专利检索 ap:"R. Scott Bitner" 第 1 页

1.

发明申请
INHIBITORS OF THE 11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1 ENZYME 有权

公开(公告)号：US20150065508A1

公开(公告)日：2015-03-05

申请号：US14226615

申请日：2014-03-26

申请人： R. Scott Bitner , Kaitlin E. Browman , Michael E. Brune , Steven Fung , Peer B. Jacobson , Lynne E. Rueter , Marina I. Strakhova , Jiahong Wang , Jyoti R. Patel , Qi Shuai , James T. Link , Jeffrey J. Rohde , Jurgen Dinges , Bryan K. Sorensen , Martin Winn , Hong Yong , Vince S. Yeh

发明人： R. Scott Bitner , Kaitlin E. Browman , Michael E. Brune , Steven Fung , Peer B. Jacobson , Lynne E. Rueter , Marina I. Strakhova , Jiahong Wang , Jyoti R. Patel , Qi Shuai , James T. Link , Jeffrey J. Rohde , Jurgen Dinges , Bryan K. Sorensen , Martin Winn , Hong Yong , Vince S. Yeh

IPC分类号： C07C235/14 , C07C235/22 , C07C271/28 , C07D295/088 , C07D207/48 , C07D257/04 , C07D401/04 , C07D261/08 , C07C237/24 , C07C311/46

CPC分类号： C07C235/14 , A61K31/165 , A61K31/19 , A61K31/4439 , C07C235/22 , C07C237/24 , C07C271/28 , C07C311/46 , C07C2601/14 , C07C2601/18 , C07C2603/74 , C07D207/48 , C07D257/04 , C07D261/08 , C07D295/088 , C07D401/04

摘要： The present invention relates to inhibitors of the 11-beta-hydroxysteroid dehydrogenase Type 1 enzyme and their use in treatment of non-insulin dependent type 2 diabetes, insulin resistance, obesity, lipid disorders, metabolic syndrome, central nervous system disorders, and diseases and conditions that are related to excessive glucocorticoids.

2.

发明授权
Inhibitors of the 11-beta-hydroxysteroid dehydrogenase type 1 enzyme 有权
标题翻译： 11-β-羟基类固醇脱氢酶1型酶的抑制剂

公开(公告)号：US08716345B2

公开(公告)日：2014-05-06

申请号：US13530422

申请日：2012-06-22

申请人： R. Scott Bitner , Kaitlin E. Browman , Michael E. Brune , Steven Fung , Peer B. Jacobson , Lynne E. Rueter , Marina I. Strakhova , Jiahong Wang , Jyoti R. Patel , Qi Shuai , James T. Link , Jeffrey J. Rohde , Jurgen Dinges , Bryan K. Sorensen , Martin Winn , Hong Yong , Vince S. Yeh

发明人： R. Scott Bitner , Kaitlin E. Browman , Michael E. Brune , Steven Fung , Peer B. Jacobson , Lynne E. Rueter , Marina I. Strakhova , Jiahong Wang , Jyoti R. Patel , Qi Shuai , James T. Link , Jeffrey J. Rohde , Jurgen Dinges , Bryan K. Sorensen , Martin Winn , Hong Yong , Vince S. Yeh

IPC分类号： A61K31/16 , C07C239/00

CPC分类号： C07C235/14 , A61K31/165 , A61K31/19 , A61K31/4439 , C07C235/22 , C07C237/24 , C07C271/28 , C07C311/46 , C07C2601/14 , C07C2601/18 , C07C2603/74 , C07D207/48 , C07D257/04 , C07D261/08 , C07D295/088 , C07D401/04

摘要： The present invention relates to inhibitors of the 11-beta-hydroxysteroid dehydrogenase Type 1 enzyme and their use in treatment of non-insulin dependent type 2 diabetes, insulin resistance, obesity, lipid disorders, metabolic syndrome, central nervous system disorders, and diseases and conditions that are related to excessive glucocorticoids.

摘要翻译： 本发明涉及11-β-羟基类固醇脱氢酶1型酶的抑制剂及其在治疗非胰岛素依赖性2型糖尿病，胰岛素抵抗，肥胖症，脂质障碍，代谢综合征，中枢神经系统疾病和疾病中的用途，以及与过量糖皮质激素有关的病症。

3.

