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41.发明授权Somatic cell reprogramming by retroviral vectors encoding Oct3/4. Klf4, c-Myc and Sox2 有权通过编码Oct3 / 4的逆转录病毒载体进行体细胞重编程。 Klf4，c-Myc和Sox2公开(公告)号：US08129187B2
公开(公告)日：2012-03-06
申请号：US12656907
申请日：2010-02-18
CPC分类号： C07K14/4702 , C12N5/0696 , C12N2501/602 , C12N2501/603 , C12N2501/604 , C12N2501/606 , C12N2510/00 , C12N2740/15043
摘要： The present invention relates to a nuclear reprogramming factor having an action of reprogramming a differentiated somatic cell to derive an induced pluripotent stem (iPS) cell. The present invention also relates to the aforementioned iPS cells, methods of generating and maintaining iPS cells, and methods of using iPS cells, including screening and testing methods as well as methods of stem cell therapy. The present invention also relates to somatic cells derived by inducing differentiation of the aforementioned iPS cells.
摘要翻译： 本发明涉及具有重新编程分化的体细胞以产生诱导多能干细胞（iPS）细胞的作用的核重编程因子。 本发明还涉及上述iPS细胞，产生和维持iPS细胞的方法，以及使用iPS细胞的方法，包括筛选和测试方法以及干细胞治疗方法。 本发明还涉及通过诱导上述iPS细胞的分化衍生的体细胞。
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42.发明授权Laser exposure device and optical axis adjustment method in laser exposure device 有权激光曝光装置中的激光曝光装置和光轴调整方法公开(公告)号：US08054326B2
公开(公告)日：2011-11-08
申请号：US12477961
申请日：2009-06-04
IPC分类号： B41J2/44
CPC分类号： G03G15/04072 , G03G15/0435
摘要： In a laser exposure device according to the present invention, a positioning pin, which is formed in a lens holder supporting a lens system, is inserted through an elongated hole for restriction of a board holder supporting a laser diode. An eccentric cam is inserted into an elongated hole for rotation movement formed in a board holder and a circular hole for rotation movement which is formed in the lens holder and which faces the elongated hole for rotation movement. An eccentric cam is inserted into an elongated hole for slide movement formed in the board holder and a circular hole for slide movement which is formed in the lens holder and which faces the elongated hole for slide movement. The eccentric cams are rotated to relatively move the board holder and lens holder with respect to each other to thereby establish alignment between the optical axes of the laser diode and lens system. In a state where the eccentric cams are fitted into the elongated holes, the board holder and lens holder are fixed to each other by screws.
摘要翻译： 在根据本发明的激光曝光装置中，形成在支撑透镜系统的透镜支架中的定位销被插入通过长孔以限制支撑激光二极管的板支架。 偏心凸轮被插入到用于旋转运动的长孔中，形成在板保持器中的旋转运动和用于旋转运动的圆形孔，其形成在透镜保持器中并面向用于旋转运动的细长孔。 偏心凸轮被插入到用于滑动运动的细长孔中，形成在板保持器中，并且用于滑动运动的圆形孔形成在透镜保持器中并面对用于滑动运动的长孔。 偏心凸轮旋转以相对于彼此相对地移动板保持器和透镜保持器，从而在激光二极管和透镜系统的光轴之间建立对准。 在将偏心凸轮装配到细长孔中的状态下，通过螺钉将板保持器和透镜保持器彼此固定。
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公开(公告)号：US20110223669A1
公开(公告)日：2011-09-15
申请号：US12672042
申请日：2009-06-26
CPC分类号： C12N5/0696 , C12N15/85 , C12N2501/60 , C12N2501/602 , C12N2501/603 , C12N2501/604 , C12N2501/606 , C12N2506/11 , C12N2510/00
摘要： The present invention provides a method of improving the efficiency of establishment of induced pluripotent stem (iPS) cells, comprising inhibiting the p53 function in the step of somatic cell nuclear reprogramming. The inhibition of p53 function is achieved by bringing a substance selected from the group consisting of (1) chemical inhibitors of p53, (2) dominant negative mutants of p53 and nucleic acids that encode the same, (3) siRNAs and shRNAs against p53 and DNAs that encode the same, and (4) p53 pathway inhibitors, into contact with a somatic cell, and the like. The present invention also provides an agent for improving the efficiency of establishment of iPS cells, the agent comprising an inhibitor of p53 function, particularly (1) chemical inhibitors of p53, (2) dominant negative mutants of p53 and nucleic acids that encode the same, (3) siRNAs and shRNAs against p53 and DNAs that encode the same, and (4) p53 pathway inhibitors. The present invention further provides a method of producing an iPS cell, comprising bringing a nuclear reprogramming substance and an inhibitor of p53 function into contact with a somatic cell.
