公开(公告)号：US20110095234A1

公开(公告)日：2011-04-28

申请号：US12606469

申请日：2009-10-27

申请人： Robert Hickey

发明人： Robert Hickey

IPC分类号： C01B3/36

CPC分类号： C10K1/102 ,  B01D53/1406 ,  B01D53/1425 ,  B01D2257/308 ,  B01D2257/406 ,  B01D2257/408 ,  B01D2257/80 ,  C01B3/52 ,  C01B2203/048 ,  C01B2203/0485 ,  C02F3/302 ,  C02F2103/18 ,  Y02E50/343

摘要： A method for the high removal of ammonia, COS and HCN from syngas (along with some polishing of particulates) in a cost effective and environmentally benign and sustainable fashion, with the need for little to no chemical addition by using a combination of water based gas scrubbing, HCN scrubbing and biological processing steps.

摘要翻译： 一种以成本有效和环境友好和可持续的方式从合成气中高度去除氨，COS和HCN（以及一些微粒抛光）的方法，需要通过使用水基气体的组合进行少量化学添加 洗涤，HCN洗涤和生物处理步骤。

公开(公告)号：US20060073477A1

公开(公告)日：2006-04-06

申请号：US10238871

申请日：2002-09-11

申请人： Linda Malkas ,  Robert Hickey ,  Pamela Bechtel

发明人： Linda Malkas ,  Robert Hickey ,  Pamela Bechtel

IPC分类号： C12Q1/68 ,  C07K16/40

CPC分类号： C07K16/18 ,  A61K38/00 ,  C07K16/30 ,  C07K16/40 ,  G01N33/5008 ,  G01N33/5011 ,  G01N33/5044 ,  G01N33/5091 ,  G01N33/57488 ,  G01N2800/52

摘要： Antibodies which specifically bind to components of the DNA synthesome which are altered in malignant cells are disclosed. These antibodies can be used, inter alia, to diagnose, prognoses, and treat malignancy and in assays to screen cells, tissues, and body fluids for the presence of a malignant phenotype. These antibodies can be further used to identify test compounds having the ability to suppress the malignant phenotype in a cell by assaying for the ability to inhibit or block the function of an altered component of the DNA synthesome associated with the malignant phenotype. Further, disclosed herein are methods and kit for minimally invasively detecting the presence of neoplasms and malignant conditions using easily obtainable body fluids, such as blood, plasma, lymph, pleural fluid, spinal fluid, saliva, sputum, urine, and semen, for example, to both detect the presence of cancer as well as assess the stage of the disease and the prognosis of the patient. By detecting the presence of an altered form of a component of the DNA synthesome in body fluid, one can diagnose and prognose malignancy. The disclosed method and kit therefor can be used as a diagnostic biomarker for malignancy as well as a means of monitoring the progress and effectiveness of therapeutics.

摘要翻译： 公开了特异性结合恶性细胞中改变的DNA合成物组分的抗体。 这些抗体尤其可用于诊断，预后和治疗恶性肿瘤，并用于筛选细胞，组织和体液以测定恶性表型的存在。 这些抗体可以进一步用于鉴定具有抑制或阻断与恶性表型相关的DNA合成物的改变的组分的功能的能力来抑制细胞中恶性表型的能力的测试化合物。 此外，本文公开了使用容易获得的体液（例如血液，血浆，淋巴，胸膜液，脊髓液，唾液，痰液，尿液和精液）来最小程度地侵入性地检测赘生物和恶性病症的存在的方法和试剂盒，例如 ，以检测癌症的存在以及评估疾病的阶段和患者的预后。 通过检测体液中DNA合成物组分的改变形式的存在，可以诊断和预测恶性肿瘤。 所公开的方法和试剂盒可用作恶性肿瘤的诊断性生物标志物，以及监测治疗进展和有效性的手段。

