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公开(公告)号：US20090270443A1
公开(公告)日：2009-10-29
申请号：US11574464
申请日：2005-09-02
申请人： Doris Stoermer , Luke T. Dressel , Karl J. Manske , George W. Griesgraber , Bernhard M. Zimmermann , Joseph F. Dellaria, JR.
发明人： Doris Stoermer , Luke T. Dressel , Karl J. Manske , George W. Griesgraber , Bernhard M. Zimmermann , Joseph F. Dellaria, JR.
IPC分类号： A61K31/4375 , C07D471/04 , A61K31/437 , C07D471/14
CPC分类号： C07D471/04
摘要： Imidazo-containing compounds (e.g., imidazonaphthyridines, imidazopyridines) with an amino substituent at the 1-position, pharmaceutical compositions containing the compounds and methods of use of these compounds as immunomodulators, for inducing cytokine biosynthesis in animals and in the treatment of diseases including viral and neoplastic diseases are disclosed.
摘要翻译： 在1位具有氨基取代基的含咪唑化合物（例如咪唑并吡啶，咪唑并吡啶），含有化合物的药物组合物以及这些化合物作为免疫调节剂的使用方法，用于诱导动物中的细胞因子生物合成和治疗包括病毒 并发现肿瘤性疾病。
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公开(公告)号：US20090253695A1
公开(公告)日：2009-10-08
申请号：US11885007
申请日：2006-02-22
申请人： Tushar A. Kshirsagar , Scott E. Langer , Shri Niwas , George W. Griesgraber , Philip D. Heppner , Kyle J. Lindstrom
发明人： Tushar A. Kshirsagar , Scott E. Langer , Shri Niwas , George W. Griesgraber , Philip D. Heppner , Kyle J. Lindstrom
IPC分类号： A61K31/5377 , C07D471/14 , A61K31/4375 , A61K31/497
CPC分类号： C07D471/14
摘要： Certain imidazonaphthyridines with a hydroxymethyl or hydroxyethyl substituent at the 2-position, pharmaceutical compositions containing the compounds, intermediates, methods of making and methods of use of these compounds as immunomodulators, for preferentially inducing IFN-α biosynthesis in animals and in the treatment of diseases including viral and neoplastic diseases are disclosed.
摘要翻译： 某些具有2-位羟基甲基或羟乙基取代基的咪唑并萘与含有化合物的药物组合物，中间体，制备方法以及这些化合物作为免疫调节剂的使用方法在动物中优先诱导IFN-α生物合成和治疗疾病 包括病毒和肿瘤疾病。
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公开(公告)号：US07393859B2
公开(公告)日：2008-07-01
申请号：US10848893
申请日：2004-05-19
申请人： Patrick L. Coleman , Stephen L. Crooks , George W. Griesgraber , Kyle J. Lindstrom , Bryon A. Merrill , Michael J. Rice
发明人： Patrick L. Coleman , Stephen L. Crooks , George W. Griesgraber , Kyle J. Lindstrom , Bryon A. Merrill , Michael J. Rice
IPC分类号： A61K31/437 , C07D471/02
CPC分类号： C07D471/04 , A61K31/4745
摘要： Imidazoquinoline and tetrahydroimidazoquinoline compounds that contain amide functionality at the 1-position are useful as immune response modifiers. The compounds and compositions of the invention can induce the biosynthesis of various cytokines and are useful in the treatment of a variety of conditions including viral diseases and neoplastic diseases.
摘要翻译： 在1位含有酰胺官能团的咪唑并喹啉和四氢咪唑并喹啉化合物可用作免疫应答调节剂。 本发明的化合物和组合物可以诱导各种细胞因子的生物合成，并且可用于治疗各种病症，包括病毒性疾病和肿瘤性疾病。
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公开(公告)号：US07078523B2
公开(公告)日：2006-07-18
申请号：US10681814
申请日：2003-10-07
IPC分类号： C07D471/04 , A61K31/4745 , A61K31/5377 , A61P37/02
CPC分类号： C07D471/04 , A61K31/4745
摘要： Imidazoquinoline and tetrahydroimidazoquinoline compounds that contain ether and urea functionality at the 1-position are useful as immune response modifiers. The compounds and compositions of the invention can induce the biosynthesis of various cytokines and are useful in the treatment of a variety of conditions including viral diseases and neoplastic diseases.
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公开(公告)号：US06784188B2
公开(公告)日：2004-08-31
申请号：US10370800
申请日：2003-02-20
申请人： Stephen L. Crooks , George W. Griesgraber , Kyle J. Lindstrom , Bryon A. Merrill , Michael J. Rice
发明人： Stephen L. Crooks , George W. Griesgraber , Kyle J. Lindstrom , Bryon A. Merrill , Michael J. Rice
IPC分类号： A61K314745
CPC分类号： C07D471/04 , A61K31/4745 , Y02A50/409
摘要： Imidazoquinoline and tetrahydroimidazoquinoline compounds that contain urea, thiourea, acylurea, or sulfonylurea functionality at the 1-position are useful as immune response modifiers. The compounds and compositions of the invention can induce the biosynthesis of various cytokines and are useful in the treatment of a variety of conditions including viral diseases and neoplastic diseases.
