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    Hydrogen Sulfide Donating Polymers
    42.
    发明申请
    Hydrogen Sulfide Donating Polymers 审中-公开
    硫化氢捐赠聚合物

    公开(公告)号：US20100198338A1

    公开(公告)日：2010-08-05

    申请号：US12362566

    申请日：2009-01-30

    申请人： Mingfei Chen ,  Christopher Storment

    发明人： Mingfei Chen ,  Christopher Storment

    IPC分类号： A61F2/82 ,  C08G75/16 ,  A61M25/00

    CPC分类号： A61L27/34 ,  A61L27/54 ,  A61L29/085 ,  A61L29/16 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/10 ,  A61L2300/45 ,  A61L2300/61 ,  C08F220/18 ,  C08G69/42 ,  C08F220/34

    摘要： Described herein are hydrogen sulfide (H2S) donating polymers and polymer systems suitable for coating or forming medical devices and methods for making and using the same. More specifically, described are H2S donating polymers comprising at least one monomer with at least one basic group that can be complexed with H2S to form a charged H2S complex. The H2S donating polymers can provide controlled release of H2S once implanted at or within the target surgical site. The H2S donating polymers can be coated onto a medical device, formed into a medical device or combined with one or more other polymers to form a polymer system.

    摘要翻译： 本文描述了提供适于涂覆或形成医疗装置的聚合物和聚合物体系的硫化氢（H 2 S）及其制备和使用方法。 更具体地，描述了包含至少一种具有至少一个碱性基团的单体的H 2 S供体聚合物，其可以与H 2 S络合以形成带电荷的H 2 S络合物。 一旦植入到靶外科手术部位或其内部，H2S供体聚合物可以提供H2S的受控释放。 供给H 2 S的聚合物可以涂覆在医疗装置上，形成医疗装置或与一种或多种其它聚合物组合以形成聚合物体系。

    Dental impression material utilizing ruthenium catalyst
    43.
    发明授权
    Dental impression material utilizing ruthenium catalyst 有权
    使用钌催化剂的牙印模材料

    公开(公告)号：US06455029B1

    公开(公告)日：2002-09-24

    申请号：US09690236

    申请日：2000-10-17

    申请人： Christos Angeletakis ,  Mingfei Chen

    发明人： Christos Angeletakis ,  Mingfei Chen

    IPC分类号： A61K716

    CPC分类号： A61K6/10

    摘要： A composition for use as a dental impression material including a polymerizable telechelic oligomer or polymer curable by ring-opening metathesis polymerization, a filler system, and a ruthenium carbene complex catalyst, whereby the catalyst initiates ring-opening metathesis polymerization of the composition. The invention includes a paste/paste system in which a base paste includes the polymerizable telechelic oligomer or polymer and a filler system and in which a catalyst paste includes the catalyst dissolved in an inert solvent and a filler system. The telechelic oligomer or polymer may be, for example, a polydimethylsiloxane end-functionalized with norbornenyl groups. The catalyst may be, for example, a ruthenium carbene complex with a ligand having a basicity higher than tricyclohexylphosphine. The composition of the present invention exhibits reduced sensitivity to sulfur impurities.

    摘要翻译： 一种用作牙科印模材料的组合物，其包括可聚合的遥爪低聚物或通过开环易位聚合可固化的聚合物，填料体系和钌卡宾配合物催化剂，由此催化剂引发组合物的开环易位聚合。 本发明包括糊状物/糊剂系统，其中基础糊料包括可聚合的远端低聚物或聚合物和填料体系，其中催化剂浆料包括溶解在惰性溶剂中的催化剂和填料体系。 遥爪低聚物或聚合物可以是例如用降冰片烯基端基官能化的聚二甲基硅氧烷。 催化剂可以是例如具有碱性高于三环己基膦的配位体的钌卡宾络合物。 本发明的组合物对硫杂质的敏感性降低。

    Hydrogen Sulfide Generating Polymers
    45.
    发明申请
    Hydrogen Sulfide Generating Polymers 有权
    硫化氢生成聚合物

