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1.发明授权Method and apparatus for magnetic resonance arteriography using contrast agents 有权使用造影剂进行磁共振动脉造影的方法和装置公开(公告)号：US06879853B2
公开(公告)日：2005-04-12
申请号：US10350487
申请日：2003-01-24
IPC分类号： A61B5/055
CPC分类号： A61B5/055 , G01R33/5601 , G01R33/5635 , G01R33/56383 , G06F19/00
摘要： The present invention is a technique of, and system for, imaging vascular anatomy over distance considerably greater than the maximum practical field of view of a magnetic resonance imaging system while using substantially one contrast agent injection. The technique and system of the present invention acquires image data of a plurality of image volumes which are representative of different portions of the patient's body. The image data of each image volume includes image data which is representative of the center of k-space. The acquisition of image data which is representative of the center of k-space is correlated with a concentration of contrast agent in the artery(ies) residing in the image volume. This provides preferential enhancement of arteries relative to adjacent veins and background tissue for each acquisition, wherein each acquisition is representative of a different portion of the arterial system (e.g., abdominal aorta, femoral, popliteal, and tibial arteries).
摘要翻译： 本发明是一种技术，并且用于在使用基本上一个造影剂注射的情况下远远超过磁共振成像系统的最大实际视野来对血管解剖结构进行成像的技术和系统。 本发明的技术和系统获取代表患者身体的不同部分的多个图像体积的图像数据。 每个图像体积的图像数据包括表示k空间中心的图像数据。 代表k空间中心的图像数据的获取与驻留在图像体积中的动脉中的造影剂的浓度相关。 这提供了相对于每个采集的相邻静脉和背景组织的动脉的优先增强，其中每个采集代表动脉系统的不同部分（例如，腹主动脉，股骨，po骨和胫骨动脉）。
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2.发明授权Method and apparatus for magnetic resonance arteriography using contrast agents 有权使用造影剂进行磁共振动脉造影的方法和装置公开(公告)号：US07313428B2
公开(公告)日：2007-12-25
申请号：US11003101
申请日：2004-12-03
IPC分类号： A61B5/055
CPC分类号： A61B5/055 , G01R33/5601 , G01R33/5635 , G01R33/56383 , G06F19/00
摘要： The present invention is a technique of, and system for, imaging vascular anatomy over distance considerably greater than the maximum practical field of view of a magnetic resonance imaging system while using substantially one contrast agent injection. The technique and system of the present invention acquires image data of a plurality of image volumes which are representative of different portions of the patient's body. The image data of each image volume includes image data which is representative of the center of k-space. The acquisition of image data which is representative of the center of k-space is correlated with a concentration of contrast agent in the artery(ies) residing in the image volume being substantially greater than the concentration of contrast agent in veins and background tissue adjacent to the artery(ies). This provides preferential enhancement of arteries relative to adjacent veins and background tissue for each acquisition, wherein each acquisition is representative of a different portion of the arterial system (e.g., abdominal aorta, femoral, popliteal, and tibial arteries).
摘要翻译： 本发明是一种技术，并且用于在使用基本上一个造影剂注射的情况下远远超过磁共振成像系统的最大实际视野来对血管解剖结构进行成像的技术和系统。 本发明的技术和系统获取代表患者身体的不同部分的多个图像体积的图像数据。 每个图像体积的图像数据包括表示k空间中心的图像数据。 代表k空间中心的图像数据的获取与静止在图像体积中的动脉中的造影剂的浓度基本上大于静脉和邻近的静脉和背景组织中造影剂的浓度相关 动脉。 这提供了相对于每个采集的相邻静脉和背景组织的动脉的优先增强，其中每个采集代表动脉系统的不同部分（例如，腹主动脉，股骨，po骨和胫骨动脉）。
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3.发明授权Method and apparatus for magnetic resonance arteriography using contrast agents 有权使用造影剂进行磁共振动脉造影的方法和装置公开(公告)号：US06311085B1
公开(公告)日：2001-10-30
申请号：US09309311
申请日：1999-05-11
IPC分类号： A61B5055
CPC分类号： A61B5/055 , G01R33/5601 , G01R33/5635 , G01R33/56383 , G06F19/00
摘要： The present invention is a technique of, and system for, imaging vascular anatomy over distance considerably greater than the maximum practical field of view of a magnetic resonance imaging system while using substantially one contrast agent injection. The technique and system of the present invention acquires image data of a plurality of image volumes which are representative of different portions of the patient's body. The image data of each image volume includes image data which is representative of the center of k-space. The acquisition of image data which is representative of the center of k-space is correlated with a concentration of contrast agent in the artery(ies) residing in the image volume being substantially greater than the concentration of contrast agent in veins and background tissue adjacent to the artery(ies). This provides preferential enhancement of arteries relative to adjacent veins and background tissue for each acquisition, wherein each acquisition is representative of a different portion of the arterial system (e.g., abdominal aorta, femoral, popliteal, and tibial arteries).
