公开(公告)号：US07465548B2

公开(公告)日：2008-12-16

申请号：US10544615

申请日：2004-02-05

申请人： Stefan Golz ,  Ulf Brüggemeier ,  Holger Summer

发明人： Stefan Golz ,  Ulf Brüggemeier ,  Holger Summer

IPC分类号： G01N33/53 ,  G01N33/567 ,  A61K49/00

CPC分类号： G01N33/566 ,  A61K38/177 ,  G01N33/74 ,  G01N2333/726 ,  G01N2500/00

摘要： The invention provides a human HM74a which is associated with the disorders of the peripheral and central nervous system, cardiovascular diseases, hematological diseases, cancer, inflammation, urological diseases, respiratory diseases and gastroenterological diseases. The invention also provides assays for the identification of compounds useful in the treatment or prevention of disorders of the peripheral and central nervous system, cardiovascular diseases, hematological diseases, cancer, inflammation, urological diseases, respiratory diseases and gastroenterological diseases. The invention also features compounds which bind to and/or activate or inhibit the activity of HM74a as well as pharmaceutical compositions comprising such compounds.

摘要翻译： 本发明提供了与周围和中枢神经系统疾病，心血管疾病，血液疾病，癌症，炎症，泌尿科疾病，呼吸系统疾病和胃肠疾病相关的人类HM74a。 本发明还提供了用于鉴定可用于治疗或预防外周和中枢神经系统疾病，心血管疾病，血液疾病，癌症，炎症，泌尿科疾病，呼吸系统疾病和胃肠疾病的化合物的化合物。 本发明还涉及结合和/或活化或抑制HM74a的活性的化合物以及包含这些化合物的药物组合物。

公开(公告)号：US20080124743A1

公开(公告)日：2008-05-29

申请号：US11964029

申请日：2007-12-25

申请人： Stefan Golz ,  Ulf Bruggemeier ,  Andreas Geerts

发明人： Stefan Golz ,  Ulf Bruggemeier ,  Andreas Geerts

IPC分类号： G01N33/567 ,  G01N33/566

CPC分类号： G01N33/74 ,  G01N2333/726 ,  G01N2500/00

摘要： The invention provides a human NMU1 which is associated with the hematological diseases, cardiovascular diseases, disorders of the peripheral and central nervous system, inflammation diseases, cancer diseases, and disorders of the liver. The invention also provides assays for the identification of compounds useful in the treatment or prevention of hematological diseases, cardiovascular diseases, disorders of the peripheral and central nervous system, inflammation diseases, cancer diseases, and disorders of the liver. The invention also features compounds which bind to and/or activate or inhibit the activity of NMU1 as well as pharmaceutical compositions comprising such compounds.

摘要翻译： 本发明提供了与血液疾病，心血管疾病，外周和中枢神经系统疾病，炎症疾病，癌症疾病和肝脏疾病相关的人NMU1。 本发明还提供用于鉴定可用于治疗或预防血液疾病，心血管疾病，外周和中枢神经系统疾病，炎症疾病，癌症疾病和肝脏疾病的化合物的测定。 本发明还涉及结合和/或活化或抑制NMU1活性的化合物以及包含这些化合物的药物组合物。

公开(公告)号：US20070286854A1

公开(公告)日：2007-12-13

申请号：US11578798

申请日：2005-04-15

申请人： Stefan Golz ,  Bruggemeiere Ulf ,  Andeas Geerts

发明人： Stefan Golz ,  Bruggemeiere Ulf ,  Andeas Geerts

IPC分类号： G01N33/53 ,  A61K38/17 ,  A61P1/00 ,  A61P11/00 ,  A61P13/00 ,  A61P17/00 ,  A61P19/00 ,  G01N33/567 ,  A61P25/00 ,  A61P3/00 ,  A61P35/00 ,  A61P7/00 ,  A61P9/00 ,  C12Q1/68

CPC分类号： C12Q1/37 ,  G01N33/573 ,  G01N33/574 ,  G01N2333/96438 ,  G01N2500/04

摘要： The invention provides a human DPP1 which is associated with the infections, cardiovascular diseases, respiratory diseases, cancer, endocrinological diseases, metabolic diseases, gastroenterological diseases, inflammation, hematological diseases, muscle skeleton diseases, neurological diseases and urological diseases. The invention also provides assays for the identification of compounds useful in the treatment or prevention of infections, cardiovascular diseases, respiratory diseases, cancer, endocrinological diseases, metabolic diseases, gastroenterological diseases, inflammation, hematological diseases, muscle skeleton diseases, neurological diseases and urological diseases. The invention also features compounds which bind to and/or activate or inhibit the activity of DPP1 as well as pharmaceutical compositions comprising such compounds.

