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公开(公告)号：US20100081868A1
公开(公告)日：2010-04-01
申请号：US12567532
申请日：2009-09-25
IPC分类号： A61F2/02
CPC分类号： A61B17/00234 , A61B17/06166 , A61B17/0644 , A61B17/068 , A61B2017/00243 , A61B2017/00867 , A61B2017/06052
摘要： Systems, methods and devices are provided for treating heart failure patients suffering from various levels of heart dilation. Such heart dilation is treated by reshaping the heart anatomy with the use of shape memory elements. Such reshaping changes the geometry of portions of the heart, particularly the right or left ventricles, to increase contractibility of the ventricles thereby increasing the stroke volume which in turn increases the cardiac output of the heart. The shape memory elements have an original shape and at least one memory shape. The elements are implanted within the heart tissue or attached externally and/or internally to a surface of the heart when in the original shape. The elements are then activated to transition from the original shape to one of the at least one memory shapes. Transitioning of the elements cause the associated heart tissue areas to readjust position, such as to decrease the width of the ventricles. Such repositioning is maintained over time by the elements, allowing the damaging effects of heart dilation to slow in progression or reverse.
摘要翻译： 提供了用于治疗患有各种心脏扩张水平的心力衰竭患者的系统，方法和装置。 通过使用形状记忆元件重建心脏解剖结构来治疗这种心脏扩张。 这种重塑改变了心脏的部分的几何形状，特别是右心室或左心室，以增加心室的收缩性，从而增加了行程体积，从而增加了心脏的心输出量。 形状记忆元件具有原始形状和至少一种存储器形状。 当原始形状时，将元件植入心脏组织内或外部和/或内部附着到心脏的表面。 元件然后被激活以从原始形状转换到至少一个存储器形状之一。 元件的过渡导致相关的心脏组织区域重新调整位置，例如减小心室的宽度。 这种重新定位由元素随时间推移而维持，从而允许心脏扩张的破坏性影响进展缓慢或逆转。
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公开(公告)号：US20090312806A1
公开(公告)日：2009-12-17
申请号：US12483180
申请日：2009-06-11
CPC分类号： A61F2/44 , A61F2/441 , A61F2/4611 , A61F2002/30583 , A61F2002/4627 , A61F2210/0085
摘要： An inflatable corpectomy device comprises a balloon, which defines a cavity for receiving a hardenable media. The device can be inserted in an un-inflated form into a space formerly occupied by a diseased or damaged vertebrae bone. When inflated with a hardenable material, the device expands and fills the space. Various bone anchors or plates can be used in combination with the inflatable device to bridge the space and stabilize the spine while the device hardens.
摘要翻译： 可充气的椎间盘切除装置包括气囊，其限定用于接收可硬化介质的空腔。 该装置可以以未膨胀的形式插入以前由患病或受损的椎骨骨骼占据的空间中。 当用可硬化材料充气时，装置膨胀并填充空间。 各种骨锚或板可以与充气装置组合使用，以在装置硬化时桥接空间并稳定脊柱。
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公开(公告)号：US07594887B2
公开(公告)日：2009-09-29
申请号：US11876586
申请日：2007-10-22
IPC分类号： A61F2/02
CPC分类号： A61B17/00234 , A61B17/06166 , A61B17/0644 , A61B17/068 , A61B2017/00243 , A61B2017/00867 , A61B2017/06052
摘要： Systems, methods and devices are provided for treating heart failure patients suffering from various levels of heart dilation. Such heart dilation is treated by reshaping the heart anatomy with the use of shape memory elements. Such reshaping changes the geometry of portions of the heart, particularly the right or left ventricles, to increase contractibility of the ventricles thereby increasing the stroke volume which in turn increases the cardiac output of the heart. The shape memory elements have an original shape and at least one memory shape. The elements are implanted within the heart tissue or attached externally and/or internally to a surface of the heart when in the original shape. The elements are then activated to transition from the original shape to one of the at least one memory shapes. Transitioning of the elements cause the associated heart tissue areas to readjust position, such as to decrease the width of the ventricles. Such repositioning is maintained over time by the elements, allowing the damaging effects of heart dilation to slow in progression or reverse.