摘要翻译： 本发明是一种技术，并且用于在使用基本上一个造影剂注射的情况下远远超过磁共振成像系统的最大实际视野来对血管解剖结构进行成像的技术和系统。 本发明的技术和系统获取代表患者身体的不同部分的多个图像体积的图像数据。 每个图像体积的图像数据包括表示k空间中心的图像数据。 代表k空间中心的图像数据的获取与静止在图像体积中的动脉中的造影剂的浓度基本上大于静脉和邻近的静脉和背景组织中造影剂的浓度相关 动脉。 这提供了相对于每个采集的相邻静脉和背景组织的动脉的优先增强，其中每个采集代表动脉系统的不同部分（例如，腹主动脉，股骨，po骨和胫骨动脉）。
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4.发明授权公开(公告)号：US07729741B2
公开(公告)日：2010-06-01
申请号：US11964037
申请日：2007-12-25
IPC分类号： A61B5/055
CPC分类号： A61B5/055 , G01R33/5601 , G01R33/5635 , G01R33/56383 , G06F19/00
摘要： The present invention is a technique of, and system for, imaging vascular anatomy over distance considerably greater than the maximum practical field of view of a magnetic resonance imaging system while using substantially one contrast agent injection. The technique and system of the present invention acquires image data of a plurality of image volumes which are representative of different portions of the patient's body. The image data of each image volume includes image data which is representative of the center of k-space. The acquisition of image data which is representative of the center of k-space is correlated with a concentration of contrast agent in the artery(ies) residing in the image volume being substantially greater than the concentration of contrast agent in veins and background tissue adjacent to the artery(ies). This provides preferential enhancement of arteries relative to adjacent veins and background tissue for each acquisition, wherein each acquisition is representative of a different portion of the arterial system (e.g., abdominal aorta, femoral, popliteal, and tibial arteries).
摘要翻译： 本发明是一种技术，并且用于在使用基本上一个造影剂注射的情况下远远超过磁共振成像系统的最大实际视野来对血管解剖结构进行成像的技术和系统。 本发明的技术和系统获取代表患者身体的不同部分的多个图像体积的图像数据。 每个图像体积的图像数据包括表示k空间中心的图像数据。 代表k空间中心的图像数据的获取与静止在图像体积中的动脉中的造影剂的浓度基本上大于静脉和邻近的静脉和背景组织中造影剂的浓度相关 动脉。 这提供了相对于每个采集的相邻静脉和背景组织的动脉的优先增强，其中每个采集代表动脉系统的不同部分（例如，腹主动脉，股骨，po骨和胫骨动脉）。
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公开(公告)号：US5924987A
公开(公告)日：1999-07-20
申请号：US944426
申请日：1997-10-06
IPC分类号： A61B5/055
CPC分类号： A61B5/055
摘要： The present invention is a technique of, and system for, imaging vascular anatomy over distance considerably greater than the maximum practical field of view of a magnetic resonance imaging system while using substantially one contrast agent injection. The technique and system of the present invention acquires image data of a plurality of image volumes which are representative of different portions of the patient's body. The image data of each image volume includes image data which is representative of the center of k-space. The acquisition of image data which is representative of the center of k-space is correlated with a concentration of contrast agent in the artery(ies) residing in the image volume being substantially greater than the concentration of contrast agent in veins and background tissue adjacent to the artery(ies). This provides preferential enhancement of arteries relative to adjacent veins and background tissue for each acquisition, wherein each acquisition is representative of a different portion of the arterial system (e.g., abdominal aorta, femoral, popliteal, and tibial arteries).
