公开(公告)号：US20060173148A1

公开(公告)日：2006-08-03

申请号：US10526381

申请日：2003-09-04

申请人： Hiroki Sasaki ,  Ryoichi Nemori

发明人： Hiroki Sasaki ,  Ryoichi Nemori

IPC分类号： C08F118/02

CPC分类号： G02B1/046 ,  C08F220/18 ,  C08F220/22 ,  C08L33/16 ,  C08L33/08

摘要： Novel optical members formed of a polymer comprising a repeating unit derived from a polymerizable monomer (A) which is a methacrylate derivative having a branched C3-8 alkyl group or a repeating unit derived from a polymerizable monomer (3) which is a (meth)acrylate derivative having a C7-20 alicyclic hydrocarbon group are disclosed. Novel processes for preparing an optical member comprising polymerization of a composition comprising the monomer (A) or the monomer (3) are also disclosed.

摘要翻译： 由包含衍生自具有支链C 3-8烷基的甲基丙烯酸酯衍生物的可聚合单体（A）的重复单元或由可聚合单体（3）衍生的作为（甲基）丙烯酸酯的聚合性单体的聚合物形成的新型光学部件， 丙烯酸酯衍生物，具有C7-20脂环族烃基。 还公开了制备含有单体（A）或单体（3）的组合物的聚合的光学构件的新方法。

公开(公告)号：US20120078189A1

公开(公告)日：2012-03-29

申请号：US13247476

申请日：2011-09-28

申请人： Shotaro OGAWA ,  Aya MOCHIZUKI ,  Ryoichi NEMORI ,  Yanlong CHE

发明人： Shotaro OGAWA ,  Aya MOCHIZUKI ,  Ryoichi NEMORI ,  Yanlong CHE

IPC分类号： A61M5/00 ,  B29C45/16

CPC分类号： A61M37/0015 ,  A61M2037/0023 ,  A61M2037/0053 ,  A61M2207/00 ,  B29C31/044 ,  B29C31/045 ,  B29C31/048 ,  B29C39/025 ,  B29C39/24 ,  B29C39/42 ,  B29L2031/7544

摘要： A needle array transdermal absorption sheet to be attached onto a skin for supplying a drug into the skin, includes: a plurality of needle portions each having a tapered shape, each of the needle portions including a needle having a conical or pyramidal shape and a body part which has a columnar shape and whose end surface is connected to a base of the needle; a sheet portion having a flat-plate shape; and a plurality of frustum portions each having a frustum shape, the frustum portions which are arranged on a surface of the sheet portion in a manner that perimeters of larger bases of adjacent frustum portions are in contact with each other on the surface of the sheet portion, and smaller bases of which are respectively connected to the body parts of the needle portions.

摘要翻译： 将用于将药物供给到皮肤上的皮肤上的针阵列透皮吸收片包括：具有锥形形状的多个针部，每个针部分包括具有锥形或锥体形状的针和主体 具有圆柱形状并且其端面连接到针的基部的部分; 具有平板形状的片状部分; 以及多个平截头体部，其各自具有截头圆锥形状，所述截头圆锥体部分以相邻平截头体部分的较大基部的周边在所述薄片部分的表面上彼此接触的方式布置在所述薄片部分的表面上 并且其较小的基部分别连接到针部的主体部分。

