C-jun phosphorylation inhibitors
    42.
    发明申请
    C-jun phosphorylation inhibitors 审中-公开
    C-jun磷酸化抑制剂

    公开(公告)号:US20050065082A1

    公开(公告)日:2005-03-24

    申请号:US10509307

    申请日:2003-03-31

    CPC分类号: A61K38/1709

    摘要: In the present invention, BMAL1, BPL1, KIAA1491 complete (SEQ ID NO: 1), and KIAA0596CT (SEQ ID NO:2), have a function for interacting with JNK3, wherein these peptides, as well as peptides derived therefrom can be used to inhibit c-Jun from being phosphorylated and exhibiting its functions (such as transcription activation activity). Inhibition of the phosphorylation of c-Jun suppresses apoptosis, such as nerve cell apoptosis. Thus, the present invention also provides a drug, a pharmaceutical composition and a method for use in preventing and/or treating a neurodegenerative disease (such as polyglutamine disease and Alzheimer's disease).

    摘要翻译: 在本发明中,BMAL1,BPL1,KIAA1491完整(SEQ ID NO:1)和KIAA0596CT(SEQ ID NO:2)具有与JNK3相互作用的功能,其中可以使用这些肽以及由其衍生的肽 以抑制c-Jun被磷酸化并显示其功能(例如转录激活活性)。 抑制c-Jun磷酸化抑制细胞凋亡,如神经细胞凋亡。 因此,本发明还提供了用于预防和/或治疗神经退行性疾病(如聚谷氨酰胺病和阿尔茨海默病)的药物,药物组合物和方法。

    Regenerated cutting blade and shearing type grinder

    公开(公告)号:US10046330B2

    公开(公告)日:2018-08-14

    申请号:US14417344

    申请日:2012-08-28

    IPC分类号: B02C18/00 B02C18/18 B02C18/14

    摘要: A regenerated cutting blade to be mounted and used in a shearing type grinder. The cutting blade includes a fixed part and a blade tip projecting outward from this fixed part, in which the blade tip has a leading edge pointed toward the rotating direction. Side edges 110 on the lateral side outer periphery including the blade tip, the leading end edge and the side edges are regenerated and formed by build-up welding. The lateral sides are provided with slip preventive build-up welding parts 111, 112, 113 extending from the side edges 110 toward the central side of its rotation or the central direction, and the build-up welding parts are formed by three regenerating processes.

    Glass composition and member having the same on substrate
    44.
    发明授权
    Glass composition and member having the same on substrate 有权
    玻璃组合物和在基材上具有相同的成分

    公开(公告)号:US08389428B2

    公开(公告)日:2013-03-05

    申请号:US13137165

    申请日:2011-07-25

    摘要: A glass composition having high refractive index, softening property at low temperature and small average thermal expansion coefficient, and a member provided with the composition on a substrate, are provided. The glass composition of the present invention has a refractive index (nd) of from 1.88 to 2.20, a glass transition temperature (Tg) of from 450 to 490° C., and an average thermal expansion coefficient at temperatures from 50° C. to 300° C. (α50-300) of from 60×10−7/K to 90×10−7/K, and includes Bi2O3 in an amount of from 5 to 25% in terms of mol % on the basis of oxides.

    摘要翻译: 提供了具有高折射率,低温软化性能和小平均热膨胀系数的玻璃组合物,以及在基板上设置有该组合物的构件。 本发明的玻璃组合物的折射率(nd)为1.88〜2.20,玻璃化转变温度(Tg)为450〜490℃,平均热膨胀系数为50〜 300℃(α50-300)为60×10-7 / K至90×10-7 / K,并且基于氧化物以摩尔%计含有5至25%的Bi 2 O 3。

    Glass for scattering layer of organic LED device and organic LED device
    45.
    发明授权
    Glass for scattering layer of organic LED device and organic LED device 有权
    有机LED器件散射层玻璃和有机LED器件

    公开(公告)号:US08368064B2

    公开(公告)日:2013-02-05

    申请号:US13137160

    申请日:2011-07-25

    摘要: A glass to be used in a scattering layer of an organic LED element, and an organic LED element using the scattering layer are provided. The organic LED element of the present invention includes, a transparent substrate, a first electrode provided on the transparent electrode, an organic layer provided on the first electrode, and a second electrode provided on the organic layer, and further includes a scattering layer including, in terms of mol % on the basis of oxides, 15 to 30% of P2O5, 5 to 25% of Bi2O3, 5 to 27% of Nb2O5, and 10 to 35% of ZnO and having a total content of alkali metal oxides including Li2O, Na2O and K2O of 5% by mass or less.

    摘要翻译: 提供了用于有机LED元件的散射层的玻璃以及使用该散射层的有机LED元件。 本发明的有机LED元件包括透明基板,设置在透明电极上的第一电极,设置在第一电极上的有机层和设置在有机层上的第二电极,还包括散射层, 以氧化物为基准的摩尔%,PbO 15为15〜30%,Bi 2 O 5为5〜25%,Nb 2 O 5为5〜27%,ZnO为10〜35重量%,Li 2 O ,Na 2 O和K 2 O为5质量%以下。

    GLASS FOR DIFFUSION LAYER IN ORGANIC LED ELEMENT, AND ORGANIC LED ELEMENT UTILIZING SAME
    46.
    发明申请
    GLASS FOR DIFFUSION LAYER IN ORGANIC LED ELEMENT, AND ORGANIC LED ELEMENT UTILIZING SAME 有权
    有机LED元件中的扩散层玻璃和有机LED元件的应用

    公开(公告)号:US20120194064A1

    公开(公告)日:2012-08-02

    申请号:US13447014

    申请日:2012-04-13

    IPC分类号: H05B33/22 F21V5/00

    摘要: The present invention relates to a glass for a scattering layer of an organic LED element, which contains, in terms of mol % on the basis of oxides, 0˜20% of P2O5, 15˜60% of B2O3, 15˜28% of Bi2O3 and 20˜50% of ZnO, in which a value obtained by dividing the content of P2O5 by the content of ZnO is less than 0.48, the sum of the contents of P2O5 and B2O3 is 30˜60%, the content of P2O5 is 10% or less when the sum of the contents of P2O5 and B2O3 exceeds 50%, and the glass does not substantially contain lead (PbO or Pb3O4), Li2O, Na2O and K2O, except for those contained as impurities.