公开(公告)号：US20050039341A1

公开(公告)日：2005-02-24

申请号：US10643094

申请日：2003-08-18

申请人： Robert Hickey

发明人： Robert Hickey

IPC分类号： G01C9/10 ,  G01C9/26 ,  G01C9/28

CPC分类号： G01C9/28

摘要： A box level including an elongate body, plumb vials, and spaced hand-holds having outer edges together defining first and second parallel application planes beyond first and second face planes of the elongate body, and further including hang openings in the elongate body near the opposite ends thereof and hang liners secured in the hang openings, each hang liner having first and second outer rims coplanar with the first and second application planes. The box level provides enlarged work application surfaces in a reliable manner not susceptible to dislodgement from long use and abuse.

公开(公告)号：US20150224420A1

公开(公告)日：2015-08-13

申请号：US14176021

申请日：2014-02-07

申请人： Robert Hickey

发明人： Robert Hickey

IPC分类号： B01D3/00 ,  B01D53/26 ,  B01D3/14

CPC分类号： B01D3/002 ,  B01D3/143 ,  B01D3/145 ,  B01D3/36

摘要： Improved processes are disclosed for obtaining discrete ethanol and at least one discrete product containing a higher boiling alcohol from an aqueous fermentation broth. In the processes a vaporous, azeotropic mixture is obtained from the fermentation broth through fractionation by distillation and is maintained at a temperature sufficient to effect dehydration without condensation of ethanol and the at least one higher alcohol. The dehydrated mixture of alcohols is further fractionated by distillation to provide a dehydrated, ethanol-rich product and a dehydrated, higher alcohol-rich product.

摘要翻译： 公开了改进的方法以从水性发酵液中获得离散乙醇和含有较高沸点醇的至少一种离散产物。 在该方法中，通过蒸馏分馏从发酵液中获得蒸气共沸混合物，并保持在足以实现脱水而不会使乙醇和至少一种高级醇缩合的温度。 通过蒸馏将脱水的醇混合物进一步分馏，以提供脱水的富含乙醇的产物和脱水的高级醇富产物。

公开(公告)号：US08980597B2

公开(公告)日：2015-03-17

申请号：US13243347

申请日：2011-09-23

申请人： Robert Hickey ,  Steven L. Donnellan

发明人： Robert Hickey ,  Steven L. Donnellan

IPC分类号： C12P7/06 ,  C12P1/04 ,  C12P7/04 ,  C12P7/24 ,  C12P7/40

CPC分类号： C12P7/04 ,  C12P7/06 ,  C12P7/16 ,  C12P7/24 ,  C12P7/40 ,  C12P7/54 ,  Y02E50/10 ,  Y02E50/17

摘要： Processes are disclosed for the low energy, anaerobic bioconversion of hydrogen and carbon monoxide in a gaseous substrate stream to oxygenated organic compounds such as ethanol by contact with microorganisms in a fermentation system with high conversion efficiency of both hydrogen and carbon monoxide. The processes of this invention use a pre-reactor and a deep, tank reactor in gaseous substrate flow sequence to obtain high conversion of gas substrate without undue risk of carbon monoxide inhibition.

摘要翻译： 公开了用于在具有高转化效率的氢气和一氧化碳的发酵系统中通过与微生物接触的气态底物物流中的氢和一氧化碳的低能，厌氧生物转化为含氧有机化合物如乙醇的方法。 本发明的方法使用气态底物流程序列中的预反应器和深槽反应器，以获得气体底物的高转化率，而不会产生一氧化碳抑制的过度风险。

公开(公告)号：US08486359B2

公开(公告)日：2013-07-16

申请号：US13190355

申请日：2011-07-25

申请人： Robert Hickey

发明人： Robert Hickey

IPC分类号： C01C3/00

CPC分类号： C01C1/26 ,  C10G2300/1011 ,  C10K1/08 ,  Y02P30/20

摘要： The processes are utilized to recover ammonium from waste water using CO2 acidified absorption water. The process is particularly suited for utilization of cellular matter and a CO2 rich tail gas from a syngas fermentation process and derives significant benefit from the recovery of ammonium bicarbonate and ammonium carbonate. Ammonia and ammonium are recovered from the treatment of the syngas as an ammonium rich solution, at least a portion of which is recycled to the fermentation zone to aid in the production of liquid products. A carbon dioxide rich gas produced by fermentation is used to capture the ammonia and ammonium, forming the ammonium rich solution.