摘要翻译： 提供了用于治疗患有各种心脏扩张水平的心力衰竭患者的系统，方法和装置。 通过使用形状记忆元件重建心脏解剖结构来治疗这种心脏扩张。 这种重塑改变了心脏的部分的几何形状，特别是右心室或左心室，以增加心室的收缩性，从而增加了行程体积，从而增加了心脏的心输出量。 形状记忆元件具有原始形状和至少一种存储器形状。 当原始形状时，将元件植入心脏组织内或外部和/或内部附着到心脏的表面。 元件然后被激活以从原始形状转换到至少一个存储器形状之一。 元件的过渡导致相关的心脏组织区域重新调整位置，例如减小心室的宽度。 这种重新定位由元素随时间推移而维持，从而允许心脏扩张的破坏性影响进展缓慢或逆转。
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公开(公告)号：US20120310330A1
公开(公告)日：2012-12-06
申请号：US13397545
申请日：2012-02-15
IPC分类号： A61F2/24
CPC分类号： A61F2/2466 , A61B17/0469 , A61B17/8855 , A61B2017/0474 , A61B2018/0025 , A61F2/2433 , A61F2/2442 , A61F2/2445 , A61F2/2448 , A61F2/95 , A61F2/958 , A61F2/962 , A61F2210/0014 , A61F2210/0023 , A61F2210/0033 , A61F2210/0066 , A61F2220/0016 , A61F2220/0025 , A61F2220/0075 , A61F2230/0006 , A61F2230/0008 , A61M25/1011
摘要： Apparatus, systems, and methods are provided for repairing heart valves through percutaneous transcatheter delivery and fixation of annuloplasty rings to heart valves via a trans-apical approach to accessing the heart. A guiding sheath may be introduced into a ventricle of the heart through an access site at an apex of the heart. A distal end of the guiding sheath can be positioned retrograde through the target valve. An annuloplasty ring arranged in a compressed delivery geometry is advanced through the guiding sheath and into a distal portion of the guiding sheath positioned within the atrium of the heart. The distal end of the guiding sheath is retracted, thereby exposing the annuloplasty ring. The annuloplasty ring may be expanded from the delivery geometry to an operable geometry. Anchors on the annuloplasty ring may be deployed to press into and engage tissue of the annulus of the target valve.
摘要翻译： 提供了装置，系统和方法，用于通过经皮经导管递送修复心脏瓣膜，并通过穿过心脏的方式将瓣膜成形术环固定在心脏瓣膜上。 引导鞘可以通过心脏顶点的进入部位引入心脏的心室。 引导护套的远端可以通过目标阀逆行定位。 以压缩的输送几何形状布置的瓣环成形术环被推进穿过引导护套并进入位于心脏心房内的引导护套的远端部分。 引导护套的远端缩回，从而暴露瓣环成形术环。 瓣环成形术环可以从输送几何形状扩展到可操作的几何形状。 瓣膜成形术环上的锚点可以被部署以压入和接合目标瓣膜的环的组织。
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公开(公告)号：US20120123531A1
公开(公告)日：2012-05-17
申请号：US13198582
申请日：2011-08-04
申请人： Ross Tsukashima , Samuel M. Shaolian , Maurice Buchbinder , Brian C. Gray , Victor S. Packham , Hung H. Cao
发明人： Ross Tsukashima , Samuel M. Shaolian , Maurice Buchbinder , Brian C. Gray , Victor S. Packham , Hung H. Cao
IPC分类号： A61F2/24
CPC分类号： A61F2/2466 , A61F2/2442 , A61F2/2445 , A61F2/2448 , A61F2210/0014 , A61F2220/0016 , A61F2220/0033 , A61F2220/0075 , A61F2250/0004 , A61F2250/001 , A61F2250/0067 , A61F2250/0096
摘要： Apparatus, systems, and methods are provided for repairing heart valves through percutaneous transcatheter delivery and fixation of annuloplasty rings to heart valves. An annuloplasty ring includes an outer hollow member including a plurality of segments. Adjacent segments cooperate with one another to change the outer hollow member from an elongate insertion geometry to an annular operable geometry. The annuloplasty ring also includes an internal anchor member located at least partially within the outer hollow member. The internal anchor member includes a plurality of anchors configured to attach the annuloplasty ring to tissue of a heart valve annulus. The internal anchor member is configured to move the plurality of anchors with respect to a plurality of windows in the outer hollow member to selectively deploy the plurality of anchors through the respective windows.
