Pyrazolyl amino imidazolines
    42.
    发明授权
    Pyrazolyl amino imidazolines 失效
    吡唑基氨基咪唑啉

    公开(公告)号:US4171367A

    公开(公告)日:1979-10-16

    申请号:US770137

    申请日:1977-02-18

    CPC分类号: C07D231/38 C07D231/40

    摘要: Described are compounds of the formula ##STR1## wherein R.sup.1 and R.sup.2 are hydrogen, alkyl, cycloalkyl, and aryl, R.sup.3 is hydrogen or halogen, and R.sup.4 is hydrogen or acyl, and pharmaceutically acceptable acid addition salts thereof. R.sup.3 can be located in the 4 or 5 position as can the amino imidazoline group. The compounds are useful as anti-inflammatory agents.

    摘要翻译: 描述了式IMA化合物,其中R 1和R 2是氢,烷基,环烷基和芳基,R 3是氢或卤素,R 4是氢或酰基,和其药学上可接受的酸加成盐。 R3可以位于氨基咪唑啉基团的4或5位。 该化合物可用作抗炎剂。

    Heterocyclic esters of alkylphenyl benzopyrans
    43.
    发明授权
    Heterocyclic esters of alkylphenyl benzopyrans 失效
    烷基苯基苯并吡喃的杂环酯

    公开(公告)号:US4049653A

    公开(公告)日:1977-09-20

    申请号:US442033

    申请日:1974-02-13

    申请人: Martin Winn

    发明人: Martin Winn

    摘要: Heterocyclic esters of benzopyrans represented by the formula ##STR1## wherein n is 1 or 2; each R and R.sub.1 are the same or different members of the group consisting of hydrogen or loweralkyl; R.sub.2 is loweralkyl; R.sub.3 is ##STR2## WITH Y' being a straight or branched chain alkylene group having from one to eight carbon atoms, a is an integer from 1 to 4, b is an integer from 1 to 4, X is CH.sub.2, O, S or NR.sub.7 with R.sub.7 being hydrogen or loweralkyl, with the limitation that when X is O, S, or NR.sub.7, a and b each must be 2; R.sub.8 is hydrogen or loweralkyl; Y is a straight or branched chain alkylene group having from one to ten carbon atoms; and each R.sub.4 and R.sub.5 and R.sub.6 are the same or different members of the group consisting of hydrogen, halo, trifluoromethyl or loweralkyl; and the pharmaceutically acceptable salts thereof.

    摘要翻译: 由式 表示的苯并吡喃的杂环酯,其中n为1或2; 每个R和R 1是由氢或低级烷基组成的组中相同或不同的成员; R2是低级烷基; R3是具有1至8个碳原子的直链或支链亚烷基,a为1至4的整数,b为1至4的整数,X为CH 2,O,S或 NR7,其中R7为氢或低级烷基,限制为当X为O,S或NR7时,a和b各自为2; R8是氢或低级烷基; Y是具有1至10个碳原子的直链或支链亚烷基; 并且每个R 4和R 5和R 6是由氢,卤素,三氟甲基或低级烷基组成的组中相同或不同的成员; 及其药学上可接受的盐。

    1,2,3,3a,8,8a-hexahydro-indeno[1,2-c]pyrroles useful in the treatment of
hypertension
    50.
    发明授权
    1,2,3,3a,8,8a-hexahydro-indeno[1,2-c]pyrroles useful in the treatment of hypertension 失效
    1,2,3,3a,8,8a-六氢 - 茚并[1,2-c]吡咯,用于治疗高血压

    公开(公告)号:US4622405A

    公开(公告)日:1986-11-11

    申请号:US695520

    申请日:1985-01-28

    CPC分类号: C07D209/94 C07C62/34

    摘要: Disclosed herein are 1,2,3,3a,8,8a-hexahydro-indeno[1,2-c]pyrroles represented by the formula ##STR1## wherein R.sub.1 is hydrogen, loweralkyl of 1 to 5 carbon atoms, arylalkyl, loweracyl or benzoalkylenedioxy; R.sub.2 and R.sub.3 may be the same or different and are hydroxy, loweralkoxy, halo, thiomethyl, loweracyl, NR.sub.4 R.sub.5, NHSO.sub.2 R.sub.6 or arylalkoxy or R.sub.2 and R.sub.3 taken together may form a methylenedioxy or ethylenedioxy bridge; R.sub.4 and R.sub.5 may be the same or different and are hydrogen, loweralkyl of 1 to 2 carbon atoms or loweracyl; and R.sub.6 is hydrogen or loweralkyl of 1 to 2 carbon atoms.

    摘要翻译: 本文公开了由下式表示的1,2,3,3a,8,8a-六氢 - 茚并[1,2-c]吡咯,其中R 1是氢,1至5个碳原子的低级烷基,芳基烷基,低级酰基或 苯并亚二氧基; R2和R3可以相同或不同,是羟基,低级烷氧基,卤素,硫代甲基,低级酰基,NR4R5,NHSO2R6或芳基烷氧基,R2和R3可以一起形成亚甲二氧基或亚乙二氧基桥; R 4和R 5可以相同或不同,为氢,1至2个碳原子的低级烷基或低级酰基; R6为氢或1〜2个碳原子的低级烷基。