公开(公告)号：US20060056786A1

公开(公告)日：2006-03-16

申请号：US10531704

申请日：2003-11-14

申请人： Takayasu Yasuda ,  Hiroki Sasaki ,  Ryoichi Nemori ,  Yuuichi Okamoto

发明人： Takayasu Yasuda ,  Hiroki Sasaki ,  Ryoichi Nemori ,  Yuuichi Okamoto

IPC分类号： G02B6/028

CPC分类号： G02B1/045 ,  C08F2/44 ,  G02B1/041

摘要： It is disclosed a polymerizable composition for producing an optical member for 850 nm wavelength comprising: a polymerizable monomer composition and a compound, having a different refractive index from that of the polymerizable monomer composition, whose structure has a benzene ring substituted by a substituent having a Hammett value of not greater than 0.04 or by plural substituents having an average value of Hammett values thereof of not greater than 0.04. It is also disclosed a polymerizable composition for producing an optical member comprising a polymerizable monomer composition comprising at least one selected from the group consisting of C7-20 alicyclic (meth) acrylates and a compound, having a different refractive index from that of the polymerizable monomer composition and having a solubility parameter of not greater than 10.9, whose structure has a benzene ring substituted by the substituent or the substituents defined above.

摘要翻译： 公开了一种用于制造850nm波长的光学部件的可聚合组合物，包括：可聚合单体组合物和具有与可聚合单体组合物的折射率不同的折射率的化合物，其结构具有被具有 哈米特值不大于0.04，或由哈米特值的平均值不大于0.04的多个取代基组成。 还公开了一种用于制造光学部件的可聚合组合物，其包含可聚合单体组合物，其包含选自由C 7-20脂环族（甲基）丙烯酸酯组成的组中的至少一种和具有不同的 折射率与可聚合单体组合物的折射率相差并且具有不大于10.9的溶解度参数，其结构具有由取代基或上述取代基取代的苯环。

公开(公告)号：US06413734B1

公开(公告)日：2002-07-02

申请号：US09641349

申请日：2000-08-18

申请人： Ryoichi Nemori ,  Hiroshi Kaise ,  Mikihiro Kusama

发明人： Ryoichi Nemori ,  Hiroshi Kaise ,  Mikihiro Kusama

IPC分类号： C12Q137

CPC分类号： C12Q1/37 ,  G01N2333/811 ,  G01N2333/96486 ,  Y10S435/968

摘要： A method for judging effectiveness of a drug having protease inhibitory activity, which comprises the steps of: (1) bringing a biosample isolated or collected from a patient with a disease in which participation of a protease is suspected into contact with a thin membrane containing a protease substrate and formed on a surface of a support; (2) detecting a trace of digestion formed on the thin membrane by action of a protease; and (3) judging that a drug having protease inhibitory activity is effective for the patient when a trace of digestion is formed on the thin membrane. The method enables accurate judgment as to whether or not a drug having protease inhibitory activity is effective for a patient with a disease in which participation of a protease is suspected such as rheumatoid arthritis and cancer before administration of the drug.

摘要翻译： 一种用于判断具有蛋白酶抑制活性的药物的有效性的方法，其包括以下步骤：（1）将患有蛋白酶参与的患者分离或收集的生物样品与含有蛋白酶抑制活性的薄膜接触的疾病 蛋白酶底物并形成在支撑体的表面上; （2）通过蛋白酶的作用检测在薄膜上形成的消化痕迹; 和（3）当在薄膜上形成消化痕迹时，判断具有蛋白酶抑制活性的药物对患者有效。 该方法能够准确判断具有蛋白酶抑制活性的药物是否有疑似患有蛋白酶参与的疾病的患者，例如类风湿性关节炎和药物给药前的癌症。

公开(公告)号：US20090304599A1

公开(公告)日：2009-12-10

申请号：US12097560

申请日：2006-12-20

申请人： Makiko Aimi ,  Ryoichi Nemori ,  Masayoshi Kojima ,  Madoks Kishima

发明人： Makiko Aimi ,  Ryoichi Nemori ,  Masayoshi Kojima ,  Madoks Kishima

IPC分类号： A61K49/18 ,  A61K38/43 ,  A61K9/14 ,  A61K33/26 ,  A61P43/00

CPC分类号： C07K17/14 ,  A61K9/5094 ,  A61K9/5115 ,  A61K9/5169 ,  A61K41/00 ,  A61K47/02 ,  A61K47/42 ,  A61K49/14 ,  A61K49/1866

摘要： An object of the present invention is to provide nanoparticles that can easily be delivered to a small site such as a capillary and can be produced using highly biocompatible and safe material. The present invention provides a nanoparticle which contains at least one pharmaceutically active component, a magnetically responsive particle, and a protein.

