公开(公告)号：US20070004920A1

公开(公告)日：2007-01-04

申请号：US11479823

申请日：2006-06-29

申请人： Chuanshen Ge ,  George Muller ,  Roger Chen ,  Manohar Saindane

发明人： Chuanshen Ge ,  George Muller ,  Roger Chen ,  Manohar Saindane

IPC分类号： C07D403/04

CPC分类号： C07D401/04

摘要： The present invention provides new processes for the preparation of unsubstituted and substituted 4-amino-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione compounds which are usefuil, for example, for preventing or treating diseases or conditions related to an abnormally high level or activity of TNF-α. The invention can provide improved and/or efficient processes for the commercial production of unsubstituted and substituted 4-amino-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione compounds, including, but not limited to, unsubstituted 4-amino-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione.

摘要翻译： 本发明提供了制备用于预防或治疗疾病的用途的未取代和取代的4-氨基-2-（2,6-二氧代哌啶-3-基）异二氢吲哚-1,3-二酮化合物的新方法 或与异常高水平或TNF-α活性相关的病症。 本发明可以提供改进的和/或有效的商业生产未取代和取代的4-氨基-2-（2,6-二氧代哌啶-3-基）异二氢吲哚-1,3-二酮化合物的方法，包括但不限于 ，未取代的4-氨基-2-（2,6-二氧代哌啶-3-基）异二氢吲哚-1,3-二酮。

公开(公告)号：US07118017B1

公开(公告)日：2006-10-10

申请号：US10604103

申请日：2003-06-26

申请人： Brian Geraghty ,  Jack B. Ridenour ,  Roger Chen ,  Saeed David Barbat

发明人： Brian Geraghty ,  Jack B. Ridenour ,  Roger Chen ,  Saeed David Barbat

IPC分类号： B60R7/02 ,  B60R11/06 ,  B65D25/04

CPC分类号： B60R13/011 ,  B60R11/06

摘要： A trunk organizer for the trunk cavity of a police vehicle that forces the orientation of long, stiff items typically carried within the trunk cavity of police vehicles into a transversely extending orientation. The transverse orientation of these items typically found in police vehicle trunks reduces the likelihood of a high speed rear collision driving the items through the walls defining the trunk cavity, particularly the waterfall of the trunk cavity, into the fuel tank. The trunk organizer is preferably formed from high density polyethylene with a forward panel of Kevlar affixed to the front panel of the trunk organizer to provide further penetration resistance. Translucent lids provide a ready inspection of the items without requiring the opening of a compartment. The trunk organizer is sized and configured to fit snuggly within the trunk cavity of a conventional police vehicle and permits an easy removal therefrom.

摘要翻译： 用于警车的躯干腔的行李箱组件器，其强制通常在警车的行李箱内携带的长而僵硬的物品朝向横向延伸的取向。 这些通常在警车车厢中发现的物品的横向取向降低了高速后碰撞的可能性，即通过将躯干腔特别是躯干空腔的瀑布限定在燃料箱中的墙壁驱动物品。 树干组合器优选由高密度聚乙烯形成，其中Kevlar的前面板固定到主干组合器的前面板，以提供进一步的耐穿透性。 半透明的盖子可以方便地检查物品，而不需要打开隔间。 主干组织器的尺寸和构造适于紧贴在常规警车的躯干腔内，并允许从其中容易地移除。

公开(公告)号：US20060205787A1

公开(公告)日：2006-09-14

申请号：US11338688

申请日：2006-01-25

申请人： George Muller ,  Roger Chen

发明人： George Muller ,  Roger Chen

IPC分类号： A61K31/454

CPC分类号： A61K31/454 ,  Y02A50/411 ,  Y02A50/491

摘要： This invention relates to racemic and stereomerically pure 4-amino-2-(3-methyl-2,6-dioxopiperidin-3-yl)-isoindole-1,3-dione, and prodrugs, salts and solvates thereof. Synthesis, methods of use, and pharmaceutical compositions of racemic and stereomerically pure 4-amino-2-(3-methyl-2,6-dioxo-piperidine-3-yl)-isoindole-1,3-dione, and prodrugs, salts and solvates thereof, are disclosed.

