公开(公告)号：US10308717B2

公开(公告)日：2019-06-04

申请号：US15182775

申请日：2016-06-15

Applicant: Novartis AG ,  The Trustees of the University of Pennsylvania ,  University of Pittsburgh—of the Commonwealth System of Higher Education

Inventor： Jennifer Brogdon ,  Laura Alexandra Johnson ,  Carl H. June ,  Andreas Loew ,  Marcela Maus ,  John Scholler ,  Hideho Okada

IPC: A61K39/395 ,  C07K16/28 ,  A61K38/00 ,  C07K16/30 ,  A61K35/17 ,  A61K39/00

Abstract: The invention provides compositions and methods for treating diseases associated with expression of EGFRvIII. The invention also relates to chimeric antigen receptor (CAR) specific to EGFRvIII, vectors encoding the same, and recombinant T cells comprising the anti-EGFRvIII CAR. The invention also includes methods of administering a genetically modified T cell expressing a CAR that comprises an anti-EGFRvIII binding domain.

公开(公告)号：US20190153061A1

公开(公告)日：2019-05-23

申请号：US16197565

申请日：2018-11-21

Applicant: Novartis AG ,  The Trustees of the University of Pennsylvania

Inventor： Jennifer Brogdon ,  Eugene Choi ,  Hilmar Erhard Ebersbach ,  David Jonathan Glass ,  Heather Huet ,  Carl H. June ,  Joan Mannick ,  Michael C. Milone ,  Leon Murphy ,  Gabriela Plesa ,  Celeste Richardson ,  Marco Ruella ,  Reshma Singh ,  Yongqiang Wang ,  Qilong Wu

IPC: C07K14/705 ,  C07K16/28 ,  C07H21/04 ,  C12N15/63 ,  C12N5/00 ,  A61K35/12 ,  A61K38/17

Abstract: The invention provides compositions and methods for treating diseases associated with expression of BCMA. The invention also relates to chimeric antigen receptor (CAR) specific to BCMA vectors encoding the same, and recombinant T cells comprising the BCMA CAR. The invention also includes methods of administering a genetically modified T cell expressing a CAR that comprises a BCMA binding domain.

公开(公告)号：US20190135940A1

公开(公告)日：2019-05-09

申请号：US16192375

申请日：2018-11-15

Applicant: Novartis AG ,  The Trustees of the University of Pennsylvania

Inventor： Jennifer Brogdon ,  Carl H. June ,  Andreas Loew ,  Marcela Maus ,  John Scholler

IPC: C07K16/30 ,  C07K16/28 ,  C12N5/0783 ,  C07K14/705 ,  C07K14/725

Abstract: The invention provides compositions and methods for treating diseases associated with expression of CD19. The invention also relates to chimeric antigen receptor (CAR) specific to CD19, vectors encoding the same, and recombinant T cells comprising the CD19 CAR. The invention also includes methods of administering a genetically modified T cell expressing a CAR that comprises a CD19 binding domain.

公开(公告)号：US10174095B2

公开(公告)日：2019-01-08

申请号：US14805193

申请日：2015-07-21

Applicant: Novartis AG ,  The Trustees of the University of Pennsylvania

Inventor： Jennifer Brogdon ,  Eugene Choi ,  Hilmar Erhard Ebersbach ,  David Glass ,  Heather Huet ,  Carl H. June ,  Joan Mannick ,  Michael C. Milone ,  Leon Murphy ,  Gabriela Plesa ,  Celeste Richardson ,  Marco Ruella ,  Reshma Singh ,  Yongqiang Wang ,  Qilong Wu

IPC: C07H21/04 ,  C12N15/63 ,  C12N5/00 ,  C07K16/28 ,  C07K14/705 ,  A61K35/12 ,  A61K38/17 ,  C07K14/715 ,  C07K19/00 ,  A61K39/395 ,  A61P35/00

Abstract: The invention provides compositions and methods for treating diseases associated with expression of BCMA. The invention also relates to chimeric antigen receptor (CAR) specific to BCMA vectors encoding the same, and recombinant T cells comprising the BCMA CAR. The invention also includes methods of administering a genetically modified T cell expressing a CAR that comprises a BCMA binding domain.

公开(公告)号：US20170306416A1

公开(公告)日：2017-10-26

申请号：US15517597

申请日：2015-10-07

Applicant: Felipe Bedoya ,  Hans Bitter ,  Jennifer Brogdon ,  Corin Dorfmeier ,  Abhishnek Garg ,  David Glass ,  Joan Mannick ,  Jan J. Melenhorst ,  Michael Milone ,  Leon Murphy ,  Elena Orlando ,  Nicholas Wilcox ,  Novartis AG ,  The Trustees of the University of Pennsylvania

Inventor： Felipe Bedoya ,  Hans Bitter ,  Jennifer Brogdon ,  Corin Dorfmeier ,  Abhishnek Garg ,  David Glass ,  Joan Mannick ,  Jan J. Melenhorst ,  Michael Milone ,  Leon Murphy ,  Elena Orlando ,  Nicholas Wilcox

IPC: C12Q1/68 ,  A61K39/00 ,  G01N33/574

Abstract: Cancer biomarkers and methods of using them are disclosed.