    公开(公告)号：US20110165216A1

    公开(公告)日：2011-07-07

    申请号：US12606346

    申请日：2010-01-05

    申请人： Mingfei Chen ,  Christopher Storment ,  David Shumaker

    发明人： Mingfei Chen ,  Christopher Storment ,  David Shumaker

    IPC分类号： A61F2/82 ,  C08G75/00 ,  C08G69/00 ,  A61K31/785 ,  A61P9/00

    CPC分类号： C08F20/38 ,  A61L27/14 ,  A61L27/54 ,  A61L29/04 ,  A61L29/16 ,  A61L31/04 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/41 ,  A61L2300/416 ,  C08F20/54 ,  C08L101/02

    摘要： Described herein are hydrogen sulfide (H2S) generating polymers and polymer systems suitable for coating or forming medical devices and methods for making and using the same. More specifically, described are H2S generating polymers comprising at least one thioamide group. The H2S generating polymers can provide controlled site-specific release of H2S once implanted at or within the target surgical site by hydrolysis of the thioamide group in physiological media. The H2S generating polymers can be coated onto a medical device, formed into a medical device or combined with one or more other polymers to form a polymer system. Also described are methods of treating restenosis and inflammation and promoting vasodilation utilizing such medical devices.

    摘要翻译： 本文描述了产生适于涂覆或形成医疗装置的聚合物和聚合物系统的硫化氢（H 2 S）及其制备和使用方法。 更具体地，描述了包含至少一个硫代酰胺基团的H 2 S生成聚合物。 H 2 S生成聚合物可以通过在生理介质中水解硫代酰胺基团一次植入到目标手术部位内或内部，从而提供控制的位点特异性释放H 2 S. 产生H 2 S的聚合物可以涂覆在医疗装置上，形成医疗装置或与一种或多种其它聚合物组合以形成聚合物体系。 还描述了使用这种医疗装置治疗再狭窄和炎症并促进血管扩张的方法。

    Compositions and methods for treating a damaged cardiovascular element
    46.
    发明申请
    Compositions and methods for treating a damaged cardiovascular element 失效
    用于治疗受损的心血管元件的组合物和方法

    公开(公告)号：US20070012323A1

    公开(公告)日：2007-01-18

    申请号：US11443594

    申请日：2006-05-31

    申请人： Josee Roy ,  Hezi-Yamit Ayala ,  Carol Sullivan ,  Mingfei Chen

    发明人： Josee Roy ,  Hezi-Yamit Ayala ,  Carol Sullivan ,  Mingfei Chen

    IPC分类号： A61B19/00

    CPC分类号： A61K31/765 ,  A61K9/0014 ,  A61K9/0019 ,  A61K31/00 ,  A61K45/06 ,  A61K47/10 ,  A61L31/06 ,  A61L31/16 ,  A61L2300/402 ,  A61L2400/06 ,  C08L71/02

    摘要： In the present invention, the applicants describe methods and compositions of treating damaged cardiovascular elements and cardiovascular conditions including hypotension, atherosclerotic lesions, vulnerable plaque, and acute myocardial infarct. The applicants demonstrate the ability of a biomembrane sealing agent to accumulate on the walls of damaged blood vessels and help improving mean arterial pressure following tissue injury. The applicants describe the use of formulations comprising at least one biomembrane sealing agent and one bioactive agent for prophylactic treatment such as they could be administered concurrently to an invasive therapeutic intervention or after the insult (i.e. post-injury or post-surgery). Alternatively, these methods and compositions could be used to reduce the severity of cardiovascular diseases after onset.

    摘要翻译： 在本发明中，申请人描述了治疗受损的心血管因子和心血管疾病的方法和组合物，包括低血压，动脉粥样硬化病变，易损斑块和急性心肌梗死。 申请人证明了生物膜密封剂积聚在受损血管壁上的能力，有助于改善组织损伤后的平均动脉压。 申请人描述了使用包含至少一种生物膜密封剂和一种用于预防性治疗的生物活性剂的制剂，例如它们可以同时施用于侵入性治疗干预或在侮辱之后（即损伤后或手术后）。 或者，这些方法和组合物可用于降低发病后心血管疾病的严重性。

    Hydrogen sulfide generating polymers
    49.
    发明授权
    Hydrogen sulfide generating polymers 有权
    产生硫化氢的聚合物

