公开(公告)号：US5122592A

公开(公告)日：1992-06-16

申请号：US402164

申请日：1989-09-01

Applicant: Yash P. Khanna ,  Georgette Chomyn ,  Rakesh Kumar ,  Annemarie C. Reimschuessel

Inventor： Yash P. Khanna ,  Georgette Chomyn ,  Rakesh Kumar ,  Annemarie C. Reimschuessel

IPC: C08F6/00 ,  C08J3/00

CPC classification number: C08J3/00 ,  C08F6/00 ,  C08J2327/18

Abstract: This invention relates to a process of preparing polytetrafluoroethylene comprising one or more fractions of polyethylene having a melting point of greater than about 340.degree. C. by subjecting a polytetrafluoroethylene to a shear at elevated temperature.

Abstract translation: 本发明涉及通过使聚四氟乙烯在升高的温度下进行剪切而制备聚四氟乙烯的方法，该方法包括熔点大于约340℃的一种或多种聚乙烯部分。

公开(公告)号：US08940616B2

公开(公告)日：2015-01-27

申请号：US13559626

申请日：2012-07-27

Applicant: Rama Krishna Kotlanka ,  Rakesh Kumar ,  Premachandran Chirayarikathuveedu Sankarapillai ,  Huamao Lin ,  Pradeep Yelehanka

Inventor： Rama Krishna Kotlanka ,  Rakesh Kumar ,  Premachandran Chirayarikathuveedu Sankarapillai ,  Huamao Lin ,  Pradeep Yelehanka

IPC: H01L21/30 ,  H01L21/46 ,  H01L21/76 ,  H01L21/00

CPC classification number: B81B7/0006 ,  B81C1/00269 ,  B81C3/001 ,  B81C2201/0115 ,  H01L21/50 ,  H01L23/481 ,  H01L23/5226 ,  H01L2924/0002 ,  H01L2924/00

Abstract: A bonded device having at least one porosified surface is disclosed. The porosification process introduces nanoporous holes into the microstructure of the bonding surfaces of the devices. The material property of a porosified material is softer as compared to a non-porosified material. For the same bonding conditions, the use of the porosified bonding surfaces enhances the bond strength of the bonded interface as compared to the non-porosified material.

Abstract translation: 公开了具有至少一个孔隙化表面的粘合装置。 孔化过程将纳米多孔孔引入装置的结合表面的微结构中。 与非孔隙化材料相比，孔化材料的材料性质更软。 对于相同的接合条件，与非孔隙化材料相比，使用孔隙化粘合表面增强了粘结界面的粘结强度。

公开(公告)号：US20130172378A1

公开(公告)日：2013-07-04

申请号：US13820834

申请日：2011-09-02

Applicant: Rakesh Kumar

Inventor： Rakesh Kumar

IPC: A61K31/506

CPC classification number: A61K31/506 ,  A61K9/0019 ,  A61K9/10 ,  A61K9/4858 ,  A61K31/185 ,  A61P35/00 ,  A61K2300/00

Abstract: A novel combination comprising the VEGFR inhibitor 5-[[4-[(2,3-dimethyl-2H-indazol-6-yl)methylamino]-2-pyrimidinyl]amino]-2-methylbenzenesulfonamide, or a pharmaceutically acceptable salt thereof, with a B-Raf inhibitor, particularly N-(3-[5-(2-Amino-4-pyrimidinyl)-2-(1,1-dimethylethyl)-1,3-thiazol-4-yl]-2-fluorophenyl)-2,6-difluorobenzenesulfonamide or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising the same and methods of using such combinations and compositions in the treatment of conditions in which the inhibition of VEGFR and/or B-Raf is beneficial.

Abstract translation: 包含VEGFR抑制剂5 - [[4 - [（2,3-二甲基-2H-吲唑-6-基）甲基氨基] -2-嘧啶基]氨基] -2-甲基苯磺酰胺或其药学上可接受的盐的新型组合， 与B-Raf抑制剂，特别是N-（3- [5-（2-氨基-4-嘧啶基）-2-（1,1-二甲基乙基）-1,3-噻唑-4-基] -2-氟苯基 ）-2,6-二氟苯磺酰胺或其药学上可接受的盐，包含其的药物组合物以及在治疗VEGFR和/或B-Raf的抑制有益的条件下使用这些组合和组合物的方法。

公开(公告)号：US20130166472A1

公开(公告)日：2013-06-27

申请号：US13335430

申请日：2011-12-22

Applicant: Frank Brunswig ,  Rakesh Kumar ,  Preeta K ,  Vijay G

Inventor： Frank Brunswig ,  Rakesh Kumar ,  Preeta K ,  Vijay G

IPC: G06Q10/06

CPC classification number: G06Q10/10 ,  G06Q10/06 ,  H04L67/02

Abstract: A method to model a business object is disclosed. An analysis module analyzes elements of a business object. A modeling module models business object logic based on the elements of the business object. An implementation module implements the modeled business object logic. A repository stores the modeled business object logic. A business object runtime module executes the modeled business object logic.