摘要翻译： 本发明涉及外消旋和立体异构纯的4-氨基-2-（3-甲基-2,6-二氧代哌啶-3-基） - 异吲哚-1,3-二酮及其前药，盐和溶剂化物。 外消旋和立体异构纯的4-氨基-2-（3-甲基-2,6-二氧代 - 哌啶-3-基） - 异吲哚-1,3-二酮的合成，使用方法和药物组合物和前药，盐 及其溶剂化物。

公开(公告)号：US20050131024A1

公开(公告)日：2005-06-16

申请号：US11035817

申请日：2005-01-14

申请人： George Muller ,  David Stirling ,  Roger Chen

发明人： George Muller ,  David Stirling ,  Roger Chen

IPC分类号： A61K31/445 ,  A61K31/454 ,  A61P1/04 ,  A61P9/02 ,  A61P9/04 ,  A61P9/10 ,  A61P17/06 ,  A61P19/02 ,  A61P29/00 ,  A61P31/06 ,  A61P33/06 ,  A61P35/00 ,  A61P37/06 ,  A61P43/00 ,  C07D401/04 ,  C07D43/04

CPC分类号： C07D401/04

摘要： Substituted 2-(2,6-dioxopiperidin-3-yl)-phthalimides and 1-oxo-2-(2,6-dioxopiperidin-3-yl)isoindolines reduce the levels of TNFα in a mammal. A typical embodiment is 1-oxo-2-(2,6-dioxo-3-methylpiperidin-3-yl)-4,5,6,7-tetrafluoroisoindoline.

摘要翻译： 取代的2-（2,6-二氧代哌啶-3-基） - 邻苯二甲酰亚胺和1-氧代-2-（2,6-二氧代哌啶-3-基）异吲哚啉降低哺乳动物TNFalpha的含量。 典型的实施方案是1-氧代-2-（2,6-二氧代-3-甲基哌啶-3-基）-4,5,6,7-四氟异吲哚啉。

公开(公告)号：US6101076A

公开(公告)日：2000-08-08

申请号：US178251

申请日：1998-10-23

申请人： Edward Tsai ,  Roger Chen ,  Dean Jau

发明人： Edward Tsai ,  Roger Chen ,  Dean Jau

IPC分类号： G06F3/00 ,  G06F13/40 ,  H02H1/00

CPC分类号： G06F11/0745 ,  G06F13/4081 ,  G06F11/0793

摘要： An electromagnetic safety (EMS) enhancement circuit is provided for a USB (Universal Serial Bus) system, which can simulate an unplugging and replugging action so as to ensure continuous operation of the USB device after being disconnected from the USB interface due to electromagnetic interferences. The EMS enhancement circuit utilizes an EMS detection unit to detect the EMS condition of the data communication between the USB device and the USB interface; if abnormal, the EMS detection unit will output an overflow signal to a resume-control unit. The resume-control unit can output a pull-up control signal to a voltage pull-up circuit so as to control the voltage pull-up circuit in such a manner that, when the USB device is disconnected from the USB interface, the voltage pull-up circuit is first inhibited from outputting a voltage signal to one data line of the USB interface to thereby simulate an unplugging action and, after a preset time, be enabled again to output the voltage signal to thereby simulate a replugging action. The simulated unplugging and replugging action can then automatically reconnect the USB device to the USB interface for continuous operation of the USB device.

摘要翻译： 为USB（通用串行总线）系统提供电磁安全（EMS）增强电路，可以模拟拔插和重新插拔动作，以确保USB设备在与USB接口断开连接后由于电磁干扰而持续运行。 EMS增强电路利用EMS检测单元检测USB设备和USB接口之间的数据通信的EMS状况; 如果异常，EMS检测单元将向恢复控制单元输出溢出信号。 恢复控制单元可以将上拉控制信号输出到电压上拉电路，以便控制电压上拉电路，使得当USB设备从USB接口断开时，电压拉 首先禁止将电压信号输出到USB接口的一个数据线，从而模拟拔插动作，并且在预设时间之后再次启用以输出电压信号从而模拟重新插入动作。 然后，模拟拔插和重新插拔操作可以自动将USB设备重新连接到USB接口，以连续操作USB设备。

公开(公告)号：US11608523B2

公开(公告)日：2023-03-21

申请号：US15712763

申请日：2017-09-22

申请人： Jingyue Ju ,  Randall Davis ,  Roger Chen

发明人： Jingyue Ju ,  Randall Davis ,  Roger Chen

IPC分类号： C12Q1/6869 ,  G01N33/487

摘要： This disclosure provides systems and methods for sequencing nucleic acids using nucleotide analogues and translocation of tags from incorporated nucleotide analogues through a nanopore. In aspects, this disclosure is related to compositions, methods, and systems for sequencing nucleic acids using tag molecules and detection of translocation through a nanopore of tags released from incorporation of the molecule.

公开(公告)号：US20230010193A1

公开(公告)日：2023-01-12

申请号：US17856923

申请日：2022-07-01

申请人： Carl W. Fuller ,  Shiv Kumar ,  Jingyue Ju ,  Randall Davis ,  Roger Chen

发明人： Carl W. Fuller ,  Shiv Kumar ,  Jingyue Ju ,  Randall Davis ,  Roger Chen

IPC分类号： C12Q1/6874 ,  C07H19/10 ,  C07H19/20 ,  C07H17/02 ,  C12Q1/6806

摘要： This disclosure provides systems and methods for attaching nanopore-detectable tags to nucleotides. The disclosure also provides methods for sequencing nucleic acids using the disclosed tagged nucleotides.