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6.发明申请METHOD AND APPARATUS FOR MAGNETIC RESONANCE ARTERIOGRAPHY USING CONTRAST AGENTS 失效使用对比剂进行磁共振成像的方法和装置公开(公告)号：US20080300480A1
公开(公告)日：2008-12-04
申请号：US11964037
申请日：2007-12-25
IPC分类号： A61B5/055
CPC分类号： A61B5/055 , G01R33/5601 , G01R33/5635 , G01R33/56383 , G06F19/00
摘要： The present invention is a technique of, and system for, imaging vascular anatomy over distance considerably greater than the maximum practical field of view of a magnetic resonance imaging system while using substantially one contrast agent injection. The technique and system of the present invention acquires image data of a plurality of image volumes which are representative of different portions of the patient's body. The image data of each image volume includes image data which is representative of the center of k-space. The acquisition of image data which is representative of the center of k-space is correlated with a concentration of contrast agent in the artery(ies) residing in the image volume being substantially greater than the concentration of contrast agent in veins and background tissue adjacent to the artery(ies). This provides preferential enhancement of arteries relative to adjacent veins and background tissue for each acquisition, wherein each acquisition is representative of a different portion of the arterial system (e.g., abdominal aorta, femoral, popliteal, and tibial arteries).
摘要翻译： 本发明是一种技术，并且用于在使用基本上一个造影剂注射的情况下远远超过磁共振成像系统的最大实际视野来对血管解剖结构进行成像的技术和系统。 本发明的技术和系统获取代表患者身体的不同部分的多个图像体积的图像数据。 每个图像体积的图像数据包括表示k空间中心的图像数据。 代表k空间中心的图像数据的获取与静止在图像体积中的动脉中的造影剂的浓度基本上大于静脉和邻近的静脉和背景组织中造影剂的浓度相关 动脉。 这提供了相对于每个采集的相邻静脉和背景组织的动脉的优先增强，其中每个采集代表动脉系统的不同部分（例如，腹主动脉，股骨，po骨和胫骨动脉）。
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7.发明授权Method and apparatus for magnetic resonance imaging of arteries using a magnetic resonance contrast agent 有权使用磁共振造影剂进行动脉磁共振成像的方法和装置公开(公告)号：US08078259B2
公开(公告)日：2011-12-13
申请号：US12750027
申请日：2010-03-30
申请人： Martin R. Prince
发明人： Martin R. Prince
IPC分类号： A61B5/055
CPC分类号： A61K49/18 , A61B5/201 , A61B5/411 , A61B5/416 , A61M5/007 , A61M5/1456 , A61M5/16827 , G01R33/281 , G01R33/5601 , G01R33/5619 , G01R33/563 , G01R33/56308 , G01R33/5635
摘要： Systems and methods for contrast-enhanced magnetic resonance angiography in which both arterial-phase image data and post-contrast image data is collected.
