公开(公告)号：US06485926B2

公开(公告)日：2002-11-26

申请号：US09742296

申请日：2000-12-22

申请人： Ryoichi Nemori ,  Koki Nakamura ,  Hideaki Naruse

发明人： Ryoichi Nemori ,  Koki Nakamura ,  Hideaki Naruse

IPC分类号： C12Q137

CPC分类号： C12Q1/37

摘要： A method for measuring protease activity, which comprises the steps of: (1) bringing a biosample containing a protease into contact with a crosslinked and/or substantially water-insoluble thin membrane that is formed on a support surface and contains at least one colorant selected from the group consisting of an emulsion-dispersed colorant and a solid-dispersed colorant and a protease substrate; and (2) washing the thin membrane with an aqueous medium and detecting traces of digestion formed on the thin membrane by an action of the protease.

摘要翻译： 一种用于测量蛋白酶活性的方法，其包括以下步骤：（1）使含有蛋白酶的生物样品与形成在支持体表面上并含有至少一种选择的着色剂的交联和/或基本上不溶于水的薄膜接触 来自由乳液分散着色剂和固体分散着色剂和蛋白酶底物组成的组; 和（2）用水介质洗涤薄膜，并通过蛋白酶的作用检测在薄膜上形成的消化痕迹。

公开(公告)号：US5889163A

公开(公告)日：1999-03-30

申请号：US756913

申请日：1996-11-26

申请人： Kiyoshi Takeuchi ,  Koki Nakamura

发明人： Kiyoshi Takeuchi ,  Koki Nakamura

IPC分类号： C07D233/70 ,  C07C245/08 ,  C07C271/28 ,  C07D207/335 ,  C07D207/34 ,  C07D207/36 ,  C07D209/14 ,  C07D209/34 ,  C07D213/42 ,  C07D213/61 ,  C07D215/38 ,  C07D215/40 ,  C07D217/26 ,  C07D231/52 ,  C07D233/74 ,  C07D239/42 ,  C07D277/20 ,  C07D277/56 ,  C07D277/82 ,  C07D307/52 ,  C07D307/80 ,  C07D401/12 ,  C07D403/12 ,  C07D405/12 ,  C07D417/12 ,  C07D475/00 ,  C09B27/00 ,  C09B41/00 ,  G03C1/83 ,  G03C7/413

CPC分类号： C09B27/00 ,  G03C1/831 ,  G03C7/413

摘要： There is disclosed a method for producing azo dye compounds, which comprises reacting a compound represented by formula (I) or (II) with a coupling component, in the presence of an oxidizing agent. ##STR1## wherein Z.sup.1 and Z.sup.2 each represent an acyl group, a carbamoyl group, an alkoxycarbonyl group, or an aryloxycarbonyl group; X.sup.1, X.sup.2, X.sup.3, X.sup.4, and X.sup.5, each represent a hydrogen atom or a substituent, provided that the sum of the Hammett substituent constant .sigma.p values of X.sup.1, X.sup.3, and X.sup.5 and the Hammett substituent constant .sigma.m values of X.sup.2 and X.sup.4 is 0.80 or more but 3.80 or below; and R.sup.3 represents a heterocyclic group. According to the above method, azo dye compounds can be produced in a high yield by the use of hydrazines or azo compounds, both of which are safe raw materials, rather than a diazonium salt compound that involves a risk of explosion.

摘要翻译： 公开了一种制备偶氮染料化合物的方法，其包括使式（I）或（II）表示的化合物与偶联组分在氧化剂存在下反应。 ein Z1和Z 2各自表示酰基，氨基甲酰基，烷氧基羰基或芳氧基羰基; X 1，X 2，X 3，X 4和X 5各自表示氢原子或取代基，条件是X 1，X 3和X 5的哈米特取代基常数σp值与Hammett取代基常数σm值的和和 X4为0.80以上且3.80以下; 并且R 3表示杂环基。 根据上述方法，偶氮染料化合物可以通过使用肼或偶氮化合物以高产率生产，二者都是安全的原料，而不是涉及爆炸危险的重氮盐化合物。

