公开(公告)号：US07470549B2

公开(公告)日：2008-12-30

申请号：US11137390

申请日：2005-05-26

申请人： Masayoshi Yamamoto ,  Toshihide Ezoe ,  Nobuhiko Ogura ,  Katsumi Hayashi

发明人： Masayoshi Yamamoto ,  Toshihide Ezoe ,  Nobuhiko Ogura ,  Katsumi Hayashi

IPC分类号： G01N33/543

CPC分类号： G01N33/54373 ,  Y10S435/808 ,  Y10S436/805 ,  Y10S436/806

摘要： It is an object of the present invention to provide a method for simultaneously carrying out the detection or measurement of a substance interacting with a physiologically active substance immobilized on a biosensor and the analysis of the effects of the above substance on the biological activity of the physiologically active substance. The present invention provides a method using a biosensor formed by immobilizing a physiologically active substance on a substrate, wherein the detection and measurement of a substance interacting with said physiologically active substance and the measurement of the biological activity of said physiologically active substance are carried out on said single biosensor.

摘要翻译： 本发明的目的是提供一种同时进行与固定在生物传感器上的生理活性物质相互作用的物质的检测或测量的方法，以及上述物质对生理活性的生物学活性的影响的分析 活性物质。 本发明提供一种使用通过将生理活性物质固定在基材上形成的生物传感器的方法，其中与所述生理活性物质相互作用的物质的检测和测量以及所述生理活性物质的生物活性的测量在 说单个生物传感器。

公开(公告)号：US20070154749A1

公开(公告)日：2007-07-05

申请号：US11716449

申请日：2007-03-09

申请人： Hideo Kato ,  Katsumi Hayashi ,  Shigeru Inai

发明人： Hideo Kato ,  Katsumi Hayashi ,  Shigeru Inai

IPC分类号： H01M8/24

CPC分类号： H01M8/0269 ,  H01M8/0258 ,  H01M8/0267 ,  H01M8/04223 ,  H01M8/04225 ,  H01M8/24 ,  H01M8/241 ,  H01M8/2457

摘要： A fuel cell stack which comprises a plurality of unit fuel cells laminated via separators, and is connected to external resistors each allowing a feeble current to flow to each unit fuel cell, whereby such problems as an open-circuit voltage generation and corrosion that may be caused by fuel gas remaining after operation shutdown can be resolved. A switch is preferably attached in series with an external resistor.

公开(公告)号：US20060216572A1

公开(公告)日：2006-09-28

申请号：US11388431

申请日：2006-03-24

申请人： Hiromichi Yoshida ,  Shigeru Inai ,  Minoru Koshinuma ,  Ryo Jinba ,  Seiji Sugiura ,  Naoki Mitsuta ,  Katsumi Hayashi

发明人： Hiromichi Yoshida ,  Shigeru Inai ,  Minoru Koshinuma ,  Ryo Jinba ,  Seiji Sugiura ,  Naoki Mitsuta ,  Katsumi Hayashi

IPC分类号： H01M8/02 ,  H01M4/94

CPC分类号： H01M8/04228 ,  H01M8/0258 ,  H01M8/0263 ,  H01M8/0265 ,  H01M8/0286 ,  H01M8/241 ,  H01M8/2457

摘要： An oxygen-containing gas flow field is formed on a surface of a first metal separator. The oxygen-containing gas flow field is connected between an oxygen-containing gas supply passage and an oxygen-containing gas discharge passage. The oxygen-containing gas flow field comprises oxygen-containing gas flow grooves, and ends of the oxygen-containing gas flow grooves are extended outwardly beyond ends of electrode catalyst layer of a membrane electrode assembly, and connected to an inlet buffer and an outlet buffer. When the purging process is performed at the time of stopping operation of the fuel cell, the purging air supplied to the oxygen-containing gas flow field discharges water retained in the electrode catalyst layers from the ends to the outlet buffer.

摘要翻译： 在第一金属分离器的表面上形成含氧气体流场。 含氧气体流场连接在含氧气体供给通道和含氧气体排出通道之间。 含氧气体流场包括含氧气体流动槽，并且含氧气体流动槽的端部向外延伸超过膜电极组件的电极催化剂层的端部，并且连接到入口缓冲器和出口缓冲器 。 当在燃料电池停止运行时执行清洗处理时，供给到含氧气体流场的净化空气从端部向出口缓冲器排出保留在电极催化剂层中的水。

公开(公告)号：US07064837B2

公开(公告)日：2006-06-20

申请号：US10120518

申请日：2002-04-12

申请人： Nobufumi Mori ,  Katsumi Hayashi ,  Masayuki Naya ,  Nobuhiko Ogura ,  Yoshiyuki Kunuki

发明人： Nobufumi Mori ,  Katsumi Hayashi ,  Masayuki Naya ,  Nobuhiko Ogura ,  Yoshiyuki Kunuki

IPC分类号： G01N21/55 ,  G01N1/10

CPC分类号： G01N21/553

摘要： Disclosed herein is a sensor utilizing attenuated total reflection. The sensor is constructed of a measuring chip, an optical system, and a measuring section. The measuring chip is equipped with a dielectric block, a thin film layer formed on the dielectric block, and a liquid-sample holding portion for holding a liquid sample. The optical system is used to make a light beam enter the dielectric block at various angles of incidence so that a total internal reflection condition is satisfied at an interface between the dielectric block and the thin film layer. The measuring section measures the state of attenuated total reflection, based on the intensity of the light beam totally reflected at the interface. The liquid-sample holding portion has an opening at its top surface. The sensor further has a lid supply mechanism for placing a lid on the opening to prevent evaporation of the liquid sample.