公开(公告)号：US10176941B1

公开(公告)日：2019-01-08

申请号：US15666990

申请日：2017-08-02

申请人： Nicholas Ciulla ,  Roger Chen ,  Elvis Chen ,  Raymond Tse

发明人： Nicholas Ciulla ,  Roger Chen ,  Elvis Chen ,  Raymond Tse

IPC分类号： A63F13/24 ,  H01H13/84 ,  H05K5/00 ,  H01H13/70 ,  H01H21/22 ,  H01H89/00 ,  G06F3/0338

摘要： An electronic device controller assembly for ergonomic dual-handed control of the electronic device includes a housing. At least one circuit board is positioned in the housing. The at least one circuit board is configured to selectively and operationally couple to the electronic device. Each of a pair of sticks is pivotally coupled to and extends between the upper face of the housing and a bottom of a respective plate. Each plate is configured to position a respective hand of a user. A plurality of first buttons is coupled to the plates. The sticks and the first buttons are operationally coupled to the at least one circuit board. Each first button is configured to be depressed to selectively control a respective function of the electronic device. Each plate is positioned to compel an associated stick to pivot relative to the housing to signal a directional movement.

公开(公告)号：US09450701B2

公开(公告)日：2016-09-20

申请号：US13576939

申请日：2011-02-03

申请人： Manh H. Do ,  Roger Chen

发明人： Manh H. Do ,  Roger Chen

IPC分类号： H04L12/24 ,  H04L1/00 ,  H04L1/16 ,  H04L1/18

CPC分类号： H04L1/0002 ,  H04L1/0034 ,  H04L1/1607 ,  H04L1/1887 ,  Y02D50/10

摘要： There is provided a method of controlling a transmission rate of a data stream by a server transmitting the data stream to a client device over a network, the method comprising receiving a feedback message from the client, the feedback message containing information indicating a positive or negative acknowledgement of receipt for each one of a plurality of data packets of the data stream; calculating values of a plurality of metrics, wherein each of the values is indicative of transmission quality of the network and is calculated based at least in part on the information contained in the feedback message, and wherein the values include a first value of a first metric representing packet loss; and adjusting the transmission rate if at least one of the values satisfies a corresponding condition; wherein the first metric is prioritized among the plurality of metrics such that an adjustment of the transmission rate responsive to a second value of a second metric satisfying the corresponding condition is conditional on the first value of the first metric not satisfying the corresponding condition.

摘要翻译： 提供了一种控制由服务器通过网络向客户端设备发送数据流的数据流的传输速率的方法，该方法包括从客户端接收反馈消息，该反馈消息包含指示正或负的信息 确认数据流的多个数据分组中的每一个的接收; 计算多个度量的值，其中每个值指示网络的传输质量，并且至少部分地基于包含在反馈消息中的信息来计算，并且其中值包括第一度量的第一值 代表丢包; 以及如果所述值中的至少一个满足相应条件，则调整所述传输速率; 其中所述第一度量在所述多个度量中被优先化，使得响应于满足相应条件的第二度量的第二值的所述传输速率的调整以所述不满足相应条件的所述第一度量的所述第一值为条件。

公开(公告)号：US09352147B2

公开(公告)日：2016-05-31

申请号：US13022415

申请日：2011-02-07

申请人： Quynh Nguyen-Stella ,  Kenny Kinyen Chinn ,  John Michael Barker ,  Surekha B. Husmann ,  Roger Chen

发明人： Quynh Nguyen-Stella ,  Kenny Kinyen Chinn ,  John Michael Barker ,  Surekha B. Husmann ,  Roger Chen

IPC分类号： A61N1/05 ,  A61N1/36 ,  H01R4/36 ,  H01R24/58

CPC分类号： A61N1/0558 ,  A61N1/0551 ,  A61N1/057 ,  H01R4/36 ,  H01R24/58 ,  H01R2107/00 ,  H01R2201/12

摘要： A lead anchor includes a body defining a lead lumen having a first opening and a second opening through which a lead can pass. The body further defines a transverse lumen that intersects the lead lumen. An exterior member is disposed around at least a portion of the body. The exterior member is formed of a biocompatible material. A fastener anchors the lead to the body through the transverse lumen by deforming a portion of the lead. The transverse lumen is configured and arranged to receive the fastener. At least at least two suture tabs extend from the exterior member and are configured and arranged for receiving a suture to suture the lead anchor to patient tissue.

摘要翻译： 引线锚固体包括限定具有第一开口和引线可以穿过的第二开口的引导内腔的主体。 身体进一步限定了与引导腔相交的横向内腔。 外部构件围绕身体的至少一部分设置。 外部构件由生物相容性材料形成。 紧固件通过使引线的一部分变形来将引线锚定到身体通过横向内腔。 横向腔被构造和布置成接收紧固件。 至少两个缝合片从外部构件延伸，并且被构造和布置成用于接收缝合线以将引线锚缝合到患者组织。