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81 条记录 (耗时 0.063 秒)

    Compounds and Compositions
    41.
    发明申请
    Compounds and Compositions 有权
    化合物和组合物

    公开(公告)号：US20130280185A1

    公开(公告)日：2013-10-24

    申请号：US13996038

    申请日：2010-12-21

    申请人： Ravi Subramanyam ,  Guofeng Xu ,  Jennifer Gronlund ,  Shamim Ansari

    发明人： Ravi Subramanyam ,  Guofeng Xu ,  Jennifer Gronlund ,  Shamim Ansari

    IPC分类号： C07C39/373 ,  A61K8/34 ,  A61Q11/00

    CPC分类号： C07C39/373 ,  A61K8/347 ,  A61Q11/00 ,  A61Q19/06

    摘要： Described herein are compounds of Formula (I): or a salt thereof; wherein: R1 and R5 are independently selected from H, OH and alkoxy; R2-R4 and R6-R8 are independently selected from H, OH, F, Cl, Br, and I; R9 and R10 are independently selected from H, alkyl, alkenyl, alkynyl, and aryl; with the proviso that: at least one of R land R5 is OH or alkoxy; and at least one of CR2-R4 and R6-R8 is F, Cl, Br or I; compositions comprising said compounds; and methods of making and using the same.

    摘要翻译： 本文描述的是式（I）的化合物或其盐; 其中：R 1和R 5独立地选自H，OH和烷氧基; R2-R4和R6-R8独立地选自H，OH，F，Cl，Br和I; R 9和R 10独立地选自H，烷基，烯基，炔基和芳基; 条件是：R land R5中的至少一个是OH或烷氧基; 并且CR 2 -R 4和R 6 -R 8中的至少一个为F，Cl，Br或I; 包含所述化合物的组合物; 以及制作和使用它们的方法。

    Antibacterial 5,5'-disubstituted 3,3'-dialkoxy-2,2'-dihydroxy-1,1'-biphenyl compounds and related methods
    45.
    发明申请
    Antibacterial 5,5'-disubstituted 3,3'-dialkoxy-2,2'-dihydroxy-1,1'-biphenyl compounds and related methods 审中-公开
    抗菌5,5'-二取代3,3'-二烷氧基-2,2'-二羟基-1,1'-联苯化合物及相关方法

    公开(公告)号：US20060233722A1

    公开(公告)日：2006-10-19

    申请号：US11374834

    申请日：2006-03-14

    申请人： Ravi Subramanyam

    发明人： Ravi Subramanyam

    IPC分类号： A61K9/68 ,  A61K8/34

    CPC分类号： A61K31/09 ,  A61K8/347 ,  A61Q11/00

    摘要： The invention provides an antiplaque oral composition that includes an orally acceptable carrier; and an antibacterially effective amount of a compound of structure (I) In the structure, R1 and R2 are independently selected from a lower C1-4 alkyl group and R3 and R4 are independently an alkenyl or alkyl group having from 1 to 20 carbon atoms. Also included in the invention are toothpastes or tooth gels that include at least one humectant; at least one abrasive compound; and an antibacterially effective amount of the compound represented by the structure of formula (I). Also provided are methods of inhibiting bacterial growth in the oral cavity of an animal by application of the compound of formula (I).

    摘要翻译： 本发明提供一种抗口腔组合物，其包含口服可接受的载体; 和抗菌有效量的结构（I）化合物在结构中，R 1和R 2独立地选自低级C 1-4烷基， R 3和R 4独立地是具有1至20个碳原子的烯基或烷基。 本发明还包括牙膏或牙膏，其包括至少一种湿润剂; 至少一种磨料化合物; 和抗菌有效量的由式（I）的结构表示的化合物。 还提供了通过施用式（I）化合物来抑制动物口腔中的细菌生长的方法。

    Surfactant system for increasing dental tissue antibacterial agent uptake
    46.
    发明授权
    Surfactant system for increasing dental tissue antibacterial agent uptake 失效
    用于增加牙科组织抗菌剂摄取的表面活性剂体系

    公开(公告)号：US06451291B1

    公开(公告)日：2002-09-17

    申请号：US09686639

    申请日：2000-10-11

    申请人： Xiaoyan Liu ,  Malcolm Williams ,  Ravi Subramanyam

    发明人： Xiaoyan Liu ,  Malcolm Williams ,  Ravi Subramanyam

    IPC分类号： A61K716

    CPC分类号： A61Q11/00 ,  A61K8/34 ,  A61K8/44 ,  A61K8/463

    摘要： An oral composition comprising in an orally acceptable vehicle, an effective antiplaque amount of an halogenated diphenyl ether or phenolic antibacterial compound, and an amount of an mixed anionic/zwitterionic surfactant system which is effective to increase the uptake of the antibacterial compound to dental tissue so as to enhance the therapeutic efficacy of the administered antibacterial compound.

    摘要翻译： 一种口服组合物，其包含口腔可接受的载体，有效抗牙釉质量的卤化二苯醚或酚类抗菌化合物，以及一定量的混合阴离子/两性离子表面活性剂体系，其有效增加抗菌化合物对牙齿组织的吸收 以提高施用的抗菌化合物的治疗功效。

    Alkoxylated alkyl glyceryl ether sulfonates and method of preparing
    50.
    发明授权
    Alkoxylated alkyl glyceryl ether sulfonates and method of preparing 失效
    烷氧基化烷基甘油醚磺酸盐及其制备方法

    公开(公告)号：US5672740A

    公开(公告)日：1997-09-30

    申请号：US465778

    申请日：1995-06-06

    申请人： Ravi Subramanyam ,  Suman Kumar Chopra

    发明人： Ravi Subramanyam ,  Suman Kumar Chopra

    IPC分类号： C07C303/02 ,  C07C303/44 ,  C07C309/10 ,  C07C305/00

    CPC分类号： C07C303/44 ,  C07C303/02

    摘要： A process for preparing alkoxylated alkyl glyceryl ether sulfonates which comprises reacting in the presence of water and the absence of ethanol a mixture of alkoxylated glycidyl ethers having as the major quantity of alkoxylated material ##STR1## with a salt of a sulfite bisulfite salt mixture at a temperature below about 110.degree. C. wherein R is an alkyl or alkenyl of 10 to 20 carbon atoms, inclusive, R' is hydrogen or methyl and n has an average value of 1 to 10 and obtaining a sulfonated alkoxylated product having as a major quantity of the alkoxylated material a salt of R(OCH.sub.2 CHR.sup.1).sub.n OCH.sub.2 CHOHCH.sub.2 SO.sub.3 -

    摘要翻译： 一种制备烷氧基化烷基甘油醚磺酸盐的方法，其包括在水和不存在乙醇存在下，将烷氧基化缩水甘油醚与烷基化亚硫酸氢盐混合物的盐在一个 温度低于约110℃，其中R为10-20个碳原子的烷基或烯基，包括端值，R'为氢或甲基，n的平均值为1至10，得到主要量的磺化烷氧基化产物 的烷氧基化物质是R（OCH 2 CHR 1）n OCH 2 CHOHCH 2 SO 3 -