公开(公告)号：US10300140B2

公开(公告)日：2019-05-28

申请号：US14235431

申请日：2012-07-27

Applicant: Ramesh R. Bhatt ,  Pamela K. Foreman ,  Lawrence C. Horowitz ,  Michael Horowitz ,  Medini Gore ,  Phil Kobel

Inventor： Ramesh R. Bhatt ,  Pamela K. Foreman ,  Lawrence C. Horowitz ,  Michael Horowitz ,  Medini Gore ,  Phil Kobel

IPC: A61K39/395 ,  C07K16/30 ,  C07K16/32 ,  A61K39/00

Abstract: Embodiments concern constructs comprising surrogate light chain sequences. In particular, embodiments concern constructs that can bind to ErbB3 and aspects relating to such constructs.

公开(公告)号：US20180022805A1

公开(公告)日：2018-01-25

申请号：US15548871

申请日：2016-02-05

Applicant: Bridget S. WILSON ,  Stuart S. WINTER ,  Michael Frank ERASMUS ,  Michael HOROWITZ ,  STC.UNM

Inventor： Bridget S. Wilson ,  Stuart S. Winter ,  Michael Frank Erasmus ,  Michael Horowitz

IPC: C07K16/28

CPC classification number: C07K16/2803 ,  A61K39/3955 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/35 ,  C07K2317/52 ,  C07K2317/55 ,  C07K2317/622 ,  C07K2317/732 ,  C07K2317/76 ,  C07K2317/92 ,  A61K2300/00

Abstract: This disclosure describes the identification of pre-B Cell Receptor (pre-BCR) antagonists and the use of pre-BCR antagonists as a targeted therapy. The compositions and methods generally involve a composition that includes a pre-B cell receptor (pre-BCR) antagonist and is engineered for expression as a T cell chimeric receptor. In some embodiments, the pre-BCR antagonists can include an anti-pre-BCR antibody.

公开(公告)号：US20170187758A1

公开(公告)日：2017-06-29

申请号：US15238566

申请日：2016-08-16

Applicant: Dennis A. Denker ,  Raymond Yung-Chien Lew ,  Debbie Hsu ,  Michael Horowitz ,  Bradford J. Bensen ,  John Carnahan

Inventor： Dennis A. Denker ,  Raymond Yung-Chien Lew ,  Debbie Hsu ,  Michael Horowitz ,  Bradford J. Bensen ,  John Carnahan

IPC: H04L29/06 ,  H04L12/911

CPC classification number: H04L65/1069 ,  G06Q10/02 ,  G06Q30/06 ,  H04L29/06 ,  H04L47/70 ,  H04L47/726 ,  H04L51/32 ,  H04L67/1002

Abstract: Systems and methods for facilitating shared access-right evaluation using linked communication channels are provided. A first communication can be received over a first communication link from a first user device, and a second communication can be received over a second communication link from a second user device. The first and second communications can include requests for the assignment of access rights. Map data can be generated and transmitted to each of the first and second user devices. Each user device can display a visual representation of access-right data. Further, a communication session can be facilitated between the first user device and the second user device. The communication session can be presented on the visual representation for each user device so that the first user and the second user can collaboratively evaluate access rights.

公开(公告)号：US20140308287A1

公开(公告)日：2014-10-16

申请号：US14235431

申请日：2012-07-27

Applicant: Ramesh R. Bhatt ,  Pamela K. Foreman ,  Lawrence C. Horowitz ,  Michael Horowitz ,  Medini Gore ,  Phil Kobel

Inventor： Ramesh R. Bhatt ,  Pamela K. Foreman ,  Lawrence C. Horowitz ,  Michael Horowitz ,  Medini Gore ,  Phil Kobel

IPC: C07K16/32

CPC classification number: A61K39/39558 ,  A61K2039/505 ,  C07K16/32 ,  C07K2317/30 ,  C07K2317/51 ,  C07K2317/76 ,  C07K2317/77 ,  C07K2317/92

Abstract: Embodiments concern constructs comprising surrogate light chain sequences. In particular, embodiments concern constructs that can bind to ErbB3 and aspects relating to such constructs.

