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公开(公告)号：US20120009325A1
公开(公告)日：2012-01-12
申请号：US12834274
申请日：2010-07-12
申请人： Christopher Storment
发明人： Christopher Storment
CPC分类号： C25D1/20 , A61F2/91 , A61F2210/0076 , A61F2240/001 , A61F2250/0068 , C25D1/08 , C25D5/022
摘要： A stent including hollow struts is formed on a cylindrical substrate. The struts of the stent are formed by electroforming metal layers of the strut in openings formed in a patterned photoresist material. A first metal layer forming the inner strut material is formed in openings in a first photoresist material. A sacrificial material to form the cavity to make the struts hollow is formed in openings in a second photoresist material. A second metal layer forming the side walls and outer wall of the struts is formed in openings in a third photoresist material and around the sacrificial material. The photoresist materials are removed. The substrate and cavity sacrificial material are removed, leaving hollow struts formed into a stent pattern. The hollow struts may be filled with a therapeutic substance for elution. Openings through the struts to the cavity may be formed during the forming process.
摘要翻译： 包括中空支柱的支架形成在圆柱形基底上。 支架的支柱通过在形成在图案化的光致抗蚀剂材料中的开口中电铸金属支柱而形成。 形成内支柱材料的第一金属层形成在第一光致抗蚀剂材料的开口中。 在第二光致抗蚀剂材料的开口中形成用于形成空腔以使支柱中空的牺牲材料。 形成支柱的侧壁和外壁的第二金属层形成在第三光致抗蚀剂材料的开口中并且围绕牺牲材料。 去除光致抗蚀剂材料。 去除衬底和腔牺牲材料，留下中空支柱形成支架图案。 中空支柱可以填充用于洗脱的治疗物质。 可以在成形过程中形成穿过支柱到空腔的开口。
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公开(公告)号：US20110251668A1
公开(公告)日：2011-10-13
申请号：US12755562
申请日：2010-04-07
申请人： Dustin Thompson , Paul Adler , Maria Arreguin , Kevin Mauch , Christopher Storment , Lance Ensign , Stephen Zimmerman
发明人： Dustin Thompson , Paul Adler , Maria Arreguin , Kevin Mauch , Christopher Storment , Lance Ensign , Stephen Zimmerman
CPC分类号： A61F2/90 , A61F2250/0067 , A61F2250/0068 , B21F45/008
摘要： A stent includes a wave form that includes a cable including a plurality of strands. The wave form has a plurality of struts and a plurality of crowns, with each crown connecting two adjacent struts. The wave form is wrapped around a longitudinal axis at a pitch to define a plurality of helical turns. The stent includes a filler located within the cable. The filler includes a therapeutic substance.
摘要翻译： 支架包括波形，其包括包括多个股线的电缆。 波形具有多个支柱和多个冠部，每个冠部连接两个相邻的支柱。 波形围绕纵向轴线以间距包围以限定多个螺旋形匝。 支架包括位于电缆内的填充物。 填料包括治疗物质。
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公开(公告)号：US20110165216A1
公开(公告)日：2011-07-07
申请号：US12606346
申请日：2010-01-05
IPC分类号： A61F2/82 , C08G75/00 , C08G69/00 , A61K31/785 , A61P9/00
CPC分类号： C08F20/38 , A61L27/14 , A61L27/54 , A61L29/04 , A61L29/16 , A61L31/04 , A61L31/10 , A61L31/16 , A61L2300/41 , A61L2300/416 , C08F20/54 , C08L101/02
摘要： Described herein are hydrogen sulfide (H2S) generating polymers and polymer systems suitable for coating or forming medical devices and methods for making and using the same. More specifically, described are H2S generating polymers comprising at least one thioamide group. The H2S generating polymers can provide controlled site-specific release of H2S once implanted at or within the target surgical site by hydrolysis of the thioamide group in physiological media. The H2S generating polymers can be coated onto a medical device, formed into a medical device or combined with one or more other polymers to form a polymer system. Also described are methods of treating restenosis and inflammation and promoting vasodilation utilizing such medical devices.