摘要翻译： 提供装置，系统和方法用于通过经皮经导管递送和瓣膜成形术环固定到心脏瓣膜来修复心脏瓣膜。 瓣膜成形术环包括包括多个段的外部中空构件。 相邻的部分彼此协作以将外部空心构件从细长插入几何形状改变为环形可操作的几何形状。 瓣膜成形术环还包括至少部分地位于外部中空构件内部的内部锚定构件。 内部锚固构件包括构造成将瓣环成形术环附接到心脏瓣膜环的组织的多个锚固件。 内部锚固构件被构造成相对于外部中空构件中的多个窗口移动多个锚固件，以选择性地将多个锚定件展开通过相应的窗口。
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公开(公告)号：US20110313516A1
公开(公告)日：2011-12-22
申请号：US13148743
申请日：2010-02-12
IPC分类号： A61F2/24
CPC分类号： A61M25/0082 , A61F2/2445 , A61F2/2448 , A61F2/2466 , A61F2210/009 , A61F2250/0004 , A61M25/0127
摘要： A percutaneous magnetic catheter may be used to position one or more magnetic components near a magnetically driven prosthesis in a patient's heart in order to adjust the magnetically driven prosthesis. In certain embodiments, the one or more magnetic components are rotatable. Rotation of the one or more magnetic components cause variations in a magnetic field. Variations in the magnetic field may be utilized to adjust the size or shape of a magnetically driven prosthesis. In this way, a magnetically driven prosthesis may be adjusted after a patient has recovered from a surgery in which the magnetically driven prosthesis was implanted. Further, a magnetically driven prosthesis may be adjusted based upon progression of a heart condition.
摘要翻译： 可以使用经皮磁导管将一个或多个磁性部件定位在患者心脏内的磁驱动假体附近，以便调整磁驱动假体。 在某些实施例中，一个或多个磁性部件是可旋转的。 一个或多个磁性部件的旋转导致磁场的变化。 可以利用磁场的变化来调节磁力驱动假体的尺寸或形状。 以这种方式，可以在患者从其中植入有磁性驱动的假体的手术中恢复之后调节磁力驱动的假体。 此外，可以基于心脏状况的进展来调整磁驱动假体。
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公开(公告)号：US20110257740A1
公开(公告)日：2011-10-20
申请号：US13079429
申请日：2011-04-04
IPC分类号： A61F2/24
CPC分类号： A61F2/2448 , A61F2/2445 , A61F2210/0014 , A61F2210/0023 , A61F2250/0001 , A61F2250/0004 , A61F2250/0082
摘要： Methods and devices are provided for support of a body structure. The devices can be adjusted within the body of a patient in a minimally invasive or non-invasive manner such as by applying energy percutaneously or external to the patient's body. The energy may include, for example, acoustic energy, radio frequency energy, light energy and magnetic energy. Thus, as the body structure changes size and/or shape, the size and/or shape of the annuloplasty rings can be adjusted to provide continued reinforcement. In certain embodiments, the devices include a first body member including a first shape memory material configured to transform the annuloplasty ring from a first configuration having a first size of a dimension to a second configuration having a second size of the dimension. The second size is less than said first size in septal lateral distance. The devices also include a second body member including a second shape memory material configured to transform the annuloplasty ring from the second configuration to a third configuration having a third size of the dimension, wherein the second size is less than the third size in septal lateral distance.