摘要翻译： 该方法用于使用CO2酸化吸收水从废水中回收铵。 该方法特别适用于从合成气发酵过程中利用细胞物质和富含CO 2的尾气，并从碳酸氢铵和碳酸铵的回收中获得显着的益处。 从作为富铵溶液的合成气的处理中回收氨和铵，其中至少一部分被再循环到发酵区以帮助生产液体产物。 通过发酵产生的富含二氧化碳的气体用于捕获氨和铵，形成富铵溶液。

公开(公告)号：US20130078689A1

公开(公告)日：2013-03-28

申请号：US13243426

申请日：2011-09-23

申请人： Robert Hickey

发明人： Robert Hickey

IPC分类号： C12P7/00 ,  C12P7/04 ,  C12M1/36 ,  C12P7/52 ,  C12P7/16 ,  C12M1/107 ,  C12P7/06 ,  C12P7/54

CPC分类号： C12P7/54 ,  C12M21/12 ,  C12M27/02 ,  C12M29/06 ,  C12P7/00 ,  C12P7/04 ,  C12P7/06 ,  C12P7/065 ,  C12P7/16 ,  C12P7/52 ,  Y02E50/10 ,  Y02E50/17 ,  Y02P20/582

摘要： Processes and apparatus are disclosed for the low energy, anaerobic bioconversion of hydrogen and carbon monoxide in a gaseous substrate stream to oxygenated organic compounds such as ethanol by contact with microorganisms in a deep, stirred tank fermentation system with high conversion efficiency of both hydrogen and carbon monoxide. Gas feed to the reactor is injected using a motive liquid to form a stable dispersion of microbubbles thereby reducing energy costs, and a portion of the off-gases from the reactor are recycled to (i) achieve a conversion of the total moles of carbon monoxide and hydrogen in the gas substrate to oxygenated organic compound of at least about 80 percent and (ii) attenuate the risk of carbon monoxide inhibition of the microorganism used for the bioconversion.

摘要翻译： 公开的方法和装置用于在气态底物物流中的氢和一氧化碳的低能，厌氧生物转化为氧化的有机化合物如乙醇，通过与氢气和碳的高转化效率的深层搅拌罐发酵系统中的微生物接触 一氧化碳 使用运动液体注入反应器的气体进料以形成稳定的微泡分散体，从而降低能量成本，并将一部分来自反应器的废气再循环至（i）实现一氧化碳总摩尔数的转化 和气体底物中的氢气至少约80％的氧化有机化合物，和（ii）减弱用于生物转化的微生物的一氧化碳抑制的风险。

公开(公告)号：US20130028827A1

公开(公告)日：2013-01-31

申请号：US13190355

申请日：2011-07-25

申请人： Robert Hickey

发明人： Robert Hickey

IPC分类号： C01C1/26

CPC分类号： C01C1/26 ,  C10G2300/1011 ,  C10K1/08 ,  Y02P30/20

摘要： The processes are utilized to recover ammonium from waste water using CO2 acidified absorption water. The process is particularly suited for utilization of cellular matter and a CO2 rich tail gas from a syngas fermentation process and derives significant benefit from the recovery of ammonium bicarbonate and ammonium carbonate. Ammonia and ammonium are recovered from the treatment of the syngas as an ammonium rich solution, at least a portion of which is recycled to the fermentation zone to aid in the production of liquid products. A carbon dioxide rich gas produced by fermentation is used to capture the ammonia and ammonium, forming the ammonium rich solution.