Abstract translation: 公开了一种用于建模业务对象的方法。 分析模块分析业务对象的元素。 建模模块基于业务对象的元素来模拟业务对象逻辑。 实现模块实现建模的业务对象逻辑。 存储库存储建模的业务对象逻辑。 业务对象运行时模块执行建模的业务对象逻辑。

公开(公告)号：US20130109705A1

公开(公告)日：2013-05-02

申请号：US13699077

申请日：2011-05-19

Applicant: Tona M. Gilmer ,  Rakesh Kumar

Inventor： Tona M. Gilmer ,  Rakesh Kumar

IPC: A61K31/519 ,  A61K31/517

CPC classification number: A61K31/519 ,  A61K9/2018 ,  A61K9/2054 ,  A61K9/4858 ,  A61K31/517 ,  A61K2300/00

Abstract: The present invention relates to a method of treating cancer in a human and to pharmaceutical combinations useful in such treatment. In particular, the method relates to a cancer treatment method that includes administering N-{3-Chloro-4-[(3-fluorobenzyl)oxy]phenyl}-6-[5-({[2-(methanesulphonyl)ethyl]amino}methyl)-2-furyl]-4-quinazolinamine, or a pharmaceutically acceptable hydrate and/or salt thereof, and N-{3-[3-cyclopropyl-5-(2-fluoro-4-iodo-phenylamino)6,8-dimethy;-2,4,7-trioxo-3,4,6,7-tetrahydro-2H-pyrido[4,3-d]pyrimidin-1-yl]phenyl}acetamide, or a pharmaceutically acceptable salt or solvate thereof, to a human in need thereof.

Abstract translation: 本发明涉及一种治疗人类癌症的方法和用于治疗的药物组合物。 特别地，该方法涉及一种癌症治疗方法，其包括给予N- {3-氯-4 - [（3-氟苄基）氧基]苯基} -6- [5 - （{[2-（甲磺酰基）乙基]氨基 }甲基）-2-呋喃基] -4-喹唑啉胺或其药学上可接受的水合物和/或盐和N- {3- [3-环丙基-5-（2-氟-4-碘 - 苯基氨基） -2,4,7-三氧代-3,4,6,7-四氢-2H-吡啶并[4,3-d]嘧啶-1-基]苯基}乙酰胺或其药学上可接受的盐或溶剂化物 对有需要的人。

公开(公告)号：US20120322817A1

公开(公告)日：2012-12-20

申请号：US13497576

申请日：2010-09-23

Applicant: Melissa Dumble ,  Tona Gilmer ,  Rakesh Kumar ,  Peter F. Lebowitz ,  Shannon Renee Morris ,  Sylvie Laquerre

Inventor： Melissa Dumble ,  Tona Gilmer ,  Rakesh Kumar ,  Peter F. Lebowitz ,  Shannon Renee Morris ,  Sylvie Laquerre

IPC: A61K31/519 ,  A61P35/02 ,  A61P35/00

CPC classification number: A61K31/519 ,  A61K9/145 ,  A61K9/2054 ,  A61K31/4155 ,  A61K2300/00

Abstract: The present invention relates to a method of treating cancer in a human and to pharmaceutical combinations useful in such treatment. In particular, the method relates to a cancer treatment method that includes administering N-{3-[3-cyclopropyl-5-(2-fluoro-4-iodo-phenylamino)-6,8-dimethyl-2,4,7-trioxo-3,4,6,7-tetrahydro-2H-pyrido[4,3-d]pyrimidin-1-yl]phenyl}acetamide, or a pharmaceutically acceptable salt or solvate thereof, and N-{(1S)-2-amino-1-[(3,4-difluorophenyl)methyl]ethyl}-5-chloro-4-(4-chloro-1-methyl-1H-pyrazol-5-yl)-2-furancarboxamide, or a pharmaceutically acceptable salt thereof, to a human in need thereof.