摘要翻译： 这里公开了一种利用衰减全反射的传感器。 传感器由测量芯片，光学系统和测量部分构成。 测量芯片配备有介质块，形成在介质块上的薄膜层和用于保持液体样品的液体样品保持部分。 光学系统用于使光束以不同的入射角进入介质块，使得在介电块和薄膜层之间的界面处满足全内反射条件。 测量部分根据在界面全反射的光束的强度来测量衰减全反射的状态。 液体样品保持部分在其顶表面上具有开口。 传感器还具有用于将盖放置在开口上以防止液体样品蒸发的盖供给机构。

公开(公告)号：US07062311B1

公开(公告)日：2006-06-13

申请号：US09611229

申请日：2000-07-06

申请人： Tomonari Sendai ,  Katsumi Hayashi ,  Kazuo Hakamata ,  Toshiro Hayakawa ,  Yoji Okazaki ,  Kenji Matsumoto

发明人： Tomonari Sendai ,  Katsumi Hayashi ,  Kazuo Hakamata ,  Toshiro Hayakawa ,  Yoji Okazaki ,  Kenji Matsumoto

IPC分类号： A61B6/00

CPC分类号： G01N21/6456 ,  A61B5/0071 ,  A61B5/0084 ,  G01N21/645 ,  G01N2021/6421 ,  G01N2201/0612

摘要： A fluorescence observing apparatus including a light source for emitting excitation light, an excitation light irradiation section for irradiating the excitation light to a sample, and a fluorescence measurement section for measuring fluorescence emitted from the sample by the irradiation of the excitation light. In the fluorescence observing apparatus, a GaN semiconductor laser is employed as the light source.

摘要翻译： 包括用于发射激发光的光源的荧光观察装置，用于将激发光照射到样品的激发光照射部分和用于通过照射激发光来测量从样品发射的荧光的荧光测量部分。 在荧光观察装置中，使用GaN半导体激光器作为光源。

公开(公告)号：US20050200853A1

公开(公告)日：2005-09-15

申请号：US11077159

申请日：2005-03-11

申请人： Nobufumi Mori ,  Katsumi Hayashi

发明人： Nobufumi Mori ,  Katsumi Hayashi

IPC分类号： G01N21/05 ,  G01N21/11 ,  G01N21/27 ,  G01N21/41 ,  G01N21/77 ,  G01N21/55

CPC分类号： G01N21/7703 ,  G01N21/553

摘要： An analysis chip comprises a thin film layer, which is formed on a dielectric material block and has two different regions. A flow path unit comprising a supply path for supplying a sample onto the thin film layer and a discharging path for discharging the sample is releasably loaded into the analysis chip. A light beam is irradiated to a first interface between one region of the thin film layer and the dielectric material block, and a second interface between the other region of the thin film layer and the dielectric material block, in a parallel manner. Refractive index information with regard to a substance to be analyzed, which is located on the thin film layer, is acquired from intensities of the light beam totally reflected from the first interface and the light beam totally reflected from the second interface.

摘要翻译： 分析芯片包括形成在电介质材料块上并具有两个不同区域的薄膜层。 包括用于将样品供应到薄膜层上的供应路径和用于排出样品的排出路径的流路单元可释放地装载到分析芯片中。 平行地将光束照射到薄膜层的一个区域和电介质材料块之间的第一界面，以及薄膜层的另一个区域和电介质材料块之间的第二界面。 从位于薄膜层上的待分析物质的折射率信息是从第一界面全反射的光束和从第二界面全反射的光束的强度获得的。

公开(公告)号：US20050074641A1

公开(公告)日：2005-04-07

申请号：US10958495

申请日：2004-10-04

申请人： Shigeru Inai ,  Katsumi Hayashi ,  Ryo Jinba ,  Hideo Kato ,  Tomoki Kobayashi ,  Minoru Uoshima ,  Yasunori Kotani

发明人： Shigeru Inai ,  Katsumi Hayashi ,  Ryo Jinba ,  Hideo Kato ,  Tomoki Kobayashi ,  Minoru Uoshima ,  Yasunori Kotani

IPC分类号： H01M8/00 ,  H01M8/04 ,  H01M8/10

CPC分类号： H01M8/04231

摘要： A stop method for a fuel cell system that includes a fuel cell unit in which hydrogen is supplied to an anode, and air is supplied to a cathode so as to generate electrical power via an electrochemical reaction. The stop method includes the steps of stopping supply of hydrogen to the anode, and supplying air to the anode so as to discharge water remaining at the anode.

