公开(公告)号：US20100240985A1

公开(公告)日：2010-09-23

申请号：US12791488

申请日：2010-06-01

申请人： James F.M. Meaney ,  Martin R. Prince

发明人： James F.M. Meaney ,  Martin R. Prince

IPC分类号： A61B5/055

CPC分类号： A61B5/055 ,  G01R33/5601 ,  G01R33/5635 ,  G01R33/56383

摘要： The present invention is a technique of, and system for, imaging vascular anatomy over distance considerably greater than the maximum practical field of view of a magnetic resonance imaging system while using substantially one contrast agent injection. The technique and system of the present invention acquires image data of a plurality of image volumes which are representative of different portions of the patient's body. The image data of each image volume includes image data which is representative of the center of k-space. The acquisition of image data which is representative of the center of k-space is correlated with a concentration of contrast agent in the artery(ies) residing in the image volume being substantially greater than the concentration of contrast agent in veins and background tissue adjacent to the artery(ies). This provides preferential enhancement of arteries relative to adjacent veins and background tissue for each acquisition, wherein each acquisition is representative of a different portion of the arterial system (e.g., abdominal aorta, femoral, popliteal, and tibial arteries).

摘要翻译： 本发明是一种技术，并且用于在使用基本上一个造影剂注射的情况下远远超过磁共振成像系统的最大实际视野来对血管解剖结构进行成像的技术和系统。 本发明的技术和系统获取代表患者身体的不同部分的多个图像体积的图像数据。 每个图像体积的图像数据包括表示k空间中心的图像数据。 代表k空间中心的图像数据的获取与静止在图像体积中的动脉中的造影剂的浓度基本上大于静脉和邻近的静脉和背景组织中造影剂的浓度相关 动脉。 这提供了相对于每个采集的相邻静脉和背景组织的动脉的优先增强，其中每个采集代表动脉系统的不同部分（例如，腹主动脉，股骨，po骨和胫骨动脉）。

公开(公告)号：US07545967B1

公开(公告)日：2009-06-09

申请号：US10664425

申请日：2003-09-17

申请人： Martin R. Prince ,  Ramin Zabih ,  Yi Wang ,  Richard Watts ,  Junhwan Kim ,  Jeff Bezanson ,  Hale Ersoy

发明人： Martin R. Prince ,  Ramin Zabih ,  Yi Wang ,  Richard Watts ,  Junhwan Kim ,  Jeff Bezanson ,  Hale Ersoy

IPC分类号： G06K9/00

CPC分类号： G06T5/50 ,  G06K2209/05 ,  G06T2207/10076 ,  G06T2207/10088 ,  G06T2207/30101 ,  Y10S128/92 ,  Y10S128/922

摘要： In time-resolved contrast-enhanced magnetic resonance angiography, a measure quantifying image quality provides a basis for generating a linear filtered composite image by facilitating selection of a mask and an arterial phase image for subtraction. Filtering of individual pixels of a temporal series of images provides enhanced contrast in a single image by allowing the temporal behavior of the pixel intensity to denote representation as an artery, vein or background tissue. Motion artifacts are suppressed by re-registering sequential images, adjusting weighting before averaging and subtraction and filtering the Fourier data to eliminate data corrupted by motion or other phenomena.

摘要翻译： 在时间分辨的对比度增强磁共振血管造影术中，量化图像质量的度量为通过促进选择掩模和用于减法的动脉相位图像生成线性滤波的复合图像提供了基础。 通过使像素强度的时间行为表示为动脉，静脉或背景组织，对时间序列图像中的各个像素进行滤波，从而在单个图像中提供增强的对比度。 通过重新注册顺序图像来抑制运动伪影，在平均和减法之前调整加权并对傅立叶数据进行滤波以消除由运动或其他现象损坏的数据。