摘要翻译： 本发明提供了与感染，心血管疾病，呼吸系统疾病，癌症，内分泌疾病，代谢疾病，胃肠疾病，炎症，血液疾病，肌肉骨骼疾病，神经系统疾病和泌尿系疾病有关的人类DPP1。 本发明还提供了用于鉴定可用于治疗或预防感染，心血管疾病，呼吸系统疾病，癌症，内分泌疾病，代谢疾病，胃肠疾病，炎症，血液疾病，肌肉骨骼疾病，神经系统疾病和泌尿系疾病的化合物的测定 。 本发明还涉及结合和/或活化或抑制DPP1的活性的化合物以及包含这些化合物的药物组合物。

公开(公告)号：US20070286853A1

公开(公告)日：2007-12-13

申请号：US10594118

申请日：2005-03-20

申请人： Stefan Golz ,  Ulf Bruggemeier ,  Andreas Geerts

发明人： Stefan Golz ,  Ulf Bruggemeier ,  Andreas Geerts

IPC分类号： A61K31/7052 ,  A61K38/02 ,  A61K39/395 ,  A61K45/00 ,  A61P1/00 ,  A61P13/00 ,  A61P17/00 ,  A61P19/00 ,  A61P21/00 ,  A61P25/00 ,  A61P29/00 ,  A61P3/00 ,  A61P35/00 ,  A61P7/00 ,  A61P9/00 ,  C12Q1/68 ,  G01N33/567

CPC分类号： G01N33/502 ,  C07K14/705 ,  C07K14/70567 ,  G01N2333/70567

摘要： The invention provides a human PPARD which is associated with the cardiovascular diseases, infections, cancer, dermatological diseases, gastroenterological diseases, inflammation, hematological diseases, metabolic diseases, muscle-skeleton diseases, neurological diseases, urological diseases and reproduction diseases. The invention also provides assays for the identification of compounds useful in the treatment or prevention of cardiovascular diseases, infections, cancer, dermatological diseases, gastroenterological diseases, inflammation, hematological diseases, metabolic diseases, muscle-skeleton diseases, neurological diseases, urological diseases and reproduction diseases. The invention also features compounds which bind to and/or activate or inhibit the activity of PPARD as well as pharmaceutical compositions comprising such compounds.

摘要翻译： 本发明提供了与心血管疾病，感染，癌症，皮肤病，胃肠疾病，炎症，血液疾病，代谢疾病，肌肉骨骼疾病，神经系统疾病，泌尿科疾病和繁殖疾病有关的人类PPARD。 本发明还提供了用于鉴定可用于治疗或预防心血管疾病，感染，癌症，皮肤病，胃肠疾病，炎症，血液疾病，代谢疾病，肌肉骨骼疾病，神经系统疾病，泌尿生殖疾病和繁殖的化合物的测定 疾病 本发明还涉及结合和/或活化或抑制PPARD活性的化合物以及包含这些化合物的药物组合物。

公开(公告)号：US20070254287A1

公开(公告)日：2007-11-01

申请号：US11579883

申请日：2005-04-28

申请人： Stefan Golz ,  Ulf Bruggemeier ,  Andreas Geerts ,  Andreas Schubel ,  Dmitry Zubov

发明人： Stefan Golz ,  Ulf Bruggemeier ,  Andreas Geerts ,  Andreas Schubel ,  Dmitry Zubov

IPC分类号： A61K31/7088 ,  A61K38/02 ,  A61P39/00 ,  C12Q1/68 ,  G01N33/53

CPC分类号： G01N33/573 ,  C12Q1/37 ,  G01N33/6893

摘要： The invention provides a human DPP10 which is associated with the cardiovascular diseases, dermatological diseases, endocrinological diseases, metabolic diseases, cancer, inflammation, gastroenterological diseases, hematological diseases, respiratory diseases, muscle skeleton diseases, neurological diseases, urological diseases. The invention also provides assays for the identification of compounds useful in the treatment or prevention of cardiovascular diseases, dermatological diseases, endocrinological diseases, metabolic diseases, cancer, inflammation, gastroenterological diseases, hematological diseases, respiratory diseases, muscle skeleton diseases, neurological diseases, urological diseases. The invention also features compounds which bind to and/or activate or inhibit the activity of DPP10 as well as pharmaceutical compositions comprising such compounds.

