摘要:
The invention provides devices useful for the delivery of active agents to the eye in a controlled manner. In the devices of the invention, the active agent is present within the device in a continuous or discontinuous concentration gradient.
摘要:
A device for use in tissue repair, a method of using the device in a surgical procedure and a method of making the device. The device is an assembly of a anchor with a cord passed through it, and a stopper to prevent the cord from passing back through the anchor.
摘要:
The invention provides punctal plugs for the delivery of active agents. The plugs have a body throughout which at least one active agent is dispersed or that is coated with a polymeric material containing at least one active agent.
摘要:
A bone anchoring device for securing suture or cable within a bone hole of a bone includes an anchor member and a cable. The anchor member includes engagement ribs and an axial cutout. The axial cutout further includes a cutout surface and at least one pin that extends radially outward from the cutout surface. The cable is secured to the anchor member by penetrating the cable with the pins that extend radially from the axial cutout surface, such that the cable distal end aligns with the anchor distal end and that the cable proximal end extends beyond the anchor proximal end. This results in a bone anchoring device in which failure due to low pullout strength of the cable is greatly minimized or eliminated.
摘要:
A door opening structure for microwave oven includes an upper hinge fastened on a door body assembly, and a lower hinge fastened on a oven body of a microwave oven, wherein the door body assembly is hinged with the oven body by the upper hinge and the lower hinge. An elastic element is provided between the upper hinge and the lower hinge, and the upper hinge is connected with a damper. Both ends of the upper hinge are provided with first connectors that are hinged with the lower hinge, and the middle portion of the upper hinge is provided with second connectors that are hinged with one end of the damper by spring pins.
摘要:
Disclosed are methods and apparatus for generating accessible documents. In one embodiment, an initial document in a print format is obtained. The print format of the initial document is identified as one of a plurality of print formats. A parser corresponding to the one of the plurality of print formats is applied such that the initial document is parsed according to the print format of the initial document. An intermediate document that conforms to an intermediate format is generated based upon results obtained from applying the parser. A template for converting the intermediate document into an accessible document is obtained. The template is then such that an accessible document corresponding to the initial document is generated, wherein the accessible document includes a plurality of tags that designate an order of a plurality of regions of the accessible document.
摘要:
6-morpholin-4-yl-pyrazolo[3,4-d]pyrimidine and 2-morpholin-4-yl-7H-pyrrolo[2,3-d]pyrimidine derivatives have unexpected drug properties as inhibitors of PI3 and/or mTOR kinases and are useful in treating disorders related to abnormal PI3K/mT0R activities such as cancer, immune disorders, cardiovascular disease, viral infection, inflammation, metabolism/endocrine disorders and neurological disorders.
摘要:
Disclosed are compounds, compositions and methods for the prevention and/or treatment of diseases which are pathophysiologically mediated by the ghrelin receptor. The compounds have the general formula (I):
摘要:
The invention relates to compounds, compositions comprising the compounds, and methods of using the compounds and compound compositions. The compounds, compositions, and methods described herein can be used for the therapeutic modulation of kinase-mediated processes, and treatment of disease and disease symptoms, particularly those mediated by certain kinase enzymes.
摘要:
Pyridazine derivatives have unexpected drug properties as inhibitors of protein kinases and are useful in treating disorders related to abnormal protein kinase activities such as cancer.