    摘要翻译: 本发明涉及一种有机LED元件的散射层用玻璃,其以氧化物为基准的摩尔%含有0〜20%的P 2 O 5,15〜60%的B 2 O 3,15〜28%的 Bi 2 O 3和20〜50%的ZnO,其中通过将P 2 O 5的含量除以ZnO的含量获得的值小于0.48,P 2 O 5和B 2 O 3的含量之和为30〜60%,P2O 5的含量为 当P 2 O 5和B 2 O 3的含量的总和超过50%时,10%以下,除了作为杂质以外,玻璃基本上不含有铅(PbO或Pb 3 O 4),Li 2 O,Na 2 O,K 2 O。

    Optical Code Division Multiplexing Access System
    48.
    发明申请
    Optical Code Division Multiplexing Access System 审中-公开
    光码分多址接入系统

    公开(公告)号:US20110013909A1

    公开(公告)日:2011-01-20

    申请号:US12918322

    申请日:2009-02-19

    IPC分类号: H04J14/00

    摘要: Problem An object of the present invention is to provide an optical code division multiple access system which is used by many people.Means for Solving The above problem is solved by an optical code division multiple access, OCDMA, system 5 which have a central office 2 comprising a multi-port optical encoder 1, a decode part 4 comprising a decoder 3 for decoding optical code signals from the multi-port optical encoder 1. The multi-port optical encoder 1 transform input optical signals into optical code signals the wavelength of them differs at predetermined amount based on code pattern. The decoder 3 is super structured fiber Bragg grating, SSFBG, which has center wavelength that corresponds to optical code signal.

    摘要翻译: 发明内容本发明的目的是提供一种由许多人使用的光码分多址系统。 解决方案上述问题通过具有包括多端口光学编码器1的中心局2的光码分多址OCDMA系统5来解决,解码部分4包括:解码器3,用于解码来自 多端口光学编码器1.多端口光学编码器1将输入光信号转换为光码信号,其波长根据码模式以预定量不同。 解码器3是具有对应于光码信号的中心波长的超结构光纤布拉格光栅SSFBG。

    Shredding machine and shredding method
    49.
    发明授权
    Shredding machine and shredding method 有权
    粉碎机和粉碎方法

    公开(公告)号:US07789334B2

    公开(公告)日:2010-09-07

    申请号:US10589927

    申请日:2005-02-17

    IPC分类号: A47J17/18

    摘要: In order to finely crush a shredable object, two rotational shafts for supporting cutting blades are provided in parallel in the transverse direction inside a shredder main body. The cutting blades that are provided with a plurality of cutting portions protruding from outer peripheral thereof are disposed in the shaft direction of the two rotational shafts so that these cutting portions engage with each other. A throw-in port for a shredable object is provided in one end portion of the rotational shafts in an upper portion of the shredder main body in the shaft direction. A discharge port for the shredable object is provided in the other end portion of the rotational shafts in a lower portion of this shredder main body in the shaft direction. Transverse feeding members for forwarding the shredable object that is thrown into the throw-in port and crushed by the cutting blades, to a discharge port side is provided and, thereby shredding the shredable object for a plurality of times inside the shredder main body.

    摘要翻译: 为了细碎可撕碎物体,用于支撑切割刀片的两个旋转轴在切碎机主体内沿横向平行设置。 设置有从其外周突出的多个切割部的切割刀沿两个旋转轴的轴方向设置,使得这些切割部彼此接合。 在切割粉碎机主体的轴向上的上部的旋转轴的一个端部设置有用于可切碎物体的投入口。 用于可撕碎物体的排出口设置在该切碎机主体的轴向的下部的旋转轴的另一端部。 设置用于将被投入到扔入口并被切割刀片破碎的可切碎物体送入排出口侧的横向供给部件,从而将破碎物体在切碎机主体内分割多次。

    Optical Multiport Spectral Phase Encoder
    50.
    发明申请
    Optical Multiport Spectral Phase Encoder 有权
    光学多端口光谱相位编码器

    公开(公告)号:US20100196005A1

    公开(公告)日:2010-08-05

    申请号:US12668025

    申请日:2008-07-07

    IPC分类号: H04J14/00 G02B6/26

    摘要: Data security of a multi-dimensional code system is increased. An optical device is provided with a single input port; a splitter splitting an input light from the input port into a plurality of lights; a plurality of phase shifters each shifting one of the lights split by the splitter; a multi-port encoder/decoder inputting the lights whose phases are shifted by the phase shifters and generating spectral encoded codes; and a plurality of output ports outputting the spectral encoded codes generated by the multi-port encoder/decoder.

    摘要翻译: 增加了多维码系统的数据安全性。 光学装置设置有单个输入端口; 分离器,将输入端口的输入光分成多个光; 多个移相器,每个移动由分离器分裂的一个光; 输入相位被移相器偏移并产生频谱编码的多端口编码器/解码器; 以及输出由多端口编码器/解码器生成的频谱编码码的多个输出端口。