发明申请
TREATMENT OF CENTRAL NERVOUS SYSTEM DISORDERS 审中-公开
标题翻译：中枢神经系统疾病的治疗

公开(公告)号：US20090054426A1

公开(公告)日：2009-02-26

申请号：US12195937

申请日：2008-08-21

申请人： R. Scott Bitner , Kaitlin E. Browman , Michael E. Brune , Yixian Chen , Jurgen Dinges , Karla Drescher , Peer Jacobson , Hwan-soo Jae , Ravi Kurukulasuriya , James T. Link , David J. Madar , Jyoti R. Patel , Marina A. Pliushchev , Jeffrey J. Rohde , Lynne E. Rueter , Qi Shuai , Bryan K. Sorensen , Jiahong Wang , Karsten M. Wicke , Martin Winn , Dariusz Wodka , Vince Yeh , Hong Yong

发明人： R. Scott Bitner , Kaitlin E. Browman , Michael E. Brune , Yixian Chen , Jurgen Dinges , Karla Drescher , Peer Jacobson , Hwan-soo Jae , Ravi Kurukulasuriya , James T. Link , David J. Madar , Jyoti R. Patel , Marina A. Pliushchev , Jeffrey J. Rohde , Lynne E. Rueter , Qi Shuai , Bryan K. Sorensen , Jiahong Wang , Karsten M. Wicke , Martin Winn , Dariusz Wodka , Vince Yeh , Hong Yong

IPC分类号： A61K31/496 , A61P25/00 , A61K31/5375 , A61K31/445 , A61K31/16

CPC分类号： C07D403/12 , A61K31/44 , A61K31/495 , C07D207/267 , C07D401/12 , C07D401/14

摘要： A method for treating a patient suffering from disorders and deficits of the central nervous system associated with diabetes, associated with aging and neurodegeneration, comprising attention deficit disorder in general, attention deficit hyperactivity disorder (ADHD), Alzheimer's disease (AD), mild cognitive impairment, senile dementia, AIDS dementia, neurodegeneration, depression, and schizophrenia, comprising administering to a patient in need of such treatment an effective amount of a selective inhibitor of the 11-β-hydroxysteroid dehydrogenase Type 1 enzyme activity.

摘要翻译： 一种治疗患有与老化和神经变性相关的糖尿病中枢神经系统紊乱和缺陷的患者的方法，包括注意力缺陷障碍，注意力缺陷多动障碍（ADHD），阿尔茨海默病（AD），轻度认知障碍老年性痴呆，艾滋病痴呆，神经变性，抑郁和精神分裂症，包括向需要这种治疗的患者施用有效量的11-β-羟基类固醇脱氢酶1型酶活性的选择性抑制剂。

4.

发明授权
Methods of use of inhibitors of the 11-beta-hydroxysteroid dehydrogenase type 1 enzyme 有权

公开(公告)号：US08415354B2

公开(公告)日：2013-04-09

申请号：US12390329

申请日：2009-02-20

申请人： R. Scott Bitner , Kaitlin E. Browman , Michael E. Brune , Steven Fung , Peer B. Jacobson , Lynne E. Rueter , Marina I. Strakhova , Jiahong Wang , James T. Link , Yixian Chen , Hwan-soo Jae , Jyoti R. Patel , Marina A. Pliushchev , Jeffrey J. Rohde , Qi Shuai , Bryan K. Sorensen , Martin Winn , Dariusz Wodka , Hong Yong

发明人： R. Scott Bitner , Kaitlin E. Browman , Michael E. Brune , Steven Fung , Peer B. Jacobson , Lynne E. Rueter , Marina I. Strakhova , Jiahong Wang , James T. Link , Yixian Chen , Hwan-soo Jae , Jyoti R. Patel , Marina A. Pliushchev , Jeffrey J. Rohde , Qi Shuai , Bryan K. Sorensen , Martin Winn , Dariusz Wodka , Hong Yong

IPC分类号： A61K31/65 , A61K31/445 , A61K31/496 , C07C233/05 , C07D211/00 , C07D401/04

CPC分类号： C07D295/155 , A61K31/496 , A61K31/5375 , A61K31/55 , C07D205/04 , C07D207/12 , C07D209/44 , C07D211/42 , C07D213/72 , C07D231/12 , C07D239/42 , C07D277/82 , C07D295/125 , C07D307/68 , C07D401/04 , C07D401/12 , C07D413/12 , C07D487/04 , C07D491/056

摘要： The present invention relates to inhibitors of 11-beta-hydroxysteroid dehydrogenase Type 1 enzyme and their use in treatment of non-insulin dependent type 2 diabetes, insulin resistance, obesity, lipid disorders, metabolic syndrome, central nervous system disorders, and diseases and conditions that are related to excessive glucocorticoids.

