公开(公告)号：US07576307B2

公开(公告)日：2009-08-18

申请号：US11741839

申请日：2007-04-30

申请人： Siavash Yazdanfar ,  Robert John Filkins

发明人： Siavash Yazdanfar ,  Robert John Filkins

IPC分类号： G02B27/16 ,  G02B27/40

CPC分类号： G02B21/245 ,  G02B21/365

摘要： A digital optical microscope includes a primary image sensor that generates a primary image of a sample at a primary frame rate, an auxiliary image sensor that generates an auxiliary image of the sample at an auxiliary frame rate that is faster than the primary frame rate, and a controller that adjusts a focal distance between an objective lens and the sample along an optical axis in response to the auxiliary image, thereby autofocusing the primary image on the sample. The primary image sensor generates the primary image in response to the autofocusing.

摘要翻译： 数字光学显微镜包括以主要帧速率产生样本的主图像的主图像传感器，以比主帧速率快的辅助帧速率生成样本的辅助图像的辅助图像传感器，以及 控制器，其响应于辅助图像，沿着光轴调整物镜和样本之间的焦距，从而将原始图像自动聚焦在样本上。 主图像传感器响应于自动对焦而产生主图像。

公开(公告)号：US07075658B2

公开(公告)日：2006-07-11

申请号：US10765010

申请日：2004-01-26

申请人： Joseph A. Izatt ,  Divakar K. Rao ,  Changhuei Yang ,  Michael A. Choma ,  Siavash Yazdanfar ,  Andrew M. Rollins ,  Brian E. Applegate

发明人： Joseph A. Izatt ,  Divakar K. Rao ,  Changhuei Yang ,  Michael A. Choma ,  Siavash Yazdanfar ,  Andrew M. Rollins ,  Brian E. Applegate

IPC分类号： G01B9/02

CPC分类号： G01B9/02004 ,  G01B9/02002 ,  G01B9/02007 ,  G01B9/02014 ,  G01B9/02044 ,  G01B9/02069 ,  G01B9/02091 ,  G01B2290/70

摘要： Spatial information, such as concentration and displacement, about a specific molecular contrast agent, may be determined by stimulating a sample containing the agent, thereby altering an optical property of the agent. A plurality of optical coherence tomography (OCT) images may be acquired, at least some of which are acquired at different stimulus intensities. The acquired images are used to profile the molecular contrast agent concentration distribution of the sample.

摘要翻译： 关于特定分子造影剂的空间信息，例如浓度和位移可以通过刺激含有试剂的样品来确定，从而改变试剂的光学性质。 可以获取多个光学相干断层摄影（OCT）图像，其中至少一些在不同的刺激强度下被获取。 采集的图像用于分析样品的分子造影剂浓度分布。

公开(公告)号：US07061622B2

公开(公告)日：2006-06-13

申请号：US10213326

申请日：2002-08-05

申请人： Andrew M. Rollins ,  Joseph A. Izatt ,  Volker Westphal ,  Siavash Yazdanfar

发明人： Andrew M. Rollins ,  Joseph A. Izatt ,  Volker Westphal ,  Siavash Yazdanfar

IPC分类号： G01B9/02

CPC分类号： G01N21/4795 ,  A61B5/0066 ,  G01B11/2441

摘要： An optical coherence tomography (OCT) system including an interferometer provides illuminating light along a first optical path to a sample and an optical delay line and collects light from the sample along a second optical path remitted at several scattering angles to a detector. In one embodiment, illuminating light is directed along a number of incident light paths through a focusing lens to a sample. The light paths and focusing lens are related to the sample and to both the incident light source and the detector. In another embodiment, a focusing system directs light to a location in the sample. A transmission grating or acousto-optic modulator directs light from the sample at an angle representative of the wavelength of the incident light on the transmission grating or acousto-optic modulator.

公开(公告)号：US06735463B2

公开(公告)日：2004-05-11

申请号：US09468674

申请日：1999-12-21

申请人： Joseph A. Izatt ,  Manish D. Kulkarni ,  Siavash Yazdanfar ,  Andrew Rollins ,  Michael V. Sivak

发明人： Joseph A. Izatt ,  Manish D. Kulkarni ,  Siavash Yazdanfar ,  Andrew Rollins ,  Michael V. Sivak

IPC分类号： A61B502

CPC分类号： A61B5/0073 ,  A61B5/0066 ,  A61B5/7257 ,  G01B9/02045 ,  G01B9/02069 ,  G01B9/02071 ,  G01B9/02072 ,  G01B9/02083 ,  G01B9/02091 ,  G01B2290/35 ,  G01B2290/60

摘要： A method for generating a velocity-indicating, tomographic image of a sample in an optical coherence tomography system includes the steps of (a) acquiring cross-correlation data from the interferometer; (b) generating a grayscale image from the cross-correlation data indicative of a depth-dependent positions of scatterers in the sample; (c) processing the cross-correlation data to produce a velocity value and location of a moving scatterer in the sample; (d) assigning a color to the velocity value; and (f) merging the color into the grayscale image, at a point in the grayscale image indicative of the moving scatterer's location, to produce a velocity-indicating, tomographic image. Preferably a first color is assigned for a positive velocity value and a second color is assigned for a negative velocity value.

摘要翻译： 一种用于在光学相干断层摄影系统中产生样本的速度指示断层图像的方法包括以下步骤：（a）从干涉仪获取互相关数据; （b）从指示样品中散射体的深度相关位置的互相关数据中生成灰度图像; （c）处理互相关数据以产生样品中运动散射体的速度值和位置; （d）为速度值分配颜色; 以及（f）在指示运动散射体位置的灰度图像中将颜色合并成灰度图像，以产生速度指示的断层图像。 优选地，将第一颜色分配给正速度值，并且将第二颜色分配给负速度值。