摘要翻译： 本发明提供了提高诱导多能干细胞（iPS）细胞的建立效率的方法，包括抑制体细胞核重编程步骤中的p53功能。 通过使选自（1）p53的化学抑制剂，（2）p53的显性失活突变体和编码其的核酸，（3）siRNA和shRNA的物质与p53和 编码相同的DNA，（4）p53途径抑制剂，与体细胞接触等。 本发明还提供了用于提高iPS细胞的建立效率的试剂，该试剂包含p53功能的抑制剂，特别是（1）p53的化学抑制剂，（2）p53的显性失活突变体和编码其的核酸 ，（3）针对p53的siRNA和shRNA，编码相同的DNA，以及（4）p53途径抑制剂。 本发明还提供了一种制备iPS细胞的方法，包括使核重编程物质和p53功能抑制剂与体细胞接触。
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公开(公告)号：US20090047263A1
公开(公告)日：2009-02-19
申请号：US12213035
申请日：2008-06-13
IPC分类号： A61K35/12 , C12N5/18 , G01N33/567 , A61P43/00 , C12N5/22
CPC分类号： C07K14/4702 , C12N5/0696 , C12N2501/60 , C12N2501/602 , C12N2501/603 , C12N2501/604 , C12N2510/00 , C12N2740/15043
摘要： The present invention relates to a nuclear reprogramming factor having an action of reprogramming a differentiated somatic cell to derive an induced pluripotent stem (iPS) cell. The present invention also relates to the aforementioned iPS cells, methods of generating and maintaining iPS cells, and methods of using iPS cells, including screening and testing methods as well as methods of stem cell therapy. The present invention also relates to somatic cells derived by inducing differentiation of the aforementioned iPS cells.
摘要翻译： 本发明涉及具有重新编程分化的体细胞以产生诱导多能干细胞（iPS）细胞的作用的核重编程因子。 本发明还涉及上述iPS细胞，产生和维持iPS细胞的方法，以及使用iPS细胞的方法，包括筛选和测试方法以及干细胞治疗方法。 本发明还涉及通过诱导上述iPS细胞的分化衍生的体细胞。
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45.发明申请LASER EXPOSURE DEVICE AND OPTICAL AXIS ADJUSTMENT METHOD IN LASER EXPOSURE DEVICE 有权激光曝光装置和激光曝光装置中的光轴调整方法公开(公告)号：US20070195212A1
公开(公告)日：2007-08-23
申请号：US11675421
申请日：2007-02-15
IPC分类号： G02F1/1335
CPC分类号： G03G15/04072 , G03G15/0435
摘要： In a laser exposure device according to the present invention, a positioning pin, which is formed in a lens holder supporting a lens system, is inserted through an elongated hole for restriction of a board holder supporting a laser diode. An eccentric cam is inserted into an elongated hole for rotation movement formed in a board holder and a circular hole for rotation movement which is formed in the lens holder and which faces the elongated hole for rotation movement. An eccentric cam is inserted into an elongated hole for slide movement formed in the board holder and a circular hole for slide movement which is formed in the lens holder and which faces the elongated hole for slide movement. The eccentric cams are rotated to relatively move the board holder and lens holder with respect to each other to thereby establish alignment between the optical axes of the laser diode and lens system. In a state where the eccentric cams are fitted into the elongated holes, the board holder and lens holder are fixed to each other by screws.