公开(公告)号：US5780210A

公开(公告)日：1998-07-14

申请号：US601683

申请日：1996-02-15

申请人： Kiyoshi Takeuchi ,  Koki Nakamura ,  Toshiki Taguchi ,  Koichi Nakamura ,  Toshiyuki Makuta

发明人： Kiyoshi Takeuchi ,  Koki Nakamura ,  Toshiki Taguchi ,  Koichi Nakamura ,  Toshiyuki Makuta

IPC分类号： G03C7/00 ,  C07C281/06 ,  C07C311/05 ,  C07C311/38 ,  C07C311/47 ,  C07C317/34 ,  C07C317/48 ,  C07D239/94 ,  C07D241/44 ,  G03C1/42 ,  G03C1/498 ,  G03C7/392 ,  G03C7/407 ,  G03C7/413 ,  G03C8/40 ,  G03C1/43

CPC分类号： G03C7/413 ,  C07C281/06 ,  C07C311/05 ,  C07C311/38 ,  C07C311/47 ,  C07C317/34 ,  C07C317/48 ,  C07D239/94 ,  C07D241/44 ,  G03C1/42 ,  G03C1/49827 ,  C07C2101/14

摘要： There is disclosed a light-sensitive material comprising, in a hydrophilic colloid provided on a base, a color-developing agent represented by formula (I) or (II): ##STR1## wherein Z.sup.1 represents an acyl group, a carbamoyl group, an alkoxycarbonyl group, or an aryloxycarbonyl group; Z.sup.2 represents a carbamoyl group, an alkoxycarbonyl group, or an aryloxycarbonyl group; X.sup.1, X.sup.2, X.sup.3, X.sup.4, and X.sup.5 each represent a hydrogen atom or a substituent, provided that the sum of the Hammett substituent constant .sigma.p values of X.sup.1, X.sup.3, and X.sup.5 and the Hammett substituent constant .sigma.m values of X.sup.2 and X.sup.4 is 0.80 or more but 3.80 or below; and R.sup.3 represents a heterocyclic group. There is also disclosed a novel color-developing agent that can be built in. By using the color-developing agent, the light-sensitive material can attain a rapid and simple formation of an image.

摘要翻译： 公开了一种感光材料，其在设置在基材上的亲水胶体中包含由式（I）或（II）表示的显色剂：其中Z1表示式（I）或（II）表示的显色剂： 酰基，氨基甲酰基，烷氧基羰基或芳氧基羰基; Z2表示氨基甲酰基，烷氧基羰基或芳氧基羰基; X 1，X 2，X 3，X 4和X 5各自表示氢原子或取代基，条件是X1，X3和X5的哈米特取代基常数σp值与X2和X4的哈米特取代基常数σm值之和 为0.80以上至3.80以下; 并且R 3表示杂环基。 还公开了可以内置的新型显色剂。通过使用显色剂，感光材料可以快速且简单地形成图像。

公开(公告)号：US5221750A

公开(公告)日：1993-06-22

申请号：US819661

申请日：1992-01-13

申请人： Koki Nakamura ,  Shigeru Nakamura

发明人： Koki Nakamura ,  Shigeru Nakamura

IPC分类号： C07D261/12

CPC分类号： C07D261/12

摘要： 2-aryl-4-isoxazolin-3-1-derivatives of formula (I), useful as intermediates for positive working compounds in silver halide photographic materials ##STR1## wherein R.sup.1 represents a substituted or unsubstituted alkyl having from 1 to 6 carbon atoms or a substituted or unsubstituted aryl having from 6 to 24 carbon atoms; and R.sup.2, R.sup.3, and R.sup.4, are the same or different, each having up to 20 carbon atoms and each represents hydrogen, a substituted or unsubstituted alkoxy, a substituted or unsubstituted aryloxy, a substituted or unsubstituted acyl, a substituted or unsubstituted alkoxycarbonyl, a substituted or unsubstituted aryloxycarbonyl, halogen, nitro, a substituted or unsubstituted carbamoyl, a substituted or unsubstituted sulfamoyl, a substituted or unsubstituted sulfonyl, cyano, or trifluoromethyl, with the proviso that at least one of said R.sup.2 and R.sup.3 is cyano, a substituted or unsubstituted sulfonyl, trifluoromethyl, or nitro.