摘要翻译： 用于对比度增强的磁共振血管造影术的系统和方法，其中收集动脉相位图像数据和造影后图像数据。
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公开(公告)号：US06741881B2
公开(公告)日：2004-05-25
申请号：US10212527
申请日：2002-08-05
申请人： Martin R. Prince
发明人： Martin R. Prince
IPC分类号： A61B5055
CPC分类号： A61K49/18 , A61B5/201 , A61B5/411 , A61B5/416 , A61M5/007 , A61M5/1456 , A61M5/16827 , G01R33/281 , G01R33/5601 , G01R33/5619 , G01R33/563 , G01R33/56308 , G01R33/5635
摘要： The present invention is a technique and apparatus for providing preferential enhancement of an artery of interest relative to adjacent veins and background tissue by correlating the collection of a predetermined portion of data of a magnetic resonance contrast image during the arterial phase of the magnetic resonance contrast enhancement. The arterial phase of the contrast enhancement may be described as a period of a maximum, substantially elevated, or elevated contrast concentration in the artery of interest relative to adjacent veins. The present invention includes a detection system for monitoring and detecting the arrival of the contrast agent in the artery and tissues of interest. When the concentration of contrast agent in the artery of the region of interest is maximum, substantially elevated or elevated (e.g., about 20-50% greater than the response of the region of interest to a series of magnetic resonance pulses before administration of a magnetic resonance contrast agent), a predetermined portion of the magnetic resonance image data (e.g., data which is representative of the center of k-space) may be acquired. Thus, the present invention facilitates synchronization between collecting the central portion of k-space image data with the arterial phase of contrast enhancement. The center of k-space corresponds to the lowest spatial frequency data which dominates image contrast.
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9.发明授权公开(公告)号：US06662038B2
公开(公告)日：2003-12-09
申请号：US09828428
申请日：2001-04-07
申请人： Martin R. Prince
发明人： Martin R. Prince
IPC分类号： A61B5055
CPC分类号： A61K49/18 , A61B5/02007 , A61B5/055 , A61B5/201 , A61B5/416 , A61B5/7285 , G01R33/281 , G01R33/5619 , G01R33/563 , G01R33/56308
摘要： The present invention is a technique and apparatus for acquiring anatomic information used in diagnosing and characterizing abdominal aortic aneurismal disease and the like. This technique provides anatomic information, in the form of images, using a combination of a plurality of magnetic resonance angiography sequences, including a spin-echo and four contrast enhanced (e.g., gadolinium) magnetic resonance angiography sequences. The anatomic images may be used in, for example, pre-operative, operative and post-operative evaluation of aortic pathology, including aneurysms, atherosclerosis, and occlusive disease of branch vessels such as the renal arteries. The gadolinium-enhanced magnetic resonance angiography provides sufficient anatomic detail to detect aneurysms and all relevant major branch vessel abnormalities seen at angiography operation. This technique and apparatus allows for imaging the aorta at a fraction of the cost of conventional aortography and without the risks of arterial catheterization or iodinated contrast.
摘要翻译： 本发明是用于获取用于诊断和表征腹主动脉瘤性疾病等的解剖信息的技术和装置。 该技术以图像的形式使用包括自旋回波和四个对比度增强（例如，钆）磁共振血管造影序列的多个磁共振血管造影术序列的组合来提供解剖信息。 解剖图像可以用于例如主动脉病理学的术前，手术和术后评价，包括动脉瘤，动脉粥样硬化和分支血管如肾动脉的闭塞性疾病。 钆增强磁共振血管造影提供足够的解剖学细节来检测血管造影术中所见的动脉瘤和所有相关主要分支血管异常。 该技术和装置允许以常规造影术的成本的一小部分成像主动脉，并且不存在动脉导管插入或碘化对比的风险。
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公开(公告)号：US06564085B2
公开(公告)日：2003-05-13
申请号：US10032860
申请日：2001-10-23
IPC分类号： A61B5055
CPC分类号： A61B5/055 , G01R33/5601 , G01R33/5635 , G01R33/56383 , G06F19/00
摘要： The present invention is a technique of, and system for, imaging vascular anatomy over distance considerably greater than the maximum practical field of view of a magnetic resonance imaging system while using substantially one contrast agent injection. The technique and system of the present invention acquires image data of a plurality of image volumes which are representative of different portions of the patient's body. The image data of each image volume includes image data which is representative of the center of k-space. The acquisition of image data which is representative of the center of k-space is correlated with a concentration of contrast agent in the artery(ies) residing in the image volume being substantially greater than the concentration of contrast agent in veins and background tissue adjacent to the artery(ies). This provides preferential enhancement of arteries relative to adjacent veins and background tissue for each acquisition, wherein each acquisition is representative of a different portion of the arterial system (e.g., abdominal aorta, femoral, popliteal, and tibial arteries).
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