摘要翻译： 在根据本发明的激光曝光装置中，形成在支撑透镜系统的透镜支架中的定位销被插入通过长孔，用于限制支撑激光二极管的板支架。 偏心凸轮被插入到用于旋转运动的长孔中，形成在板保持器中的旋转运动和用于旋转运动的圆形孔，其形成在透镜保持器中并面向用于旋转运动的细长孔。 偏心凸轮被插入到用于滑动运动的细长孔中，形成在板保持器中，并且用于滑动运动的圆形孔形成在透镜保持器中并面对用于滑动运动的长孔。 偏心凸轮旋转以相对于彼此相对地移动板保持器和透镜保持器，从而在激光二极管和透镜系统的光轴之间建立对准。 在将偏心凸轮装配到细长孔中的状态下，通过螺钉将板保持器和透镜保持器彼此固定。
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公开(公告)号：US20050253976A1
公开(公告)日：2005-11-17
申请号：US10508936
申请日：2003-04-11
申请人： Kanetaka Sekiguchi , Kazutoshi Takahashi , Kosei Miyabe , Takakazu Yano , Takahiko Watanabe , Toshiaki Ishiyama , Shinya Ikeda
发明人： Kanetaka Sekiguchi , Kazutoshi Takahashi , Kosei Miyabe , Takakazu Yano , Takahiko Watanabe , Toshiaki Ishiyama , Shinya Ikeda
IPC分类号： G02F1/1362 , G02F1/1333
CPC分类号： G02F1/1362 , G02F1/134327 , G02F2001/133391
摘要： A liquid crystal display panel includes a moving image display area in which the pixel portions are arranged in a matrix shape and a pictograph display area in which the pixel portions are formed in a fixed pictograph shape. Moreover, first protective elements are inserted between the respective pixel portions in the moving image display area and a drive circuit for the pixel portions and are arranged in an outer periphery of the moving image display area. Second protective elements are inserted between the respective pixel portions in the pictograph display area and a drive circuit for the pixel portions and arranged in an outer periphery of the pictograph display area.
摘要翻译： 液晶显示面板包括其中像素部分以矩阵形状排列的运动图像显示区域和其中以固定的象形图形状形成像素部分的象形文字显示区域。 此外，第一保护元件插入在运动图像显示区域中的各个像素部分和用于像素部分的驱动电路之间并且布置在运动图像显示区域的外周。 第二保护元件插入象形显示区域中的各个像素部分和用于像素部分的驱动电路并且布置在象形文字显示区域的外周。
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47.发明授权
公开(公告)号：US5699531A
公开(公告)日：1997-12-16
申请号：US546083
申请日：1995-10-20
申请人： Kazutoshi Takahashi
发明人： Kazutoshi Takahashi
IPC分类号： G06F15/16 , G06F15/177 , H04L1/00 , G06F7/00 , G06F13/00
CPC分类号： H04L1/0061 , H04L1/0041 , H04L1/0078
摘要： A computer system includes first and second subsystems. The first subsystem is provided with a function of generating control data of message data. The second subsystem does not have such a function. The message data is stored in the second subsystem. When the second subsystem transmits the message data, the second subsystem sends format information of the message data to the first subsystem. The first subsystem generates intermediate control data referring to the format information. When the first subsystem encounters an operation requiring reference to the message data, the first subsystem skips this operation. As a result, some portions of the intermediate control data remain blank. The first subsystem sends the intermediate control data back to the second subsystem. The second subsystem generates the control data from the intermediate control data referring to the message data stored therein. Thus, the control data is generated without exchanging the message data between the first and second subsystems.
摘要翻译： 计算机系统包括第一和第二子系统。 第一子系统具有生成消息数据的控制数据的功能。 第二个子系统没有这样的功能。 消息数据存储在第二子系统中。 当第二子系统发送消息数据时，第二子系统向第一子系统发送消息数据的格式信息。 第一个子系统参考格式信息生成中间控制数据。 当第一个子系统遇到需要引用消息数据的操作时，第一个子系统跳过此操作。 结果，中间控制数据的一些部分保持空白。 第一子系统将中间控制数据发送回第二子系统。 第二子系统根据存储在其中的消息数据从中间控制数据生成控制数据。 因此，在不交换第一和第二子系统之间的消息数据的情况下生成控制数据。
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公开(公告)号：US3946625A
公开(公告)日：1976-03-30
申请号：US468260
申请日：1974-05-08
申请人： Ken Miyazaki , Narumi Kubota , Kooichi Igarashi , Hiroshi Sato , Kazutoshi Takahashi , Takeshi Maki , Akira Hatano , Masamitsu Kai
发明人： Ken Miyazaki , Narumi Kubota , Kooichi Igarashi , Hiroshi Sato , Kazutoshi Takahashi , Takeshi Maki , Akira Hatano , Masamitsu Kai
IPC分类号： G01F23/60 , G01F23/64 , G01F23/74 , G01F23/76 , G01N9/12 , G01N33/18 , H01H36/02 , G08B21/00
CPC分类号： G01N33/1886 , G01F23/606 , G01F23/64 , G01F23/74 , G01F23/76 , G01N33/1833 , G01N9/12 , H01H36/02
摘要： A detecting float is normally made floating on a first liquid, and when a liquid to be detected having a specific gravity less than the first liquid is oncoming, the detecting float sinks relative to the new liquid level as compared with the position which it assumed relative to the level of the first liquid. When the layer of the liquid to be detected increases to a given thickness, the detecting float sinks by a given distance or amount to permit the ingress of the liquid to be detected into the float, which therefore becomes heavier and sinks further downward. An external float surrounds the detecting float, and is formed with a liquid port at a location slightly below the level of the first liquid for allowing the passage of the liquid which reaches the internally located detecting float, but intercepting the liquid to be detected which is in the form of an oil film. Detection means is provided in conjunction with the detecting float and the external float for producing a signal when the detecting float has sunk by a given distance relative to the external float upon ingress of the liquid to be detected.