Abstract translation: 本发明涉及一种治疗人类癌症的方法和用于治疗的药物组合物。 特别地，该方法涉及一种癌症治疗方法，其包括给予N- {3- [3-环丙基-5-（2-氟-4-碘 - 苯基氨基）-6,8-二甲基-2,4,7- 三氧代-3,4,6,7-四氢-2H-吡啶并[4,3-d]嘧啶-1-基]苯基}乙酰胺或其药学上可接受的盐或溶剂化物，和N - {（1S）-2 - 氨基-1 - [（3,4-二氟苯基）甲基]乙基} -5-氯-4-（4-氯-1-甲基-1H-吡唑-5-基）-2-呋喃甲酰胺或其药学上可接受的 其盐，需要其的人。

公开(公告)号：US20120283278A1

公开(公告)日：2012-11-08

申请号：US13497580

申请日：2010-09-23

Applicant: Melissa Dumble ,  Tona Gilmer ,  Rakesh Kumar ,  Peter F. Lebowitz ,  Shannon Renae Morris ,  Sylvie Laquerre

Inventor： Melissa Dumble ,  Tona Gilmer ,  Rakesh Kumar ,  Peter F. Lebowitz ,  Shannon Renae Morris ,  Sylvie Laquerre

IPC: A61K31/519 ,  A61P35/02 ,  A61P35/00

CPC classification number: A61K31/519 ,  A61K9/2018 ,  A61K9/2054 ,  A61K9/4858 ,  A61K31/4155 ,  A61K2300/00

Abstract: The present invention relates to a method of treating cancer in a human and to pharmaceutical combinations useful in such treatment. In particular, the method relates to a cancer treatment method that includes administering N-{3-[3-cyclopropyl-5-(2-fluoro-4-iodo-phenylamino)-6,8-dimethyl-2,4,7-trioxo-3,4,6,7-tetrahydro-2H-pyrido[4,3-d]pyrimidin-1-yl]phenyl}acetamide, or a pharmaceutically acceptable salt or solvate thereof, and N-{(1S)-2-amino-1-[(3-fluorophenyl)methyl]ethyl}-5-chloro-4-(4-chloro-1-methyl-1H-pyrazol-5-yl)-2-thiophenecarboxamide, or a pharmaceutically acceptable salt thereof, to a human in need thereof.

Abstract translation: 本发明涉及一种治疗人类癌症的方法和用于治疗的药物组合物。 特别地，该方法涉及一种癌症治疗方法，其包括给予N- {3- [3-环丙基-5-（2-氟-4-碘 - 苯基氨基）-6,8-二甲基-2,4,7- 三氧代-3,4,6,7-四氢-2H-吡啶并[4,3-d]嘧啶-1-基]苯基}乙酰胺或其药学上可接受的盐或溶剂化物，和N - {（1S）-2 - 氨基-1 - [（3-氟苯基）甲基]乙基} -5-氯-4-（4-氯-1-甲基-1H-吡唑-5-基）-2-噻吩甲酰胺或其药学上可接受的盐 ，对有需要的人。

公开(公告)号：US08289390B2

公开(公告)日：2012-10-16

申请号：US11192486

申请日：2005-07-28

Applicant: Manoj Aggarwal ,  Keith Hanna ,  Harpreet Sawhney ,  Vincent Paragano ,  Rakesh Kumar ,  Supun Samarasekera ,  Aydin Arpa ,  Thomas Germano ,  Tao Zhao ,  David Kalokitis ,  David R. Patterson

Inventor： Manoj Aggarwal ,  Keith Hanna ,  Harpreet Sawhney ,  Vincent Paragano ,  Rakesh Kumar ,  Supun Samarasekera ,  Aydin Arpa ,  Thomas Germano ,  Tao Zhao ,  David Kalokitis ,  David R. Patterson

IPC: H04N7/18

CPC classification number: G01S3/7864 ,  G06K9/00771 ,  G06K9/32 ,  G06K9/6289 ,  G06T7/246 ,  G06T7/285 ,  G06T7/292 ,  G06T7/70 ,  G06T2207/30232 ,  G06T2207/30241 ,  G08B13/19608 ,  G08B13/19641 ,  G08B13/19645 ,  G08B13/19682 ,  H04N5/2224 ,  H04N5/76 ,  H04N13/204 ,  H04N13/239 ,  H04N13/243 ,  H04N2013/0081 ,  H04N2013/0085

Abstract: A sentient system combines detection, tracking, and immersive visualization of a cluttered and crowded environment, such as an office building, terminal, or other enclosed site using a network of stereo cameras. A guard monitors the site using a live 3D model, which is updated from different directions using the multiple video streams. As a person moves within the view of a camera, the system detects its motion and tracks the person's path, it hands off the track to the next camera when the person goes out of that camera's view. Multiple people can be tracked simultaneously both within and across cameras, with each track shown on a map display. The track system includes a track map browser that displays the tracks of all moving objects as well as a history of recent tracks and a video flashlight viewer that displays live immersive video of any person that is being tracked.