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公开(公告)号：US06756382B2
公开(公告)日：2004-06-29
申请号：US10027218
申请日：2001-12-21
申请人： Patrick L. Coleman , Stephen L. Crooks , George W. Griesgraber , Kyle J. Lindstrom , Bryon A. Merrill , Michael J. Rice
发明人： Patrick L. Coleman , Stephen L. Crooks , George W. Griesgraber , Kyle J. Lindstrom , Bryon A. Merrill , Michael J. Rice
IPC分类号： A61K3144
CPC分类号： C07D471/04 , A61K31/4745
摘要： Imidazoquinoline and tetrahydroimidazoquinoline compounds that contain amide functionality at the 1-position are useful as immune response modifiers. The compounds and compositions of the invention can induce the biosynthesis of various cytokines and are useful in the treatment of a variety of conditions including viral diseases and neoplastic diseases.
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公开(公告)号：US06677347B2
公开(公告)日：2004-01-13
申请号：US10165443
申请日：2002-06-07
申请人： Stephen L. Crooks , George W. Griesgraber , Philip D. Heppner , Bryon A. Merrill , Ralph R. Roberts , Ai-Ping Wei
发明人： Stephen L. Crooks , George W. Griesgraber , Philip D. Heppner , Bryon A. Merrill , Ralph R. Roberts , Ai-Ping Wei
IPC分类号： A61K314745
CPC分类号： C07D471/04
摘要： Imidazoquinoline and tetrahydroimidazoquinoline compounds that contain ether and sulfonamide or sulfamide functionality at the 1-position are useful as immune response modifiers. The compounds and compositions of the invention can induce the biosynthesis of various cytokines and are useful in the treatment of a variety of conditions including viral diseases and neoplastic diseases.
摘要翻译： 在1位含有醚和磺酰胺或磺酰胺官能团的咪唑并喹啉和四氢咪唑并喹啉化合物可用作免疫应答调节剂。 本发明的化合物和组合物可以诱导各种细胞因子的生物合成，并且可用于治疗各种病症，包括病毒性疾病和肿瘤性疾病。
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公开(公告)号：US5750510A
公开(公告)日：1998-05-12
申请号：US832741
申请日：1997-04-04
申请人： Richard L. Elliott , Yat Sun Or , Daniel T. Chu , George W. Griesgraber , Jacob J. Plattner , Daisy Pireh
发明人： Richard L. Elliott , Yat Sun Or , Daniel T. Chu , George W. Griesgraber , Jacob J. Plattner , Daisy Pireh
CPC分类号： C07H17/08
摘要： Novel 3-descladinose-2,3-anhydroerythromycin compounds and pharmaceutically acceptable salts and esters thereof having antibacterial activity.
摘要翻译： 具有抗菌活性的新型3-脱水氨基-2,3-脱水红霉素化合物及其药学上可接受的盐和酯。
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公开(公告)号：US10005772B2
公开(公告)日：2018-06-26
申请号：US12519463
申请日：2007-12-20
IPC分类号： A61K39/395 , C07D401/02 , C07D471/04 , A61K47/66 , A61K47/68
CPC分类号： C07D471/04 , A01K13/002 , A01K13/003 , A46B11/0013 , A46B11/0055 , A46B11/0062 , A46B11/0079 , A46B2200/104 , A61K31/437 , A61K47/556 , A61K47/66 , A61K47/68 , A61K47/6801 , C07D513/04
摘要： The present invention provides an immune response modifier (IRM) composition that includes an IRM moiety and a second active moiety covalently linked to the IRM moiety, wherein the covalent link comprises a labile bond directly attached to the IRM moiety.
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公开(公告)号：US09272246B2
公开(公告)日：2016-03-01
申请号：US13353413
申请日：2012-01-19
申请人： Jerald K. Rasmussen , Catherine A. Bothof , Kannan Seshadri , James I. Hembre , Robert T. Fitzsimons, Jr. , George W. Griesgraber , Yi He
发明人： Jerald K. Rasmussen , Catherine A. Bothof , Kannan Seshadri , James I. Hembre , Robert T. Fitzsimons, Jr. , George W. Griesgraber , Yi He
IPC分类号： C12N9/00 , B01D67/00 , B01D71/56 , C09D179/02
CPC分类号： C07K1/22 , B01D67/0093 , B01D71/56 , B01D2323/30 , B01D2323/385 , C07H1/08 , C07K14/765 , C09D179/02 , Y10T428/31663 , Y10T428/31721 , Y10T428/31725 , Y10T428/31855 , Y10T428/31928
摘要： A substrate comprising a crosslinked polymer primer layer, and grafted thereto a ligand-functionalized polymer is provided. The grafted polymer has the requisite affinity for binding neutral or negatively charged biomaterials, such as cells, cell debris, bacteria, spores, viruses, nucleic acids, and proteins, at pH's near or below the pI's of the biomaterials.
摘要翻译： 提供了包含交联聚合物底漆层并接枝到配体官能化聚合物上的底物。 在接近或低于生物材料的pI的pH值下，接枝聚合物对结合中性或带负电荷的生物材料如细胞，细胞碎片，细菌，孢子，病毒，核酸和蛋白质具有必要的亲和力。
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