利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

49 条记录 (耗时 0.053 秒)

    Mucopolysaccharides having biological properties, preparation and method of use
    45.
    发明授权
    Mucopolysaccharides having biological properties, preparation and method of use 失效
    具有生物学特性的粘多糖，制备方法和使用方法

    公开(公告)号：US4500519A

    公开(公告)日：1985-02-19

    申请号：US323567

    申请日：1981-11-20

    申请人： Jean-Claude Lormeau ,  Maurice Petitou ,  Jean Choay

    发明人： Jean-Claude Lormeau ,  Maurice Petitou ,  Jean Choay

    IPC分类号： C08B37/10 ,  G01N33/86 ,  A61K31/725

    CPC分类号： A61K31/715 ,  C08B37/0075 ,  G01N33/86 ,  G01N2333/8128 ,  G01N2400/40 ,  Y10S514/822

    摘要： Mucopolysaccharides biologically active and more specific than heparin, particularly with respect to the blood factor Xa. These mucopolysaccharides may be obtained by partial depolymerisation, under controlled conditions, of heparin, by the action of a chemical agent such as nitrous acid. The conditions implemented allow the preparation of mucopolysaccharides having a USP titer lower than that of the starting heparin and a Yin-Wessler titer at least equal to that of said heparin. These products may be used particularly as antithrombotic drugs.

    摘要翻译： 粘多糖具有生物活性，比肝素更具体，特别是血液因子Xa。 这些粘多糖可以通过在控制条件下肝素通过化学试剂如亚硝酸的作用进行部分解聚来获得。 实施的条件允许制备具有低于起始肝素的USP滴度的粘多糖和至少等于所述肝素的Yin-Wessler效价的粘多糖。 这些产品可以特别用作抗血栓药物。

    Process of preparing mixed heparin salts
    47.
    发明授权
    Process of preparing mixed heparin salts 失效
    制备混合肝素盐的方法

    公开(公告)号：US4168377A

    公开(公告)日：1979-09-18

    申请号：US459712

    申请日：1974-04-10

    申请人： Jean Choay ,  Jean Goulay ,  Jean-Louis Amiot

    发明人： Jean Choay ,  Jean Goulay ,  Jean-Louis Amiot

    IPC分类号： C08B37/10

    CPC分类号： C08B37/0075 ,  Y10S514/822

    摘要： Mixed or simple heparin salt having a reduced amount of a selected metal ion alone or with another metal ion in a mixed heparin. A heparin salt having a reduced sodium content being essentially sodium free and having a selectively high calcium or other selected salt content. A process for making these heparin salts by reaction with the selected metal salt, including, optionally, dialysis or precipitation. A typical heparin salt is a calcium heparin essentially free of sodium (like containing less than about 1% by weight of sodium), or mixed calcium-sodium heparin with a limited, predetermined content of sodium. Drug compositions containing these heparin salts and a pharmaceutical carrier. The drugs made from these heparin salts are useful as anti-coagulants.

    摘要翻译： 混合或简单的肝素盐，其中单独选择的金属离子量与混合肝素中的另一种金属离子的量减少。 具有降低的钠含量的肝素盐基本上不含钠且具有选择性高钙或其它选择的盐含量。 通过与选择的金属盐反应制备这些肝素盐的方法，包括任选的透析或沉淀。 典型的肝素盐是基本上不含钠的钙肝素（如含有少于约1重量％的钠）或具有有限的预定含量的钠的混合的钙 - 钠肝素。 含有这些肝素盐和药物载体的药物组合物。 由这些肝素盐制成的药物可用作抗凝剂。

    Pharmaceutical composition containing vitamin B.sub.12, process of making the same and method of treatment
    48.
    发明授权
    Pharmaceutical composition containing vitamin B.sub.12, process of making the same and method of treatment 失效
    含有维生素B的药物组合物{HD 12 {B，制备方法和治疗方法

    公开(公告)号：US4007266A

    公开(公告)日：1977-02-08

    申请号：US553434

    申请日：1975-02-26

    申请人： Jean Choay

    发明人： Jean Choay

    IPC分类号： A61K8/44 ,  A61K8/67 ,  A61K8/98 ,  A61K31/44 ,  A61Q19/00 ,  A61Q19/08 ,  A61K31/48 ,  A61K31/195 ,  A61K31/68 ,  A61K31/70

    CPC分类号： A61K8/44 ,  A61K31/44 ,  A61K8/673 ,  A61K8/982 ,  A61Q19/00 ,  A61Q19/08

    摘要： A pharmaceutical composition for the treatment of disorders in the formation or regeneration of the cutaneous connective tissue including disorders due to aging of the skin, which composition comprises a homogeneous mixture of vitamin B.sub.12 in an amount effective for the above treatment and a carrier vehicle therefor. The carrier vehicle is a fatty skin cream of a pH between about 4 and 7 which is non-oxidizing and non-reducing and is pharmaceutically acceptable for repeated applications to the skin over prolonged periods of time.

    摘要翻译： 一种用于治疗皮肤结缔组织形成或再生中的疾病的药物组合物，包括皮肤老化引起的疾病，该组合物包含对上述治疗有效量的维生素B12的均匀混合物及其载体载体。 载体载体是约4至7之间的pH值为非氧化性和非还原性的脂肪护肤霜，并且其药学上可接受以在长时间内重复施用于皮肤。