摘要翻译： 一种用于燃料电池系统的停止方法，其包括将氢气供应到阳极的燃料电池单元，并且向阴极供应空气以通过电化学反应产生电力。 停止方法包括停止向阳极供应氢气，并向阳极供应空气以排出残留在阳极的水的步骤。

公开(公告)号：US20050042492A1

公开(公告)日：2005-02-24

申请号：US10491836

申请日：2002-10-03

申请人： Hideo Kato ,  Katsumi Hayashi ,  Shigeru Inal

发明人： Hideo Kato ,  Katsumi Hayashi ,  Shigeru Inal

IPC分类号： H01M8/02 ,  H01M8/04 ,  H01M8/24

CPC分类号： H01M8/0269 ,  H01M8/0258 ,  H01M8/0267 ,  H01M8/04223 ,  H01M8/04225 ,  H01M8/24 ,  H01M8/241 ,  H01M8/2457

摘要： A fuel cell stack which comprises a plurality of unit fuel cells laminated via separators, and is connected to external resistors each allowing a feeble current to flow to each unit fuel cell, whereby such problems as an open-circuit voltage generation and corrosion that may be caused by fuel gas remaining after operation shutdown can be resolved. A switch is preferably attached in series with an external resistor.

摘要翻译： 一种燃料电池堆，其包括通过隔板层压的多个单元燃料电池，并且连接到各自允许微弱电流流向每个单位燃料电池的外部电阻器，由此可能存在可能是开放式电压产生和腐蚀的问题 造成燃油余量运行停机后可以解决。 开关优选地与外部电阻器串联连接。

公开(公告)号：US06804549B2

公开(公告)日：2004-10-12

申请号：US09841729

申请日：2001-04-25

申请人： Katsumi Hayashi

发明人： Katsumi Hayashi

IPC分类号： A61B600

CPC分类号： A61K49/0034 ,  A61B1/043 ,  A61B5/0071 ,  A61B5/0086 ,  A61B5/418

摘要： A method and system by which the sentinel lymph node, which is the first lymph node to which cancer is transferred when cancer is transferred to lymph nodes, is detected easily and with a high degree of accuracy. A fluorescent colorant is injected near a tumor, and after a predetermined period of time an abdominal operation is performed and stimulating light is projected onto the area being examined. Because the fluorescent colorant has been accumulated on the sentinel lymph node, it emits fluorescent light, which is then magnified and converted to a visual image. The examiner can view the normal image and the visible image at the same time. Because the stimulating light is in the near-infrared wavelength band, which is difficult for the fatty and other tissue that cover the sentinel lymph node to absorb, the sentinel lymph node is detected from the surface of the tissue.

摘要翻译： 当癌症转移至淋巴结时癌细胞转移的第一淋巴结的前哨淋巴结容易且准确度高的方法和系统。 在肿瘤附近注入荧光着色剂，经过规定的时间后进行腹部手术，将刺激光投射到被检查的区域上。 因为荧光着色剂已经积聚在前哨淋巴结上，所以它发出荧光，然后放大并转换为视觉图像。 审查员可以同时查看正常图像和可见图像。 由于刺激光在覆盖前哨淋巴结的脂肪等组织难以吸收的近红外波长带中，所以从组织表面检测前哨淋巴结。

公开(公告)号：US06686085B1

公开(公告)日：2004-02-03

申请号：US09656910

申请日：2000-09-07

申请人： Yosuke Fujii ,  Noriaki Osao ,  Yoshinori Wariishi ,  Takaki Nakagawa ,  Hiroshi Shinkai ,  Katsumi Hayashi

发明人： Yosuke Fujii ,  Noriaki Osao ,  Yoshinori Wariishi ,  Takaki Nakagawa ,  Hiroshi Shinkai ,  Katsumi Hayashi

IPC分类号： H01M804

CPC分类号： H01M8/0271 ,  H01M8/0263 ,  H01M8/04029 ,  H01M8/241 ,  H01M8/2483

摘要： A fuel gas inlet is provided at an outer circumferential edge portion of a second separator. First fuel gas flow passage grooves for supplying a fuel gas to an anode electrode are formed on a side of a surface of the second separator. First fuel gas connecting flow passages, which make communication between the fuel gas inlet and the first fuel gas flow passage grooves, include flow passage lo grooves which are provided on a side of a surface, and through-holes which penetrate through the second separator to make communication with the first fuel gas flow passage grooves. Accordingly, excellent sealing performance is ensured with a simple structure, and it is possible to realize a thin-walled fuel cell.

摘要翻译： 燃料气体入口设置在第二分离器的外周边缘部分。 在第二分离器的表面的一侧形成用于向阳极电极供给燃料气体的第一燃料气体流路。 使燃料气体入口和第一燃料气体流路槽之间的连通的第一燃料气体连通流路包括设置在表面一侧的流路槽，贯通第二隔板的通孔， 与第一燃料气体流通槽沟通。 因此，通过简单的结构确保优异的密封性能，并且可以实现薄壁燃料电池。