摘要翻译： 本文描述了产生适于涂覆或形成医疗装置的聚合物和聚合物系统的硫化氢（H 2 S）及其制备和使用方法。 更具体地，描述了包含至少一个硫代酰胺基团的H 2 S生成聚合物。 H 2 S生成聚合物可以通过在生理介质中水解硫代酰胺基团一次植入到目标手术部位内或内部，从而提供控制的位点特异性释放H 2 S. 产生H 2 S的聚合物可以涂覆在医疗装置上，形成医疗装置或与一种或多种其它聚合物组合以形成聚合物体系。 还描述了使用这种医疗装置治疗再狭窄和炎症并促进血管扩张的方法。
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公开(公告)号：US20110008405A1
公开(公告)日：2011-01-13
申请号：US12500359
申请日：2009-07-09
CPC分类号： A61M25/0015 , A61B2017/00526 , A61L31/022 , A61L31/16 , A61M25/0012 , A61N1/0587
摘要： A method of a forming a hollow, drug-eluting medical device includes providing composite member having an outer member and a core member disposed within a lumen of the outer member. The composite member is shaped into a pattern. Openings are formed through the outer member of the composite member. The composite member is processed to remove the core member from the lumen of the outer member without harming the outer member, leaving a hollow tubular member already formed into the desired pattern. The lumen of the outer member is filled with a therapeutic substance.
摘要翻译： 形成中空药物洗脱医疗装置的方法包括提供具有外部构件和设置在外部构件的内腔内的芯构件的复合构件。 复合构件成形为图案。 通过复合构件的外部构件形成开口。 处理复合构件以从外部构件的内腔移除芯构件而不损害外部构件，留下已经形成为期望图案的中空管状构件。 外部构件的内腔填充有治疗物质。
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公开(公告)号：US08353952B2
公开(公告)日：2013-01-15
申请号：US12755562
申请日：2010-04-07
申请人： Dustin Thompson , Paul Adler , Maria Arreguin , Kevin Mauch , Christopher Storment , Lance Ensign , Stephen Zimmerman
发明人： Dustin Thompson , Paul Adler , Maria Arreguin , Kevin Mauch , Christopher Storment , Lance Ensign , Stephen Zimmerman
IPC分类号： A61F2/82
CPC分类号： A61F2/90 , A61F2250/0067 , A61F2250/0068 , B21F45/008
摘要： A stent includes a wave form that includes a cable including a plurality of strands. The wave form has a plurality of struts and a plurality of crowns, with each crown connecting two adjacent struts. The wave form is wrapped around a longitudinal axis at a pitch to define a plurality of helical turns. The stent includes a filler located within the cable. The filler includes a therapeutic substance.
摘要翻译： 支架包括波形，其包括包括多个股线的电缆。 波形具有多个支柱和多个冠部，每个冠部连接两个相邻的支柱。 波形围绕纵向轴线以间距包围以限定多个螺旋形匝。 支架包括位于电缆内的填充物。 填料包括治疗物质。
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公开(公告)号：US20100198338A1
公开(公告)日：2010-08-05
申请号：US12362566
申请日：2009-01-30
申请人： Mingfei Chen , Christopher Storment
发明人： Mingfei Chen , Christopher Storment
CPC分类号： A61L27/34 , A61L27/54 , A61L29/085 , A61L29/16 , A61L31/10 , A61L31/16 , A61L2300/10 , A61L2300/45 , A61L2300/61 , C08F220/18 , C08G69/42 , C08F220/34
摘要： Described herein are hydrogen sulfide (H2S) donating polymers and polymer systems suitable for coating or forming medical devices and methods for making and using the same. More specifically, described are H2S donating polymers comprising at least one monomer with at least one basic group that can be complexed with H2S to form a charged H2S complex. The H2S donating polymers can provide controlled release of H2S once implanted at or within the target surgical site. The H2S donating polymers can be coated onto a medical device, formed into a medical device or combined with one or more other polymers to form a polymer system.
摘要翻译： 本文描述了提供适于涂覆或形成医疗装置的聚合物和聚合物体系的硫化氢（H 2 S）及其制备和使用方法。 更具体地，描述了包含至少一种具有至少一个碱性基团的单体的H 2 S供体聚合物，其可以与H 2 S络合以形成带电荷的H 2 S络合物。 一旦植入到靶外科手术部位或其内部，H2S供体聚合物可以提供H2S的受控释放。 供给H 2 S的聚合物可以涂覆在医疗装置上，形成医疗装置或与一种或多种其它聚合物组合以形成聚合物体系。
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公开(公告)号：US09283305B2
公开(公告)日：2016-03-15
申请号：US12500359
申请日：2009-07-09
CPC分类号： A61M25/0015 , A61B2017/00526 , A61L31/022 , A61L31/16 , A61M25/0012 , A61N1/0587
摘要： A method of a forming a hollow, drug-eluting medical device includes providing composite member having an outer member and a core member disposed within a lumen of the outer member. The composite member is shaped into a pattern. Openings are formed through the outer member of the composite member. The composite member is processed to remove the core member from the lumen of the outer member without harming the outer member, leaving a hollow tubular member already formed into the desired pattern. The lumen of the outer member is filled with a therapeutic substance.
