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公开(公告)号：US09072660B2
公开(公告)日：2015-07-07
申请号：US13607489
申请日：2012-09-07
CPC分类号： A61K9/0014 , A61K31/496 , A61K47/10 , A61K47/14 , A61K47/26 , A61K47/32 , A61K47/40
摘要： Methods of transdermally delivering a therapeutic amount of a triazole-triazolone compound are provided, e.g. for the prevention or treatment of basal cell carcinoma (BCC) in a subject. A therapeutic level of a triazole-triazolone compound such as itraconazole is delivered transdermally to a subject. Also provided are topical triazole-triazolone compositions that find use in practicing the subject methods.
摘要翻译： 提供治疗量的三唑 - 三唑酮化合物的经皮递送方法。 用于预防或治疗受试者的基底细胞癌（BCC）。 治疗水平的三唑 - 三唑酮化合物如伊曲康唑经皮递送给受试者。 还提供了用于实践本发明方法的局部三唑 - 三唑酮组合物。
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公开(公告)号：US20130109700A1
公开(公告)日：2013-05-02
申请号：US13607489
申请日：2012-09-07
IPC分类号： A61K9/00
CPC分类号： A61K9/0014 , A61K31/496 , A61K47/10 , A61K47/14 , A61K47/26 , A61K47/32 , A61K47/40
摘要： Methods of transdermally delivering a therapeutic amount of a triazole-triazolone compound are provided, e.g. for the prevention or treatment of basal cell carcinoma (BCC) in a subject. A therapeutic level of a triazole-triazolone compound such as itraconazole is delivered transdermally to a subject. Also provided are topical triazole-triazolone compositions that find use in practicing the subject methods.
摘要翻译： 提供治疗量的三唑 - 三唑酮化合物的经皮递送方法。 用于预防或治疗受试者的基底细胞癌（BCC）。 治疗水平的三唑 - 三唑酮化合物如伊曲康唑经皮递送给受试者。 还提供了用于实践本发明方法的局部三唑 - 三唑酮组合物。
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43.发明申请REGULATORS OF THE HEDGEHOG PATHWAY, COMPOSITIONS AND USES RELATED THERETO 审中-公开HEDGEHOG路径的调节器，组件和与之相关的用途公开(公告)号：US20120135066A1
公开(公告)日：2012-05-31
申请号：US13363934
申请日：2012-02-01
IPC分类号： A61K31/4355 , A61P35/00 , A61K9/127
CPC分类号： C07D491/10 , A61K31/4355 , A61K31/58 , C07D491/048 , C07D519/00 , C07J69/00
摘要： The present invention makes available, inter alia, methods and reagents for modulating smoothened-dependent pathway activation. In certain embodiments, the subject methods can be used to counteract the phenotypic effects of unwanted activation of a hedgehog pathway, such as resulting from hedgehog gain-of-function, ptc loss-of-function or smoothened gain-of-function mutations.
摘要翻译： 本发明尤其可用于调节平滑依赖性途径活化的方法和试剂。 在某些实施方案中，本发明的方法可用于抵消刺猬蛋白途径的不期望的激活的表型效应，例如由刺猬蛋白获得功能，ptc功能丧失或平滑增益功能突变引起的表型效应。
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公开(公告)号：US08067608B2
公开(公告)日：2011-11-29
申请号：US10573945
申请日：2004-09-29
IPC分类号： C07D213/56 , A61K31/44
CPC分类号： C07D213/56 , C07D209/40 , C07D233/78 , C07D237/34 , C07D239/74 , C07D239/84 , C07D263/57 , C07D277/42 , C07D311/30 , C07D311/36 , C07D311/80 , C07D311/92 , C07D401/12 , C07D403/12 , C07D405/12 , C07D407/12 , C07D407/14 , C07D409/12 , C07D413/12 , C07D417/04 , C07D417/12 , C07D471/04 , C07D495/04 , C07D513/04
摘要： Aromatic compounds for treating various diseases and pathologies are disclosed. The methods use of such compounds are also provided. Accordingly, the present invention makes available methods and compositions for inhibiting aberrant growth states resulting from hedgehog gain-of-function, ptc loss-of-function or smoothened gain-of-function.
