公开(公告)号：US11678890B2

公开(公告)日：2023-06-20

申请号：US13482348

申请日：2012-05-29

Applicant: Martin R. Prince

Inventor： Martin R. Prince

IPC: A61B17/135 ,  A61B17/132 ,  A61B5/055 ,  A61B90/00

CPC classification number: A61B17/135 ,  A61B17/1322 ,  A61B17/1355 ,  A61B5/055 ,  A61B2090/374

Abstract: A thigh compression device and technique to control, time, delay and/or prevent excessive early venous enhancement relative to arterial enhancement and thereby improve and/or enhance MRA images, including peripheral MRA images, is disclosed. In one embodiment, the present invention uses a curved strip of material which is longer on the superior edge and shorter along the inferior edge. When wrapped around the conical shape of the thigh of a subject, for example, a human, the thigh compression device more uniformly conforms to and/or fits around the thigh, providing more even/uniform compression as well as reducing, minimizing and/or eliminating significant movement of the thigh compression device towards the knees of the subject. A snug fit on the thighs may also enable the thigh compression device to be inflated with less fluid, which is faster and less cumbersome for the operator.

公开(公告)号：US20130030284A1

公开(公告)日：2013-01-31

申请号：US13482348

申请日：2012-05-29

Applicant: Martin R. Prince

Inventor： Martin R. Prince

IPC: A61B5/055

CPC classification number: A61B17/135 ,  A61B5/055 ,  A61B17/1322 ,  A61B17/1355 ,  A61B2090/374

Abstract: A thigh compression device and technique to control, time, delay and/or prevent excessive early venous enhancement relative to arterial enhancement and thereby improve and/or enhance MRA images, including peripheral MRA images, is disclosed. In one embodiment, the present invention uses a curved strip of material which is longer on the superior edge and shorter along the inferior edge. When wrapped around the conical shape of the thigh of a subject, for example, a human, the thigh compression device more uniformly conforms to and/or fits around the thigh, providing more even/uniform compression as well as reducing, minimizing and/or eliminating significant movement of the thigh compression device towards the knees of the subject. A snug fit on the thighs may also enable the thigh compression device to be inflated with less fluid, which is faster and less cumbersome for the operator.

Abstract translation: 公开了一种大腿压缩装置和技术，用于控制，时间，延迟和/或防止相对于动脉增强的过度的早期静脉增强，从而改善和/或增强包括外围MRA图像在内的MRA图像。 在一个实施例中，本发明使用弯曲的材料条，其在上边缘上较长并且沿着下边缘较短。 当围绕受试者的大腿的圆锥形形状（例如人）缠绕时，大腿压缩装置更均匀地适应和/或配合大腿周围，提供更均匀/均匀的压缩以及减少，最小化和/或 消除大腿压缩装置朝向受试者的膝盖的显着运动。 在大腿上贴合适合也可以使大腿压缩装置以更少的流体充气，这对于操作者而言更快且不那么麻烦。

公开(公告)号：US08190236B2

公开(公告)日：2012-05-29

申请号：US11331519

申请日：2006-01-13

Applicant: Martin R. Prince

Inventor： Martin R. Prince

IPC: A61B5/055

CPC classification number: A61B17/135 ,  A61B5/055 ,  A61B17/1322 ,  A61B17/1355 ,  A61B2090/374

Abstract: There are many inventions described herein as well as many aspects and embodiments of those inventions. A thigh compression device and technique to control, time, delay and/or prevent excessive early venous enhancement relative to arterial enhancement and thereby improve and/or enhance MRA images, including peripheral MRA images. In one embodiment, the present invention uses a curved strip of material which is longer on the superior edge and shorter along the inferior edge. When wrapped around the conical or conal-like shape of the thigh of a subject (for example, a human), the thigh compression device more uniformly conforms to and/or fits around the thigh, providing more even/uniform compression as well as reducing, minimizing and/or eliminating significant movement of the thigh compression device towards the knees of the subject. Notably, a snug fit on the thighs may also enable the thigh compression device to be inflated with less fluid (for example, air) which is faster and less cumbersome for the operator.