Abstract translation: 实施方案涉及包含替代轻链序列的构建体。 具体地，实施方案涉及可以结合ErbB3的结构和与这些构建相关的方面。

公开(公告)号：US08750373B2

公开(公告)日：2014-06-10

申请号：US13010570

申请日：2011-01-20

Applicant: Michael Horowitz ,  Wonkap Jang ,  Ofer Shapiro

Inventor： Michael Horowitz ,  Wonkap Jang ,  Ofer Shapiro

IPC: H04N7/12

CPC classification number: H04N19/164 ,  H04N19/124 ,  H04N19/146 ,  H04N19/162 ,  H04N19/172

Abstract: The present invention provides bit rate control techniques for a hybrid block based motion compensated predictive video encoder (e.g., H.264, as well as other video coding algorithms and standards). The techniques aim to reduce the picture-to-picture bit rate fluctuations within a prediction structure or over a short time interval that can lead to undesirable additional delay on links without over-provisioned capacity. In one embodiment of the present invention, the end to end delay is estimated. The end to end delay is used to determine limits on the modulation of the target coded picture size, with the goal of trading an acceptable amount of additional delay for a better coding efficiency.

Abstract translation: 本发明提供了一种用于基于混合块的运动补偿预测视频编码器（例如，H.264以及其他视频编码算法和标准）的比特率控制技术。 这些技术旨在减少预测结构内的图像到图像比特率波动，或者在短时间间隔内，这可能导致链路上不期望的附加延迟而没有过度提供的容量。 在本发明的一个实施例中，估计端到端延迟。 端到端延迟用于确定目标编码图像大小的调制限制，目的是交换可接受的额外延迟量以获得更好的编码效率。

公开(公告)号：US20120082237A1

公开(公告)日：2012-04-05

申请号：US12897365

申请日：2010-10-04

Applicant: Wonkap Jang ,  Michael Horowitz

Inventor： Wonkap Jang ,  Michael Horowitz

IPC: H04N7/26

CPC classification number: H04N19/31 ,  H04N19/149 ,  H04N19/172 ,  H04N19/187 ,  H04N19/36

Abstract: Disclosed herein are techniques and computer readable media containing instructions arranged to determine a bit allocation for a temporal base layer and at least one temporal enhancement layer. The techniques are enhanced to yield improved reproduced quality for the case where both a temporal base layer and at least one temporal enhancement layer is being used. An exemplary method for determining a bit allocation to one base layer includes initializing a bit allocation between the base layer and the at least one enhancement layer, determining a quality difference between the base layer and the at least one enhancement layer, expressed, for example, in the Quantizer Parameter of the last picture of each layer within a GOP, and determining a new bit allocation between the base layer and the at least one enhancement layer based on the quality difference and at least one constant factor.

Abstract translation: 这里公开的技术和计算机可读介质包含被布置为确定时间基础层和至少一个时间增强层的比特分配的指令。 增强这些技术以在使用时基基层和至少一个时间增强层的情况下产生改进的再现质量。 用于确定对一个基本层的比特分配的示例性方法包括初始化基本层和至少一个增强层之间的比特分配，确定基本层和至少一个增强层之间的质量差异，例如， 在GOP的每个层的最后图像的量化器参数中，并且基于质量差异和至少一个常数因子确定基本层和至少一个增强层之间的新的比特分配。

公开(公告)号：US20120082214A1

公开(公告)日：2012-04-05

申请号：US13010570

申请日：2011-01-20

Applicant: Michael Horowitz ,  Wonkap Jang ,  Ofer Shapiro

Inventor： Michael Horowitz ,  Wonkap Jang ,  Ofer Shapiro

IPC: H04N7/26 ,  H04N7/32

CPC classification number: H04N19/164 ,  H04N19/124 ,  H04N19/146 ,  H04N19/162 ,  H04N19/172

Abstract: The present invention provides bit rate control techniques for a hybrid block based motion compensated predictive video encoder (e.g., H.264, as well as other video coding algorithms and standards). The techniques aim to reduce the picture-to-picture bit rate fluctuations within a prediction structure or over a short time interval that can lead to undesirable additional delay on links without over-provisioned capacity. In one embodiment of the present invention, the end to end delay is estimated. The end to end delay is used to determine limits on the modulation of the target coded picture size, with the goal of trading an acceptable amount of additional delay for a better coding efficiency.