5.

发明申请
INHIBITORS OF THE 11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1 ENZYME 有权

公开(公告)号：US20130045978A1

公开(公告)日：2013-02-21

申请号：US13530422

申请日：2012-06-22

申请人： R. Scott Bitner , Kaitlin E. Browman , Michael E. Brune , Steven Fung , Peer B. Jacobson , Lynne E. Rueter , Marina I. Strakhova , Jiahong Wang , Jyoti R. Patel , Qi Shuai , James T. Link , Jeffrey J. Rohde , Jurgen Dinges , Bryan K. Sorensen , Martin Winn , Hong Yong , Vince S. Yeh

发明人： R. Scott Bitner , Kaitlin E. Browman , Michael E. Brune , Steven Fung , Peer B. Jacobson , Lynne E. Rueter , Marina I. Strakhova , Jiahong Wang , Jyoti R. Patel , Qi Shuai , James T. Link , Jeffrey J. Rohde , Jurgen Dinges , Bryan K. Sorensen , Martin Winn , Hong Yong , Vince S. Yeh

IPC分类号： A61K31/16 , A61K31/196 , A61K31/27 , A61K31/44 , A61K31/277 , A61K31/41 , A61K31/4439 , A61K31/5375 , A61P3/10 , A61P3/04 , A61P3/00 , A61P9/12 , A61P25/28 , A61P25/24 , A61P25/22 , A61P25/18 , A61K31/165

CPC分类号： C07C235/14 , A61K31/165 , A61K31/19 , A61K31/4439 , C07C235/22 , C07C237/24 , C07C271/28 , C07C311/46 , C07C2601/14 , C07C2601/18 , C07C2603/74 , C07D207/48 , C07D257/04 , C07D261/08 , C07D295/088 , C07D401/04

摘要： The present invention relates to inhibitors of the 11-beta-hydroxysteroid dehydrogenase Type 1 enzyme and their use in treatment of non-insulin dependent type 2 diabetes, insulin resistance, obesity, lipid disorders, metabolic syndrome, central nervous system disorders, and diseases and conditions that are related to excessive glucocorticoids.

6.

发明申请
METHODS OF USE OF INHIBITORS OF THE 11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1 ENZYME 有权
标题翻译： 11-羟基脱氢酶脱氢酶1型酶的抑制剂的使用方法

公开(公告)号：US20090192141A1

公开(公告)日：2009-07-30

申请号：US12390329

申请日：2009-02-20

申请人： R. Scott Bitner , Kaitlin E. Browman , Michael E. Brune , Steven Fung , Peer B. Jacobson , Lynne E. Rueter , Marina I. Strakhova , Jiahong Wang , James T. Link , Yixian Chen , Hwan-soo Jae , Jyoti R. Patel , Marina A. Pliushchev , Jeffrey J. Rohde , Qi Shuai , Bryan K. Sorensen , Martin Winn , Dariusz Wodka , Hong Yong

发明人： R. Scott Bitner , Kaitlin E. Browman , Michael E. Brune , Steven Fung , Peer B. Jacobson , Lynne E. Rueter , Marina I. Strakhova , Jiahong Wang , James T. Link , Yixian Chen , Hwan-soo Jae , Jyoti R. Patel , Marina A. Pliushchev , Jeffrey J. Rohde , Qi Shuai , Bryan K. Sorensen , Martin Winn , Dariusz Wodka , Hong Yong

IPC分类号： A61K31/55 , C07D401/02 , A61K31/496 , A61K31/5375 , C07D295/00 , C07D223/16 , A61P25/24

CPC分类号： C07D295/155 , A61K31/496 , A61K31/5375 , A61K31/55 , C07D205/04 , C07D207/12 , C07D209/44 , C07D211/42 , C07D213/72 , C07D231/12 , C07D239/42 , C07D277/82 , C07D295/125 , C07D307/68 , C07D401/04 , C07D401/12 , C07D413/12 , C07D487/04 , C07D491/056

摘要： The present invention relates to inhibitors of 11-beta-hydroxysteroid dehydrogenase Type 1 enzyme and their use in treatment of non-insulin dependent type 2 diabetes, insulin resistance, obesity, lipid disorders, metabolic syndrome, central nervous system disorders, and diseases and conditions that are related to excessive glucocorticoids.