Abstract translation: 这里描述了许多发明以及这些发明的许多方面和实施例。 一种大腿压缩装置和技术，用于相对于动脉增强来控制，时间，延迟和/或预防过度的早期静脉增强，从而改善和/或增强MRA图像，包括外围MRA图像。 在一个实施例中，本发明使用弯曲的材料条，其在上边缘上较长并且沿着下边缘较短。 当围绕受试者（例如人）的大腿的锥形或锥形形状缠绕时，大腿压缩装置更均匀地适应和/或适合大腿周围，提供更均匀/均匀的压缩以及减少 ，最大限度地减少和/或消除大腿压缩装置朝向受试者的膝盖的显着运动。 值得注意的是，大腿上的紧贴配合还可以使得较少的流体（例如，空气）使大腿压缩装置膨胀，这对于操作者而言更快且不那么麻烦。

公开(公告)号：US20110054301A1

公开(公告)日：2011-03-03

申请号：US12750027

申请日：2010-03-30

Applicant: Martin R. Prince

Inventor： Martin R. Prince

IPC: A61B5/055

CPC classification number: A61K49/18 ,  A61B5/201 ,  A61B5/411 ,  A61B5/416 ,  A61M5/007 ,  A61M5/1456 ,  A61M5/16827 ,  G01R33/281 ,  G01R33/5601 ,  G01R33/5619 ,  G01R33/563 ,  G01R33/56308 ,  G01R33/5635

Abstract: Systems and methods for contrast-enhanced magnetic resonance angiography in which both arterial-phase image data and post-contrast image data is collected.

Abstract translation: 用于对比度增强的磁共振血管造影术的系统和方法，其中收集动脉相位图像数据和造影后图像数据。

公开(公告)号：US20100240985A1

公开(公告)日：2010-09-23

申请号：US12791488

申请日：2010-06-01

Applicant: James F.M. Meaney ,  Martin R. Prince

Inventor： James F.M. Meaney ,  Martin R. Prince

IPC: A61B5/055

CPC classification number: A61B5/055 ,  G01R33/5601 ,  G01R33/5635 ,  G01R33/56383

Abstract: The present invention is a technique of, and system for, imaging vascular anatomy over distance considerably greater than the maximum practical field of view of a magnetic resonance imaging system while using substantially one contrast agent injection. The technique and system of the present invention acquires image data of a plurality of image volumes which are representative of different portions of the patient's body. The image data of each image volume includes image data which is representative of the center of k-space. The acquisition of image data which is representative of the center of k-space is correlated with a concentration of contrast agent in the artery(ies) residing in the image volume being substantially greater than the concentration of contrast agent in veins and background tissue adjacent to the artery(ies). This provides preferential enhancement of arteries relative to adjacent veins and background tissue for each acquisition, wherein each acquisition is representative of a different portion of the arterial system (e.g., abdominal aorta, femoral, popliteal, and tibial arteries).

Abstract translation: 本发明是一种技术，并且用于在使用基本上一个造影剂注射的情况下远远超过磁共振成像系统的最大实际视野来对血管解剖结构进行成像的技术和系统。 本发明的技术和系统获取代表患者身体的不同部分的多个图像体积的图像数据。 每个图像体积的图像数据包括表示k空间中心的图像数据。 代表k空间中心的图像数据的获取与静止在图像体积中的动脉中的造影剂的浓度基本上大于静脉和邻近的静脉和背景组织中造影剂的浓度相关 动脉。 这提供了相对于每个采集的相邻静脉和背景组织的动脉的优先增强，其中每个采集代表动脉系统的不同部分（例如，腹主动脉，股骨，po骨和胫骨动脉）。

公开(公告)号：US07545967B1

公开(公告)日：2009-06-09

申请号：US10664425

申请日：2003-09-17

Applicant: Martin R. Prince ,  Ramin Zabih ,  Yi Wang ,  Richard Watts ,  Junhwan Kim ,  Jeff Bezanson ,  Hale Ersoy

Inventor： Martin R. Prince ,  Ramin Zabih ,  Yi Wang ,  Richard Watts ,  Junhwan Kim ,  Jeff Bezanson ,  Hale Ersoy

IPC: G06K9/00

CPC classification number: G06T5/50 ,  G06K2209/05 ,  G06T2207/10076 ,  G06T2207/10088 ,  G06T2207/30101 ,  Y10S128/92 ,  Y10S128/922

Abstract: In time-resolved contrast-enhanced magnetic resonance angiography, a measure quantifying image quality provides a basis for generating a linear filtered composite image by facilitating selection of a mask and an arterial phase image for subtraction. Filtering of individual pixels of a temporal series of images provides enhanced contrast in a single image by allowing the temporal behavior of the pixel intensity to denote representation as an artery, vein or background tissue. Motion artifacts are suppressed by re-registering sequential images, adjusting weighting before averaging and subtraction and filtering the Fourier data to eliminate data corrupted by motion or other phenomena.