摘要翻译： 可用作卤化银照相材料中正性化合物的中间体的式（I）的2-芳基-4-异恶唑啉-3-酮衍生物，其中R 1表示取代或未取代的具有1至6个碳原子的烷基或 具有6至24个碳原子的取代或未取代的芳基; 和R 2，R 3和R 4相同或不同，各自具有至多20个碳原子并且各自表示氢，取代或未取代的烷氧基，取代或未取代的芳氧基，取代或未取代的酰基，取代或未取代的烷氧基羰基， 取代或未取代的芳氧基羰基，卤素，硝基，取代或未取代的氨基甲酰基，取代或未取代的氨磺酰基，取代或未取代的磺酰基，氰基或三氟甲基，条件是所述R 2和R 3中的至少一个为氰基， 或未取代的磺酰基，三氟甲基或硝基。

公开(公告)号：US5206131A

公开(公告)日：1993-04-27

申请号：US683913

申请日：1991-04-11

申请人： Naoto Matsuda ,  Takeshi Nakamine ,  Koki Nakamura ,  Hiroyuki Hirai

发明人： Naoto Matsuda ,  Takeshi Nakamine ,  Koki Nakamura ,  Hiroyuki Hirai

IPC分类号： G03C8/08 ,  G03C7/305 ,  G03C7/392 ,  G03C8/40

CPC分类号： G03C7/30511 ,  G03C7/39208 ,  Y10S430/158

摘要： A diffusion transfer-type silver halide color photographic photosensitive material comprising a support, having thereon at least a photosensitive thermally developable silver halide, a binder, a dye donating compound which is fast to diffusion and which forms or releases a diffusible dye, a development inhibitor releasing compound which releases a development inhibitor and a compound represented by formula (I)R.sup.1 --Y--O--H [I]wherein R.sup.1 represents an alkyl group, an aryl group, an alkylamino group, an arylamino group, an alkoxy group, an aryloxy group, a heterocyclic residual group or a polymer residual group of said groups, Y represents ##STR1## or --SO.sub.2 --NR.sup.2 -- and R.sup.2 represents a hydrogen atom, an alkyl group, an aryl group or an acyl group, and R.sup.1 and R.sup.2 may be joined together to form a five or eight membered ring is disclosed.

公开(公告)号：US5142029A

公开(公告)日：1992-08-25

申请号：US741229

申请日：1991-08-05

申请人： Keiichi Adachi ,  Shingo Sato ,  Shigeo Hirano ,  Koki Nakamura ,  Morio Yagihara ,  Isamu Ito ,  Tadashi Ikeda ,  Kenichi Kuwabara

发明人： Keiichi Adachi ,  Shingo Sato ,  Shigeo Hirano ,  Koki Nakamura ,  Morio Yagihara ,  Isamu Ito ,  Tadashi Ikeda ,  Kenichi Kuwabara

IPC分类号： C07C51/15 ,  C07C65/17 ,  C07D249/20 ,  C07D257/04 ,  C07D403/06 ,  G03C1/43 ,  G03C7/305

CPC分类号： C07D257/04 ,  C07C317/00 ,  C07C51/15 ,  C07C65/17 ,  C07D249/20 ,  C07D403/06 ,  G03C1/43 ,  G03C7/305 ,  G03C2005/168 ,  G03C7/30541 ,  Y10S430/156 ,  Y10S430/158

摘要： The compounds in a preferred form are represented by general formula (I): ##STR1## wherein A and A' are each a group which can be hydrolyzed by hydrogen or alkali; X, Y and Z are each hydrogen, a halogen atom, a substituted or unsubstituted alkyl group, a substituted or unsubstituted alkoxy group, a substituted or unsubstituted aryl group, a thioalkyl group or an electron-withdrawing group; PUG is a group released by a reaction with a light-exposed silver halide and/or the oxidized product of the developing agent, Time is a timing group; Time.sub.t PUG is a group released as .crclbar.TimePUG first when the oxidation-reduction moiety causes a cross reaction during the development and becomes an oxidized product, and is bonded to the benzene nucleus via a sulfur atom, a nitrogen atom or a selenium atom; and t is 0 or 1.

