公开(公告)号：US20080219989A1

公开(公告)日：2008-09-11

申请号：US11930074

申请日：2007-10-30

申请人： Gary R. Fanger ,  Shannon Kathleen Hirst ,  Davin C. Dillon ,  Teresa M. Foy ,  Raymond L. Houghton ,  David H. Persing ,  Michael D. Kalos

发明人： Gary R. Fanger ,  Shannon Kathleen Hirst ,  Davin C. Dillon ,  Teresa M. Foy ,  Raymond L. Houghton ,  David H. Persing ,  Michael D. Kalos

IPC分类号： A61K39/395 ,  C07H21/04 ,  C12N15/00 ,  C12N5/00 ,  C12Q1/68 ,  A61K48/00 ,  C07K16/00 ,  G01N33/53 ,  C12N5/06

CPC分类号： C07K14/4748 ,  A61K35/12 ,  A61K38/00 ,  A61K39/00 ,  A61K48/00 ,  A61K2039/505 ,  A61K2039/5154 ,  A61K2039/5156 ,  A61K2039/53 ,  A61K2039/57 ,  C07K14/005 ,  C07K14/47 ,  C07K14/82 ,  C07K16/3015 ,  C07K2317/21 ,  C07K2319/00 ,  C12N2710/14143 ,  C12N2710/24143 ,  C12N2740/10022 ,  C12N2740/14022 ,  C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/158

摘要： Compositions and methods for the therapy and diagnosis of cancer, particularly breast cancer, are disclosed. Illustrative compositions comprise one or more breast tumor polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of diseases, particularly breast cancer.

公开(公告)号：US20080206249A1

公开(公告)日：2008-08-28

申请号：US11930075

申请日：2007-10-30

申请人： Gary R. Fanger ,  Shannon Kathleen Hirst ,  Davin C. Dillon ,  Teresa M. Foy ,  Raymond L. Houghton ,  David H. Persing ,  Michael D. Kalos

发明人： Gary R. Fanger ,  Shannon Kathleen Hirst ,  Davin C. Dillon ,  Teresa M. Foy ,  Raymond L. Houghton ,  David H. Persing ,  Michael D. Kalos

IPC分类号： A61K39/395 ,  C12N15/11 ,  C07K14/00 ,  C12N15/00 ,  C12Q1/68 ,  A61P43/00 ,  A61K35/12 ,  C12N5/06 ,  C07K16/18 ,  G01N33/574

CPC分类号： C07K14/4748 ,  A61K35/12 ,  A61K38/00 ,  A61K39/00 ,  A61K48/00 ,  A61K2039/505 ,  A61K2039/5154 ,  A61K2039/5156 ,  A61K2039/53 ,  A61K2039/57 ,  C07K14/005 ,  C07K14/47 ,  C07K14/82 ,  C07K16/3015 ,  C07K2317/21 ,  C07K2319/00 ,  C12N2710/14143 ,  C12N2710/24143 ,  C12N2740/10022 ,  C12N2740/14022 ,  C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/158

摘要： Compositions and methods for the therapy and diagnosis of cancer, particularly breast cancer, are disclosed. Illustrative compositions comprise one or more breast tumor polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of diseases, particularly breast cancer.

公开(公告)号：US20110150883A1

公开(公告)日：2011-06-23

申请号：US11930084

申请日：2007-10-30

申请人： Gary R. Fanger ,  Shannon Kathleen Hirst ,  Davin C. Dillon ,  Teresa M. Foy ,  Raymond L. Houghton ,  David H. Persing ,  Michael D. Kalos

发明人： Gary R. Fanger ,  Shannon Kathleen Hirst ,  Davin C. Dillon ,  Teresa M. Foy ,  Raymond L. Houghton ,  David H. Persing ,  Michael D. Kalos