Abstract translation: 有声系统使用立体相机网络将杂乱无章的环境（例如办公楼，终端或其他封闭场所）的检测，跟踪和沉浸式可视化相结合。 守卫使用实时3D模型监视站点，该模型使用多个视频流从不同方向更新。 当一个人在相机的视野内移动时，系统会检测到其运动并跟踪人的路径，当人离开该相机视图时，它将该轨迹移离下一个相机。 可以在摄像机内和摄像机上同时跟踪多个人，每个轨道显示在地图显示上。 轨道系统包括轨迹映射浏览器，其显示所有运动对象的轨迹以及最近轨道的历史以及显示正在被跟踪的任何人的现场沉浸式视频的视频手电筒观看者。

公开(公告)号：US20120196886A1

公开(公告)日：2012-08-02

申请号：US13500241

申请日：2010-10-08

Applicant: Melissa Dumble ,  Tona Gilmer ,  Rakesh Kumar ,  Peter F. Lebowitz ,  Shannon Renae Morris ,  Sylvie Laquerre

Inventor： Melissa Dumble ,  Tona Gilmer ,  Rakesh Kumar ,  Peter F. Lebowitz ,  Shannon Renae Morris ,  Sylvie Laquerre

IPC: A61K31/506 ,  A61P35/02 ,  A61P35/00

CPC classification number: A61K31/506 ,  A61K31/4155 ,  A61K45/06 ,  A61K2300/00

Abstract: The present invention relates to a method of treating cancer in a human and to pharmaceutical combinations useful in such treatment. In particular, the method relates to a cancer treatment method that includes administering N-{3-[5-(2-Amino-4-pyrimidinyl)-2-(1,1-dimethylethyl)-1,3-thiazol-4-yl]-2-fluorophenyl}-2,6-difluorobenzenesulfonamide or a pharmaceutically acceptable salt thereof, and N-{(1S)-2-amino-1-[(3,4-difluorophenyl)methyl]ethyl}-5-chloro-4-(4-chloro-1-methyl-1H-pyrazol-5-yl)-2-furancarboxamide, or a pharmaceutically acceptable salt thereof, to a human in need thereof.

Abstract translation: 本发明涉及一种治疗人类癌症的方法和用于治疗的药物组合物。 特别地，该方法涉及一种癌症治疗方法，其包括给予N- {3- [5-（2-氨基-4-嘧啶基）-2-（1,1-二甲基乙基）-1,3-噻唑-4-基） 吡啶-2-基] -2-氟苯基} -2,6-二氟苯磺酰胺或其药学上可接受的盐和N - {（1S）-2-氨基-1 - [（3,4-二氟苯基）甲基]乙基} -4-（4-氯-1-甲基-1H-吡唑-5-基）-2-呋喃甲酰胺或其药学上可接受的盐给有需要的人。

公开(公告)号：US08174568B2

公开(公告)日：2012-05-08

申请号：US11949433

申请日：2007-12-03

Applicant: Supun Samarasekera ,  Rakesh Kumar ,  Taragay Oskiper ,  Zhiwei Zhu ,  Oleg Naroditsky ,  Harpreet Sawhney

Inventor： Supun Samarasekera ,  Rakesh Kumar ,  Taragay Oskiper ,  Zhiwei Zhu ,  Oleg Naroditsky ,  Harpreet Sawhney

IPC: H04N7/00 ,  H04N7/18 ,  G01C22/00 ,  G01C21/30

CPC classification number: G06K9/00791 ,  B60R1/00 ,  G01C21/005 ,  G01C21/165 ,  G06K9/3216 ,  G06K9/4642 ,  G06K9/52 ,  G06K9/6215 ,  G06T7/74 ,  H04N13/239 ,  H04N2013/0081

Abstract: A system and method for efficiently locating in 3D an object of interest in a target scene using video information captured by a plurality of cameras. The system and method provide for multi-camera visual odometry wherein pose estimates are generated for each camera by all of the cameras in the multi-camera configuration. Furthermore, the system and method can locate and identify salient landmarks in the target scene using any of the cameras in the multi-camera configuration and compare the identified landmark against a database of previously identified landmarks. In addition, the system and method provide for the integration of video-based pose estimations with position measurement data captured by one or more secondary measurement sensors, such as, for example, Inertial Measurement Units (IMUs) and Global Positioning System (GPS) units.

Abstract translation: 一种用于使用由多个摄像机捕获的视频信息有效地定位目标场景中的感兴趣对象的系统和方法。 该系统和方法提供多摄像机视觉测距，其中由多摄像机配置中的所有摄像机为每个摄像机生成姿态估计。 此外，系统和方法可以使用多摄像机配置中的任何摄像机来定位和识别目标场景中的突出地标，并将识别的地标与先前识别的地标的数据库进行比较。 另外，该系统和方法提供了基于视频的姿势估计与由一个或多个二次测量传感器捕获的位置测量数据的集成，例如惯性测量单元（IMU）和全球定位系统（GPS）单元 。