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54 条记录 (耗时 0.024 秒)

    4-amino-3-hydroxy-phthalide, and a process for its preparation
    46.
    发明授权
    4-amino-3-hydroxy-phthalide, and a process for its preparation 失效
    4-氨基-3-羟基磷酸酯及其制备方法

    公开(公告)号：US5210231A

    公开(公告)日：1993-05-11

    申请号：US757865

    申请日：1991-09-11

    申请人： Jurgen Stoltefuss

    发明人： Jurgen Stoltefuss

    IPC分类号： C07D215/48 ,  C07D307/89

    CPC分类号： C07D307/89

    摘要： The present invention relates to 4-amino-3-hydroxy-phthalide, an important intermediate for the synthesis of 3-substituted-5-quinoline-carboxylic acids and to a process for its preparation.

    摘要翻译： 本发明涉及4-氨基-3-羟基 - 苯酞，其是合成3-取代-5-喹啉羧酸的重要中间体及其制备方法。

    Positive inotropic 3-nitro-5-substituted ester and thioester-1,4-dihydropyridines
    50.
    发明授权
    Positive inotropic 3-nitro-5-substituted ester and thioester-1,4-dihydropyridines 失效
    正性收缩性3-硝基-5-取代酯和硫酯-1,4-二氢吡啶

    公开(公告)号：US4645775A

    公开(公告)日：1987-02-24

    申请号：US734502

    申请日：1985-05-15

    申请人： Jurgen Stoltefuss ,  Fred R. Heiker ,  Gerhard Franckowiak ,  Matthias Schramm ,  Gunter Thomas ,  Rainer Gross

    发明人： Jurgen Stoltefuss ,  Fred R. Heiker ,  Gerhard Franckowiak ,  Matthias Schramm ,  Gunter Thomas ,  Rainer Gross

    IPC分类号： A61K31/4427 ,  A61K31/455 ,  A61P9/04 ,  A61P9/12 ,  C07D211/90 ,  C07D401/12 ,  C07D413/04

    CPC分类号： C07D401/12 ,  C07D211/90 ,  C07D413/04

    摘要： Novel 3-nitro-dihydropyridine derivatives of the formula ##STR1## in which R.sub.1 and R.sub.2 each independently is hydrogen, C.sub.1 -C.sub.4 -alkyl, C.sub.1 -C.sub.12 -alkoxy, C.sub.1 -C.sub.4 -halogenoalkoxy, halogen, nitro, C.sub.1 -C.sub.4 -halogenoalkyl, C.sub.1 -C.sub.4 -halogenoalkylmercapto, ##STR2## Z is oxygen or sulphur, R.sub.4 and R.sub.5 each independently is hydrogen, C.sub.1 -C.sub.4 -alkyl, C.sub.1 -C.sub.6 -alkoxy, halogen, C.sub.1 -C.sub.4 -halogenoalkyl, C.sub.1 -C.sub.4 -halogenoalkoxy or nitro, orR.sub.1 and R.sub.2, together with 2 C atoms of the phenyl ring form the ring ##STR3## X is oxygen or sulphur, A is a hydrocarbon radical with up to 12 C atoms which optionally contains one or two identical or different chain members from the group comprising O, S and CO and/or which is optionally substituted by hydroxyl or aliphatic acyloxy with up to 4 C atoms,R.sub.3 is --O--COR.sub.6, --S--CO--R.sub.6, SH, OH , NH.sub.2, ##STR4## NH--COR.sub.6, COOR.sub.6, NR.sub.7 R.sub.8 or CONR.sub.7 R.sub.8, R.sub.6 is hydrogen or an aliphatic radical with up to 6 C atoms or a phenyl radical, andR.sub.7 and R.sub.8 each independently is hydrogen or an aliphatic radical with up to 6 C atoms or a phenyl radical,or a physiologically acceptable salts thereof, which are active in circulation and exhibit positive inotropic activity.

    摘要翻译： 其中R 1和R 2各自独立地为氢，C 1 -C 4 - 烷基，C 1 -C 12 - 烷氧基，C 1 -C 4 - 卤代烷氧基，卤素，硝基，C 1 -C 4 - 卤代烷基的新颖的3-硝基 - 二氢吡啶衍生物 ，C 1 -C 4卤代烷基巯基，Z为氧或硫，R 4和R 5各自独立地为氢，C 1 -C 4 - 烷基，C 1 -C 6 - 烷氧基，卤素，C 1 -C 4 - 卤代烷基，C 1 -C 4卤代烷氧基或 硝基或R1和R2与苯环的2 C原子一起形成环，X是氧或硫，A是具有至多12个C原子的烃基，其任选地含有一个或两个相同或不同的链成员 由包含O，S和CO的基团和/或其任选被具有至多4个C原子的羟基或脂族酰氧基取代，R 3是-O-COR 6，-S-CO-R 6，SH，OH，NH 2， > NH-COR 6，COOR 6，NR 7 R 8或CONR 7 R 8，R 6是氢或具有至多6个C原子或苯基的脂族基团，并且R 7和R 8各自独立地为氢或至多6个碳原子的脂族基团 oms或苯基或其生理上可接受的盐，其在循环中具有活性并表现出正性肌力活性。