IPC分类号： A61K39/395 ,  A61K39/00 ,  A61K35/26 ,  C12Q1/68 ,  G01N33/53 ,  C12N5/10 ,  C12N5/02 ,  C12N15/63 ,  A61K38/00 ,  A61P35/00 ,  A61K31/7088 ,  C07K14/00 ,  C07K16/00 ,  C07H21/04 ,  C12N5/0783

CPC分类号： C07K14/4748 ,  A61K35/12 ,  A61K38/00 ,  A61K39/00 ,  A61K48/00 ,  A61K2039/505 ,  A61K2039/5154 ,  A61K2039/5156 ,  A61K2039/53 ,  A61K2039/57 ,  C07K14/005 ,  C07K14/47 ,  C07K14/82 ,  C07K16/3015 ,  C07K2317/21 ,  C07K2319/00 ,  C12N2710/14143 ,  C12N2710/24143 ,  C12N2740/10022 ,  C12N2740/14022 ,  C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/158

摘要： Compositions and methods for the therapy and diagnosis of cancer, particularly breast cancer, are disclosed. Illustrative compositions comprise one or more breast tumor polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of diseases, particularly breast cancer.

公开(公告)号：US20080206245A1

公开(公告)日：2008-08-28

申请号：US11930076

申请日：2007-10-30

申请人： Gary R. Fanger ,  Shannon Kathleen Hirst ,  Davin C. Dillon ,  Teresa M. Foy ,  Raymond L. Houghton ,  David H. Persing ,  Michael D. Kalos

发明人： Gary R. Fanger ,  Shannon Kathleen Hirst ,  Davin C. Dillon ,  Teresa M. Foy ,  Raymond L. Houghton ,  David H. Persing ,  Michael D. Kalos

IPC分类号： A61K38/00 ,  C07H21/04 ,  C07K16/00 ,  C12N15/00 ,  A61K48/00 ,  C12Q1/68 ,  C12N5/00 ,  G01N33/53 ,  C12N5/06

CPC分类号： C07K14/4748 ,  A61K35/12 ,  A61K38/00 ,  A61K39/00 ,  A61K48/00 ,  A61K2039/505 ,  A61K2039/5154 ,  A61K2039/5156 ,  A61K2039/53 ,  A61K2039/57 ,  C07K14/005 ,  C07K14/47 ,  C07K14/82 ,  C07K16/3015 ,  C07K2317/21 ,  C07K2319/00 ,  C12N2710/14143 ,  C12N2710/24143 ,  C12N2740/10022 ,  C12N2740/14022 ,  C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/158

摘要： Compositions and methods for the therapy and diagnosis of cancer, particularly breast cancer, are disclosed. Illustrative compositions comprise one or more breast tumor polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of diseases, particularly breast cancer.

公开(公告)号：US20080206244A1

公开(公告)日：2008-08-28

申请号：US11930073

申请日：2007-10-30

申请人： Gary R. Fanger ,  Shannon Kathleen Hirst ,  Davin C. Dillon ,  Teresa M. Foy ,  Raymond L. Houghton ,  David H. Persing ,  Michael D. Kalos

发明人： Gary R. Fanger ,  Shannon Kathleen Hirst ,  Davin C. Dillon ,  Teresa M. Foy ,  Raymond L. Houghton ,  David H. Persing ,  Michael D. Kalos

IPC分类号： A61K38/00 ,  C07H21/04 ,  C07K16/00 ,  C12N15/00 ,  C12Q1/68 ,  A61K48/00 ,  C12N5/00 ,  G01N33/53 ,  C12N5/06

CPC分类号： C07K14/4748 ,  A61K35/12 ,  A61K38/00 ,  A61K39/00 ,  A61K48/00 ,  A61K2039/505 ,  A61K2039/5154 ,  A61K2039/5156 ,  A61K2039/53 ,  A61K2039/57 ,  C07K14/005 ,  C07K14/47 ,  C07K14/82 ,  C07K16/3015 ,  C07K2317/21 ,  C07K2319/00 ,  C12N2710/14143 ,  C12N2710/24143 ,  C12N2740/10022 ,  C12N2740/14022 ,  C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/158

摘要： Compositions and methods for the therapy and diagnosis of cancer, particularly breast cancer, are disclosed. Illustrative compositions comprise one or more breast tumor polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of diseases, particularly breast cancer.