摘要翻译： 本发明的目的是提供可以容易地传递到诸如毛细管的小部位的纳米颗粒，并且可以使用高生物相容性和安全性的材料制造。 本发明提供了含有至少一种药物活性成分，磁响应性颗粒和蛋白质的纳米颗粒。

公开(公告)号：US06790609B1

公开(公告)日：2004-09-14

申请号：US09786883

申请日：2001-06-07

申请人： Ryoichi Nemori ,  Junji Nishigaki ,  Yutaka Tamura

发明人： Ryoichi Nemori ,  Junji Nishigaki ,  Yutaka Tamura

IPC分类号： C12Q100

CPC分类号： G01N33/68 ,  G01N31/22 ,  G01N33/6815

摘要： A method for measuring a thiol group-containing compound, which comprises the steps of (1) contacting a sample containing a thiol group-containing compound with a thin membrane comprising a microparticle of a substance selected from the group consisting of a metal and a metal compound and comprising a hydrophilic binder; and (2) detecting a color change on the thin membrane resulting from interaction of the thiol group-containing compound and the microparticle, and a thin membrane used for said method. A thiol group containing compound such as an alkylmercaptan or a protein containing thiol groups can be conveniently and accurately measured.

摘要翻译： 一种含硫醇基化合物的测定方法，其特征在于，包括以下步骤：（1）使含有硫醇基的化合物的试样与包含选自金属和金属的物质的微粒的薄膜接触 化合物并包含亲水性粘合剂; 和（2）检测由含硫醇基的化合物和微粒的相互作用产生的薄膜上的颜色变化，以及用于所述方法的薄膜。 含硫醇基的化合物如烷基硫醇或含巯基的蛋白质可以方便，准确地测量。

公开(公告)号：US06485926B2

公开(公告)日：2002-11-26

申请号：US09742296

申请日：2000-12-22

申请人： Ryoichi Nemori ,  Koki Nakamura ,  Hideaki Naruse

发明人： Ryoichi Nemori ,  Koki Nakamura ,  Hideaki Naruse

IPC分类号： C12Q137

CPC分类号： C12Q1/37

摘要： A method for measuring protease activity, which comprises the steps of: (1) bringing a biosample containing a protease into contact with a crosslinked and/or substantially water-insoluble thin membrane that is formed on a support surface and contains at least one colorant selected from the group consisting of an emulsion-dispersed colorant and a solid-dispersed colorant and a protease substrate; and (2) washing the thin membrane with an aqueous medium and detecting traces of digestion formed on the thin membrane by an action of the protease.

摘要翻译： 一种用于测量蛋白酶活性的方法，其包括以下步骤：（1）使含有蛋白酶的生物样品与形成在支持体表面上并含有至少一种选择的着色剂的交联和/或基本上不溶于水的薄膜接触 来自由乳液分散着色剂和固体分散着色剂和蛋白酶底物组成的组; 和（2）用水介质洗涤薄膜，并通过蛋白酶的作用检测在薄膜上形成的消化痕迹。

公开(公告)号：US4649102A

公开(公告)日：1987-03-10

申请号：US817648

申请日：1986-01-10

申请人： Yasuo Mukunoki ,  Shigeki Yokoyama ,  Hiroshi Kawasaki ,  Ryoichi Nemori ,  Tetsuo Takeuchi

发明人： Yasuo Mukunoki ,  Shigeki Yokoyama ,  Hiroshi Kawasaki ,  Ryoichi Nemori ,  Tetsuo Takeuchi

IPC分类号： G03C1/38 ,  G03C1/94

CPC分类号： G03C1/38

摘要： A silver halide photographic light-sensitive material is described, comprising a support having provided thereon at least one silver halide emulsion layer, wherein there is at least one hydrophilic colloidal layer containing at least one nonionic surface active agent and at least one anionic surface active agent having a polyoxyethylene group therein.