摘要翻译： 优选形式的化合物由通式（I）表示：其中A和A'各自是可以被氢或碱水解的基团; X，Y和Z各自为氢，卤素原子，取代或未取代的烷基，取代或未取代的烷氧基，取代或未取代的芳基，硫代烷基或吸电子基团; PUG是通过与曝光的卤化银和/或显影剂的氧化产物反应释放的基团，时间是定时组; TimetPUG是当氧化还原部分在显影期间引起交叉反应而变成氧化产物时首先发布为（ - ）TimePUG的基团，并且通过硫原子，氮原子或硒原子与苯核键合; t为0或1。

公开(公告)号：US5066577A

公开(公告)日：1991-11-19

申请号：US513736

申请日：1990-04-24

申请人： Koki Nakamura ,  Takayuki Ito ,  Masaaki Tsukase ,  Toshiki Taguchi

发明人： Koki Nakamura ,  Takayuki Ito ,  Masaaki Tsukase ,  Toshiki Taguchi

IPC分类号： C09B29/15 ,  C09B29/28 ,  G03C8/10

CPC分类号： G03C8/10 ,  C09B29/103 ,  C09B29/28

摘要： A silver halide color photographic material comprising a support having thereon at least one silver halide emulsion layer, wherein the silver halide color photographic material contains an image forming compound represented by the following general formula (I):(Dye--X).sub.q --Y (I)wherein Dye represents a cyan dye group represented by the general formula (II) described below or a precursor thereof; X represents a chemical bond or a linking group; Y represents a group having a property of releasing Dye in correspondence or counter-correspondence to development of a light-sensitive silver salt having a latent image distributed imagewise and making a difference in diffusibility between the dye thus-released and the compound represented by (Dye--X).sub.q --Y; Dye and X are connected with each other by C or E in the general formula (II); and q represents an integer of 1 or 2, and when q is 2, the two groups (Dye--X) may be the same or different: ##STR1## wherein A represents a halogen atom, --OR.sup.1 or --SR.sup.1 (wherein R.sup.1 represents an alkyl group, an aryl group or a heterocyclic group); B represents an electron withdrawing group having a Hammett's op value of not less than 0.3; C represents a chemical bond, a hydrogen atom, an alkyl group, a cycloalkyl group, an aryl group, a halogen atom, --OR.sup.4, --CONR.sup.4 R.sup.5, --SO.sub.2 NR.sup.4 R.sup.5, --N(R.sup.3)--COR.sub.4 or --N(R.sup.3)--SO.sub.2 R.sub.4 (wherein R.sup.3, R.sup.4 and R.sup.5 each represents a hydrogen atom or a group selected from those defined for R.sup.1, or R.sup.4 and R.sup.5 may combine with each other to form a 5-membered or 6-membered ring); E represents a chemical bond, a hydrogen atom, an alkyl group, a halogen atom, --OR.sup.4, --CONR.sup.4 R.sup.5, --SO.sub.2 NR.sup.4 R.sup.5, --N(R.sup.5)--COR.sup.4 or --N(R.sup.5)--SO.sub.2 R.sup.4 (wherein R.sup.4 and R.sup.5 have the same meaning as defined above); and G represents a hydroxy group or a salt thereof, or a group selected from those represented by the formula (T), (U) or (V): ##STR2## wherein R.sup.21 and R.sup.22, which may be the same or different, each represents an alkyl group, a cycloalkyl group, an alkenyl group, an aralkyl group, an aryl group, a heterocyclic group, an alkylthio group, an arylthio group, an alkoxy group, an aryloxy group or an amino group, or R.sup.21 and R.sup.22 may combine with each other to form a 5-membered or 6-membered ring.