摘要翻译： 本发明涉及11-β-羟基类固醇脱氢酶1型酶的抑制剂及其在治疗非胰岛素依赖性2型糖尿病，胰岛素抵抗，肥胖，脂质障碍，代谢综合征，中枢神经系统疾病和疾病和病症中的用途这与过量的糖皮质激素有关。

7.

发明申请
DETERMINATION OF HISTAMINE-3 BIOACTIVITY 审中-公开
标题翻译：组胺3生物活性的测定

公开(公告)号：US20080159958A1

公开(公告)日：2008-07-03

申请号：US11950560

申请日：2007-12-05

申请人： Richard J. Radek , R. Scott Bitner , Marlon D. Cowart , Jorge D. Brioni , Timothy A. Esbenshade

发明人： Richard J. Radek , R. Scott Bitner , Marlon D. Cowart , Jorge D. Brioni , Timothy A. Esbenshade

IPC分类号： A61K49/00

CPC分类号： A61K49/0004 , A61K31/00 , A61K49/0008

摘要： The invention relates to an in vivo method for determining the bioactivity of chemical compounds as histamine-3 receptor (H3R) ligands, and provides animal models to determine such bioactivity. The invention further relates to methods for screening therapeutic compounds demonstrating a desired property, using such methods and models described.

摘要翻译： 本发明涉及一种用于测定化学化合物作为组胺-3受体（H 3 R 3 R）配体的生物活性的体内方法，并提供确定此类生物活性的动物模型。本发明还涉及使用所述方法和模型来筛选表现出所需性质的治疗化合物的方法。

8.

发明授权
Treatment of central nervous system disorders 有权
标题翻译：治疗中枢神经系统疾病

公开(公告)号：US08940902B2

公开(公告)日：2015-01-27

申请号：US13554698

申请日：2012-07-20

申请人： R. Scott Bitner , Kaitlin E. Browman , Michael E. Brune , Yixian Chen , Jurgen Dinges , Karla Drescher , Peer Jacobson , Hwan-soo Jae , Ravi Kurukulasuriya , James T. Link , David J. Madar , Jyoti R. Patel , Marina A. Pliushchev , Jeffrey J. Rohde , Lynne E. Rueter , Qi Shuai , Bryan K. Sorensen , Jiahong Wang , Karsten M. Wicke , Martin Winn , Dariusz Wodka , Vince Yeh , Hong Yong

发明人： R. Scott Bitner , Kaitlin E. Browman , Michael E. Brune , Yixian Chen , Jurgen Dinges , Karla Drescher , Peer Jacobson , Hwan-soo Jae , Ravi Kurukulasuriya , James T. Link , David J. Madar , Jyoti R. Patel , Marina A. Pliushchev , Jeffrey J. Rohde , Lynne E. Rueter , Qi Shuai , Bryan K. Sorensen , Jiahong Wang , Karsten M. Wicke , Martin Winn , Dariusz Wodka , Vince Yeh , Hong Yong

IPC分类号： C07D211/74 , A61K31/44 , A61K31/495

CPC分类号： C07D403/12 , A61K31/44 , A61K31/495 , C07D207/267 , C07D401/12 , C07D401/14

摘要： A method for treating a patient suffering from disorders and deficits of the central nervous system associated with diabetes, associated with aging and neurodegeneration, comprising attention deficit disorder in general, attention deficit hyperactivity disorder (ADHD), Alzheimer's disease (AD), mild cognitive impairment, senile dementia, AIDS dementia, neurodegeneration, depression, and schizophrenia, comprising administering to a patient in need of such treatment an effective amount of a selective inhibitor of the 11-β-hydroxysteroid dehydrogenase Type 1 enzyme activity.

摘要翻译： 一种治疗患有与老化和神经变性相关的糖尿病中枢神经系统紊乱和缺陷的患者的方法，包括注意力缺陷障碍，注意力缺陷多动障碍（ADHD），阿尔茨海默病（AD），轻度认知障碍老年性痴呆，艾滋病痴呆，神经退行性疾病，抑郁症和精神分裂症，包括向需要这种治疗的患者施用有效量的11-羟基类固醇脱氢酶1型酶活性的选择性抑制剂。