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41.发明授权公开(公告)号：US12109258B2
公开(公告)日：2024-10-08
申请号：US16302718
申请日：2017-05-19
申请人： The Trustees of the University of Pennsylvania , Inovio Pharmaceuticals, Inc. , THE WISTAR INSTITUTE OF ANATOMY AND BIOLOGY , Ahmed S. I. Aly
IPC分类号： A61K39/015 , A61K39/00 , A61P33/06 , C07K14/445
CPC分类号： A61K39/015 , A61P33/06 , C07K14/445 , A61K2039/53 , A61K2039/55527 , A61K2039/55538 , C07K2319/02 , C07K2319/42 , Y02A50/30
摘要： Provided herein are sequences of Plasmodium spp. liver stage exported proteins as well as expression constructs expressing the sequences. Also provided herein are methods for generating an immune response against malaria using the expression constructs provided herein.
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42.发明授权公开(公告)号：US12054537B2
公开(公告)日：2024-08-06
申请号：US16611943
申请日：2018-05-10
发明人： David Weiner , Ghiabe Guibinga , Neil Cooch , Charles Reed
CPC分类号： C07K16/1027 , C07K16/00 , A61K2039/505 , A61K48/00 , C07K16/10 , C07K2317/522 , C07K2317/524 , C07K2317/53 , C07K2317/565 , C07K2317/567 , C07K2317/622 , C07K2317/66 , C12N15/1031 , C12N15/1079 , G16B15/20 , G16B30/10
摘要： Disclosed herein are compositions comprising structurally modified DNA encoded antibodies (DMAbs), methods of structurally modifying DMAbs, and methods of using structurally modified DMAbs.
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公开(公告)号：US20240115689A1
公开(公告)日：2024-04-11
申请号：US18318061
申请日：2023-05-16
发明人： David Weiner , Kar Muthumani
CPC分类号： A61K39/12 , C07K14/1816 , C12N7/00 , A61K2039/53
摘要： An aspect of the present invention is related to nucleic acid constructs capable of expressing a Zika antigen that elicits an immune response in a mammal against Zika virus, and methods of use thereof. Additionally, there are DNA plasmid vaccines capable of generating in a mammal an immune response against a Zika virus, comprising a DNA plasmid and a pharmaceutically acceptable excipient, and methods of use thereof. The DNA plasmid is capable of expressing a Zika antigen in a cell of the mammal in a quantity effective to elicit an immune response in the mammal that is cross reactive against all Zika strains.
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公开(公告)号：US11945851B2
公开(公告)日：2024-04-02
申请号：US16619500
申请日：2018-06-07
发明人： David Weiner , Elizabeth Duperret
CPC分类号： C07K14/4748 , A61K39/001186 , A61K39/39 , A61K45/06 , A61P35/00 , A61K2039/53 , A61K2039/55527 , A61K2039/55533 , A61K2039/572 , A61K2039/86 , A61K2039/876
摘要： Disclosed herein are compositions and methods for treating and/or preventing cancer in mammals, and in particular, vaccines that treat and provide protection against tumor growth.
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公开(公告)号：US11883484B2
公开(公告)日：2024-01-30
申请号：US17093927
申请日：2020-11-10
发明人： David Weiner , Megan Wise
IPC分类号： A61K39/21 , C07K14/005 , A61K39/02 , A61K39/00
CPC分类号： A61K39/02 , C07K14/005 , A61K2039/53 , A61K2039/54 , A61K2039/545 , C12N2740/16134 , C12N2740/16171
摘要： The present invention relates to compositions comprising two or more DNA plasmids encoding consensus and transmitted founder HIV envelope glycoproteins which expressed and induce a potent immune response.
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公开(公告)号：US20240016919A1
公开(公告)日：2024-01-18
申请号：US18042796
申请日：2021-08-24
发明人： Ami Patel , David Weiner , Kar Muthumani , Emma Reuschel
IPC分类号： A61K39/215 , C12N15/85 , C07K14/165
CPC分类号： A61K39/215 , C12N15/85 , C07K14/165 , C12N2770/20022 , A61K2039/5258
摘要： The present invention disclosed an intradermal vaccine that protects against Middle East Respiratory Syndrome coronavirus (MERS-CoV). In one embodiment, the vaccine is a DNA vaccine. In one embodiment, the vaccine comprises an antigen. The antigen can be a consensus antigen. The consensus antigen can be a consensus spike antigen. The present invention also discloses methods of treating or preventing MERS-CoV in a subject in need thereof by administering the vaccine intradermally to the subject.
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公开(公告)号：US20230256074A1
公开(公告)日：2023-08-17
申请号：US17787729
申请日：2020-12-21
发明人： Kar Muthumani , David Weiner
IPC分类号： A61K39/12 , C07K14/005 , C07K14/705 , A61K41/00 , C12N15/86
CPC分类号： A61K39/12 , C07K14/005 , C07K14/70507 , A61K41/0047 , C12N15/86 , A61K2039/53
摘要： An aspect of the present invention is related to nucleic acid constructs capable of expressing at least one African swine fever virus (ASFV) antigen that elicits an immune response in a mammal against ASFV virus, and methods of use thereof.
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公开(公告)号：US20230210981A1
公开(公告)日：2023-07-06
申请号：US18001116
申请日：2021-06-09
发明人： David Weiner , Ami Patel
IPC分类号： A61K39/215 , A61P31/14
CPC分类号： A61K39/215 , A61P31/14 , A61K2039/53
摘要： Disclosed herein is a vaccine comprising a Coronavirus disease 2019 (COVID-19) antigen in a combination with an immunoglobulin from post-exposure treatment. The antigen can be a consensus antigen. The consensus antigen can be a consensus spike antigen. Also disclosed herein is a method of treating a subject in need thereof, by administering the vaccine to the subject.
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公开(公告)号：US20220324948A1
公开(公告)日：2022-10-13
申请号：US17631709
申请日：2020-07-31
发明人： David Weiner , Elizabeth Parzych , Ami Patel
摘要： Disclosed herein are compositions for generating a synthetic antibody or synthetic multivalent antibody in a subject. Also disclosed are methods for generating a synthetic antibody or synthetic multivalent antibody in a subject by administering a composition including one or more recombinant nucleic acid sequence that encodes a synthetic antibody or synthetic multivalent antibody to the subject. The disclosure also provides a compositions and methods of preventing and/or treating a Neisseria gonorrhoeae infection in a subject using said synthetic antibody or synthetic multivalent antibody.
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公开(公告)号：US11464841B2
公开(公告)日：2022-10-11
申请号：US16337637
申请日：2017-09-29
申请人： The Trustees of the University of Pennsylvania , THE WISTAR INSTITUTE OF ANATOMY AND BIOLOGY , INOVIO PHARMACEUTICALS, INC.
发明人： David Weiner , Jian Yan
摘要： Disclosed herein are compositions comprising optimized consensus TERT antigens and methods for treating cancer and in particular immunogenic compositions that treat and provide protection against tumor.
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