公开(公告)号：US06861506B1

公开(公告)日：2005-03-01

申请号：US09534825

申请日：2000-03-23

申请人： Tony N. Frudakis ,  John M. Smith ,  Steven G. Reed ,  Lynda E. Misher ,  Marc W. Retter ,  Davin C. Dillon

发明人： Tony N. Frudakis ,  John M. Smith ,  Steven G. Reed ,  Lynda E. Misher ,  Marc W. Retter ,  Davin C. Dillon

IPC分类号： A61K35/12 ,  A61K38/00 ,  A61K39/00 ,  A61K48/00 ,  C07K14/15 ,  C07K14/47 ,  C07K14/82 ,  C12Q1/68 ,  C07K1/00 ,  C07K14/00 ,  C07K17/00 ,  C07K2/00

CPC分类号： C07K14/005 ,  A61K35/12 ,  A61K38/00 ,  A61K39/00 ,  A61K48/00 ,  A61K2039/505 ,  A61K2039/5154 ,  A61K2039/53 ,  A61K2039/57 ,  C07K14/47 ,  C07K14/82 ,  C07K2319/00 ,  C12N2740/12022 ,  C12Q1/6886 ,  C12Q2600/158

摘要： Compositions and methods for the detection and therapy of breast cancer are disclosed. The compounds provided include nucleotide sequences that are preferentially expressed in breast tumor tissue, as well as polypeptides encoded by such nucleotide sequences. Vaccines and pharmaceutical compositions comprising such compounds are also provided and may be used, for example, for the prevention and treatment of breast cancer. The polypeptides may also be used for the production of antibodies, which are useful for diagnosing and monitoring the progression of breast cancer in a patient.

摘要翻译： 公开了用于乳腺癌检测和治疗的组合物和方法。 所提供的化合物包括优先在乳腺肿瘤组织中表达的核苷酸序列，以及由该核苷酸序列编码的多肽。 还提供包含这些化合物的疫苗和药物组合物，并且可以用于例如乳腺癌的预防和治疗。 多肽也可用于生产抗体，其可用于诊断和监测患者乳腺癌的进展。

公开(公告)号：US06410507B1

公开(公告)日：2002-06-25

申请号：US09346327

申请日：1999-07-02

申请人： Steven G. Reed ,  Jiangchun Xu ,  Davin C. Dillon

发明人： Steven G. Reed ,  Jiangchun Xu ,  Davin C. Dillon

IPC分类号： A61K3818

CPC分类号： C12N9/0077 ,  A61K35/12 ,  A61K38/00 ,  A61K39/00 ,  A61K48/00 ,  A61K2039/53 ,  C07K14/47 ,  C07K14/82 ,  C07K2319/00

摘要： Compounds and methods for the treatment and diagnosis of breast cancer are provided. The inventive compounds include polypeptides containing at least a portion of a breast tumor protein. Vaccines and pharmaceutical compositions for immunotherapy of breast cancer comprising such polypeptides, or polynucleotides encoding such polypeptides, are also provided, together with polynucleotides for preparing the inventive polypeptides.