摘要翻译： 检测浮子通常浮在第一液体上，并且当比重小于第一液体的被检测液体即将到来时，检测浮子相对于新液位相对于其假定相对的位置而相对下降 到第一液体的水平。 当要检测的液体层增加到给定厚度时，检测浮子下沉给定的距离或数量，以允许待检测液体进入浮子，因此浮子变得更重并进一步下沉。 外部浮子围绕检测浮子，并且在略低于第一液体的水平的位置处形成有液体端口，用于允许到达内部位置的检测浮子的液体通过，但是拦截被检测的液体是 以油膜的形式。 检测装置与检测浮子和外部浮子一起提供，用于当检测浮子在待检测液体进入时相对于外部浮子沉没给定距离时产生信号。
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公开(公告)号：US09506039B2
公开(公告)日：2016-11-29
申请号：US13991341
申请日：2011-12-02
CPC分类号： C12N5/0696 , C12N15/85 , C12N2501/115 , C12N2501/415 , C12N2501/60 , C12N2501/602 , C12N2501/603 , C12N2501/604 , C12N2501/606 , C12N2501/998 , C12N2506/1307 , C12N2510/00
摘要： The invention provides a method of improving the efficiency of establishment of induced pluripotent stem cells by increasing, in a nuclear reprogramming step of somatic cell, the level of activated form of one or more proteins selected from the group consisting of Ras family members, PI3 kinase, RalGEF, Raf, AKT family members, Rheb, TCL1 and S6K. The invention also provides a method of producing induced pluripotent stem cells by contacting a somatic cell with a nuclear reprogramming substance and one or more of such proteins and nucleic acids that encode such proteins. The invention further provides an induced pluripotent stem cell that has an exogenous nucleic acid encoding such a protein, as well as agents for use in the aforesaid methods.
摘要翻译： 本发明提供了一种通过在体细胞核重编程步骤中增加一种或多种蛋白质的活化形式的水平来提高诱导多能干细胞的建立效率的方法，该蛋白质选自Ras家族成员，PI3激酶 ，RalGEF，Raf，AKT家族成员，Rheb，TCL1和S6K。 本发明还提供了通过使体细胞与核重编程物质和一种或多种这样的蛋白质和编码这种蛋白质的核酸接触来产生诱导性多能干细胞的方法。 本发明还提供了具有编码这种蛋白质的外源核酸的诱导多能干细胞，以及用于上述方法的试剂。
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公开(公告)号：US09075362B2
公开(公告)日：2015-07-07
申请号：US13528652
申请日：2012-06-20
IPC分类号： G03G15/20
CPC分类号： G03G15/206 , G03G2215/2009
摘要： According to one embodiment, a fuser includes a heat roller, an endless belt, a first press roller and a second press roller. The heat roller rotates and contacts a toner surface side of a sheet, and heats the sheet. The endless belt contacts a part of an outer peripheral surface of the heat roller. The first press roller contacts a part of an inner peripheral surface of the endless belt, and is provided at an insertion part of the sheet in a nip portion where the heat roller contacts the endless belt. The second press roller contacts a part of the inner peripheral surface of the endless belt, is provided at an exit part of the sheet in the nip portion, and has a lower rotational resistance than the first press roller.
摘要翻译： 根据一个实施例，定影器包括加热辊，环形带，第一压辊和第二压辊。 加热辊旋转并接触片材的调色剂表面侧，并加热片材。 环形带接触加热辊的外周面的一部分。 第一按压辊接触环形带的内周面的一部分，并且设置在片材的插入部分中，加热辊与环形带接触。 第二按压辊与环形带的内周面的一部分接触，设置在夹持部的片材的出口部，并且具有比第一按压辊低的旋转阻力。
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