Abstract translation: 本发明提供了一种用于基于混合块的运动补偿预测视频编码器（例如，H.264以及其他视频编码算法和标准）的比特率控制技术。 这些技术旨在减少预测结构内的图像到图像比特率波动，或者在短时间间隔内，这可能导致链路上不期望的附加延迟而没有过度提供的容量。 在本发明的一个实施例中，估计端到端延迟。 端到端延迟用于确定目标编码图像大小的调制限制，目的是交换可接受的额外延迟量以获得更好的编码效率。

公开(公告)号：US07136394B2

公开(公告)日：2006-11-14

申请号：US10098849

申请日：2002-03-12

Applicant: Michael Horowitz ,  Rick Flott ,  Athar Shah ,  Kevin Raper

Inventor： Michael Horowitz ,  Rick Flott ,  Athar Shah ,  Kevin Raper

IPC: H04L12/56

CPC classification number: H04L65/80 ,  H04L29/06 ,  H04L29/06027 ,  H04L45/00 ,  H04L45/30 ,  H04L45/3065 ,  H04L65/607 ,  H04L69/14 ,  H04N19/107 ,  H04N19/114 ,  H04N19/115 ,  H04N19/159 ,  H04N19/172 ,  H04N19/89 ,  H04N21/2343 ,  H04N21/234327 ,  H04N21/234381 ,  H04N21/2402 ,  H04N21/2662 ,  H04N21/631

Abstract: A method for encoding digital video with low delay for transport on a multi-channel QoS packet-switched network using multiple reference pictures with specially designated “key frames” to minimize the undesired effects of packet loss on video quality.

公开(公告)号：US20050198134A1

公开(公告)日：2005-09-08

申请号：US11101317

申请日：2005-04-07

Applicant: Michael Kenoyer ,  Michael Horowitz

Inventor： Michael Kenoyer ,  Michael Horowitz

IPC: G09B5/06 ,  H04N7/14 ,  H04N7/15 ,  G06F15/16

CPC classification number: H04N7/15 ,  G09B5/06 ,  H04L12/28 ,  H04N7/147 ,  H04N7/148

Abstract: A system and method for integrating a personal computer based presentation with a videoconferencing system. A coupling device includes a card, insertable into a PCMCIA slot of a laptop computer or like machine, which includes a cable coupled to the card at a first end and to a connector coupled at a second end. The card includes firmware for loading into RAM of the computer and software operable to execute code.

公开(公告)号：US20050025236A1

公开(公告)日：2005-02-03

申请号：US10633273

申请日：2003-08-01

Applicant: Yong Yan ,  Michael Horowitz ,  Athar Shah ,  Richard Hall

Inventor： Yong Yan ,  Michael Horowitz ,  Athar Shah ,  Richard Hall

IPC: H04N7/12 ,  H04N7/26

CPC classification number: H04N19/86 ,  H04N19/80

Abstract: A method for reducing or eliminating coding artifacts in video pictures processed using intra block prediction methods, for example, according to the H.264 standard. The causes of the coding artifacts are identified to be the intra prediction modes with prediction directions that are not in the direction of the raster scan. Filtering the affected blocks with a simple one-dimensional spatial filter will reduce or even eliminate these coding artifacts.

Abstract translation: 一种减少或消除使用帧内预测方法处理的视频图像中的伪像的方法，例如根据H.264标准。 编码伪像的原因被识别为具有不在光栅扫描方向上的预测方向的帧内预测模式。 用简单的一维空间过滤器过滤受影响的块将减少甚至消除这些编码工件。