摘要翻译： 提供了用于支撑身体结构的方法和装置。 可以以微创或非侵入性方式在患者体内调节装置，例如通过经皮或外部给患者的身体施加能量。 能量可以包括例如声能，射频能量，光能和磁能。 因此，随着身体结构改变尺寸和/或形状，可以调节瓣膜成形术环的尺寸和/或形状以提供持续的加强。 在某些实施例中，所述装置包括第一主体构件，所述第一主体构件包括第一形状记忆材料，所述第一形状记忆材料构造成将瓣膜成形术环从具有尺寸的第一尺寸的第一构型转换成具有尺寸的第二尺寸的第二构型。 第二尺寸小于所述第一尺寸在间隔侧向距离。 所述装置还包括第二主体构件，所述第二主体构件包括第二形状记忆材料，所述第二形状记忆材料构造成将瓣膜成形术环从第二构型转换成具有尺寸的第三尺寸的第三构型，其中第二尺寸小于第三尺寸的间隔横向距离 。
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48.发明申请INDUCTION ACTIVATION OF ADJUSTABLE ANNULOPLASTY RINGS AND OTHER IMPLANTABLE DEVICES 审中-公开可调节性静脉环和其他可植入装置的诱导激活公开(公告)号：US20110218622A1
公开(公告)日：2011-09-08
申请号：US13040657
申请日：2011-03-04
摘要： Systems and methods to adjust an adjustable medical device that is implanted subcutaneously within the body of a patient. The adjustable medical device is coupled to an adjustment mechanism configured to, when powered, effect a desired adjustment to the adjustable medical device. The adjustment mechanism is electrically coupled to a receiving coil configured to resonate at a desired frequency such that an electric current induced in the receiving coil powers the adjustment mechanism. An induction activation system is configured to utilize magnetic resonance to wirelessly activate the adjustable medical device assembly, from outside the patient's body, through a skin barrier of the patient. The induction activation system comprises a power source and a delivery coil. The power source creates an alternating electrical signal. The delivery coil is electrically coupled to the power source and configured to resonate in response to the alternating electrical signal created by the power source, and thereby generate a resonating magnetic field. The delivery coil is tuned to have a resonant frequency that is the same as a frequency of the alternating electrical signal created by the power source. The receiving coil can also be tuned to resonate at the resonant frequency of the delivery coil. When the delivery coil is positioned near the patient's body, such that the receiving coil is within the magnetic field generated by the delivery coil, an electric current is induced in the receiving coil to drive the adjustment mechanism and thereby effect an adjustment of the adjustable medical device.
摘要翻译： 用于调整可植入在患者体内皮下的可调节医疗装置的系统和方法。 可调节医疗装置联接到调节机构，该调节机构被配置为在被供电时对可调节的医疗装置进行期望的调整。 调节机构电耦合到接收线圈，该接收线圈被配置为以期望的频率谐振，使得在接收线圈中感应的电流为调节机构供电。 感应激活系统被配置为利用磁共振来从患者身体外部通过患者的皮肤屏障无线地激活可调节的医疗装置组件。 感应激活系统包括电源和输送线圈。 电源产生交流电信号。 输送线圈电耦合到电源并且被配置为响应于由电源产生的交流电信号而谐振，从而产生谐振磁场。 传送线圈被调谐为具有与由电源产生的交流电信号的频率相同的谐振频率。 接收线圈也可以被调谐以在输送线圈的谐振频率处共振。 当输送线圈位于患者身体附近时，使得接收线圈处于由输送线圈产生的磁场内，在接收线圈中感应出电流以驱动调节机构，从而实现可调医疗 设备。
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公开(公告)号：US07722668B2
公开(公告)日：2010-05-25
申请号：US12032476
申请日：2008-02-15
IPC分类号： A61F2/06
CPC分类号： A61F2/2448 , A61F2/2445 , A61F2210/0014 , A61F2210/0023 , A61F2250/0001 , A61F2250/0004 , A61F2250/0082
摘要： Methods and devices are provided for support of a body structure. The devices can be adjusted within the body of a patient in a minimally invasive or non-invasive manner such as by applying energy percutaneously or external to the patient's body. The energy may include, for example, acoustic energy, radio frequency energy, light energy and magnetic energy. Thus, as the body structure changes size and/or shape, the size and/or shape of the annuloplasty rings can be adjusted to provide continued reinforcement. In certain embodiments, the devices include a body member including a shape memory material, and an energy absorption enhancement material configured to absorb energy in response to an activation energy. The energy absorption enhancement material is in thermal communication with said shape memory material. The body member has a first size of a dimension in a first configuration and a second size of the dimension in a second configuration, and is configured to be implanted in the first configuration into a heart. The body member is configured to transform from the first configuration to the second configuration in response to the activation energy. The second configuration is configured to reduce a dimension of a cardiac valve annulus in the heart.