公开(公告)号：US5049477A

公开(公告)日：1991-09-17

申请号：US338089

申请日：1989-04-14

申请人： Koki Nakamura ,  Masayoshi Tsuboi ,  Keizo Koya

发明人： Koki Nakamura ,  Masayoshi Tsuboi ,  Keizo Koya

IPC分类号： G03C1/00 ,  C07D231/24 ,  C07D231/46 ,  C07D249/12 ,  C07D249/14 ,  C07D261/12 ,  C07D261/14 ,  C07D265/02 ,  C07D271/06 ,  C07D271/10 ,  C07D273/01 ,  C07D273/04 ,  C07D285/125 ,  C07D421/00 ,  C09K9/02 ,  G03C1/675 ,  G03C1/73 ,  G03C7/00 ,  G03C8/12 ,  G03C8/40 ,  G03F7/004

CPC分类号： G03C1/73

摘要： A radiation responsive composition containing a compound represented by the following formula (I) and a photoreducing agent capable of forming a redox couple together with said compound for many uses, e.g., image formation, etching, plating, etc.: ##STR1## wherein N represents a nitrogen atom; X represents an oxygen atom (--O--), a sulfur atom (--S--), or a nitrogen-containing group of formula, ##STR2## R.sup.1, R.sup.2, R.sup.3 and R.sup.4 each represents a mere bond, a substituted or unsubstituted alkyl, aryl, heterocyclic, acyl, aralkyl, alkenyl, alkynyl or carbamoyl group, or a sulfonyl group into which a substituted or unsubstituted alkyl or aryl group has been introduced, provided that at least one of the substituents R.sup.1 to R.sup.3 be a substituted or unsubstituted aryl or heterocyclic group and that two or more of R.sup.1, R.sup.2 and R.sup.3, or of R.sup.1, R.sup.2, R.sup.3 and R.sup.4 when X represents a nitrogen containing group of formula, ##STR3## may be taken together to form a ring; UG represents a group to be released from said compound of formula (I) taking advantage of the N--X bond cleavage as a trigger, which takes place when a redox couple is formed between said compound of formula (I) and the photoreducing agent irradiated with radiant rays; and the solid lines represent bonds, while broken lines indicate that a bond may or may not be present, but at least one of the broken lines forms a bond.

摘要翻译： 含有由下式（I）表示的化合物和能够与所述化合物一起形成氧化还原对的许多用途的光致变化组合物，例如图像形成，蚀刻，电镀等。 ）其中N表示氮原子; X表示氧原子（-O-），硫原子（-S-）或式的含氮基团，R 1，R 2，R 3和R 4各自表示单键，取代或未取代的烷基 ，芳基，杂环，酰基，芳烷基，烯基，炔基或氨基甲酰基，或其中引入取代或未取代的烷基或芳基的磺酰基，条件是至少一个取代基R 1至R 3为取代或未取代的 芳基或杂环基，当X代表含氮基团时，R 1，R 2和R 3，或R 1，R 2，R 3和R 4中的两个或多个可以一起形成环; UG表示利用NX键断裂作为触发剂从式（I）化合物释放的基团，当在所述式（I）化合物与用辐射剂照射的光还原剂之间形成氧化还原对时发生 射线 而实线表示键，而虚线表示键可以存在或不存在，但至少一个虚线形成键。

公开(公告)号：US4886736A

公开(公告)日：1989-12-12

申请号：US065194

申请日：1987-06-12

申请人： Koki Nakamura ,  Kei Sakanoue ,  Seiji Ichijima

发明人： Koki Nakamura ,  Kei Sakanoue ,  Seiji Ichijima

IPC分类号： G03C7/26 ,  G03C7/305 ,  G03C7/32

CPC分类号： G03C7/305 ,  Y10S430/156 ,  Y10S430/159

摘要： A silver halide color photographic material comprising (1) at least one coupler and (2) at least one compound represented by formula (I) ##STR1## wherein EAG represents a group capable of accepting an electron from a reducing substance; R.sup.1 and R.sup.2 each represents a chemical bond or a divalent substituent, or R.sup.1 and R.sup.2 are linked together to form a cyclic structure when linked with (Time).sub.t PUG; or R.sup.1 and R.sup.2 each represents a substituent, or R.sup.1 and R.sup.2 are linked together to form a cyclic structure when not linked with (Time).sub.t PUG; Time represents a group capable of releasing PUG, which is released by the cleavage of the single bond between the oxygen atom and the nitrogen atom in the compound; t represents 0 or 1; PUG represents a photographically useful group; and the dotted lines mean that at least one of them forms a chemical bond, and a method for forming an image using the material.