Abstract translation: 在时间分辨的对比度增强磁共振血管造影术中，量化图像质量的度量为通过促进选择掩模和用于减法的动脉相位图像生成线性滤波的复合图像提供了基础。 通过使像素强度的时间行为表示为动脉，静脉或背景组织，对时间序列图像中的各个像素进行滤波，从而在单个图像中提供增强的对比度。 通过重新注册顺序图像来抑制运动伪影，在平均和减法之前调整加权并对傅立叶数据进行滤波以消除由运动或其他现象损坏的数据。

公开(公告)号：US07313428B2

公开(公告)日：2007-12-25

申请号：US11003101

申请日：2004-12-03

Applicant: James F. M. Meaney ,  Martin R. Prince

Inventor： James F. M. Meaney ,  Martin R. Prince

IPC: A61B5/055

CPC classification number: A61B5/055 ,  G01R33/5601 ,  G01R33/5635 ,  G01R33/56383 ,  G06F19/00

Abstract: The present invention is a technique of, and system for, imaging vascular anatomy over distance considerably greater than the maximum practical field of view of a magnetic resonance imaging system while using substantially one contrast agent injection. The technique and system of the present invention acquires image data of a plurality of image volumes which are representative of different portions of the patient's body. The image data of each image volume includes image data which is representative of the center of k-space. The acquisition of image data which is representative of the center of k-space is correlated with a concentration of contrast agent in the artery(ies) residing in the image volume being substantially greater than the concentration of contrast agent in veins and background tissue adjacent to the artery(ies). This provides preferential enhancement of arteries relative to adjacent veins and background tissue for each acquisition, wherein each acquisition is representative of a different portion of the arterial system (e.g., abdominal aorta, femoral, popliteal, and tibial arteries).

Abstract translation: 本发明是一种技术，并且用于在使用基本上一个造影剂注射的情况下远远超过磁共振成像系统的最大实际视野来对血管解剖结构进行成像的技术和系统。 本发明的技术和系统获取代表患者身体的不同部分的多个图像体积的图像数据。 每个图像体积的图像数据包括表示k空间中心的图像数据。 代表k空间中心的图像数据的获取与静止在图像体积中的动脉中的造影剂的浓度基本上大于静脉和邻近的静脉和背景组织中造影剂的浓度相关 动脉。 这提供了相对于每个采集的相邻静脉和背景组织的动脉的优先增强，其中每个采集代表动脉系统的不同部分（例如，腹主动脉，股骨，po骨和胫骨动脉）。

公开(公告)号：US06754521B2

公开(公告)日：2004-06-22

申请号：US10375825

申请日：2003-02-27

Applicant: Martin R. Prince

Inventor： Martin R. Prince

IPC: A61B5055

CPC classification number: A61K49/18 ,  A61B5/201 ,  A61B5/411 ,  A61B5/416 ,  A61M5/007 ,  A61M5/1456 ,  A61M5/16827 ,  G01R33/281 ,  G01R33/5601 ,  G01R33/5619 ,  G01R33/563 ,  G01R33/56308 ,  G01R33/5635

Abstract: The present invention is a technique and apparatus for providing preferential enhancement of an artery of interest relative to adjacent veins and background tissue by correlating the collection of a predetermined portion of data of a magnetic resonance contrast image during the arterial phase of the magnetic resonance contrast enhancement. The arterial phase of the contrast enhancement may be described as a period of a maximum, substantially elevated, or elevated contrast concentration in the artery of interest relative to adjacent veins. The present invention includes a detection system for monitoring and detecting the arrival of the contrast agent in the artery and tissues of interest. When the concentration of contrast agent in the artery of the region of interest is maximum, substantially elevated or elevated (e.g., about 20-50% greater than the response of the region of interest to a series of magnetic resonance pulses before administration of a magnetic resonance contrast agent), a predetermined portion of the magnetic resonance image data (e.g., data which is representative of the center of k-space) may be acquired. Thus, the present invention facilitates synchronization between collecting the central portion of k-space image data with the arterial phase of contrast enhancement. The center of k-space corresponds to the lowest spatial frequency data which dominates image contrast.

