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    Circulation-active fluoromethoxyphenyl dihydropyridine compounds
    4.
    发明授权
    Circulation-active fluoromethoxyphenyl dihydropyridine compounds 失效
    循环活性氟甲氧基苯基二氢吡啶化合物

    公开(公告)号：US5008279A

    公开(公告)日：1991-04-16

    申请号：US263671

    申请日：1988-10-27

    申请人： Gerhard Franckowiak ,  Jurgen Stoltefuss ,  Martin Bechem ,  Rainer Gross ,  Michael Kayser ,  Siegbert Hebisch ,  Matthias Schramm

    发明人： Gerhard Franckowiak ,  Jurgen Stoltefuss ,  Martin Bechem ,  Rainer Gross ,  Michael Kayser ,  Siegbert Hebisch ,  Matthias Schramm

    IPC分类号： A61K31/445 ,  A61K31/451 ,  A61P9/08 ,  C07D211/90 ,  C07D401/12

    CPC分类号： C07D401/12 ,  C07D211/90

    摘要： Circulation-active fluoromethoxyphenyldihydropyridines of the formula ##STR1## in which X stands for hydrogen or fluorine andR stands for straight-chain, branched or cyclic alkyl or alkenyl having 2 to 12 carbon atoms which can be interrupted by 1 to 2 oxygen and/or sulphur atoms in the chain, and which can be monosubstituted or polysubstituted(a) by hydroxyl, aryl having 6 to 12 carbon atoms, aryloxy having 6 to 12 carbon atoms, where the aryl radical is again substituted by alkyl having up to 4 carbon atoms, alkoxy having up to 4 carbon atoms or halogen, the substituents being identical or different, or(b) by carboxyl, alkoxycarbonyl having up to 6 carbon atoms, pyridyl, piperidyl, pyrimidyl, acyloxy having up to 7 carbon atoms, sulphamoyl, carbamoyl, halogen or cyano, the substituents being identical or different, or(c) by an amino group, where the amino group can carry one or two identical or different substituents from the group consisting of alkyl having up to 6 carbon atoms, benzyl, phenyl or acyl having up to 7 carbon atoms,and salts thereof.

    摘要翻译： 式（I）的循环活性氟甲氧基苯基二氢吡啶，其中X代表氢或氟，R代表可被1至2个氧中断的具有2至12个碳原子的直链，支链或环状烷基或链烯基 和/或链中的硫原子，并且其可以被羟基，具有6至12个碳原子的芳基，具有6至12个碳原子的芳氧基单取代或多取代（a），其中芳基再次被具有至多 4个碳原子，具有至多4个碳原子的烷氧基或卤素，取代基相同或不同，或（b）由羧基，具有至多6个碳原子的烷氧基羰基，吡啶基，哌啶基，嘧啶基，具有至多7个碳原子的酰氧基， 氨基甲酰基，氨基甲酰基，卤素或氰基，取代基相同或不同，或（c）氨基，其中氨基可以带有一个或两个相同或不同的取代基，由至多6个碳原子的烷基 ms，苄基，苯基或具有至多7个碳原子的酰基及其盐。