公开(公告)号：US07313428B2

公开(公告)日：2007-12-25

申请号：US11003101

申请日：2004-12-03

申请人： James F. M. Meaney ,  Martin R. Prince

发明人： James F. M. Meaney ,  Martin R. Prince

IPC分类号： A61B5/055

CPC分类号： A61B5/055 ,  G01R33/5601 ,  G01R33/5635 ,  G01R33/56383 ,  G06F19/00

摘要： The present invention is a technique of, and system for, imaging vascular anatomy over distance considerably greater than the maximum practical field of view of a magnetic resonance imaging system while using substantially one contrast agent injection. The technique and system of the present invention acquires image data of a plurality of image volumes which are representative of different portions of the patient's body. The image data of each image volume includes image data which is representative of the center of k-space. The acquisition of image data which is representative of the center of k-space is correlated with a concentration of contrast agent in the artery(ies) residing in the image volume being substantially greater than the concentration of contrast agent in veins and background tissue adjacent to the artery(ies). This provides preferential enhancement of arteries relative to adjacent veins and background tissue for each acquisition, wherein each acquisition is representative of a different portion of the arterial system (e.g., abdominal aorta, femoral, popliteal, and tibial arteries).

摘要翻译： 本发明是一种技术，并且用于在使用基本上一个造影剂注射的情况下远远超过磁共振成像系统的最大实际视野来对血管解剖结构进行成像的技术和系统。 本发明的技术和系统获取代表患者身体的不同部分的多个图像体积的图像数据。 每个图像体积的图像数据包括表示k空间中心的图像数据。 代表k空间中心的图像数据的获取与静止在图像体积中的动脉中的造影剂的浓度基本上大于静脉和邻近的静脉和背景组织中造影剂的浓度相关 动脉。 这提供了相对于每个采集的相邻静脉和背景组织的动脉的优先增强，其中每个采集代表动脉系统的不同部分（例如，腹主动脉，股骨，po骨和胫骨动脉）。

公开(公告)号：US06754521B2

公开(公告)日：2004-06-22

申请号：US10375825

申请日：2003-02-27

申请人： Martin R. Prince

发明人： Martin R. Prince

IPC分类号： A61B5055

CPC分类号： A61K49/18 ,  A61B5/201 ,  A61B5/411 ,  A61B5/416 ,  A61M5/007 ,  A61M5/1456 ,  A61M5/16827 ,  G01R33/281 ,  G01R33/5601 ,  G01R33/5619 ,  G01R33/563 ,  G01R33/56308 ,  G01R33/5635

摘要： The present invention is a technique and apparatus for providing preferential enhancement of an artery of interest relative to adjacent veins and background tissue by correlating the collection of a predetermined portion of data of a magnetic resonance contrast image during the arterial phase of the magnetic resonance contrast enhancement. The arterial phase of the contrast enhancement may be described as a period of a maximum, substantially elevated, or elevated contrast concentration in the artery of interest relative to adjacent veins. The present invention includes a detection system for monitoring and detecting the arrival of the contrast agent in the artery and tissues of interest. When the concentration of contrast agent in the artery of the region of interest is maximum, substantially elevated or elevated (e.g., about 20-50% greater than the response of the region of interest to a series of magnetic resonance pulses before administration of a magnetic resonance contrast agent), a predetermined portion of the magnetic resonance image data (e.g., data which is representative of the center of k-space) may be acquired. Thus, the present invention facilitates synchronization between collecting the central portion of k-space image data with the arterial phase of contrast enhancement. The center of k-space corresponds to the lowest spatial frequency data which dominates image contrast.

摘要翻译： 本发明是一种通过将磁共振对比度增强的动脉期期间的磁共振对比度图像的预定部分数据的收集相关联来提供相对于相邻静脉和背景组织的感兴趣的动脉的优先增强的技术和装置 。 对比度增强的动脉期可以描述为相对于相邻静脉的感兴趣动脉中的最大，基本升高或升高的对比浓度的周期。 本发明包括用于监测和检测造影剂到动脉和感兴趣组织的检测系统。 当感兴趣区域的动脉中的造影剂的浓度最大时，基本升高或升高（例如，在给予磁性之前一系列磁共振脉冲的感兴趣区域的响应大约20-50％ 共振造影剂），可以获取磁共振图像数据的预定部分（例如，表示k空间的中心的数据）。 因此，本发明有助于将k空间图像数据的中心部分与对比度增强的动脉相位之间的同步。 k空间的中心对应于支配图像对比度的最低空间频率数据。