摘要翻译： 公开了用于治疗各种疾病和病症的芳族化合物。 还提供了这些化合物的使用方法。 因此，本发明提供了用于抑制由刺猬获得功能，ptc功能丧失或平滑获得功能引起的异常生长状态的可用方法和组合物。
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公开(公告)号：US07829333B2
公开(公告)日：2010-11-09
申请号：US11438933
申请日：2006-05-22
CPC分类号： C07K14/43577 , C07K14/46 , C07K14/47 , C07K14/4702 , G01N33/573 , G01N33/6872 , G01N2500/00
摘要： The present invention provides transcription factors associated with the hedgehog signaling pathway that are regulated by dephosphorylation by phosphatases. Hedgehog response elements (HRE) that interact with the dephosphorylated transcription factors are also provided as well as methods for identifying compounds that are phosphatase inhibitors. Methods of treating tumors in a subject by modulating the phosphorylation of the transcription factor are also included.
摘要翻译： 本发明提供与通过磷酸酶脱磷酸化调节的刺猬蛋白信号传导途径相关的转录因子。 还提供了与脱磷酸化转录因子相互作用的刺猬反应元件（HRE）以及用于鉴定作为磷酸酶抑制剂的化合物的方法。 还包括通过调节转录因子的磷酸化来治疗受试者的肿瘤的方法。
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46.发明申请HEDGEHOG SIGNALING AND CANCER STEM CELLS IN HEMATOPOIETIC CELL MALIGNANCIES 审中-公开肝细胞恶性疾病中的HEDGEHOG信号和癌细胞公开(公告)号：US20100080855A1
公开(公告)日：2010-04-01
申请号：US12558429
申请日：2009-09-11
申请人： Philip A. Beachy , Tannishtha Reya
发明人： Philip A. Beachy , Tannishtha Reya
IPC分类号： A61K33/36 , A61K31/343 , A61K31/497 , A61K31/506
CPC分类号： A61K31/343 , A61K31/497 , A61K31/506 , A61K33/36
摘要： The present disclosure relates generally to methods of treating hematopoietic cell malignancy in a subject by administering to the subject a Hedgehog (Hh) pathway antagonist, such as a Smoothen (Smo) antagonist alone or in combination with an ABL-kinase antagonist. Specifically, the disclosure relates to a method of treating hematopoietic cell malignancy in a subject by administering the Hh pathway antagonist, such as the Smo antagonist cyclopamine, in combination with the ABL-kinase antagonist imatinib.
摘要翻译： 本公开一般涉及通过向受试者施用单独或与ABL-激酶拮抗剂组合的刺激（Hh）途径拮抗剂如Smoothen（Smo）拮抗剂来治疗受试者的造血细胞恶性肿瘤的方法。 具体地，本公开涉及通过与ABL-激酶拮抗剂伊马替尼组合施用Hh途径拮抗剂，例如Smo拮抗剂环巴胺，治疗受试者的造血细胞恶性肿瘤的方法。
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公开(公告)号：US07462457B2
公开(公告)日：2008-12-09
申请号：US09943641
申请日：2001-08-30
申请人： Philip A. Beachy , Jussi Taipale
发明人： Philip A. Beachy , Jussi Taipale
CPC分类号： C12N15/1058 , A01K2217/05 , C07K14/705 , C12N15/1034 , G06Q50/22 , Y02A90/22
摘要： The present invention related to methods and reagents for generating and using activating mutations of receptors and ion channels.
摘要翻译： 本发明涉及用于产生和使用受体和离子通道活化突变的方法和试剂。
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公开(公告)号：US06942988B2
公开(公告)日：2005-09-13
申请号：US09969520
申请日：2001-09-24
申请人： Philip A. Beachy
发明人： Philip A. Beachy
IPC分类号： C07K14/435 , C12Q1/02
CPC分类号： C07K14/43581
摘要： The invention relates to hedgehog proteins that are involved in signaling developmental processes. The proteins of the invention modulate differentiation of neural plate. Also provided are methods for identifying compounds that modulate early events in development and more particularly to methods to identify compounds that modulate differentiation of neural plate using hedgehog proteins as ligands for the patched receptor.
摘要翻译： 本发明涉及涉及信号发育过程的刺猬蛋白。 本发明的蛋白质调节神经板的分化。 还提供了用于鉴定调节发育中的早期事件的化合物的方法，更具体地涉及鉴定使用刺猬蛋白作为修补受体的配体来调节神经板的分化的化合物的方法。
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