摘要翻译： 一种卤化银彩色照相材料，其包含（1）至少一种成色剂和（2）至少一种由式（I）表示的化合物，其中EAG表示能够从还原物质接受电子的基团; R1和R2各自表示化学键或二价取代基，或者当与（Time）tPUG连接时，R 1和R 2连接在一起形成环状结构; 或者R 1和R 2各自表示取代基，或者当不与（时间）tPUG连接时，R 1和R 2连接在一起形成环状结构; 时间表示能够释放PUG的基团，其通过化合物中氧原子和氮原子之间的单键的切割而释放; t表示0或1; PUG代表一个摄影有用的组; 并且虚线意味着它们中的至少一个形成化学键，以及使用该材料形成图像的方法。

公开(公告)号：US4783396A

公开(公告)日：1988-11-08

申请号：US925350

申请日：1986-10-30

申请人： Koki Nakamura ,  Sahigeru Nakamura

发明人： Koki Nakamura ,  Sahigeru Nakamura

IPC分类号： G03C7/305 ,  G03C8/40 ,  G03C5/54 ,  G03C1/06 ,  G03C1/34 ,  G03C7/26

CPC分类号： G03C8/4033 ,  G03C7/30511 ,  Y10S430/156 ,  Y10S430/157 ,  Y10S430/158 ,  Y10S430/159 ,  Y10S430/16

摘要： The present invention provides silver halide photographic materials containing a havel compound, which when reduced, releases a photographically useful group as triggered off by the cleavage of the nitrogen-oxygen single bond in the compound and which is represented by the following general formula (I): ##STR1## wherein EAG represents a group which accepts an electron from a reducing substance; N and O each represents nitrogen atom and an oxygen atom, respectively; R.sup.1 and R.sup.2 each represents a substituent other than a hydrogen atom, and when R.sup.1 or R.sup.2 is bonded to --(Time).sub.t PUG, R.sup.1 or R.sup.2 is a mere bond or a substituent other than a hydrogen atom, and R.sup.1 and R.sup.2 may be bonded to each other to form a ring; Time represents a group for releasing PUG via the subsequent reaction as triggered off by the cleavage of the nitrogen-oxygen single bond in the compound of general formula (I); PUG represents a photographically useful group; t is an integer of 0 or 1; the full lines in the formula each means a bond; and the dotted lines therein mean that at least one of the dotted lines is a bond.In particular, compounds of the following formula (II) and (III) are preferred among those of the formula (I): ##STR2## wherein R.sup.3 is bonded to the nitrogen atom or oxygen atom in the formula, and represents an atomic group necessary for the formation of a 3 to 8-membered mono- or fused-hetero ring; ##STR3## wherein R.sup.4 and R.sup.5 each represents a mere bond, a hydrogen atom or a substituent group, and they may be bonded to each other to form a saturated or unsaturated carbon ring or hetero ring; and X represents a divalent binding group.

摘要翻译： 本发明提供含有卤化银照相材料，其含有化合物，当其还原时，通过化合物中的氮 - 氧单键的切割而触发照射有用的基团，并由下列通式（I）表示： （I）其中EAG表示从还原物质接受电子的基团; N和O分别表示氮原子和氧原子; R 1和R 2各自表示除氢原子以外的取代基，当R 1或R 2与 - （时间）tPUG键合时，R 1或R 2仅为氢键的键或取代基，R 1和R 2可以键合 彼此形成一个戒指; 时间表示通过由通式（I）的化合物中的氮 - 氧单键的裂解而触发的随后反应释放PUG的基团。 PUG代表一个摄影有用的组; t是0或1的整数; 公式中的全部行为表示一个债券; 并且其中的虚线表示虚线中的至少一个是键。 特别地，下式（II）和（III）的化合物在式（I）的化合物中是优选的：其中R 3与式中的氮原子或氧原子键合，并且表示 形成3至8元单或稠合杂环所必需的原子团; （III）其中R4和R5各自表示单键，氢原子或取代基，它们可以相互结合形成饱和或不饱和的碳环或杂环; X表示二价结合基团。