摘要翻译： 提供了用于治疗和诊断乳腺癌的化合物和方法。 本发明化合物包括含有至少一部分乳腺肿瘤蛋白质的多肽。 包含此类多肽的乳腺癌的免疫治疗用疫苗和药物组合物，或编码此类多肽的多核苷酸也与制备本发明多肽的多核苷酸一起提供。

公开(公告)号：US06432707B1

公开(公告)日：2002-08-13

申请号：US09602877

申请日：2000-06-22

申请人： Steven G. Reed ,  Jiangchun Xu ,  Davin C. Dillon

发明人： Steven G. Reed ,  Jiangchun Xu ,  Davin C. Dillon

IPC分类号： C12H502

CPC分类号： C07K14/82 ,  A61K35/12 ,  A61K38/00 ,  A61K39/00 ,  A61K48/00 ,  A61K2039/53 ,  C07K14/47 ,  C07K2317/21 ,  C07K2319/00

摘要： Compositions and methods for the therapy and diagnosis of cancer, such as breast cancer, are disclosed. Compositions may comprise one or more breast tumor proteins, immunogenic portions thereof, or polynucleotides that encode such portions. Alternatively, a therapeutic composition may comprise an antigen presenting cell that expresses a breast tumor protein, or a T cell that is specific for cells expressing such a protein. Such compositions may be used, for example, for the prevention and treatment of diseases such as breast cancer. Diagnostic methods based on detecting a breast tumor protein, or mRNA encoding such a protein, in a sample are also provided.

摘要翻译： 公开了用于癌症的治疗和诊断的组合物和方法，例如乳腺癌。 组合物可以包含一种或多种乳腺肿瘤蛋白质，其免疫原性部分或编码这些部分的多核苷酸。 或者，治疗组合物可以包含表达乳腺肿瘤蛋白的抗原呈递细胞，或表达这种蛋白质的细胞特异的T细胞。 这样的组合物可以用于例如预防和治疗诸如乳腺癌的疾病。 还提供了基于检测样品中的乳腺肿瘤蛋白或编码这种蛋白质的mRNA的诊断方法。

公开(公告)号：US06656480B2

公开(公告)日：2003-12-02

申请号：US09429755

申请日：1999-10-28

申请人： Marc W. Retter ,  Davin C. Dillon

发明人： Marc W. Retter ,  Davin C. Dillon

IPC分类号： A61K3900

CPC分类号： C07K14/005 ,  A61K35/12 ,  A61K38/00 ,  A61K39/00 ,  A61K48/00 ,  A61K2039/505 ,  A61K2039/5154 ,  A61K2039/53 ,  A61K2039/57 ,  C07K14/47 ,  C07K14/82 ,  C07K2319/00 ,  C12N2740/10022 ,  C12Q1/6886 ,  C12Q2600/158 ,  Y10S436/813 ,  Y10S530/806 ,  Y10S530/828

摘要： Compositions and methods for the detection and therapy of breast cancer are disclosed. The compounds provided include nucleotide sequences that are preferentially expressed in breast tumor tissue, as well as polypeptides encoded by such nucleotide sequences. Vaccines and pharmaceutical compositions comprising such compounds are also provided and may be used, for example, for the prevention and treatment of breast cancer. The polypeptides may also be used for the production of antibodies, which are useful for diagnosing and monitoring the progression of breast cancer in a patient.

公开(公告)号：US06261562B1

公开(公告)日：2001-07-17

申请号：US09020956

申请日：1998-02-09

申请人： Jiangchun Xu ,  Davin C. Dillon

发明人： Jiangchun Xu ,  Davin C. Dillon

IPC分类号： A61K3900

CPC分类号： C07K14/4748 ,  A61K38/00 ,  A61K39/00 ,  C07K14/705 ,  C07K2319/00 ,  C12N9/90

摘要： Compounds and methods for treating prostate cancer are provided. The inventive compounds include polypeptides containing at least a portion of a prostate tumor protein. Vaccines and pharmaceutical compositions for immunotherapy of prostate cancer comprising such polypeptides, or DNA molecules encoding such polypeptides, are also provided, together with DNA molecules for preparing the inventive polypeptides.

摘要翻译： 提供了治疗前列腺癌的化合物和方法。 本发明化合物包括含有前列腺肿瘤蛋白质的至少一部分的多肽。 包含此类多肽的前列腺癌的免疫治疗用疫苗和药物组合物或编码此类多肽的DNA分子也与制备本发明多肽的DNA分子一起提供。