摘要翻译： 描述了一种卤化银摄影感光材料，其包括其上提供有至少一个卤化银乳剂层的载体，其中存在至少一种含有至少一种非离子表面活性剂的亲水胶体层和至少一种阴离子表面活性剂 其中具有聚氧乙烯基团。

公开(公告)号：US4596766A

公开(公告)日：1986-06-24

申请号：US658742

申请日：1984-10-09

申请人： Ryoichi Nemori ,  Hiroshi Kawasaki ,  Yasuo Mukunoki

发明人： Ryoichi Nemori ,  Hiroshi Kawasaki ,  Yasuo Mukunoki

IPC分类号： C09K3/16 ,  G03C1/38 ,  G03C1/85 ,  G03C1/89 ,  G03C1/78 ,  G03C1/96

CPC分类号： G03C1/385 ,  G03C1/895

摘要： A silver halide photographic material is disclosed comprising a support having thereon at least one layer containing a nonionic surface active agent having a polyoxyethylene group and a fluorine-containing compound, wherein the element composition of the surface of said layer has a ratio of F.sub.ls peak intensity/C.sub.ls peak intensity in the range of 0.3 to 2.0 when measured by an X-ray photoelectron spectrometry.

摘要翻译： 公开了一种卤化银照相材料，其包含其上具有至少一层含有聚氧乙烯基和含氟化合物的非离子表面活性剂的载体的载体，其中所述层的表面的元素组成具有Fls峰强度 / Cls峰强度在0.3〜2.0的范围内，通过X射线光电子能谱测定。

公开(公告)号：US20090280148A1

公开(公告)日：2009-11-12

申请号：US12295287

申请日：2007-03-29

申请人： Makiko Aimi ,  Ryoichi Nemori ,  Kazutaka Ogiwara

发明人： Makiko Aimi ,  Ryoichi Nemori ,  Kazutaka Ogiwara

IPC分类号： A61K9/14 ,  A61K47/42 ,  A61K8/02 ,  A61K31/7088 ,  A61K38/22 ,  A61K39/00 ,  A61K9/127 ,  A61Q19/00 ,  A61Q19/02 ,  A61P17/00

CPC分类号： B82Y5/00 ,  A61K8/64 ,  A61K9/0014 ,  A61K9/5169 ,  A61K9/5192 ,  A61K31/00 ,  A61K2800/413 ,  A61Q19/00

摘要： An object of the present invention to provide: a nanoparticle, which can be produced without the use of surfactants and synthetic polymers, which has a controllable size and is stable in the acidic range, and which further contains an active substance; and a method for producing the same. The present invention provides a casein nanoparticle which contains an active substance and has an average particle size between 10 nm or more and less than 300 nm, which is produced by the following steps (a) to (c): (a) a step of mixing casein into a basic aqueous medium between pH 8 or more and less than pH 11; (b) a step of adding at least one type of active substance to the solution obtained in the step (a); and (c) a step of injecting the solution obtained in the step (b) into an acidic aqueous medium at pH 3.5 to pH 7.5.

摘要翻译： 本发明的目的是提供：纳米颗粒，其可以不使用表面活性剂和合成聚合物来制造，其具有可控的尺寸并且在酸性范围内是稳定的，并且还含有活性物质; 及其制造方法。 本发明提供一种含有活性物质并具有10nm以上且小于300nm的平均粒径的酪蛋白纳米颗粒，其通过以下步骤（a）至（c）制备：（a）步骤 将酪蛋白混合在pH8以上且小于pH11之间的碱性水性介质中; （b）向步骤（a）获得的溶液中加入至少一种活性物质的步骤; 和（c）将步骤（b）中得到的溶液注入pH 3.5至pH7.5的酸性水性介质中的步骤。