    公开(公告)号：US08182830B2

    公开(公告)日：2012-05-22

    申请号：US12606346

    申请日：2010-01-05

    申请人： Mingfei Chen ,  Christopher Storment ,  David Shumaker

    发明人： Mingfei Chen ,  Christopher Storment ,  David Shumaker

    IPC分类号： C08F20/38 ,  A61F2/00

    CPC分类号： C08F20/38 ,  A61L27/14 ,  A61L27/54 ,  A61L29/04 ,  A61L29/16 ,  A61L31/04 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/41 ,  A61L2300/416 ,  C08F20/54 ,  C08L101/02

    摘要： Described herein are hydrogen sulfide (H2S) generating polymers and polymer systems suitable for coating or forming medical devices and methods for making and using the same. More specifically, described are H2S generating polymers comprising at least one thioamide group. The H2S generating polymers can provide controlled site-specific release of H2S once implanted at or within the target surgical site by hydrolysis of the thioamide group in physiological media. The H2S generating polymers can be coated onto a medical device, formed into a medical device or combined with one or more other polymers to form a polymer system. Also described are methods of treating restenosis and inflammation and promoting vasodilation utilizing such medical devices.

    摘要翻译： 本文描述了产生适于涂覆或形成医疗装置的聚合物和聚合物系统的硫化氢（H 2 S）及其制备和使用方法。 更具体地，描述了包含至少一个硫代酰胺基团的H 2 S生成聚合物。 H 2 S生成聚合物可以通过在生理介质中水解硫代酰胺基团一次植入到目标手术部位内或内部，从而提供控制的位点特异性释放H 2 S. 产生H 2 S的聚合物可以涂覆在医疗装置上，形成医疗装置或与一种或多种其它聚合物组合以形成聚合物体系。 还描述了使用这种医疗装置治疗再狭窄和炎症并促进血管扩张的方法。

    Composition curable by metathesis reaction
    50.
    发明授权
    Composition curable by metathesis reaction 有权
    通过复分解反应可固化的组合物

    公开(公告)号：US06844409B2

    公开(公告)日：2005-01-18

    申请号：US10430953

    申请日：2003-05-06

    申请人： Christos Angeletakis ,  Mingfei Chen

    发明人： Christos Angeletakis ,  Mingfei Chen

    IPC分类号： C07F15/00 ,  A61K6/10 ,  C08G61/08 ,  C08G77/20 ,  C08G77/38 ,  C08L83/07 ,  C08G77/08

    CPC分类号： C08L83/04 ,  A61K6/10 ,  C08G61/08 ,  C08G77/045 ,  C08G77/20 ,  C08K5/56

    摘要： A composition curable by a metathesis reaction and comprising an olefin-containing resin system and metathesis catalyst. The resin system comprises siloxane-based oligomers or polymers end-capped and/or tethered with olefin functional groups that are capable of undergoing a metathesis reaction. The composition also includes a ruthenium carbene complex catalyst, whereby the catalyst initiates the metathesis reaction of the composition. The oligomer or polymer may be, for example, one or a combination of a telechelic polydimethylsiloxane end-capped with norbornenylethyl groups, a polydimethylsiloxane tethered and end-capped with norbornenylethyl groups, a tri-functional polydimethylsiloxane end-capped with norbornenylethyl groups, or a quadri-functional polydimethylsiloxane end-capped with norbornenylethyl groups. The catalyst may be, for example, a ruthenium carbene complex, such as 1,3-bis-(2,4,6-trimethylphenyl)-2-(imidazolidinylidene) dichloro(o-isopropoxyphenylmethylene) ruthenium.

    摘要翻译： 通过复分解反应可固化的组合物，其包含含烯烃的树脂体系和复分解催化剂。 树脂体系包含硅氧烷基低聚物或端基和/或与能够进行复分解反应的烯烃官能团连接的聚合物。 该组合物还包括钌卡宾络合物催化剂，由此催化剂引发组合物的复分解反应。 低聚物或聚合物可以是例如一种或其末端封端有降冰片烯乙基的遥爪聚二甲基硅氧烷，连接并用降冰片烯基乙基封端的聚二甲基硅氧烷，用降冰片烯乙基封端的三官能聚二甲基硅氧烷，或 用降冰片烯乙基封端的四官能聚二甲基硅氧烷。 催化剂可以是例如钌卡宾络合物，例如1,3-双 - （2,4,6-三甲基苯基）-2-（咪唑烷亚基）二氯（邻异丙氧基苯基亚甲基）钌。