摘要翻译： 本发明提供了与心血管疾病，皮肤病，内分泌疾病，代谢疾病，癌症，炎症，胃肠病，血液疾病，呼吸系统疾病，肌肉骨骼疾病，神经系统疾病，泌尿系疾病有关的人DPP10。 本发明还提供了用于鉴定可用于治疗或预防心血管疾病，皮肤病，内分泌疾病，代谢疾病，癌症，炎症，胃肠疾病，血液疾病，呼吸系统疾病，肌肉骨骼疾病，神经系统疾病，泌尿系统疾病 疾病 本发明还涉及结合和/或活化或抑制DPP10的活性的化合物以及包含这些化合物的药物组合物。

公开(公告)号：US20070253949A1

公开(公告)日：2007-11-01

申请号：US10588234

申请日：2005-01-22

申请人： Stefan Golz ,  Ulf Bruggemeier ,  Andreas Geerts ,  Holger Summer

发明人： Stefan Golz ,  Ulf Bruggemeier ,  Andreas Geerts ,  Holger Summer

IPC分类号： A61K48/00 ,  A61K38/17 ,  A61K39/395 ,  G01N33/53

CPC分类号： C12Q1/37 ,  G01N33/573 ,  G01N33/6893

摘要： The invention provides a human KLKB1 which is associated with the cardiovascular disorders, endocrine system and hormone disorders, metabolic diseases, gastrointestinal and liver diseases, inflammatory diseases, cancer disorders, muscle-skeleton disorders, neurological disorders and urological disorders. The invention also provides assays for the identification of compounds useful in the treatment or prevention of cardiovascular disorders, endocrine system and hormone disorders, metabolic diseases, gastrointestinal and liver diseases, inflammatory diseases, cancer disorders, muscle-skeleton disorders, neurological disorders and urological disorders. The invention also features compounds which bind to and/or activate or inhibit the activity of KLKB1 as well as pharmaceutical compositions comprising such compounds.

摘要翻译： 本发明提供了与心血管疾病，内分泌系统和激素失调，代谢疾病，胃肠和肝脏疾病，炎性疾病，癌症，肌肉骨骼疾病，神经障碍和泌尿系统疾病相关的人KLKB1。 本发明还提供了用于鉴定可用于治疗或预防心血管疾病，内分泌系统和激素障碍，代谢疾病，胃肠和肝脏疾病，炎性疾病，癌症，肌肉骨骼疾病，神经障碍和泌尿系统疾病的化合物的测定 。 本发明还涉及结合和/或活化或抑制KLKB1活性的化合物以及包含这些化合物的药物组合物。

公开(公告)号：US20070202567A1

公开(公告)日：2007-08-30

申请号：US10573584

申请日：2004-09-16

申请人： Stefan Golz ,  Ulf Bruggemeier ,  Andreas Geerts ,  Stefanie Polej

发明人： Stefan Golz ,  Ulf Bruggemeier ,  Andreas Geerts ,  Stefanie Polej

IPC分类号： C12P21/06

CPC分类号： G01N33/6893 ,  C12N9/48 ,  C12Q1/37 ,  G01N33/6896 ,  G01N2500/00

摘要： The invention provides a human RNPEP which is associated with the cardiovascular diseases, cancer, dermatological diseases, hematological diseases, neurological diseases, urological diseases, respiratory diseases. The invention also provides assays for the identification of compounds useful in the treatment or prevention of cardiovascular diseases, cancer, dermatological diseases, hematological diseases, neurological diseases, urological diseases, respiratory diseases. The invention also features compounds which bind to and/or activate or inhibit the activity of RNPEP as well as pharmaceutical compositions comprising such compounds.

摘要翻译： 本发明提供了与心血管疾病，癌症，皮肤病，血液疾病，神经系统疾病，泌尿科疾病，呼吸系统疾病有关的人类RNPEP。 本发明还提供了用于鉴定可用于治疗或预防心血管疾病，癌症，皮肤病，血液疾病，神经疾病，泌尿科疾病，呼吸系统疾病的化合物的测定。 本发明还涉及结合和/或活化或抑制RNPEP的活性的化合物以及包含这些化合物的药物组合物。