公开(公告)号：US12214037B2

公开(公告)日：2025-02-04

申请号：US17359211

申请日：2021-06-25

Applicant: The Trustees of the University of Pennsylvania ,  Novartis AG

Inventor： Jennifer Brogdon ,  Eugene Choi ,  Hilmar Erhard Ebersbach ,  David Jonathan Glass ,  Heather Huet ,  Carl H. June ,  Joan Mannick ,  Michael C. Milone ,  Leon Murphy ,  Gabriela Plesa ,  Celeste Richardson ,  Marco Ruella ,  Reshma Singh ,  Yongqiang Wang ,  Qilong Wu

IPC: A61K39/00 ,  A61K39/395 ,  C07K14/705 ,  C07K14/725 ,  C07K16/28 ,  A61K35/12 ,  A61K38/17 ,  A61P35/00 ,  C07H21/04 ,  C07K14/715 ,  C07K19/00 ,  C12N5/00 ,  C12N15/63

Abstract: The invention provides compositions and methods for treating diseases associated with expression of BCMA. The invention also relates to chimeric antigen receptor (CAR) specific to BCMA vectors encoding the same, and recombinant T cells comprising the BCMA CAR. The invention also includes methods of administering a genetically modified T cell expressing a CAR that comprises a BCMA binding domain.

公开(公告)号：US11851659B2

公开(公告)日：2023-12-26

申请号：US16498361

申请日：2018-03-21

Applicant: Novartis AG ,  Intellia Therapeutics, Inc.

Inventor： Jennifer Brogdon ,  Ming-Wei Chen ,  Hyungwook Lim ,  Yi Yang ,  Morag Stewart ,  Sarah Hesse

IPC: C12N9/22 ,  C12N15/86 ,  C12N15/113 ,  A61K35/17 ,  C07K14/705

CPC classification number: C12N15/1138 ,  A61K35/17 ,  C07K14/70503 ,  C07K14/70578 ,  C12N9/22 ,  C12N15/86 ,  C07K2319/30 ,  C07K2319/33 ,  C12N2310/20 ,  C12N2750/14143 ,  C12N2800/80

Abstract: The present disclosure is directed to genome editing systems, reagents and methods for immunooncology.

公开(公告)号：US11578130B2

公开(公告)日：2023-02-14

申请号：US16210480

申请日：2018-12-05

Applicant: Novartis AG ,  The Trustees of the University of Pennsylvania

Inventor： Jennifer Brogdon ,  Boris Engels ,  David Jonathan Glass ,  Brian Granda ,  John Hastewell ,  Andreas Loew ,  Joan Mannick ,  Michael C. Milone ,  Leon Murphy ,  William Raj Sellers ,  Huijuan Song ,  Brian Edward Vash ,  Jan Weiler ,  Qilong Wu ,  Li Zhou

IPC: C07K16/28 ,  A61K31/436 ,  A61K35/17 ,  C07K14/705 ,  C07K14/71 ,  C07K14/725 ,  C07K14/74 ,  C12N9/12 ,  C12N9/90

Abstract: Compositions and methods relating to regulatable chimeric antigen receptors (RCARs), where the intracellular signaling or proliferation of the RCAR can be controlled to optimize the use of an RCAR-expressing cell to provide an immune response, are provided. For example, a RCAR can comprise a dimerization switch that, upon the presence of a dimerization molecule, can couple an intracellular signaling domain to an extracellular recognition element, e.g., an antigen binding domain, an inhibitory counter ligand binding domain, or costimulatory ECD domain. An RCAR can be engineered to include an appropriate antigen binding domain that is specific to a desired antigen target and used in the treatment of a disease.

公开(公告)号：US20220364055A1

公开(公告)日：2022-11-17

申请号：US17271430

申请日：2019-08-30

Applicant: Novartis AG

Inventor： Louise Treanor ,  Michael R. Greene ,  Jennifer Brogdon ,  Boris Engels ,  Glenn Dranoff ,  Olja Kodrasi ,  Hyungwook Lim ,  Akash Sohoni ,  Elizabeth Dorothy Pratico ,  Anniesha Hack ,  Aida Abujoub ,  Tony Fleming ,  Lu Huang ,  Connie Hong ,  John Blankenship ,  Brian Holmberg ,  Chonghui Zhang ,  Dexiu Bu ,  Andrew Price ,  Xu Zhu ,  Andrew Stein ,  Attilio Bondanza

IPC: C12N5/0783 ,  A61K35/17 ,  A61K31/519 ,  A61K38/20 ,  C07K16/28 ,  C07K14/705

Abstract: The invention provides methods of making immune effector cells (for example, T cells, NK cells) that express a chimeric antigen receptor (CAR), and compositions generated by such methods.

公开(公告)号：US11084880B2

公开(公告)日：2021-08-10

申请号：US16197565

申请日：2018-11-21

Applicant: Novartis AG ,  The Trustees of the University of Pennsylvania

Inventor： Jennifer Brogdon ,  Eugene Choi ,  Hilmar Erhard Ebersbach ,  David Jonathan Glass ,  Heather Huet ,  Carl H. June ,  Joan Mannick ,  Michael C. Milone ,  Leon Murphy ,  Gabriela Plesa ,  Celeste Richardson ,  Marco Ruella ,  Reshma Singh ,  Yongqiang Wang ,  Qilong Wu

IPC: C07K16/28 ,  C07K14/705 ,  C07K19/00 ,  C07K14/725 ,  A61P35/00 ,  A61K39/395 ,  A61K35/12 ,  A61K38/17 ,  C07K14/715 ,  C07H21/04 ,  C12N15/63 ,  C12N5/00

Abstract: The invention provides compositions and methods for treating diseases associated with expression of BCMA. The invention also relates to chimeric antigen receptor (CAR) specific to BCMA vectors encoding the same, and recombinant T cells comprising the BCMA CAR. The invention also includes methods of administering a genetically modified T cell expressing a CAR that comprises a BCMA binding domain.