摘要翻译： 形成中空药物洗脱医疗装置的方法包括提供具有外部构件和设置在外部构件的内腔内的芯构件的复合构件。 复合构件成形为图案。 通过复合构件的外部构件形成开口。 处理复合构件以从外部构件的内腔移除芯构件而不损害外部构件，留下已经形成为期望图案的中空管状构件。 外部构件的内腔填充有治疗物质。
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公开(公告)号：US08268382B2
公开(公告)日：2012-09-18
申请号：US12834274
申请日：2010-07-12
申请人： Christopher Storment
发明人： Christopher Storment
CPC分类号： C25D1/20 , A61F2/91 , A61F2210/0076 , A61F2240/001 , A61F2250/0068 , C25D1/08 , C25D5/022
摘要： A stent including hollow struts is formed on a cylindrical substrate. The struts of the stent are formed by electroforming metal layers of the strut in openings formed in a patterned photoresist material. A first metal layer forming the inner strut material is formed in openings in a first photoresist material. A sacrificial material to form the cavity to make the struts hollow is formed in openings in a second photoresist material. A second metal layer forming the side walls and outer wall of the struts is formed in openings in a third photoresist material and around the sacrificial material. The photoresist materials are removed. The substrate and cavity sacrificial material are removed, leaving hollow struts formed into a stent pattern. The hollow struts may be filled with a therapeutic substance for elution. Openings through the struts to the cavity may be formed during the forming process.
摘要翻译： 包括中空支柱的支架形成在圆柱形基底上。 支架的支柱通过在形成在图案化的光致抗蚀剂材料中的开口中电铸金属支柱而形成。 形成内支柱材料的第一金属层形成在第一光致抗蚀剂材料的开口中。 在第二光致抗蚀剂材料的开口中形成用于形成空腔以使支柱中空的牺牲材料。 形成支柱的侧壁和外壁的第二金属层形成在第三光致抗蚀剂材料的开口中并且围绕牺牲材料。 去除光致抗蚀剂材料。 去除衬底和腔牺牲材料，留下中空支柱形成支架图案。 中空支柱可以填充用于洗脱的治疗物质。 可以在成形过程中形成穿过支柱到空腔的开口。
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公开(公告)号：US08182830B2
公开(公告)日：2012-05-22
申请号：US12606346
申请日：2010-01-05
CPC分类号： C08F20/38 , A61L27/14 , A61L27/54 , A61L29/04 , A61L29/16 , A61L31/04 , A61L31/10 , A61L31/16 , A61L2300/41 , A61L2300/416 , C08F20/54 , C08L101/02
摘要： Described herein are hydrogen sulfide (H2S) generating polymers and polymer systems suitable for coating or forming medical devices and methods for making and using the same. More specifically, described are H2S generating polymers comprising at least one thioamide group. The H2S generating polymers can provide controlled site-specific release of H2S once implanted at or within the target surgical site by hydrolysis of the thioamide group in physiological media. The H2S generating polymers can be coated onto a medical device, formed into a medical device or combined with one or more other polymers to form a polymer system. Also described are methods of treating restenosis and inflammation and promoting vasodilation utilizing such medical devices.
摘要翻译： 本文描述了产生适于涂覆或形成医疗装置的聚合物和聚合物系统的硫化氢（H 2 S）及其制备和使用方法。 更具体地，描述了包含至少一个硫代酰胺基团的H 2 S生成聚合物。 H 2 S生成聚合物可以通过在生理介质中水解硫代酰胺基团一次植入到目标手术部位内或内部，从而提供控制的位点特异性释放H 2 S. 产生H 2 S的聚合物可以涂覆在医疗装置上，形成医疗装置或与一种或多种其它聚合物组合以形成聚合物体系。 还描述了使用这种医疗装置治疗再狭窄和炎症并促进血管扩张的方法。
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