摘要翻译： 提供了用于支撑身体结构的方法和装置。 可以以微创或非侵入性方式在患者体内调节装置，例如通过经皮或外部给患者的身体施加能量。 能量可以包括例如声能，射频能量，光能和磁能。 因此，随着身体结构改变尺寸和/或形状，可以调节瓣膜成形术环的尺寸和/或形状以提供持续的加强。 在某些实施方案中，所述装置包括包括形状记忆材料的主体构件和被配置为响应于活化能吸收能量的能量吸收增强材料。 能量吸收增强材料与所述形状记忆材料热连通。 主体构件具有第一构造的尺寸的第一尺寸和第二构造中的尺寸的第二尺寸，并且构造成以第一构造植入心脏。 身体构件被配置为响应于激活能量从第一配置变换到第二配置。 第二配置被配置为减小心脏中的心脏瓣膜环的尺寸。
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公开(公告)号：US07510577B2
公开(公告)日：2009-03-31
申请号：US11124408
申请日：2005-05-06
IPC分类号： A61F2/24
CPC分类号： A61F2/2448 , A61F2/2445 , A61F2210/0014 , A61F2210/0023 , A61F2250/0001 , A61F2250/0004 , A61F2250/0082
摘要： Methods and devices are provided for support of a body structure. The devices can be adjusted within the body of a patient in a minimally invasive or non-invasive manner such as by applying energy percutaneously or external to the patient's body. The energy may include, for example, acoustic energy, radio frequency energy, light energy and magnetic energy. Thus, as the body structure changes size and/or shape, the size and/or shape of the annuloplasty rings can be adjusted to provide continued reinforcement. In certain embodiments, the devices include a body member including a ferromagnetic shape memory material. The body member has a first size of a dimension in a first configuration and a second size of the dimension in a second configuration. The body member is configured to be implanted into a heart so as to reinforce a cardiac valve annulus in the first configuration. The body member is configured to transform from the first configuration to the second configuration in vivo in response to a magnetic field. The body member in the second configuration is configured to reduce a size of the cardiac valve annulus.
摘要翻译： 提供了用于支撑身体结构的方法和装置。 可以以微创或非侵入性方式在患者体内调节装置，例如通过经皮或外部给患者的身体施加能量。 能量可以包括例如声能，射频能量，光能和磁能。 因此，随着身体结构改变尺寸和/或形状，可以调节瓣膜成形术环的尺寸和/或形状以提供持续的加强。 在某些实施例中，装置包括包括铁磁形状记忆材料的主体构件。 主体构件具有第一构造的尺寸的第一尺寸和第二构造中的尺寸的第二尺寸。 身体构件被配置成植入心脏中，以便在第一构型中加强心脏瓣膜环。 身体构件被配置为响应于磁场在体内从第一配置转变为第二配置。 第二构造中的本体构件被构造成减小心脏瓣膜环的尺寸。
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