公开(公告)号：US20140312002A1

公开(公告)日：2014-10-23

申请号：US13865669

申请日：2013-04-18

Applicant: International Business Machines Corporation

Inventor： Hongbo Peng ,  Stephen M. Rossnagel ,  Ajay K. Royyuru ,  Gustavo A. Stolovitzky ,  Deqiang Wang

IPC: C12Q1/68

CPC classification number: G01N33/48721 ,  C12Q1/6869 ,  C23C18/161 ,  C23C18/1644 ,  C23C18/1675 ,  C23C18/42 ,  C25D3/50 ,  C25D5/02 ,  C25D7/00 ,  C25D7/12 ,  C25D21/12

Abstract: A mechanism is provided for forming a nanodevice. A reservoir is filled with a conductive fluid, and a membrane is formed to separate the reservoir in the nanodevice. The membrane includes an electrode layer having a tunneling junction formed therein. The membrane is formed to have a nanopore formed through one or more other layers of the membrane such that the nanopore is aligned with the tunneling junction of the electrode layer. The tunneling junction of the electrode layer is narrowed to a narrowed size by electroplating or electroless deposition. When a voltage is applied to the electrode layer, a tunneling current is generated by a base in the tunneling junction to be measured as a current signature for distinguishing the base. When an organic coating is formed on an inside surface of the tunneling junction, transient bonds are formed between the electrode layer and the base.

公开(公告)号：US20140147835A1

公开(公告)日：2014-05-29

申请号：US13970036

申请日：2013-08-19

Applicant: International Business Machines Corporation

Inventor： Yann Astier ,  Jingwei Bai ,  Gustavo A. Stolovitzky ,  Deqiang Wang

IPC: C12Q1/68

CPC classification number: C12Q1/6869 ,  C12Q2521/101 ,  C12Q2565/133 ,  C12Q2565/631

Abstract: A mechanism is provided for base recognition in a nanopore detection system. A complex including a long chain polynucleotide and a motor molecule is formed. The complex is localized in a nanopore of the nanopore detection system. A conformation change of the motor molecule is detected while localized in the nanopore by an ionic current having an amplitude and duration time. The detected conformation change includes the motor molecule forming a base pair by incorporating a single base of the long chain polynucleotide and by synthesizing a complementary base of the single base. An identity of the single base of the long change polynucleotide is determined from the amplitude and the duration time of the conformation change of the motor molecule for the base pair.

公开(公告)号：US20140131202A1

公开(公告)日：2014-05-15

申请号：US13675389

申请日：2012-11-13

Applicant: INTERNATIONAL BUSINESS MACHINES CORPORATION

Inventor： Hongbo Peng ,  Gustavo A. Stolovitzky ,  Deqiang Wang

IPC: G01N27/447

CPC classification number: G01N33/48721 ,  B82Y30/00 ,  C12Q1/6869 ,  C12Q2565/631

Abstract: A mechanism is provided for capturing a molecule via an integrated system. An alternating voltage is applied to a Paul trap device in an electrically conductive solution to generate electric fields. The Paul trap device is integrated with a nanopore device to form the integrated system. Forces from the electric fields of the Paul trap device position the molecule to a nanopore in the nanopore device. A first voltage is applied to the nanopore device to capture the molecule in the nanopore of the nanopore device.

Abstract translation: 提供了用于通过集成系统捕获分子的机制。 将交流电压施加到导电溶液中的保持阱陷阱装置以产生电场。 保存陷阱装置与纳米孔装置集成以形成集成系统。 来自保护陷阱装置的电场的力将分子定位在纳米孔装置中的纳米孔。 将第一电压施加到纳米孔装置以捕获纳米孔装置的纳米孔中的分子。

公开(公告)号：US08652337B1

公开(公告)日：2014-02-18

申请号：US13971468

申请日：2013-08-20

Applicant: International Business Machines Corporation

Inventor： Ali Afzali-Ardakani ,  Binquan Luan ,  Gustavo A. Stolovitzky ,  Chao Wang ,  Deqiang Wang

IPC: H01B13/00

CPC classification number: H01B13/06 ,  B82Y40/00 ,  G01N33/48721 ,  Y10S977/70

Abstract: A mechanism is provided for fabricating nanochannels for a nanodevice. Insulating film is deposited on a substrate. A nanowire is patterned on the film. Insulating material is deposited on the nanowire and film. A first circular hole is formed in the insulating material as an inlet, over a first tip of the nanowire to expose the first tip. A second circular hole is formed as an outlet, over a second tip of the nanowire opposite the first tip to expose the second tip. A nanochannel connects the first and second holes by etching away the nanowire via an etchant in the first and the second holes. A first reservoir is attached over the first hole in connection with the nanochannel at a previous location of the first tip. A second reservoir is attached over the second hole in connection with the nanochannel at a previous location of the second tip.

Abstract translation: 提供了一种用于制造纳米器件的纳米通道的机制。 绝缘膜沉积在基底上。 纳米线在电影上图案化。 绝缘材料沉积在纳米线和薄膜上。 在绝缘材料中形成第一圆形孔作为入口，在纳米线的第一尖端上露出第一尖端。 在与第一尖端相对的纳米线的第二尖端上方形成第二圆形孔作为出口，以露出第二尖端。 纳米通道通过第一孔和第二孔中的蚀刻剂蚀刻掉纳米线而连接第一孔和第二孔。 在第一尖端的先前位置处，与纳通道相连接的第一孔附接第一储存器。 在第二个尖端的先前位置处，与第二孔相连接的第二个贮存器连接到纳米通道上。