Abstract translation: 本发明是一种通过将磁共振对比度增强的动脉期期间的磁共振对比度图像的预定部分数据的收集相关联来提供相对于相邻静脉和背景组织的感兴趣的动脉的优先增强的技术和装置 。 对比度增强的动脉期可以描述为相对于相邻静脉的感兴趣动脉中的最大，基本升高或升高的对比浓度的周期。 本发明包括用于监测和检测造影剂到动脉和感兴趣组织的检测系统。 当感兴趣区域的动脉中的造影剂的浓度最大时，基本升高或升高（例如，在给予磁性之前一系列磁共振脉冲的感兴趣区域的响应大约20-50％ 共振造影剂），可以获取磁共振图像数据的预定部分（例如，表示k空间的中心的数据）。 因此，本发明有助于将k空间图像数据的中心部分与对比度增强的动脉相位之间的同步。 k空间的中心对应于支配图像对比度的最低空间频率数据。

公开(公告)号：US06311085B1

公开(公告)日：2001-10-30

申请号：US09309311

申请日：1999-05-11

Applicant: James F. M. Meaney ,  Martin R. Prince

Inventor： James F. M. Meaney ,  Martin R. Prince

IPC: A61B5055

CPC classification number: A61B5/055 ,  G01R33/5601 ,  G01R33/5635 ,  G01R33/56383 ,  G06F19/00

Abstract: The present invention is a technique of, and system for, imaging vascular anatomy over distance considerably greater than the maximum practical field of view of a magnetic resonance imaging system while using substantially one contrast agent injection. The technique and system of the present invention acquires image data of a plurality of image volumes which are representative of different portions of the patient's body. The image data of each image volume includes image data which is representative of the center of k-space. The acquisition of image data which is representative of the center of k-space is correlated with a concentration of contrast agent in the artery(ies) residing in the image volume being substantially greater than the concentration of contrast agent in veins and background tissue adjacent to the artery(ies). This provides preferential enhancement of arteries relative to adjacent veins and background tissue for each acquisition, wherein each acquisition is representative of a different portion of the arterial system (e.g., abdominal aorta, femoral, popliteal, and tibial arteries).

Abstract translation: 本发明是一种技术，并且用于在使用基本上一个造影剂注射的情况下远远超过磁共振成像系统的最大实际视野来对血管解剖结构进行成像的技术和系统。 本发明的技术和系统获取代表患者身体的不同部分的多个图像体积的图像数据。 每个图像体积的图像数据包括表示k空间中心的图像数据。 代表k空间中心的图像数据的获取与静止在图像体积中的动脉中的造影剂的浓度基本上大于静脉和邻近的静脉和背景组织中造影剂的浓度相关 动脉。 这提供了相对于每个采集的相邻静脉和背景组织的动脉的优先增强，其中每个采集代表动脉系统的不同部分（例如，腹主动脉，股骨，po骨和胫骨动脉）。

公开(公告)号：US5590654A

公开(公告)日：1997-01-07

申请号：US580195

申请日：1995-12-28

Applicant: Martin R. Prince

Inventor： Martin R. Prince

IPC: A61K49/18 ,  G01R33/28 ,  G01R33/561 ,  G01R33/563 ,  A61B5/055

CPC classification number: A61K49/18 ,  A61B5/411 ,  A61B5/416 ,  A61M5/007 ,  A61M5/1456 ,  A61M5/16827 ,  G01R33/5601 ,  G01R33/563 ,  G01R33/5635 ,  A61B5/201 ,  G01R33/281 ,  G01R33/5619 ,  G01R33/56308

Abstract: The present invention is a technique and apparatus for monitoring and detecting the arrival of a contrast agent in a region of interest (e.g., an artery or tissues of interest). In one embodiment, upon detecting a maximum, substantially elevated or elevated concentration of contrast agent in the region of interest, a predetermined portion of the magnetic resonance image data (e.g., data which is representative of the center of k-space) may be acquired. Thus, the present invention may be employed to facilitate synchronization between collecting the central portion of k-space image data with the arterial phase of contrast enhancement.

Abstract translation: 本发明是用于监测和检测造影剂到感兴趣区域（例如感兴趣的动脉或组织）的技术和装置。 在一个实施方案中，当检测到感兴趣区域中造影剂的最大，基本上升高或升高的浓度时，可以获得磁共振图像数据的预定部分（例如，代表k空间中心的数据） 。 因此，本发明可以用于促进将k空间图像数据的中心部分与对比度增强的动脉相位之间的同步。