preparation method of the same, and the expeditious and practical synthetic processes for lycopene and β-carotene by the use of the above novel compound are disclosed. The syntheses of lycopene and β-carotene are characterized by the processes of the coupling reaction between two equivalents of geranyl sulfone or cyclic geranyl sulfone and the above C dialdehyde, the functional group transformation reactions of the diol in the resulting C 40 coupling products to X's (either halogens or ethers), and the double elimination reactions of the functional groups of the benzenesulfonyl and X to produce the fully conjugated polyene chain of the carotenoids.

Abstract translation: 基于砜化学合成类胡萝卜素化合物的新型C二醛化合物及其制备方法，以及通过使用上述新化合物对番茄红素和β-胡萝卜素的快速和实用的合成方法 被披露。 番茄红素和β-胡萝卜素的合成的特征在于两当量的香叶基砜或环状香叶基砜与上述C二醛之间的偶联反应的过程，所得C 40偶联产物中二醇的官能团转化反应与X （卤素或醚），以及苯磺酰基和X的官能团的双重消除反应，以产生类胡萝卜素的完全共轭多烯链。

公开(公告)号：US20030066988A1

公开(公告)日：2003-04-10

申请号：US10253970

申请日：2002-09-24

Inventor： Christophe Michot ,  Michel Armand ,  Michel Gauthier ,  Yves Choquette

IPC: H01C001/00 ,  H01B001/00

CPC classification number: B01J31/0224 ,  B01J31/0215 ,  B01J31/0222 ,  B01J31/0225 ,  B01J31/0227 ,  B01J31/0235 ,  B01J31/0239 ,  B01J31/0247 ,  B01J31/0251 ,  B01J31/0252 ,  B01J31/0267 ,  B01J31/0271 ,  B01J31/0281 ,  B01J31/0288 ,  B01J31/0289 ,  B01J31/04 ,  B01J31/06 ,  B01J31/068 ,  B01J31/124 ,  B01J31/1815 ,  B01J31/2208 ,  B01J2231/122 ,  B01J2231/14 ,  B01J2231/326 ,  B01J2231/341 ,  B01J2231/348 ,  B01J2231/4205 ,  B01J2231/543 ,  B01J2531/35 ,  B01J2531/824 ,  C07B37/02 ,  C07B37/12 ,  C07C45/46 ,  C07C45/69 ,  C07C67/00 ,  C07C255/10 ,  C07C255/17 ,  C07C255/27 ,  C07C255/46 ,  C07C255/65 ,  C07C257/14 ,  C07C311/03 ,  C07C311/04 ,  C07C311/09 ,  C07C311/48 ,  C07C317/04 ,  C07C317/08 ,  C07C317/14 ,  C07C317/22 ,  C07C317/24 ,  C07C317/34 ,  C07C317/44 ,  C07C2601/10 ,  C07C2602/42 ,  C07D207/452 ,  C07D213/76 ,  C07D219/10 ,  C07D231/18 ,  C07D233/90 ,  C07D239/60 ,  C07D241/42 ,  C07D249/04 ,  C07D249/10 ,  C07D249/12 ,  C07D251/70 ,  C07D277/64 ,  C07D277/82 ,  C07D285/125 ,  C07D285/135 ,  C07D285/15 ,  C07D285/16 ,  C07D303/34 ,  C07D307/54 ,  C07D307/64 ,  C07D311/52 ,  C07D311/58 ,  C07D311/82 ,  C07D319/06 ,  C07D333/16 ,  C07D333/24 ,  C07D405/06 ,  C07D409/12 ,  C07D417/10 ,  C07D417/14 ,  C07F17/02 ,  C08F4/04 ,  C08G65/3344 ,  C09B69/00 ,  C09B69/02 ,  C09B69/10 ,  G02F1/1525 ,  G02F2001/1518 ,  H01B1/122 ,  H01B1/128 ,  H01G9/022 ,  H01G9/038 ,  H01G11/02 ,  H01G11/62 ,  H01M4/00 ,  H01M4/02 ,  H01M4/131 ,  H01M4/133 ,  H01M4/134 ,  H01M4/382 ,  H01M4/405 ,  H01M4/48 ,  H01M4/485 ,  H01M4/505 ,  H01M4/525 ,  H01M4/5815 ,  H01M4/5825 ,  H01M4/60 ,  H01M4/625 ,  H01M4/661 ,  H01M6/00 ,  H01M6/04 ,  H01M6/164 ,  H01M6/166 ,  H01M6/168 ,  H01M6/181 ,  H01M6/183 ,  H01M10/052 ,  H01M10/0525 ,  H01M10/0565 ,  H01M10/0567 ,  H01M10/0568 ,  Y02E60/13 ,  Y10S430/127 ,  Y10T29/49108 ,  Y10T428/2918 ,  C07C49/84 ,  C07C49/553

Abstract: The invention is related to ionic compounds, derivatives of malononitrile, in which the anionic load has been displaced. An ionic compound disclosed by the invention includes an anionic portion combined with at least one cationic portion Mnullm in sufficient number to ensure overall electronic neutrality; the compound is further comprised of M as a hydroxonium, a nitrosonium NOnull, an ammonium nullNH4null, a metallic cation with the valence m, an organic cation with the valence m, or an organometallic cation with the valence m. The anionic portion corresponds to one of the formulas RDnullYnullC(CnullN)2null or Z-C(CnullN)2null in which Z is an electroattractive group, RD is an organic radical, and Y is a carbonyl, a thiocarbonyl, a sulfonyl, a sulfinyl, or a phosphonyl. The compounds can be used notably for ionic conducting materials, electronic conducting materials, colorants, and the catalysis of various chemical reactions.

Abstract translation: 本发明涉及离子化合物，其中阴离子负载已被置换的丙二腈衍生物。 本发明公开的离子化合物包括与足够数量的至少一个阳离子部分M + m结合的阴离子部分以确保整体电子中性; 该化合物还包含M为氢氧化物，亚硝酸铵NO +，铵NH4 +，价数m的金属阳离子，价数m的有机阳离子或价数m的有机金属阳离子。 阴离子部分对应于式RD-YC（C = N）2 - 或ZC（C = N）2 - 中的一种，其中Z为电吸引基团，RD为有机基团，Y为 羰基，硫代羰基，磺酰基，亚磺酰基或膦酰基。 该化合物特别用于离子导电材料，电子导电材料，着色剂和各种化学反应的催化。