摘要:
The present invention relates to a nuclear reprogramming factor having an action of reprogramming a differentiated somatic cell to derive an induced pluripotent stem (iPS) cell. The present invention also relates to the aforementioned iPS cells, methods of generating and maintaining iPS cells, and methods of using iPS cells, including screening and testing methods as well as methods of stem cell therapy. The present invention also relates to somatic cells derived by inducing differentiation of the aforementioned iPS cells.
摘要:
In a laser exposure device according to the present invention, a positioning pin, which is formed in a lens holder supporting a lens system, is inserted through an elongated hole for restriction of a board holder supporting a laser diode. An eccentric cam is inserted into an elongated hole for rotation movement formed in a board holder and a circular hole for rotation movement which is formed in the lens holder and which faces the elongated hole for rotation movement. An eccentric cam is inserted into an elongated hole for slide movement formed in the board holder and a circular hole for slide movement which is formed in the lens holder and which faces the elongated hole for slide movement. The eccentric cams are rotated to relatively move the board holder and lens holder with respect to each other to thereby establish alignment between the optical axes of the laser diode and lens system. In a state where the eccentric cams are fitted into the elongated holes, the board holder and lens holder are fixed to each other by screws.
摘要:
A liquid crystal display panel includes a moving image display area in which the pixel portions are arranged in a matrix shape and a pictograph display area in which the pixel portions are formed in a fixed pictograph shape. Moreover, first protective elements are inserted between the respective pixel portions in the moving image display area and a drive circuit for the pixel portions and are arranged in an outer periphery of the moving image display area. Second protective elements are inserted between the respective pixel portions in the pictograph display area and a drive circuit for the pixel portions and arranged in an outer periphery of the pictograph display area.
摘要:
A computer system includes first and second subsystems. The first subsystem is provided with a function of generating control data of message data. The second subsystem does not have such a function. The message data is stored in the second subsystem. When the second subsystem transmits the message data, the second subsystem sends format information of the message data to the first subsystem. The first subsystem generates intermediate control data referring to the format information. When the first subsystem encounters an operation requiring reference to the message data, the first subsystem skips this operation. As a result, some portions of the intermediate control data remain blank. The first subsystem sends the intermediate control data back to the second subsystem. The second subsystem generates the control data from the intermediate control data referring to the message data stored therein. Thus, the control data is generated without exchanging the message data between the first and second subsystems.
摘要:
A detecting float is normally made floating on a first liquid, and when a liquid to be detected having a specific gravity less than the first liquid is oncoming, the detecting float sinks relative to the new liquid level as compared with the position which it assumed relative to the level of the first liquid. When the layer of the liquid to be detected increases to a given thickness, the detecting float sinks by a given distance or amount to permit the ingress of the liquid to be detected into the float, which therefore becomes heavier and sinks further downward. An external float surrounds the detecting float, and is formed with a liquid port at a location slightly below the level of the first liquid for allowing the passage of the liquid which reaches the internally located detecting float, but intercepting the liquid to be detected which is in the form of an oil film. Detection means is provided in conjunction with the detecting float and the external float for producing a signal when the detecting float has sunk by a given distance relative to the external float upon ingress of the liquid to be detected.
摘要:
The invention provides a method of improving the efficiency of establishment of induced pluripotent stem cells by increasing, in a nuclear reprogramming step of somatic cell, the level of activated form of one or more proteins selected from the group consisting of Ras family members, PI3 kinase, RalGEF, Raf, AKT family members, Rheb, TCL1 and S6K. The invention also provides a method of producing induced pluripotent stem cells by contacting a somatic cell with a nuclear reprogramming substance and one or more of such proteins and nucleic acids that encode such proteins. The invention further provides an induced pluripotent stem cell that has an exogenous nucleic acid encoding such a protein, as well as agents for use in the aforesaid methods.
摘要:
According to one embodiment, a fuser includes a heat roller, an endless belt, a first press roller and a second press roller. The heat roller rotates and contacts a toner surface side of a sheet, and heats the sheet. The endless belt contacts a part of an outer peripheral surface of the heat roller. The first press roller contacts a part of an inner peripheral surface of the endless belt, and is provided at an insertion part of the sheet in a nip portion where the heat roller contacts the endless belt. The second press roller contacts a part of the inner peripheral surface of the endless belt, is provided at an exit part of the sheet in the nip portion, and has a lower rotational resistance than the first press roller.
摘要:
An image forming apparatus according to an embodiment includes: an image erasing section including a first member which has an elastic layer and heats a recording medium having a thermally decolorizable toner image on the toner image side and a second member which erases the toner image by allowing the recording medium in cooperation with the first member; an image forming section which transfers a thermally decolorizable toner image onto the recording medium on which the toner image is erased to form an unfixed toner image; and an image fixing section including a third member which does not have an elastic layer and heats the recording medium on the unfixed toner image side and a fourth member which fixes the unfixed toner image by allowing the recording medium in cooperation with the third member.
摘要:
The present invention provides a method for screening for iPS cells exhibiting differentiation resistance using a marker identified as lincRNA or mRNA that is specifically expressed in an iPS cell line exhibiting differentiation resistance, and such markers.
摘要:
According to one embodiment, a fuser includes a fixing belt including a conductive layer, an induction-current generating section to electromagnetically induction-heat the conductive layer, an opposed section to form a nip in cooperation with the fixing belt, an auxiliary heat generating section electromagnetically induction-heated by the induction-current generating section, and a moving section to move the auxiliary heat generating section with respect to the fixing belt.