摘要翻译： 该方法用于使用CO2酸化吸收水从废水中回收铵。 该方法特别适用于从合成气发酵过程中利用细胞物质和富含CO 2的尾气，并从碳酸氢铵和碳酸铵的回收中获得显着的益处。 从作为富铵溶液的合成气的处理中回收氨和铵，其中至少一部分被再循环到发酵区以帮助生产液体产物。 通过发酵产生的富含二氧化碳的气体用于捕获氨和铵，形成富铵溶液。

公开(公告)号：US20120003707A1

公开(公告)日：2012-01-05

申请号：US12826991

申请日：2010-06-30

申请人： Robert Hickey ,  Mark Neville

发明人： Robert Hickey ,  Mark Neville

IPC分类号： C12P7/52 ,  C12P7/16 ,  C12P7/06 ,  C12P7/04

CPC分类号： C12P7/065 ,  C12M29/06 ,  Y02E50/17

摘要： A process for conversion of syngas to liquid products that serve as surface acting agents uses the gas stream at a relatively low pressure to eliminate the use of a compressor. The process uses a liquid stream as the primary energy input to a gas injector that intensely mixes gas and the liquid with reduced compression costs while the presence of the liquid product maintains the gas-liquid dispersion as it flows downward to build a static pressure head. The process lowers the required gas pressure by adjusting the elevation of the gas injector such that a conduit receives the gas-liquid dispersion from the outlet of the injector and confines it as it travels downward to enter the bottom of a column of liquid. The liquid product provides a surface acting agent that prolongs the creation and duration of microbubbles in the gas-liquid dispersion.

摘要翻译： 将合成气转化为用作表面作用剂的液体产物的方法使用相对较低压力的气流来消除压缩机的使用。 该过程使用液体流作为气体注入器的主要能量输入，其以降低的压缩成本强烈地混合气体和液体，同时液体产物的存在在其向下流动时保持气液分散体以构建静压头。 该过程通过调节气体注射器的高度来降低所需的气体压力，使得导管从喷射器的出口接收气液分散体，并在其向下行进时限制其进入液柱的底部。 液体产品提供了一种表面作用剂，其延长气 - 液分散体中微泡的产生和持续时间。

公开(公告)号：US4103546A

公开(公告)日：1978-08-01

申请号：US725666

申请日：1976-09-22

申请人： Robert Hickey ,  Erik Fahnoe

发明人： Robert Hickey ,  Erik Fahnoe

IPC分类号： A63B51/00 ,  G01L5/06

CPC分类号： A63B51/005 ,  G01L5/06

摘要： An inexpensive, accurate and portable gauge is disclosed for measuring the tension in the strings of a tennis racquet after it has been strung. The gauge includes a rigid frame supported across the head and an upper spring housing affixed to the frame and projecting toward the racquet face. A lower spring housing telescopically engages the upper housing which includes a pressure plate on its lower end for engaging a number of strings on the racquet face. A spring is disposed inside the upper and lower housings for biasing the pressure plate against the strings and an indicator on the upper and lower housings is calibrated to measure the force exerted by the tennis racquet strings on the spring by means of the pressure plate and thereby to provide an indication of the tension in the strings of the racquet.

摘要翻译： 公开了一种便宜，准确和便携的量具，用于测量网球拍串串后的张力。 该计量器包括支撑在头部上的刚性框架和固定到框架并朝向球拍面突出的上弹簧壳体。 下弹簧壳体可伸缩地接合上壳体，其在其下端包括压板，用于接合球拍面上的多个弦。 弹簧设置在上壳体和下壳体的内部，用于将压板偏置抵抗琴弦，并且上和下壳体上的指示器被校准以通过压板测量网球拍弦对弹簧施加的力，从而 以提供球拍琴弦中的张力的指示。