公开(公告)号：US20070155662A1

公开(公告)日：2007-07-05

申请号：US10548422

申请日：2004-02-26

申请人： Stefan Golz ,  Ulf Bruggemeier ,  Andreas Geerts

发明人： Stefan Golz ,  Ulf Bruggemeier ,  Andreas Geerts

IPC分类号： A61K48/00 ,  A61K38/55 ,  C12Q1/68 ,  G01N33/574 ,  A61K39/395

CPC分类号： C12Q1/44 ,  G01N2500/04

摘要： The invention provides a human PDE1A which is associated with the cardiovascular disorders, endocrine system and hormone disorders, cancer disorders, gastrointestinal and liver diseases, hematological disorders, respiratory diseases, neurological disorders and urological disorders. The invention also provides assays for the identification of compounds useful in the treatment or prevention of cardiovascular disorders, endocrine system and hormone disorders, cancer disorders, gastrointestinal and liver diseases, hematological disorders, respiratory diseases, neurological disorders and urological disorders. The invention also features compounds which bind to and/or activate or inhibit the activity of PDE1A as well as pharmaceutical compositions comprising such compounds.

摘要翻译： 本发明提供了与心血管疾病，内分泌系统和激素失调，癌症疾病，胃肠和肝脏疾病，血液病症，呼吸系统疾病，神经障碍和泌尿系统疾病有关的人类PDE1A。 本发明还提供了用于鉴定可用于治疗或预防心血管疾病，内分泌系统和激素障碍，癌症疾病，胃肠和肝脏疾病，血液病症，呼吸系统疾病，神经障碍和泌尿系统疾病的化合物的测定。 本发明还涉及结合和/或活化或抑制PDE1A活性的化合物以及包含这些化合物的药物组合物。

公开(公告)号：US20070105104A1

公开(公告)日：2007-05-10

申请号：US10555771

申请日：2004-04-24

申请人： Stefan Golz ,  Ulf Bruggemeier ,  Holger Summer

发明人： Stefan Golz ,  Ulf Bruggemeier ,  Holger Summer

IPC分类号： C12Q1/68 ,  C12Q1/26 ,  A61K48/00 ,  A61K38/55

CPC分类号： G01N33/74 ,  G01N33/6893 ,  G01N2333/72

摘要： The invention provides a human LTB4 which is associated with the cardiovascular disorders, endocrine system and hormone disorders, metabolic diseases, gastrointestinal and liver diseases, hematological disorders, respiratory diseases, neurological disorders and urological disorders. The invention also provides assays for the identification of compounds useful in the treatment or prevention of cardiovascular disorders, endocrine system and hormone disorders, metabolic diseases, gastrointestinal and liver diseases, hematological disorders, respiratory diseases, neurological disorders and urological disorders. The invention also features compounds which bind to and/or activate or inhibit the activity of LTB4 as well as pharmaceutical compositions comprising such compounds.

摘要翻译： 本发明提供与心血管疾病，内分泌系统和激素失调，代谢疾病，胃肠和肝脏疾病，血液病症，呼吸系统疾病，神经障碍和泌尿系统疾病相关的人LTB4。 本发明还提供了用于鉴定可用于治疗或预防心血管疾病，内分泌系统和激素障碍，代谢疾病，胃肠和肝脏疾病，血液病症，呼吸系统疾病，神经障碍和泌尿系统疾病的化合物的测定。 本发明还涉及结合和/或活化或抑制LTB4的活性的化合物以及包含这些化合物的药物组合物。

公开(公告)号：US20060240436A1

公开(公告)日：2006-10-26

申请号：US10548962

申请日：2004-03-04

申请人： Stefan Golz ,  Ulf Bruggemeier ,  Holger Summer

发明人： Stefan Golz ,  Ulf Bruggemeier ,  Holger Summer

IPC分类号： C12Q1/68 ,  G01N33/567

CPC分类号： G01N33/564

摘要： The invention provides a human C5AR which is associated with the cardiovascular disorders, inflammatory diseases, gastrointestinal and liver diseases, cancer disorders, hematological disorders, respiratory diseases and urological disorders. The invention also provides assays for the identification of compounds useful in the treatment or prevention of cardiovascular disorders, inflammatory diseases, gastrointestinal and liver diseases, cancer disorders, hematological disorders, respiratory diseases and urological disorders. The invention also features compounds which bind to and/or activate or inhibit the activity of C5AR as well as pharmaceutical compositions comprising such compounds.

摘要翻译： 本发明提供了与心血管疾病，炎性疾病，胃肠和肝脏疾病，癌症疾病，血液病症，呼吸系统疾病和泌尿系统疾病相关的人C5AR。 本发明还提供了用于鉴定可用于治疗或预防心血管疾病，炎性疾病，胃肠和肝脏疾病，癌症疾病，血液病症，呼吸系统疾病和泌尿系统疾病的化合物的测定。 本发明还涉及结合和/或活化或抑制C5AR的活性的化合物以及包含这些化合物的药物组合物。