公开(公告)号：US06311085B1

公开(公告)日：2001-10-30

申请号：US09309311

申请日：1999-05-11

申请人： James F. M. Meaney ,  Martin R. Prince

发明人： James F. M. Meaney ,  Martin R. Prince

IPC分类号： A61B5055

CPC分类号： A61B5/055 ,  G01R33/5601 ,  G01R33/5635 ,  G01R33/56383 ,  G06F19/00

摘要： The present invention is a technique of, and system for, imaging vascular anatomy over distance considerably greater than the maximum practical field of view of a magnetic resonance imaging system while using substantially one contrast agent injection. The technique and system of the present invention acquires image data of a plurality of image volumes which are representative of different portions of the patient's body. The image data of each image volume includes image data which is representative of the center of k-space. The acquisition of image data which is representative of the center of k-space is correlated with a concentration of contrast agent in the artery(ies) residing in the image volume being substantially greater than the concentration of contrast agent in veins and background tissue adjacent to the artery(ies). This provides preferential enhancement of arteries relative to adjacent veins and background tissue for each acquisition, wherein each acquisition is representative of a different portion of the arterial system (e.g., abdominal aorta, femoral, popliteal, and tibial arteries).

摘要翻译： 本发明是一种技术，并且用于在使用基本上一个造影剂注射的情况下远远超过磁共振成像系统的最大实际视野来对血管解剖结构进行成像的技术和系统。 本发明的技术和系统获取代表患者身体的不同部分的多个图像体积的图像数据。 每个图像体积的图像数据包括表示k空间中心的图像数据。 代表k空间中心的图像数据的获取与静止在图像体积中的动脉中的造影剂的浓度基本上大于静脉和邻近的静脉和背景组织中造影剂的浓度相关 动脉。 这提供了相对于每个采集的相邻静脉和背景组织的动脉的优先增强，其中每个采集代表动脉系统的不同部分（例如，腹主动脉，股骨，po骨和胫骨动脉）。

公开(公告)号：US5590654A

公开(公告)日：1997-01-07

申请号：US580195

申请日：1995-12-28

申请人： Martin R. Prince

发明人： Martin R. Prince

IPC分类号： A61K49/18 ,  G01R33/28 ,  G01R33/561 ,  G01R33/563 ,  A61B5/055

CPC分类号： A61K49/18 ,  A61B5/411 ,  A61B5/416 ,  A61M5/007 ,  A61M5/1456 ,  A61M5/16827 ,  G01R33/5601 ,  G01R33/563 ,  G01R33/5635 ,  A61B5/201 ,  G01R33/281 ,  G01R33/5619 ,  G01R33/56308

摘要： The present invention is a technique and apparatus for monitoring and detecting the arrival of a contrast agent in a region of interest (e.g., an artery or tissues of interest). In one embodiment, upon detecting a maximum, substantially elevated or elevated concentration of contrast agent in the region of interest, a predetermined portion of the magnetic resonance image data (e.g., data which is representative of the center of k-space) may be acquired. Thus, the present invention may be employed to facilitate synchronization between collecting the central portion of k-space image data with the arterial phase of contrast enhancement.

摘要翻译： 本发明是用于监测和检测造影剂到感兴趣区域（例如感兴趣的动脉或组织）的技术和装置。 在一个实施方案中，当检测到感兴趣区域中造影剂的最大，基本上升高或升高的浓度时，可以获得磁共振图像数据的预定部分（例如，代表k空间中心的数据） 。 因此，本发明可以用于促进将k空间图像数据的中心部分与对比度增强的动脉相位之间的同步。

公开(公告)号：US5579767A

公开(公告)日：1996-12-03

申请号：US420815

申请日：1995-04-12

申请人： Martin R. Prince

发明人： Martin R. Prince

IPC分类号： A61K49/18 ,  G01R33/28 ,  G01R33/561 ,  G01R33/563 ,  A61B5/055

CPC分类号： A61K49/18 ,  A61B5/02007 ,  A61B5/055 ,  G01R33/563 ,  A61B5/201 ,  A61B5/416 ,  A61B5/7285 ,  G01R33/281 ,  G01R33/5619 ,  G01R33/56308

摘要： The present invention is a technique and apparatus for acquiring anatomic information used in diagnosing and characterizing abdominal aortic aneurismal disease and the like. This technique provides anatomic information, in the form of images, using a combination of a plurality of magnetic resonance angiography sequences, including a spin-echo and four contrast enhanced (e.g., gadolinium) magnetic resonance angiography sequences. The anatomic images may be used in, for example, pre-operative, operative and post-operative evaluation of aortic pathology, including aneurysms, atherosclerosis, and occlusive disease of branch vessels such as the renal arteries. The gadolinium-enhanced magnetic resonance angiography provides sufficient anatomic detail to detect aneurysms and all relevant major branch vessel abnormalities seen at angiography operation. This technique and apparatus allows for imaging the aorta at a fraction of the cost of conventional aortography and without the risks of arterial catheterization or iodinated contrast.

摘要翻译： 本发明是用于获取用于诊断和表征腹主动脉瘤性疾病等的解剖信息的技术和装置。 该技术以图像的形式使用包括自旋回波和四个对比度增强（例如，钆）磁共振血管造影序列的多个磁共振血管造影术序列的组合来提供解剖信息。 解剖图像可以用于例如主动脉病理学的术前，手术和术后评价，包括动脉瘤，动脉粥样硬化和分支血管如肾动脉的闭塞性疾病。 钆增强磁共振血管造影提供足够的解剖学细节来检测血管造影术中所见的动脉瘤和所有相关主要分支血管异常。 该技术和装置允许以常规造影术的成本的一小部分成像主动脉，并且不存在动脉导管插入或碘化对比的风险。

公开(公告)号：US5553619A

公开(公告)日：1996-09-10

申请号：US378384

申请日：1995-01-25

申请人： Martin R. Prince

发明人： Martin R. Prince

IPC分类号： A61K49/18 ,  G01R33/28 ,  G01R33/561 ,  G01R33/563 ,  A61B5/055

CPC分类号： A61B5/416 ,  A61B5/411 ,  A61K49/18 ,  G01R33/5601 ,  G01R33/563 ,  A61B5/201 ,  A61B5/7285 ,  G01R33/281 ,  G01R33/5619 ,  G01R33/56308

摘要： The present invention is a method and apparatus for providing preferential enhancement of an artery of interest relative to adjacent veins and background tissue. The method and apparatus adapts the timing of a maximum or substantially elevated rate of infusion to correlate with the collection of image data corresponding to the center of k-space. The technique and apparatus temporally correlates the timing of a maximum or substantially elevated rate of infusion and the mapping of k-space according to the location of the artery of interest, the size of the artery of interest, the physical condition of the patient, the time delay due to the configuration of the contrast agent delivery system, and/or the type of pulse sequence employed by the imaging apparatus. Adapting the timing of a maximum or substantially elevated rate of infusion to correlate with the collection of image data corresponding to the center of k-space provides a period of a maximum or substantially elevated contrast concentration in the artery of interest relative to adjacent veins during collection of at least a portion of the image data corresponding to the center of k-space.

公开(公告)号：US5417213A

公开(公告)日：1995-05-23

申请号：US71970

申请日：1993-06-07

申请人： Martin R. Prince

发明人： Martin R. Prince

IPC分类号： A61K49/18 ,  G01R33/28 ,  G01R33/561 ,  G01R33/563 ,  A61B5/055

CPC分类号： A61B5/416 ,  A61B5/411 ,  A61K49/18 ,  G01R33/5601 ,  G01R33/563 ,  A61B5/201 ,  A61B5/7285 ,  G01R33/281 ,  G01R33/5619 ,  G01R33/56308

摘要： This invention is a method of imaging arteries distinctly from veins using nuclear magnetic resonance imaging in combination with intravenous administration of an magnetic resonance contrast agent. The contrast agent is intravenously injected in such a way that the arterial contrast concentration is substantially higher than the venous and background tissue concentration for a sufficiently long period of time to acquire the magnetic resonance image. The injection site of the contrast agent is chosen such that it is in a vein which is remote from the artery of interest. The magnetic resonance contrast agent may be intravenously infused at a variable infusion rate.

摘要翻译： 本发明是使用核磁共振成像与静脉内施用磁共振造影剂组合地静脉成像动脉的方法。 静脉注射造影剂，使得动脉对比浓度在足够长的时间段内基本上高于静脉和背景组织浓度以获得磁共振图像。 选择造影剂的注射部位，使得其处于远离感兴趣动脉的静脉中。 磁共振造影剂可以以可变的输注速率静脉内输注。